148 research outputs found
Bostonia: The Boston University Alumni Magazine. Volume 12
Founded in 1900, Bostonia magazine is Boston University’s main alumni publication
CFD Approach to the Influence of Particle Size on Erosive Wear in Coal Riser Pipes
Pneumatic conveying of finely pulverised coal particles is an important process in the steelmaking industry, used to transport coal to the blast furnace. Erosive wear caused by high velocity particles impacting on the inner wall surfaces of pneumatic conveying riser pipes causes a severe problem in the steel-making industry. Continuous erosion left unmaintained eventually leads to pipe punctures. This paper aims to help minimise the erosive wear in industrial risers by investigating the effects of different particle sizes on the wear rates in industrial coal conveying ducts to control the grind size in industrial gas-solid flow processes and optimise reduced wear. Computational fluid dynamics (CFD) simulations and 4 semi empirical erosion models were used to analyse these effects, with an Eulerian-Lagrangian technique to model the multiphase gas-solid flow in the riser. The continuous phase (air) was modelled by solving Eulerian Reynolds-averaged Navier Stokes equations and the discrete phase (coal) was modelled using the Lagrangian discrete phase model (DPM) approach. The particle sizes investigated ranged from 1 to 1000 µm. The results showed the curves for each erosion model representing the changes in erosive wear with an increase in particle size for each erosion model. Every model showed similar curve shapes but varied in degree of wear rates. The curves of each model showed a steady increase in wear between particle diameters of 1 and 150 µm, followed by a sharp increase in wear at 200 µm, with the maximum erosion rates recorded between 300 and 350 µm. Subsequently, the wear rates began to drop, with a steady decrease in wear with particle diameters between 600 and 1000 µm. The behaviour of the curves was characterised by analysing the Stokes’ number and kinetic energy at each particle size. It was concluded that the sharp increase at 200 µm occurred, due to the number of particles (which possess sufficient kinetic energy) and the number density escaping the continuous phase and impacting the riser walls. Larger particles may have possessed greater individual kinetic energies; however, the fewer particles tend to impact the riser walls at higher particles sizes due to significantly lower number densities, resulting in a decrease in wear rates
Nordic Seas Heat Loss, Atlantic Inflow, and Arctic Sea Ice cover over the last century
Poleward ocean heat transport is a key process in the earth system. We detail and review the northward Atlantic Water (AW) flow, Arctic Ocean heat transport, and heat loss to the atmosphere since 1900 in relation to sea ice cover. Our synthesis is largely based on a sea ice-ocean model forced by a reanalysis atmosphere (1900-2018) corroborated by a comprehensive hydrographic database (1950-), AW inflow observations (1996-), and other long-term time series of sea ice extent (1900-), glacier retreat (1984-) and Barents Sea hydrography (1900-). The Arctic Ocean, including the Nordic and Barents Seas, has warmed since the 1970s. This warming is congruent with increased ocean heat transport and sea ice loss and has contributed to the retreat of marine-terminating glaciers on Greenland. Heat loss to the atmosphere is largest in the Nordic Seas (60% of total) with large variability linked to the frequency of Cold Air Outbreaks and cyclones in the region, but there is no long-term statistically significant trend. Heat loss from the Barents Sea (∼30%) and Arctic seas farther north (∼10%) is overall smaller, but exhibit large positive trends. The AW inflow, total heat loss to the atmosphere, and dense outflow have all increased since 1900. These are consistently related through theoretical scaling, but the AW inflow increase is also wind-driven. The Arctic Ocean CO2 uptake has increased by ∼30% over the last century - consistent with Arctic sea ice loss allowing stronger air-sea interaction and is ∼8% of the global uptake
The net effects of medical malpractice tort reform on health insurance losses: the Texas experience
In this paper, we examine the influence of medical malpractice tort reform on the level of private health insurance company losses incurred. We employ a natural experiment framework centered on a series of tort reform measures enacted in Texas in 2003 that drastically altered the medical malpractice environment in the state. The results of a difference-in-differences analysis using a variety of comparison states, as well as a difference-in-difference-in-differences analysis, indicate that ameliorating medical malpractice risk has little effect on health insurance losses incurred by private health insurers
International Commercial Arbitration: Fifty Years After the New York Convention
a one-day conference held at the Dean Rusk Center on January 30, 2009. The event, co-sponsored by the Georgia Journal of International and Comparative Law, featured Gary Born as keynote speaker and other leaders in the field of international commercial arbitration including Robert Davidson, Executive Director of JAMS Arbitration Practice; William K. Slate, II, President, American Arbitration Association; and Anne Marie Whitesell, Former Secretary General of the ICC International Court of Arbitration
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PATH-38. ROSETTE-FORMING GLIONEURONAL TUMOR IS DEFINED BY FGFR1 ACTIVATING ALTERATIONS WITH FREQUENT ACCOMPANYING PI3K AND MAPK PATHWAY MUTATIONS
Abstract
BACKGROUND
Rosette-forming glioneuronal tumor (RGNT) is an uncommon CNS tumor originally described in the fourth ventricle characterized by a low-grade glial neoplasm admixed with a rosette-forming neurocytic component.
METHODS
We reviewed clinicopathologic features of 42 patients with RGNT. Targeted next-generation sequencing was performed, and genome-wide methylation profiling is underway.
RESULTS
The 20 male and 22 female patients had a mean age of 25 years (range 3–47) at time of diagnosis. Tumors were located within or adjacent to the lateral ventricle (n=16), fourth ventricle (15), third ventricle (9), and spinal cord (2). All 31 tumors assessed to date contained FGFR1 activating alterations, either in-frame gene fusion, kinase domain tandem duplication, or hotspot missense mutation in the kinase domain (p.N546 or p.K656). While 7 of these 31 tumors harbored FGFR1 alterations as the solitary pathogenic event, 24 contained additional pathogenic alterations within PI3-kinase or MAP kinase pathway genes: 5 with additional PIK3CA and NF1 mutations, 4 with PIK3CA mutation, 3 with PIK3R1 mutation (one of which also contained focal RAF1 amplification), 5 with PTPN11 mutation (one with additional PIK3R1 mutation), and 2 with NF1 deletion. The other 5 cases demonstrated anaplastic features including hypercellularity and increased mitotic activity. Among these anaplastic cases, 3 harbored inactivating ATRX mutations and two harbored CDKN2A homozygous deletion, in addition to the FGFR1 alterations plus other PI3-kinase and MAP kinase gene mutations seen in those RGNT without anaplasia.
CONCLUSION
Independent of ventricular location, RGNT is defined by FGFR1 activating mutations or rearrangements, which are frequently accompanied by mutations involving PIK3CA, PIK3R1, PTPN11, NF1, and KRAS. Whereas pilocytic astrocytoma and ganglioglioma are characterized by solitary activating MAP kinase pathway alterations (e.g. BRAF fusion or mutation), RGNT are genetically more complex with dual PI3K-Akt-mTOR and Ras-Raf-MAPK pathway activation. Rare anaplastic examples may show additional ATRX and/or CDKN2A inactivation
Relational Quantum Mechanics
I suggest that the common unease with taking quantum mechanics as a
fundamental description of nature (the "measurement problem") could derive from
the use of an incorrect notion, as the unease with the Lorentz transformations
before Einstein derived from the notion of observer-independent time. I suggest
that this incorrect notion is the notion of observer-independent state of a
system (or observer-independent values of physical quantities). I reformulate
the problem of the "interpretation of quantum mechanics" as the problem of
deriving the formalism from a few simple physical postulates. I consider a
reformulation of quantum mechanics in terms of information theory. All systems
are assumed to be equivalent, there is no observer-observed distinction, and
the theory describes only the information that systems have about each other;
nevertheless, the theory is complete.Comment: Substantially revised version. LaTeX fil
Getting farming on the agenda: Planning, policymaking, and governance practices of urban agriculture in New York City
How and why is urban agriculture taken up into local food policies and sustainability plans? This paper uses a case study of urban agriculture policymaking in New York City from 2007 to 2011 to examine the power-laden operation of urban environmental governance. It explores several ‘faces of power,’ including overt authority, institutionalized ‘rules of the game,’ and hegemony. It also investigates how multiple actors interact in policymaking processes, including through the construction and use of broad discursive concepts. Findings draw upon analysis of policy documents and semi-structured interviews with 43 subjects engaged in food systems policymaking. Some municipal decision-makers questioned the significance of urban agriculture, due to the challenges of quantifying its benefits and the relative scarcity of open space in the developed city. Yet, these challenges proved insufficient to prevent a coalition of civic activists working in collaboration with public officials to envision plans on food policy that included urban agriculture. Actors created the ‘local/regional food system’ as a narrative concept in order to build broad coalitions and gain entry to the municipal policy sphere. Tracing the roll-out of plans reveals the way in which both the food systems concept and specific policy proposals were repeated and legitimized.Unpacking the dynamics of this iterative policymaking contributes to an understanding of how urban environmental governance happens in this case
The Virtual Sociality of Rights: The Case of Women\u27s Rights are Human Rights
This essay traces the relationship between activists and academics involved in the campaign for women\u27s rights as human rights as a case study of the relationship between different classes of what I call knowledge professionals self-consciously acting in a transnational domain. The puzzle that animates this essay is the following: how was it that at the very moment at which a critique of rights and a reimagination of rights as rights talk proved to be such fertile ground for academic scholarship did the same rights prove to be an equally fertile ground for activist networking and lobbying activities? The paper answers this question with respect to the work of self-reflexivity in creating a virtual sociality of rights
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