A Multihorizon Approach for the Reliability Oriented Network Restructuring Problem, Considering Learning Effects, Construction Time, and Cables Maintenance Costs

This paper presents a techno-economic optimisation tool to study how the power system expansion decisions can be taken in a more economical and efficient way, by minimising the consequent costs of network reinforcement and reconfiguration. Analyses are performed to investigate how the network reinforcement and reconfiguration should be planned, within a time horizon of several years, by continuously keeping the network feasibility and ability to satisfy the load. The main contribution of this study is the inclusion of key features within the mathematical model to enhance the investment decision making process. A representative maintenance cost of existing cables and apparatus is included, to analyse the influence of the historical performance of the electric items on the investment decisions. A multihorizon methodology is developed to take into account the long term variation of the demand, combined with the long term variation of cables maintenance costs. Moreover, technological learning coefficients are considered, to take into account the investment costs reductions that arise when an investment in network restructuring and/or reconfiguration is repeated throughout the years. Finally, construction time constraints are included to find a proper investment scheduling that allows a feasible power flow, also during the years required to build a new connection or restructure an existing one. This study is also providing recommendations for future research directions within the power system reliability field. The analyses show the important and urgent need of proper methodologies for a better definition of cables projected maintenance costs and learning coefficients dedicated to network restructuring, reconfiguration and expansion.Comment: 22 pages, 21 figure

Mathematical Optimization Applied to Thermal and Electrical Energy Systems

This Thesis aims at building and discussing mathematical models applications focused on Energy problems, both on the thermal and electrical side. The objective is to show how mathematical programming techniques developed within Operational Research can give useful answers in the Energy Sector, how they can provide tools to support decision making processes of Companies operating in the Energy production and distribution and how they can be successfully used to make simulations and sensitivity analyses to better understand the state of the art and convenience of a particular technology by comparing it with the available alternatives. The first part discusses the fundamental mathematical background followed by a comprehensive literature review about mathematical modelling in the Energy Sector. The second part presents mathematical models for the District Heating strategic network design and incremental network design. The objective is the selection of an optimal set of new users to be connected to an existing thermal network, maximizing revenues, minimizing infrastructure and operational costs and taking into account the main technical requirements of the real world application. Results on real and randomly generated benchmark networks are discussed with particular attention to instances characterized by big networks dimensions. The third part is devoted to the development of linear programming models for optimal battery operation in off-grid solar power schemes, with consideration of battery degradation. The key contribution of this work is the inclusion of battery degradation costs in the optimisation models. As available data on relating degradation costs to the nature of charge/discharge cycles are limited, we concentrate on investigating the sensitivity of operational patterns to the degradation cost structure. The objective is to investigate the combination of battery costs and performance at which such systems become economic. We also investigate how the system design should change when battery degradation is taken into account

Educating the energy informatics specialist: opportunities and challenges in light of research and industrial trends

Contemporary energy research is becoming more interdisciplinary through the involvement of technical, economic, and social aspects that must be addressed simultaneously. Within such interdisciplinary energy research, the novel domain of energy informatics plays an important role, as it involves different disciplines addressing the socio-techno-economic challenges of sustainable energy and power systems in a holistic manner. The objective of this paper is to draw an overview of the novel domain of energy informatics by addressing the educational opportunities as well as related challenges in light of current trends and the future direction of research and industrial innovation. In this study we discuss the energy informatics domain in a way that goes beyond a purely scientific research perspective. This paper widens the analyses by including reflections on current and future didactic approaches with industrial innovation and research as a background. This paper provides key recommendations for the content of a foundational introductory energy informatics course, as well as suggestions on distinguishing features to be addressed through more specialized courses in the field. The importance of this work is based on the need for better guidelines for a more appropriate education of a new generation of experts who can take on the novel interdisciplinary challenges present in future integrated, sustainable energy systems

Transient hypercortisolism and symptomatic hyperthyroidism associated to primary hyperparathyroidism in an elderly patient: case report and literature review.

Abstract Background: Primary hyperparathyroidism (PHPT) is often found on routine blood tests, at a relatively asymptomatic stage. However many studies suggest different systemic effects related to PHPT, which could be enhanced by an abnormal cortisol release due to chronic stress of hyperparathyroidism. Being PHPT frequently found in the 6th to 7th decade of life, a careful and multifaceted approach should be taken. Case presentation: We report the case of an elderly patient with symptomatic PHPT and incidental pulmonary embolism. He was treated with hydration, zoledronic acid, cinacalcet and high-dose unfractionated heparin. Parathyroid surgery was successfully performed, but patient's conditions suddenly worsened because of a transient thyrotoxicosis, probably induced by a previous exposure to iodine load and/or thyroid surgical manipulation. A short-term treatment with beta-blockers was introduced for symptomatic relief. The patient also presented a transient hypercortisolism with elevated ACTH, likely due to stress related not only to aging and hospitalization but also to PHPT, resolved only four months after parathyroid surgery. Conclusion: Chronic hyperparathyroidism has been linked with increased all-cause mortality. A functional chronic hypercortisolism could be established, enhancing PHPT related disorders. Only parathyroid surgery has been demonstrated to cure PHPT and complications related, showing similar outcome between older and younger patients. However, the management of post-operative period should be more careful in fragile patients. In particular, the early diagnosis and treatment of a transient post-operative thyrotoxicosis could improve recovery. Due to the increase in prevalence and the evidence of many related complications even in asymptomatic PHPT, expert opinion-based guidelines for surgical treatment of PHPT should be developed especially for elderly patients

Surgical Therapy of Migraine and Tension-Type Headache

During the last few years, multiple studies have demonstrated the efficacy of migraine and tension-type headache trigger site deactivation surgery, hence expanding the therapeutic potentiality of plastic surgery. These procedures are performed based on headache onset and location: four trigger points that may cause the compression of the trigeminal branches have been described. In the present chapter, we describe indications, contraindications, procedures, and results of this therapy, focusing on our approach that relies on one 1-cm incision, and it is performed under local anesthesia

Reliability framework for power network assessment

Reliability of power system in terms of investments in network maintenance and restructuring for power distribution network has gained importance due to increase in distributed generation. To determine the reliability of the power distribution network, the state of power apparatus, losses in the network and consumer satisfaction indices are key factors. Considering the aforementioned, this paper proposes a holistic reliability framework for power distribution networks. The framework lists the following factors: life cycle of power apparatus, environmental and sociological, node reliability, arc reliability. A case study for reliability evaluation is performed on a modified IEEE 14 bus network. Furthermore, multiple scenarios of generation fault or outage are studied and results are presented. The key contribution of this paper is to present a novel and holistic reliability framework to model distribution network

Smart contract formation enabling energy-as-a-service in a virtual power plant

Energy as a service (EaaS) is an emerging business model that enables the otherwise passive energy consumers to play an active role and participate in the energy utility services. This platform is formed through smart contracts registering peer-to-peer (P2P) transactions of energy through price and quantity. Many industries, including finance, have already leveraged smart contracts to introduce digital currencies. At this time, the utility industry is faced with the challenge of how to structure smart contract formation in a local energy market. Specifically, they are faced with the challenge of maintaining a balance between energy generation and demand while enabling traceability, security, and unbiased peer-to-peer energy transactions, especially within a virtual power plant. This article aims at addressing the aforementioned challenges. In particular, this article investigates how to structure the microgrids in a local energy market, and how to ensure balance and resiliency with incomplete information. Taking various generation asset dimensions and demand profiles into account, simulations are performed. A novel evolutionary computing strategy to structure the simulation is proposed. A comparison is made among random order, random selection, profit-based ranking, and evolutionary strategy for coordinating the contract formation. The discussions draw attention to each method's advantages and disadvantages in terms of their value as a strategy for forming smart contracts in a local energy market

Astaxanthin Prevents Human Papillomavirus L1 Protein Binding in Human Sperm Membranes

Astaxanthin (Asta), red pigment of the carotenoid family, is known for its anti-oxidant, anti-cancer, anti-diabetic, and anti-inflammatory properties. In this study, we evaluated the effects of Asta on isolated human sperm in the presence of human papillomavirus (HPV) 16 capsid protein, L1. Sperm, purified by gradient separation, were treated with HPV16-L1 in both a dose and time-dependent manner in the absence or presence of 30 min-Asta pre-incubation. Effects of HPV16-L1 alone after Asta pre-incubation were evaluated by rafts (CTB) and Lyn dislocation, Tyr-phosphorylation (Tyr-P) of the head, percentages of acrosome-reacted cells (ARC) and endogenous reactive oxygen species (ROS) generation. Sperm membranes were also analyzed for the HPV16-L1 content. Results show that HPV16-L1 drastically reduced membrane rearrangement with percentage of sperm showing head CTB and Lyn displacement decreasing from 72% to 15.8%, and from 63.1% to 13.9%, respectively. Accordingly, both Tyr-P of the head and ARC decreased from 68.4% to 10.2%, and from 65.7% to 14.6%, respectively. Asta pre-incubation prevented this drop and restored values of the percentage of ARC up to 40.8%. No alteration was found in either the ROS generation curve or sperm motility. In conclusion, Asta is able to preserve sperm by reducing the amount of HPV16-L1 bound onto membranes

Post COVID-19 irritable bowel syndrome

Objectives: The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction after hospitalisation for SARS-CoV-2 infection. Design: GI-COVID-19 is a prospective, multicentre, controlled study. Patients with and without COVID-19 diagnosis were evaluated on hospital admission and after 1, 6 and 12 months post hospitalisation. Gastrointestinal symptoms, anxiety and depression were assessed using validated questionnaires. Results: The study included 2183 hospitalised patients. The primary analysis included a total of 883 patients (614 patients with COVID-19 and 269 controls) due to the exclusion of patients with pre-existing gastrointestinal symptoms and/or surgery. At enrolment, gastrointestinal symptoms were more frequent among patients with COVID-19 than in the control group (59.3% vs 39.7%, p<0.001). At the 12-month follow-up, constipation and hard stools were significantly more prevalent in controls than in patients with COVID-19 (16% vs 9.6%, p=0.019 and 17.7% vs 10.9%, p=0.011, respectively). Compared with controls, patients with COVID-19 reported higher rates of irritable bowel syndrome (IBS) according to Rome IV criteria: 0.5% versus 3.2%, p=0.045. Factors significantly associated with IBS diagnosis included history of allergies, chronic intake of proton pump inhibitors and presence of dyspnoea. At the 6-month follow-up, the rate of patients with COVID-19 fulfilling the criteria for depression was higher than among controls. Conclusion: Compared with controls, hospitalised patients with COVID-19 had fewer problems of constipation and hard stools at 12 months after acute infection. Patients with COVID-19 had significantly higher rates of IBS than controls. Trial registration number: NCT04691895