2,626 research outputs found
A description of gametogenesis in the panga Pterogymnus laniarius (Pisces: Sparidae) with comments on changes in maturity patterns over the past two decades
A description of gametogenesis in the panga Pferogymnus laniarius, a common endemic seabream species inhabiting the Agulhas Bank, South Africa, is presented. After sexual maturity, oogenesis and spermatogenesis continued throughout the year and were found to be similar to these processes in other seabream species and teleosts in general. Analysis of maturity data over the past two decades revealed a significant change in both age and size-at-maturity, a response to fishing pressure.S. Afr. J. Zool. 1997,32(2
Assessment of the monkfish Lophius vomerinus resource off Namibia
The Lophius vomerinus component of the monkfish resource off Namibia was assessed by means of deterministic length- and age-based models. Steady state length cohort analyses illustrated that, although the model was sensitive to the rate of natural mortality, it was relatively insensitive to changes in terminal fishing mortality. These biases may, however, not be serious provided that estimates of abundance are used to reflect relative changes in the biomass dynamics of the population. The age-structured production model, tuned to trends in General-Linear-Modelling-standardized catch-per-unit-effort data and relative abundance indices calculated from hake (Merluccius spp.) biomass surveys, together with observed commercial and survey catches-at-age, showed similar trends. Both models provided evidence that the monkfish resource was fully to overexploited, with current harvesting levels higher than those concomitant with sustainable yields.Keywords: age-structured production model, length-based cohort analysis, Lophius vomerinus, NamibiaAfrican Journal of Marine Science 2001, 23: 275–29
Quantifying commercial catch and effort of monkfish Lophius vomerinus and L. Vaillanti off Namibia
Abundance and exploitation patterns of monkfish Lophius vomerinus and L. vaillanti were investigated for use as inputs into a stock assessment framework to be used for management of the Namibian monkfish resource. Total numbers of monkfish caught per size-class were estimated using industry records of tail products classified into six commercial categories. The proportions per category varied each year. Analysis of the commercial data suggests that large numbers of juvenile monkfish are harvested annually. Catch-per-unit-effort (cpue) data of vessels targeting monkfish and sole (the two species are combined in terms of Namibian fleet legislation) for the period 1991–1999 were analysed using two different methods to construct indices of abundance. Both indices, one standardized on vessel horsepower and the other standardized by means of a Generalized Linear Model, showed an increase in catch rate of monkfish from 1991 to 1994 and between 1996 and 1998, but a decline from 1994 to 1996 as well as during 1999. Conversion factors for landed or tail weight to whole weight for four different tail products of monkfish were estimated. Results obtained from the study suggest that the factor of 3.04 currently applied in Namibia to all tail-weight classes is not appropriate for the current fishery and needs
to be amended. For management purposes it is also suggested that four different conversion factors, one for each monkfish tail product, be implemented.Keywords: catch per unit effort, Generalized Linear Model, Lophius vaillanti, Lophius vomerinus, monkfish, weight conversion factorsAfrican Journal of Marine Science 2001, 23: 291–30
Biology of the redspotted tonguesole Cynoglossus Zanzibarensis (Pleuronectiformes: Cynoglossidae) on the Agulhas bank, South Africa
The biology of the redspotted tonguesole Cynoglossus zanzibarensis, a common African cynoglossid inhabiting the Agulhas Bank, South Africa, is described. Growth studies based on sectioned sagittal otoliths revealed that C. zanzibarensis is relatively fast-growing and long-lived, attaining ages >8 years. Growth in length was rapid in immature fish, fish attaining 56% of their maximum size within their first year. By sexual maturity, fish had attained 28% of their maximum age and 68% of their maximum length. Total length-at-age was best described by the Von Bertalanffy growth model with combined-sex growth described as Lt = 354.78(1–e-0.43 (t+1.17)) mm TL. Sexually dimorphic growth patterns were evident, females attaining larger lengths, but at a slower growth rate than males. Despite the similar mean size of adult fish, the trawl-sampled adult population was dominated by females, with a sex ratio of 1 male:2.4 females. Female C. zanzibarensis mature in their second year of life (275 mm TL), after which they spawn small, pelagic eggs throughout the year. Approximations of the rates of total, natural and fishing mortality were estimated to be 0.62, 0.48 and 0.14 year-1 respectively
Considerations on the feasibility of a directed fishery for Panga pterogymnus laniarius (Pisces: sparidae)
Recent assessments of the status of the panga Pterogymnus laniarius stock on the Agulhas Bank, South Africa, showed that catches could be sustained at considerably higher levels than those harvested at present. Although the stock could be successfully harvested using available fishing methods, the sympatry of this species with other commercial species, such as shallow-water Cape hake Merluccius capensis, Cape horse mackerel Trachurus trachurus capensis and other deep-reef species was of concern, because these species would form a significant bycatch in a panga-directed fishery. These findings highlight the problems of bycatch management and emphasize the need for creativity by both scientists and fishers in designing new and improved methods for selectively exploiting bycatch fish resources
Evidence of a past disc-disc encounter: HV and DO Tau
© 2018 The Author(s). Published by Oxford University Press on behalf of The Royal Astronomical Society. Theory and observations suggest that star formation occurs hierarchically due to the fragmentation of giant molecular clouds. In this case we would expect substructure and enhanced stellar multiplicity in the primordial cluster. This substructure is expected to decay quickly in most environments, however historic stellar encounters might leave imprints in a protoplanetary disc (PPD) population. In a low-density environment such as Taurus, tidal tails from violent star-disc or disc-disc encounters might be preserved over timescales sufficient to be observed. In this work, we investigate the possibility that just such an event occurred between HV Tau C (itself a component of a triple system) and DO Tau ~0.1 Myr ago, as evidenced by an apparent 'bridge' structure evident in the 160 μ m emission. By modelling the encounter using smoothed particle hydrodynamics (SPH) we reproduce the main features of the observed extended structure ('V'-shaped emission pointing west of HV Tau and a tail-like structure extending east of DO Tau). We suggest that HV Tau and DO Tau formed together in a quadruple system on a scale of ~5000 au (0.025 pc)
Immune Reconstitution After Gene Therapy Approaches in Patients With X-Linked Severe Combined Immunodeficiency Disease
X-linked severe immunodeficiency disease (SCID-X1) is an inherited, rare, and life-threating disease. The genetic origin is a defect in the interleukin 2 receptor γ chain (IL2RG) gene and patients are classically characterized by absence of T and NK cells, as well as presence of partially-functional B cells. Without any treatment the disease is usually lethal during the first year of life. The treatment of choice for these patients is hematopoietic stem cell transplantation, with an excellent survival rate (>90%) if an HLA-matched sibling donor is available. However, when alternative donors are used, the success and survival rates are often lower. Gene therapy has been developed as an alternative treatment initially using γ-retroviral vectors to correct the defective γ chain in the absence of pre-conditioning treatment. The results were highly promising in SCID-X1 infants, showing long-term T-cell recovery and clinical benefit, although NK and B cell recovery was less robust. However, some infants developed T-cell acute lymphoblastic leukemia after the gene therapy, due to vector-mediated insertional mutagenesis. Consequently, considerable efforts have been made to develop safer vectors. The most recent clinical trials using lentiviral vectors together with a low-dose pre-conditioning regimen have demonstrated excellent sustained T cell recovery, but also B and NK cells, in both children and adults. This review provides an overview about the different gene therapy approaches used over the last 20 years to treat SCID-X1 patients, particularly focusing on lymphoid immune reconstitution, as well as the developments that have improved the process and outcomes
Sources of uncertainty in future projections of the carbon cycle
This is the final version of the article. Available from the publisher via the DOI in this record.The inclusion of carbon cycle processes within CMIP5 Earth System Models provides the opportunity to explore the relative importance of differences in scenario and climate model representation
to future land and ocean carbon fluxes. A two-way ANOVA approach was used to quantify the
variability owing to differences between scenarios and between climate models at different lead
times.
For global ocean carbon fluxes, the variance attributed to differences between Representative
Concentration Pathway scenarios exceeds the variance attributed to differences between climate
models by around 2025, completely dominating by 2100. This contrasts with global land carbon
fluxes, where the variance attributed to differences between climate models continues to dominate
beyond 2100. This suggests that modelled processes that determine ocean fluxes are currently
better constrained than those of land fluxes, thus we can be more confident in linking different
future socio-economic pathways to consequences of ocean carbon uptake than for land carbon
uptake.
The apparent agreement in atmosphere-ocean carbon fluxes, globally, masks strong climate
model differences at a regional level. The North Atlantic and Southern Ocean are key regions,
where differences in modelled processes represent an important source of variability in projected
regional fluxesMOHC authors were supported by the Joint DECC / Defra Met Office Hadley Centre Cli-
mate Programme (GA01101). SY was supported by the Hong Kong Polytechnic University grant
“Bayesian Modelling for Quantifying Uncertainty in Climate Predictions” (1-ZV9Z). We acknowl-
edge use of R software package (R Core Team 2013). We acknowledge the World Climate Re-
search Programme’s Working Group on Coupled Modelling, which is responsible for CMIP and
we thank the climate modelling groups for providing their GCM output (listed in Table 1). Support
of this dataset was provided by the Office of Science, U.S. Department of Energy
The origin of the eccentricity of the hot Jupiter in CI Tau
Following the recent discovery of the first radial velocity planet in a star
still possessing a protoplanetary disc (CI Tau), we examine the origin of the
planet's eccentricity (e ). We show through long timescale (
orbits) simulations that the planetary eccentricity can be pumped by the disc,
even when its local surface density is well below the threshold previously
derived from short timescale integrations. We show that the disc may be able to
excite the planet's orbital eccentricity in a Myr for the system parameters
of CI Tau. We also perform two planet scattering experiments and show that
alternatively the observed planet may plausibly have acquired its eccentricity
through dynamical scattering of a migrating lower mass planet, which has either
been ejected from the system or swallowed by the central star. In the latter
case the present location and eccentricity of the observed planet can be
recovered if it was previously stalled within the disc's magnetospheric cavity.This work has been supported by the DISCSIM project, grant agreement 341137 funded by the European Research Council under ERC-2013-ADG, and from STFC through grant ST/L000636/1. This work used the DIRAC Shared Memory Processing and Data Analytic systems, both at the University of Cambridge and operated, respectively, by the COSMOS Project at the Department of Applied Mathematics and Theoretical Physics and the Cambridge High Performance Computing Service, on behalf of the STFC DiRAC HPC Facility (www.dirac.ac.uk). This equipment was funded by BIS National E-infrastructure capital grants ST/J005673/1 and ST/K001590/1, STFC capital grants ST/H008586/1, ST/H008861/1 and ST/H00887X/1, STFC DiRAC Operations grant ST/K00333X/1, and STFC DiRAC Operations grant ST/K00333X/1. DiRAC is part of the National E-Infrastructure.This is the final version of the article. It first appeared from Oxford University Press via https://doi.org/10.1093/mnrasl/slw18
T Cell Gene Therapy Corrects Humoral and Cytotoxic Defects in X-Linked Lymphoproliferative Disease (XLP)
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