Forty-seven Years of Research on the Devon Island Ice Cap, Arctic Canada

The Devon Island ice cap has been the subject of scientific study for almost half a century, beginning with the first mass balance measurements in 1961. Research on the ice cap was the first to investigate (1) the role of meltwater in seasonal ice-velocity variations on a polythermal Arctic ice cap, (2) the use of air temperature rather than net radiation as a proxy for the energy driving surface melt, and (3) the influence of the changing frequency of specific synoptic weather configurations on glacier melt and mass balance. Other research has included investigations of ice cap geometry, flow dynamics, and mass balance; ice core analyses for records of past climate and contaminant deposition; and studies of changes in ice cap area and volume and their relationship to surface mass balance and ice dynamics. Current research includes ground studies connected to efforts to calibrate and validate the radar altimeter that will be carried by the European Space Agency’s (ESA) CryoSat2 satellite, and a major collaborative Canadian International Polar Year (IPY) project focused on the Belcher Glacier, on the northeast side of the ice cap, that examines hydrodynamics of large tidewater glaciers. This paper summarizes our current knowledge of the Devon Island ice cap and identifies some of the outstanding questions that continue to limit our understanding of climate-ice cap interactions in Arctic regions.La calotte glaciaire de l’île Devon fait l’objet d’une étude scientifique depuis près d’un demi-siècle, les premières mesures du bilan massique remontant à 1961. C’est la première fois que des travaux de recherche sur la calotte glaciaire permettent de faire enquête sur 1) le rôle de l’eau de fonte dans les variations caractérisant la vélocité de la glace d’une calotte glaciaire polytherme de l’Arctique; 2) l’utilisation de la température de l’air au lieu du bilan radiatif en surface en guise d’approximation pour la fonte superficielle conductrice d’énergie, et 3) l’influence exercée par la fréquence changeante de configurations climatiques synoptiques spécifiques sur la fonte du glacier et le bilan massique. Parmi les autres travaux de recherche, notons des enquêtes sur la géométrie de la calotte glaciaire, la dynamique des débits d’écoulement et le bilan massique; l’analyse des enregistrements relatifs aux carottes glaciaires en ce qui a trait à d’anciens dépôts climatiques et dépôts de contaminants; et l’étude des changements caractérisant l’aire et le volume de la calotte glaciaire de même que leur relation par rapport au bilan massique en surface et à la dynamique des glaces. Par ailleurs, les travaux de recherche actuels prennent la forme d’études sur le terrain se rapportant aux efforts visant à calibrer et à valider l’altimètre radar, études qui seront effectuées par le satellite CryoSat2 de l’Agence spatiale européenne (ASE), et un projet d’envergure en collaboration avec l’Année polaire internationale (API) au Canada portant sur le glacier Belcher, du côté nord-est de la carotte glaciaire, projet qui examine l’hydrodynamique des gros glaciers de marée. La présente communication résume nos connaissances actuelles de la calotte glaciaire de l’île Devon de même que certaines des questions en suspens qui continuent de restreindre la façon dont nous comprenons les interactions entre le climat et la calotte glaciaire dans les régions arctiques

Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium : 2020 update

To guide health care professionals in Belgium in selecting the appropriate antiepileptic drugs (AEDs) for their epilepsy patients, a group of Belgian epilepsy experts developed recommendations for AED treatment in adults and children (initial recommendations in 2008, updated in 2012). As new drugs have become available, others have been withdrawn, new indications have been approved and recommendations for pregnant women have changed, a new update was pertinent. A group of Belgian epilepsy experts (partly overlapping with the group in charge of the 2008/2012 recommendations) evaluated the most recent international guidelines and relevant literature for their applicability to the Belgian situation (registration status, reimbursement, clinical practice) and updated the recommendations for initial monotherapy in adults and children and add-on treatment in adults. Recommendations for add-on treatment in children were also included (not covered in the 2008/2012 publications). Like the 2008/2012 publications, the current update also covers other important aspects related to the management of epilepsy, including the importance of early referral in drug-resistant epilepsy, pharmacokinetic properties and tolerability of AEDs, comorbidities, specific considerations in elderly and pregnant patients, generic substitution and the rapidly evolving field of precision medicine

Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

The management of the dysbiosed gut microbiota in inflammatory bowel diseases (IBD) is gaining more attention as a novel target to control this disease. Probiotic treatment with butyrate-producing bacteria has therapeutic potential since these bacteria are depleted in IBD patients and butyrate has beneficial effects on epithelial barrier function and overall gut health. However, studies assessing the effect of probiotic supplementation on microbe-microbe and host-microbe interactions are rare. In this study, butyrate-producing bacteria (three mono-species and one multispecies mix) were supplemented to the fecal microbial communities of ten Crohn's disease (CD) patients in an in vitro system simulating the mucus-and lumen-associated microbiota. Effects of supplementation in short-chain fatty acid levels, bacterial colonization of mucus environment and intestinal epithelial barrier function were evaluated. Treatment with F. prausnitzii and the mix of six butyrate-producers significantly increased the butyrate production by 5-11 mol%, and colonization capacity in mucus-and lumen-associated CD microbiota. Treatments with B. pullicaecorum 25-3(T) and the mix of six butyrate-producers improved epithelial barrier integrity in vitro. This study provides proof-of-concept data for the therapeutic potential of butyrate-producing bacteria in CD and supports the future preclinical development of a probiotic product containing butyrate-producing species

Teaching higher education staff to understand and support autistic students: evaluation of a novel training program

BackgroundAutistic students are particularly vulnerable to stressors within a university environment and are more likely to experience poor mental health than their non-autistic peers. Students’ experiences of stigma from staff and peers, and the masking behaviors they deploy to minimize it, can also result in worsening mental health. Despite these concerns, there is a lack of tailored support for autistic students at university. The current project assesses a co-created training course for university staff focused on debunking stereotypes, educating about the autistic experience at university, mental health presentation among autistic individuals, and practical strategies to improve interactions with autistic students.MethodsThe Autism Stigma and Knowledge Questionnaire [ASK-Q] was administered before and after the training, to examine changes in trainees’ understanding and acceptance of autism and autistic people. Post-training interviews and surveys were also conducted with trainees, covering the impact the training has had on their perceptions of autism, the strategies they found beneficial, and how they will use the materials in future.ResultsThere were no statistically significant differences between pre- and post-training scores on the ASK-Q, likely due to ceiling effects as pre-training scores were high. Thematic analysis of interviews identified five themes: value of lived experience; developing nuanced, in-depth knowledge of autism; training as acceptable and feasible; links to professional practice; and systemic barriers.ConclusionAlthough ceiling effects meant there were no changes to participant’s knowledge about autism and autistic people statistically, the qualitative data reveals the extensive benefits they gained from taking part in the training programs. Scoring highly on the ASK-Q did not mean that people could not learn important new information and benefit from the course. This more nuanced understanding of autism led to practical changes in their practice. Listening to and learning from autistic people was seen as particularly important, highlighting the value of co-production. Our results also emphasize the need for varied approaches to evaluating training effectiveness, as reliance on quantitative data alone would have missed the subtler, but impactful, changes our participants experienced. This has important implications for professional practice, both within higher education and more broadly

Numerical Methods for the Stochastic Landau-Lifshitz Navier-Stokes Equations

The Landau-Lifshitz Navier-Stokes (LLNS) equations incorporate thermal fluctuations into macroscopic hydrodynamics by using stochastic fluxes. This paper examines explicit Eulerian discretizations of the full LLNS equations. Several CFD approaches are considered (including MacCormack's two-step Lax-Wendroff scheme and the Piecewise Parabolic Method) and are found to give good results (about 10% error) for the variances of momentum and energy fluctuations. However, neither of these schemes accurately reproduces the density fluctuations. We introduce a conservative centered scheme with a third-order Runge-Kutta temporal integrator that does accurately produce density fluctuations. A variety of numerical tests, including the random walk of a standing shock wave, are considered and results from the stochastic LLNS PDE solver are compared with theory, when available, and with molecular simulations using a Direct Simulation Monte Carlo (DSMC) algorithm

How accurate is your model between boreholes? Using shallow geophysics to test the best method to model buried tunnel valleys in Scotland, UK

The accuracy and uncertainty of geological models is becoming increasingly of interest as more and more end users rely on them for subsurface prediction. Since 2001 the British Geological Survey has published a National Superficial Deposit Thickness Model (SDTM) derived by interpolation of borehole data. It includes all deposits of fluvial, glacial, marine, residual, aeolian or anthropogenic in origin. It is know that this model is poor at identifying features such as buried tunnel valleys and overfilled bedrock depressions. Here we explore the characterisation of these features using an example from central Scotland, and test whether alternative modelling methodologies enhance our ability to predict the geometry of these features. This study we focus on the Ochil’s buried tunnel valley, east of Stirling in central Scotland. In the UK Superficial Thickness model, the Ochil’s trough is not completely resolved; there are apparent gaps in the longitudinal continuity in areas with no borehole data. To examine the degree to which the method of interpolation has affected the surface morphology, two additional interpolation methods were applied to the SDTM borehole dataset: Direct Triangulation and Implicit Geological Gridding. To test the accuracy of the different interpolation methods we used a TROMINO® passive seismic instrument to provide geophysical constraint on the bedrock surface. The results reveal that in the apparent gaps the SDTM and Direct Triangulation methods underestimated the thickness of superficial deposits by between 50-60 m. The Implicit Geological Grid, however, overestimated the thickness of superficial deposits by only 16 m. This raises the question should we consider using different gridding methods for different buried surfaces

Influenza A Virus Infections in Land Birds, People’s Republic of China

Water birds are considered the reservoir for avian influenza viruses. We examined this assumption by sampling and real-time reverse transcription–PCR testing of 939 Asian land birds of 153 species. Influenza A infection was found, particularly among migratory species. Surveillance programs for monitoring spread of these viruses need to be redesigned