Use of Standardized Assessments and Online Resources in Stroke Rehabilitation

Background: The extent to which movement-related standardized assessments and online resources are used in stroke rehabilitation is unclear in the United States. Method: The researchers used a cross-sectional descriptive survey that examined (a) therapists use of movement-related standardized assessments, (b) factors influencing learning of new assessments, and (c) use of frequency of online resources by occupational therapists and physical therapists in the United States. Results: Of 151 respondents (46.4% occupational therapists, 53.6% physical therapists), the most frequently used movement-related assessments by occupational and physical therapists were the Berg and Fugl-Meyer Assessment, respectively. More physical therapists use motor-related standardized assessments regularly than occupational therapists, and physical therapists showed more consensus among standardized assessments. Both professions cited quality of patient care for motivating them to integrate outcome measures into practice. Most therapists in stroke rehabilitation used online resources to access movement-related standardized assessment content at least 25% of the time. The Rehabilitation Measures Database was the most frequently used website. Conclusion: Both occupational and physical therapists use online resources for movement-related standardized assessments on a regular basis. However, occupational therapists do not use standardized assessments as frequently as physical therapists. A systematic study of factors that impact the integration of standardized assessments is needed to further identify barriers and inform clinical practice change

Collective patterns arising out of spatio-temporal chaos

We present a simple mathematical model in which a time averaged pattern emerges out of spatio-temporal chaos as a result of the collective action of chaotic fluctuations. Our evolution equation possesses spatial translational symmetry under a periodic boundary condition. Thus the spatial inhomogeneity of the statistical state arises through a spontaneous symmetry breaking. The transition from a state of homogeneous spatio-temporal chaos to one exhibiting spatial order is explained by introducing a collective viscosity which relates the averaged pattern with a correlation of the fluctuations.Comment: 11 pages (Revtex) + 5 figures (postscript

Optical vernier technique for in-situ measurement of the length of long Fabry-Perot cavities

We propose a method for in-situ measurement of the length of kilometer size Fabry-Perot cavities in laser gravitational wave detectors. The method is based on the vernier, which occurs naturally when the laser incident on the cavity has a sideband. By changing the length of the cavity over several wavelengths we obtain a set of carrier resonances alternating with sideband resonances. From the measurement of the separation between the carrier and a sideband resonance we determine the length of the cavity. We apply the technique to the measurement of the length of a Fabry-Perot cavity in the Caltech 40m Interferometer and discuss the accuracy of the technique.Comment: LaTeX 2e, 12 pages, 4 figure

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum circumsporozoite protein (PfCSP). In contrast to the well-studied responses to the repeat region and the C-terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure. Here, we characterized the molecular recognition and functional efficacy of the N-CSP-specific monoclonal antibody 5D5. The crystal structure at 1.85 Åresolution revealed that 5D5 binds an α-helical epitope in N-CSP with high affinity through extensive shape and charge complementarity, and the unusual utilization of an N-linked glycan. Nevertheless, functional studies indicated low 5D5 binding to live Pf sporozoites, and lack of sporozoite inhibition in vitro and in mosquitoes. Overall, our data on low recognition and inhibition of sporozoites do not support the inclusion of the 5D5 epitope into the next generation of CSP-based vaccines.Summary Statement The Plasmodium falciparum sporozoite surface protein, PfCSP, is an attractive vaccine target, but the antibody response against the CSP N-terminal domain has remained understudied. Here, to guide immunogen design, Thai et al. provide insights into the binding motif and functional efficacy of the N-terminal domain-specific monoclonal antibody, 5D5

Dynamical Modeling of SAURON Galaxies

We describe our program for the dynamical modeling of early-type galaxies observed with the panoramic integral-field spectrograph SAURON. We are using Schwarzschild's numerical orbit superposition method to reproduce in detail all kinematical and photometric observables, and recover the intrinsic orbital structure of the galaxies. Since catastrophes are the most prominent features in the orbital observables, two-dimensional kinematical coverage is essential to constrain the dynamical models.Comment: 5 pages, 4 figures, LaTeX. Published in 2003, Carnegie Observatories Astrophysics Series, Vol. 1: Coevolution of Black Holes and Galaxies, ed. L. C. Ho (Pasadena: Carnegie Observatories, http://www.ociw.edu/ociw/symposia/series/symposium1/proceedings.html

Разработка и изготовление действующей модели роликовой транспортной системы для ГПС

There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2.3-fold;

What influences the speed of prototyping? An empirical investigation of twenty software startups

It is essential for startups to quickly experiment business ideas by building tangible prototypes and collecting user feedback on them. As prototyping is an inevitable part of learning for early stage software startups, how fast startups can learn depends on how fast they can prototype. Despite of the importance, there is a lack of research about prototyping in software startups. In this study, we aimed at understanding what are factors influencing different types of prototyping activities. We conducted a multiple case study on twenty European software startups. The results are two folds, firstly we propose a prototype-centric learning model in early stage software startups. Secondly, we identify factors occur as barriers but also facilitators for prototyping in early stage software startups. The factors are grouped into (1) artifacts, (2) team competence, (3) collaboration, (4) customer and (5) process dimensions. To speed up a startups progress at the early stage, it is important to incorporate the learning objective into a well-defined collaborative approach of prototypingComment: This is the author's version of the work. Copyright owner's version can be accessed at doi.org/10.1007/978-3-319-57633-6_2, XP2017, Cologne, German

How Do Software Startups Pivot? Empirical Results from a Multiple Case Study

In order to handle intense time pressure and survive in dynamic market, software startups have to make crucial decisions constantly on whether to change directions or stay on chosen courses, or in the terms of Lean Startup, to pivot or to persevere. The existing research and knowledge on software startup pivots are very limited. In this study, we focused on understanding the pivoting processes of software startups, and identified the triggering factors and pivot types. To achieve this, we employed a multiple case study approach, and analyzed the data obtained from four software startups. The initial findings show that different software startups make different types of pivots related to business and technology during their product development life cycle. The pivots are triggered by various factors including negative customer feedback.Comment: Conference publication, International Conference on Software Business (ICSOB'16), Sloveni

Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts

Tenidap (TD) was initially defined as a dual inhibitor of cyclooxygenase and lipoxygenase. This study was designed to assess its inhibitory activity against proinflammatory phospholipase A2. This study shows that TD inhibits the synthesis of pro-inflammatory secretory non-pancreatic phospholipase A2 (sPLA2). Concentrations as low as 0.25 μg/ml (0.725 μM) reduced the release of sPLA2 by 40% from foetal rat calvarial osteoblasts stimulated with IL-1β and TNFα, whereas a concentration of 2.5 μg/ml (7.25 μM) reduced the release by over 80%. TD also markedly reduced the release of sPLA2 from unstimulated cells. There was no direct inhibition of sPLA2 enzymatic activity by TD in vitro. Northern blot analysis showed that TD did not affect the sPLA2 mRNA levels; however, immunoblotting showed a dose-dependent reduction in sPLA2 enzyme. These results, together with a marked reduction in sPLA2 enzymatic activity, suggest that TD inhibits sPLA2 synthesis at the post-transcriptional level. Therefore TD seems to inhibit the arachidonic acid cascade proximally to cyclooxygenase and lipoxygenase and its anti-inflammatory activity may be related at least in part to the inhibition of sPLA2 synthesis

The SAURON project – XVII. Stellar population analysis of the absorption line strength maps of 48 early-type galaxies

The definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright Royal Astronomical SocietyWe present a stellar population analysis of the absorption line strength maps for 48 early-type galaxies from the SAURON sample. Using the line strength index maps of Hβ, Fe5015 and Mg b, measured in the Lick/IDS system and spatially binned to a constant signal-to-noise ratio, together with predictions from up-to-date stellar population models, we estimate the simple stellar population-equivalent (SSP-equivalent) age, metallicity and abundance ratio [α/Fe] over a two-dimensional field extending up to approximately one effective radius. A discussion of calibrations and differences between model predictions is given. Maps of SSP-equivalent age, metallicity and abundance ratio [α/Fe] are presented for each galaxy. We find a large range of SSP-equivalent ages in our sample, of which ∼40 per cent of the galaxies show signs of a contribution from a young stellar population. The most extreme cases of post-starburst galaxies, with SSP-equivalent ages of ≤3 Gyr observed over the full field-of-view, and sometimes even showing signs of residual star formation, are restricted to low-mass systems (σe≤ 100 km s−1 or ∼2 × 1010 M⊙). Spatially restricted cases of young stellar populations in circumnuclear regions can almost exclusively be linked to the presence of star formation in a thin, dusty disc/ring, also seen in the near-UV or mid-IR on top of an older underlying stellar population. The flattened components with disc-like kinematics previously identified in all fast rotators are shown to be connected to regions of distinct stellar populations. These range from the young, still star-forming circumnuclear discs and rings with increased metallicity preferentially found in intermediate-mass fast rotators, to apparently old structures with extended disc-like kinematics, which are observed to have an increased metallicity and mildly depressed [α/Fe] ratio compared to the main body of the galaxy. The slow rotators, often harbouring kinematically decoupled components (KDC) in their central regions, generally show no stellar population signatures over and above the well-known metallicity gradients in early-type galaxies and are largely consistent with old (≥10 Gyr) stellar populations. Using radially averaged stellar population gradients we find in agreement with Spolaor et al. a mass–metallicity gradient relation where low-mass fast rotators form a sequence of increasing metallicity gradient with increasing mass. For more massive systems (above ∼3.5 × 1010 M⊙) there is an overall downturn such that metallicity gradients become shallower with increased scatter at a given mass leading to the most massive systems being slow rotators with relatively shallow metallicity gradients. The observed shallower metallicity gradients and increased scatter could be a consequence of the competition between different star formation and assembly scenarios following a general trend of diminishing gas fractions and more equal-mass mergers with increasing mass, leading to the most massive systems being devoid of ordered motion and signs of recent star formation.Peer reviewe