Measurements of SCRF cavity dynamic heat load in horizontal test system

The Horizontal Test System (HTS) at Fermilab is currently testing fully assembled, dressed superconducting radio frequency (SCRF) cavities. These cavities are cooled in a bath of superfluid helium at 1.8K. Dissipated RF power from the cavities is a dynamic heat load on the cryogenic system. The magnitude of heat flux from these cavities into the helium is also an important variable for understanding cavity performance. Methods and hardware used to measure this dynamic heat load are presented. Results are presented from several cavity tests and testing accuracy is discussed.Comment: 6 pp. Cryogenic Engineering Conference and International Cryogenic Materials Conference 28 Jun - 2 Jul 2009. Tucson, Arizon

Dynamic PID loop control

The Horizontal Test Stand (HTS) SRF Cavity and Cryomodule 1 (CM1) of eight 9-cell, 1.3GHz SRF cavities are operating at Fermilab. For the cryogenic control system, how to hold liquid level constant in the cryostat by regulation of its Joule-Thompson JT-valve is very important after cryostat cool down to 2.0 K. The 72-cell cryostat liquid level response generally takes a long time delay after regulating its JT-valve; therefore, typical PID control loop should result in some cryostat parameter oscillations. This paper presents a type of PID parameter self-optimal and Time-Delay control method used to reduce cryogenic system parameters' oscillation.Comment: 7 pp. Cryogenic Engineering Conference and International Cryogenic Materials Conference CEC-ICMC 2011, 13-17 June 2011. Spokane, Washingto

Examining decentralization and managerial decision making for child immunization program performance in India

Despite widespread adoption of decentralization reforms, the impact of decentralization on health system attributes, such as access to health services, responsiveness to population health needs, and effectiveness in affecting health outcomes, remains unclear. This study examines how decision space, institutional capacities, and accountability mechanisms of the Intensified Mission Indradhanush (IMI) in India relate to measurable performance of the immunization program. Data on decision space and its related dimensions of institutional capacity and accountability were collected by conducting structured interviews with managers based in 24 districts, 61 blocks, and 279 subcenters. Two measures by which to assess performance were selected: (1) proportion reduction in the DTP3 coverage gap (i.e., effectiveness), and (2) total IMI doses delivered per incremental USD spent on program implementation (i.e., efficiency). Descriptive statistics on decision space, institutional capacity, and accountability for IMI managers were generated. Structural equation models (SEM) were specified to detect any potential associations between decision space dimensions and performance measures. The majority of districts and blocks indicated low levels of decision space. Institutional capacity and accountability were similar across areas. Increases in decision space were associated with less progress towards closing the immunization coverage gap in the IMI context. Initiatives to support health workers and managers based on their specific contextual challenges could further improve outcomes of the program. Similar to previous studies, results revealed strong associations between each of the three decentralization dimensions. Health systems should consider the impact that management structures have on the efficiency and effectiveness of health services delivery. Future research could provide greater evidence for directionality of direct and indirect effects, interaction effects, and/or mediators of relationships

Role of dopamine in dorsal medial prefrontal cortex in yohimbine-induced reinstatement of food seeking in rats

In humans, relapse to maladaptive eating habits during dieting is often provoked by stress.Weadapted a drug relapse-reinstatement model to study the role of stress in relapse to food seeking (Nair et al., Prog. Neurobiol., 2009). In our model, the anxiogenic drug yohimbine, an alpha-2 adrenoceptor antagonist, that causes stress-like responses in humans and laboratory animals, reliably reinstates food seeking.Werecently found that yohimbine-induced reinstatement of food seeking is attenuated by systemic injections of SCH23390 (a D1-family receptor antagonist) but not clonidine (an alpha-2 adrenoceptor agonist). Here, we studied the role of the medial prefrontal cortex (mPFC) in yohimbine-induced reinstatement. We trained food-restricted rats to lever-press for 35% high-fat pellets every other day (9–15 3 h sessions). We then extinguished the food-reinforced operant responding for 10–14 days by removing the pellets. Subsequently, we tested the effect of systemic injections of yohimbine (0, 2 mg/kg) on reinstatement of food seeking. In Exp. 1we found that yohimbine-induced reinstatement was associated with strong induction of Fos (a marker of neuronal activity) in the dorsal mPFC and weaker Fos induction in the ventral mPFC. In Exp. 2 we found that dorsal but not ventral mPFC injections of the D1-family receptor antagonist SCH23390 (0.5, 1.0g/side) decreased yohimbine-induced reinstatement of food seeking. Our data indicate a critical role of dorsal mPFC dopamine in reinstatement food seeking induced by the pharmacological stressor yohimbine

Midtropospheric influences on boundary layer evolution in the Mexico City basin

Mexico City lies in a horseshoe-shaped basin at 2250 m AGL. These authors have simulated the effects of thermally-forced local to regional-scale circulation patterns on the ozone distribution within the basin. On most of the case days studied a relationship could be found between the spatial and temporal evolution of wind patterns and ozone concentration, particularly in the southwestern part of the basin. In this paper, the authors focus upon defining the relationship between the vertical structure of the atmosphere, by examining stability and wind shear, and the near surface pollution. This work was prompted by the need to better understand the role of midtropospheric flow in contributing to, or alleviating, the pollution problem in the basin. The role of vertical exchange processes in this locale has so far been only peripherally explored. From this investigation the authors hope to assess the importance of upper level winds in contributing to ventilation of pollutants out of the basin above the mountaintop level, in flushing the polluted airmass out of the basin, and in the development of basin-wide recirculation patterns. The results of preliminary data analyses are described

Harmonic Analysis of Boolean Networks: Determinative Power and Perturbations

Consider a large Boolean network with a feed forward structure. Given a probability distribution on the inputs, can one find, possibly small, collections of input nodes that determine the states of most other nodes in the network? To answer this question, a notion that quantifies the determinative power of an input over the states of the nodes in the network is needed. We argue that the mutual information (MI) between a given subset of the inputs X = {X_1, ..., X_n} of some node i and its associated function f_i(X) quantifies the determinative power of this set of inputs over node i. We compare the determinative power of a set of inputs to the sensitivity to perturbations to these inputs, and find that, maybe surprisingly, an input that has large sensitivity to perturbations does not necessarily have large determinative power. However, for unate functions, which play an important role in genetic regulatory networks, we find a direct relation between MI and sensitivity to perturbations. As an application of our results, we analyze the large-scale regulatory network of Escherichia coli. We identify the most determinative nodes and show that a small subset of those reduces the overall uncertainty of the network state significantly. Furthermore, the network is found to be tolerant to perturbations of its inputs

Water resources simulation in the Rio Grande basin using coupled models

Regional assessments of water resources under global climate change require models that can resolve management, land use, and climate effects. Los Alamos National Laboratory is developing a coupled model of water resources that places a river basin in its global context. The upper Rio Grande basin above El Paso, Texas is the testbed for this model. The model structure and computational approach are emphasize and issues such as nonlinear feedback between components and spatial and temporal scaling of processes are discussed. Using simulations of regional meteorology, the effects of high spatial resolution simulations on the distribution of precipitation are demonstrated

Fos-expressing neuronal ensemble in rat ventromedial prefrontal cortex encodes cocaine seeking but not food seeking in rats

Neuronal ensembles in ventromedial prefrontal cortex (vmPFC) play a role in both cocaine and palatable food seeking. However, it is unknown whether similar or different vmPFC neuronal ensembles mediate food and cocaine seeking. Here, we used the Daun02 inactivation procedure to assess whether the neuronal ensembles mediating food and cocaine seeking can be functionally distinguished. We trained male and female Fos-LacZ rats to self-administer palatable food pellets and cocaine on alternating days for 18 days. We then exposed the rats to a brief nonreinforced food- or cocaine-seeking test to induce Fos and β-gal in neuronal ensembles associated with food or cocaine seeking, respectively and infused Daun02 into vmPFC to ablate the β-gal-expressing ensembles. Two days later, we tested the rats for food or cocaine seeking under extinction conditions. Although inactivation of the food-seeking ensemble did not influence food or cocaine seeking, inactivation of the cocaine-seeking ensemble reduced cocaine seeking but not food seeking. Results indicate that the neuronal ensemble activated by cocaine seeking in vmPFC is functionally separate from the ensemble activated by food seeking

Secondary Gravity Waves Generated by Breaking Mountain Waves Over Europe

A strong mountain wave, observed over Central Europe on 12 January 2016, is simulated in 2D under two fixed background wind conditions representing opposite tidal phases. The aim of the simulation is to investigate the breaking of the mountain wave and subsequent generation of nonprimary waves in the upper atmosphere. The model results show that the mountain wave first breaks as it approaches a mesospheric critical level creating turbulence on horizontal scales of 8–30 km. These turbulence scales couple directly to horizontal secondary waves scales, but those scales are prevented from reaching the thermosphere by the tidal winds, which act like a filter. Initial secondary waves that can reach the thermosphere range from 60 to 120 km in horizontal scale and are influenced by the scales of the horizontal and vertical forcing associated with wave breaking at mountain wave zonal phase width, and horizontal wavelength scales. Large-scale nonprimary waves dominate over the whole duration of the simulation with horizontal scales of 107–300 km and periods of 11–22 minutes. The thermosphere winds heavily influence the time-averaged spatial distribution of wave forcing in the thermosphere, which peaks at 150 km altitude and occurs both westward and eastward of the source in the 2 UT background simulation and primarily eastward of the source in the 7 UT background simulation. The forcing amplitude is ∼2× that of the primary mountain wave breaking and dissipation. This suggests that nonprimary waves play a significant role in gravity waves dynamics and improved understanding of the thermospheric winds is crucial to understanding their forcing distribution