Quantum Key Distribution using Continuous-variable non-Gaussian States

In this work we present a quantum key distribution protocol using continuous-variable non-Gaussian states, homodyne detection and post-selection. The employed signal states are the Photon Added then Subtracted Coherent States (PASCS) in which one photon is added and subsequently one photon is subtracted. We analyze the performance of our protocol, compared to a coherent state based protocol, for two different attacks that could be carried out by the eavesdropper (Eve). We calculate the secret key rate transmission in a lossy line for a superior channel (beam-splitter) attack, and we show that we may increase the secret key generation rate by using the non-Gaussian PASCS rather than coherent states. We also consider the simultaneous quadrature measurement (intercept-resend) attack and we show that the efficiency of Eve's attack is substantially reduced if PASCS are used as signal states.Comment: We have included an analysis of the simultaneous quadrature measurement attack plus 2 figures; we have also clarified some point

Derivative expansion of quadratic operators in a general 't Hooft gauge

A derivative expansion technique is developed to compute functional determinants of quadratic operators, non diagonal in spacetime indices. This kind of operators arise in general 't Hooft gauge fixed Lagrangians. Elaborate applications of the developed derivative expansion are presented.Comment: 40 pages, to appear in Phys. Rev.

Feasibility of a Pulsed Ponderomotive Phase Plate for Electron Beams

We propose a scheme for constructing a phase plate for use in an ultrafast Zernike-type phase contrast electron microscope, based on the interaction of the electron beam with a strongly focused, high-power femtosecond laser pulse and a pulsed electron beam. Analytical expressions for the phase shift using the time-averaged ponderomotive potential and a paraxial approximation for the focused laser beam are presented, as well as more rigorous quasiclassical simulations based on the quantum phase integral along classical, relativistic electron trajectories in an accurate, non-paraxial description of the laser beam. The results are shown to agree well unless the laser beam is focused to a waist size below a wavelength. For realistic (off-the-shelf) laser parameters the optimum phase shift of $-\pi/2$ is shown to be achievable. When combined with RF-cavity based electron chopping and compression techniques to produce electron pulses, a femtosecond regime pulsed phase contrast microscope can be constructed. The feasibility and robustness of the scheme are further investigated using the simulations, leading to motivated choices for design parameters such as wavelength, focus size and polarization.Comment: 16 pages, 6 figure

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay

Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). Materials and Methods: Two DM 0.25% formulations {[}ointment (DM-o) and fatty ointment (DM-fo, water-free); class III corticosteroids], the corresponding active ingredient-free vehicles and three comparators of different strength {[}clobetasol propionate 0.05% (CP 0.05%), fatty ointment, class IV; hydrocortisone (HC) 1%, fatty ointment, class I, and betamethasone (BM) 0.05%, fatty ointment, class III] were tested using the vasoconstriction assay. The degree of vasoconstriction (blanching) in the treatment field was compared to the one found in untreated control fields using chromametric measurements and clinical assessment. Results/Conclusion: DM-o 0.25%, DM-fo 0.25% and BM 0.05% showed similar vasoconstrictive potential, i.e., clear blanching. In fact, both DM preparations were proven to be non-inferior to BM 0.05%, while CP 0.05% was found a little less active. HC 1.0% and the DM vehicles showed no clear-cut vasoconstrictive effect. No adverse events related to the study medications were observed. Good topical bioavailability of both DM formulations was detected by chromametric measurement and clinical assessment. Copyright (C) 2008 S. Karger AG, Basel

Deep subcutaneous application of poly-L-lactic acid as a filler for facial lipoatrophy in HIV-infected patients

Introduction: Facial lipoatrophy is a crucial problem of HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Poly-L-lactic acid (PLA), provided as New-Fill(R)/Sculptra(TM), is known as one possible treatment option. In 2004 PLA was approved by the FDA as Sculptra(TM) for the treatment of lipoatrophy of the face in HIV-infected patients. While the first trials demonstrated relevant efficacy, this was to some extent linked to unwanted effects. As the depth of injection was considered relevant in this context, the application modalities of the preparation were changed. The preparation was to be injected more deeply into subcutaneous tissue, after increased dilution. Material and Methods: To test this approach we performed a pilot study following the new recommendations in 14 patients. Results: While the efficacy turned out to be about the same, tolerability was markedly improved. The increase in facial dermal thickness was particularly obvious in those patients who had suffered from lipoatrophy for a comparatively small period of time. Conclusion: With the new recommendations to dilute PLA powder and to inject it into the deeper subcutaneous tissue nodule formation is a minor problem. However, good treatment results can only be achieved if lipoatrophy is not too intense; treatment intervals should be about 2 - 3 weeks. Copyright (C) 2005 S. Karger AG, Basel

Chiral Fermions on the Lattice through Gauge Fixing -- Perturbation Theory

We study the gauge-fixing approach to the construction of lattice chiral gauge theories in one-loop weak-coupling perturbation theory. We show how infrared properties of the gauge degrees of freedom determine the nature of the continuous phase transition at which we take the continuum limit. The fermion self-energy and the vacuum polarization are calculated, and confirm that, in the abelian case, this approach can be used to put chiral gauge theories on the lattice in four dimensions. We comment on the generalization to the nonabelian case.Comment: 31 pages, 5 figures, two refs. adde

Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1%

Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders. The purpose of the investigation presented here was to determine the noninferiority of a topical mometasone formulation, a light cream (O/W 60/40 emulsion) with mometasone furoate 0.1% (water content of 33%) versus marketed comparators. Using the vasoconstrictor assay, a strong blanching effect of the new cream (called Mometasone cream) comparable to that of a mometasone comparator, a fatty cream with mometasone furoate 0.1%, could be demonstrated. Thus, the topical bioavailability of the active ingredient mometasone furoate (0.1%) was regarded to be similar for Mometasone cream and the mometasone comparator. Using the psoriasis plaque test, a strong antipsoriatic effect comparable to that of the mometasone comparator was found for Mometasone cream after 12 days of occlusive treatment. A nearly identical reduction in the mean infiltrate thickness and similar mean AUC values were noted with both formulations confirmed by clinical assessment data. The noninferiority of Mometasone cream to its active comparator with re-spect to the AUC of change to baseline in infiltrate thickness was demonstrated. Both medications were well tolerated. Overall, Mometasone cream and the mometasone comparator showed similar efficacy and tolerability. Mometasone cream, in addition to its high potency and good tolerability, provides the properties of a light cream, which might make this new medication particularly suitable for application on acutely inflamed and sensitive skin. Copyright (C) 2012 S. Karger AG, Base

Inicio de pubertad y caracteres reproductivos en toritos Braford del nordeste argentino

El presente estudio tuvo como objetivo determinar la edad de inicio de pubertad en toritos Braford 3/8, por medio de la evaluación del semen, junto a mediciones de circunferencia escrotal y características zoométricas. Para tal fin, durante 120 días se trabajó con 34 animales, que fueron identificados por medio de caravana y destetados el 1° de marzo del año 2010, entre los 6 y 8 meses de edad. Los toritos fueron mantenidos a campo con pasturas implantadas, con amplio predominio de avena (Avena sativa), trébol blanco (Trifolium repens) y alfalfa (Medicago sativa), además de la administración de alimento balanceado a razón del 1 al 2% de su peso vivo. En forma seriada, cada 14 días a partir del mes de junio, se evaluaron parámetros como circunferencia escrotal, consistencia testicular (por palpación bimanual), altura a la cruz y al sacro, así como perímetro torácico y peso corporal individual. El semen extraído por medio de un electroeyaculador fue evaluado macro y microscópicamente. Se concluye que, en promedio, los toritos alcanzan la pubertad a la edad de 13,1 meses, con un peso promedio de 333 kg y una circunferencia escrotal de 27,5 cm.