Avaliação da resistência à ferrugem em progênies de cafeeiro F4 obtidas por cruzamentos de 'icatu' com catimor.

Com o objetivo de selecionar progênies de cafeeiro resistentes à ferrugem foram instalados e conduzidos experimentos em Três Pontas, São Sebastião do Paraíso e Machado. Foram avaliadas 17 progênies desenvolvidas pelo programa de Melhoramento Genético do Cafeeiro em Minas Gerais, coordenado pela EPAMIG e obtidas pelo cruzamento ?Icatu? x Catimor, e a cultivar Rubi MG 1192 utilizada como testemunha. O delineamento foi o de blocos casualizados com três repetições. Foram analisadas as características incidência da ferrugem no primeiro semestre de 2006.Os resultados obtidos permitem verificar que as progênies avaliadas apresentam variabilidade para a resistência a ferrugem, isso é confirmado pelas estimativas da herdabilidade que foram de boa magnitude, chegando até o valor de 92,8%. Essa condição aliada à baixa incidência da doença apresentada por algumas progênies, demonstrou que é possível selecionar progênies superiores em relação à resistência a ferrugem na população estudada

Schistosoma mansoni infection impairs reproduction in mice

AIM: To study the effect of S. mansoni infection in fertility using a mouse model. BACKGROUND: - Our group is listed in the Top 10 most publishing authors in the field of schistosomiasis as a cause of infertility; - Estrogen-like molecules produced by schistosomes haematobia and mansoni induce hormonal imbalances in infected persons; - These estrogenic metabolites down-regulate Estrogen Receptor in an in vitro model; - We have identified these estrogenic metabolites as catechol-estrogens (oxidative metabolites derived from estrogens); - These catechol-estrogens were found to be associated with infertility in women infected with S. haematobium.N/

Online Searching in PBL Tutorials

This study aims to explore how online searching plays a role during PBL tutorials in two undergraduate health sciences curricula, Medicine and Dentistry. Utilizing Interactional Ethnography (IE) as an organizing framework for data collection and analysis, and drawing on a critical theory of technology as an explanatory lens, enabled a textured understanding of student practices and beliefs regarding online searching during face-to-face PBL tutorials. Two event maps trace key transitions in learning regarding online searching in one cycle of problem-based learning in each program. From a critical perspective, analysis of students’ stimulated recall interviews indicated that the use of students’ personal mobile devices with online searching capacity is considered a dynamic pedagogically and socially constructed process. Online searching during the PBL process is also viewed as a “site-of-struggle” where there are challenges for first-year undergraduates when implementing such learning technologies in PBL tutorials

Difficulties inadaptationand academic performance in higher education: ananalysis in terms of vocational preferences and level of education

[Resumo] Assiste-se a urna maior sensibilidade por parte dos investigadores e autoridades académicas com as dificuldades de adaptaçao e de realizaçao dos estudantes do Ensino Superior. Tais dificuldades sao particularmente sentidas junto dos alunos do 10 ano. Um projecto de investigaçao neste dominio decorre na Universidade do Minho. Neste artigo apresentam- se alguns dados descritivos das dificuldades académicas de urna amostra portuguesa de estudantes do Ensino Superior (n=370), tomando-se quer o facto dos estudantes poderem ou nao estarem a frequentar o curso e estabelecimento de ensino correspondente a sua 1ª escolha vocacional, quer o ano escolar em que os estudantes se encontram. Os resultados sugerem que as dificuldades académicas nas áreas avaliadas nao se diferenciam de acordo com as opçoes vocacionais dos estudantes, muito embora algumas diferenzas sao encontradas quando comparamos os alunos dos anos iniciais e terminais do curso superior que frequentam

Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson´s disease patient with a triplication of the human SNCA genomic locus. In parallel, comparative studies were performed on two control lines derived from healthy individuals and lines generated from the patient iPS-derived neuroprogenitor lines infected with a lentivirus incorporating a small hairpin RNA to knock down the SNCA mRNA. The SNCA triplication lines exhibited a reduced capacity to differentiate into dopaminergic or GABAergic neurons and decreased neurite outgrowth and lower neuronal activity compared with control cultures. This delayed maturation phenotype was confirmed by gene expression profiling, which revealed a significant reduction in mRNA for genes implicated in neuronal differentiation such as delta-like homolog 1 (DLK1), gamma-aminobutyric acid type B receptor subunit 2 (GABABR2), nuclear receptor related 1 protein (NURR1), G-protein-regulated inward-rectifier potassium channel 2 (GIRK-2) and tyrosine hydroxylase (TH). The differentiated patient cells also demonstrated increased autophagic flux when stressed with chloroquine. We conclude that a two-fold overexpression of α-synuclein caused by a triplication of the SNCA gene is sufficient to impair the differentiation of neuronal progenitor cells, a finding with implications for adult neurogenesis and Parkinson´s disease progression, particularly in the context of bioenergetic dysfunction.Fil: Oliveira, L. M. A.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Falomir Lockhart, Lisandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Botelho, M. G.. Max-Planck-Institut für biophysikalische Chemie; Alemania. Universidade Federal do Rio de Janeiro; BrasilFil: Lin, K. H.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Wales, P.. Universität Göttingen; AlemaniaFil: Koch, J. C.. Universität Göttingen; AlemaniaFil: Gerhardt, Elizabeth. Universität Göttingen; AlemaniaFil: Taschenberger, H.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Outeiro, T. F.. Universität Göttingen; AlemaniaFil: Lingor, P.. Universität Göttingen; AlemaniaFil: Schüele, B.. The Parkinson’s Institute; Estados UnidosFil: Arndt Jovin, D. J.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Jovin, T. M.. Max-Planck-Institut für biophysikalische Chemie; Alemani