Improving Nutrition and Health through Non-timber Forest Products in Ghana

Nutrition and health are fundamental pillars of human development across the entire life-span. The potential role of non-timber forest products (NTFPs) in improving nutrition and health and reduction of poverty has been recognized in recent years. NTFPs continue to be an important source of household food security, nutrition, and health. Despite their significant contribution to food security, nutrition, and sustainable livelihoods, these tend to be overlooked by policy-makers. NTFPs have not been accorded adequate attention in development planning and in nutrition-improvement programmes in Ghana. Using exploratory and participatory research methods, this study identified the potentials of NTFPs in improving nutrition and food security in the country. Data collected from the survey were analyzed using the SPSS software (version 16.0). Pearson's correlation (p<0.05) showed that a significant association exists between NTFPs and household food security, nutrition, and income among the populations of Bibiani-Bekwai and Sefwi Wiawso districts in the western region of Ghana. NTFPs contributed significantly to nutrition and health of the poor in the two districts, especially during the lean seasons. The results of the survey also indicated that 90% of the sampled population used plant medicine to cure various ailments, including malaria, typhoid, fever, diarrhoea, arthritis, rheumatism, and snake-bite. However, a number of factors, including policy vacuum, increased overharvesting of NTFPs, destruction of natural habitats, bushfires, poor farming practices, population growth, and market demand, are hindering the use and development of NTFPs in Ghana. The study also provides relevant information that policy-makers and development actors require for improving nutrition and health in Ghana

Non-suicidal Self-Injury in Clinical Practice

Background: Non-suicidal self-injury (NSSI) among adolescents is a major public health concern and a common problem in clinical practice. The aim of this study was to examine different aspects of NSSI in a high-risk adolescent sample in clinical practice in association with personality disorders, symptoms, and coping skills to enhance the understanding of NSSI and improve treatment interventions.Methods: In a sample of 140 adolescent inpatients treated for personality disorders, assessments were performed pre-treatment and post-treatment using a questionnaire on NSSI developed for clinical practice, the Structured Clinical Interview for DSM personality disorders, the Symptom Check List 90, and the Cognitive Emotion Regulation Questionnaire.Results: NSSI was common (66.4%) among the inpatient adolescents. Of those without NSSI behaviour (n = 47), 10 (21.3%) started NSSI during treatment. NSSI was related to number of personality disorders and not to one specific. Participants who experienced NSSI (n = 93) reported significantly more symptoms and the negative coping strategy self-blame. They scored lower on the positive coping strategies of refocusing and reappraisal.Conclusion: NSSI in adolescent clinical practice is common, not exclusive to borderline personality disorder and could be contagious. Reducing self-blame and enhancing positive refocusing and positive reappraisal seem important treatment targets

Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia

In 11 adult patients with suspicion of Focal cortical dysplasia (FCD) on 1.5 T (n = 1) or 3 T (n = 10) magnetic resonance imaging (MRI), 7 T MRI was performed. Visibility, extent, morphological features and delineation were independently rated and subsequently discussed by three observers. Additionally, head-to-head comparisons with corresponding 3 T images were made in the eight patients with a previous 3 T MRI and sustained suspicion of FCD. Comparison with histopathology was done in the five patients that underwent surgery. All lesions, seen at 1.5 and 3 T, were also recognized on 7 T. At 7 T FLAIR highlighted the FCD-like lesions best, whereas T2 and T2* were deemed better suited to review structure and extent of the lesion. Image quality with the used 7 T MRI setup was higher than the quality with the used 3 T MRI setup. In 2 out of 11 patients diagnosis changed, in one after re-evaluation of the images, and in the other based on histopathology. With the used 7 T MRI setup, FCD-like lesions can be detected with more confidence and detail as compared to lower field strength. However, concordance between radiologic diagnosis and final diagnosis seems to be lower than expected

Improving Nutrition and Health through Non-timber Forest Products in Ghana

Nutrition and health are fundamental pillars of human development across the entire life-span. The potential role of non-timber forest products (NTFPs) in improving nutrition and health and reduction of poverty has been recognized in recent years. NTFPs continue to be an important source of household food security, nutrition, and health. Despite their significant contribution to food security, nutrition, and sustainable livelihoods, these tend to be overlooked by policy-makers. NTFPs have not been accorded adequate attention in development planning and in nutrition-improvement programmes in Ghana. Using exploratory and participatory research methods, this study identified the potentials of NTFPs in improving nutrition and food security in the country. Data collected from the survey were analyzed using the SPSS software (version 16.0). Pearson\u2019s correlation (p&lt;0.05) showed that a significant association exists between NTFPs and household food security, nutrition, and income among the populations of Bibiani-Bekwai and Sefwi Wiawso districts in the western region of Ghana. NTFPs contributed significantly to nutrition and health of the poor in the two districts, especially during the lean seasons. The results of the survey also indicated that 90% of the sampled population used plant medicine to cure various ailments, including malaria, typhoid, fever, diarrhoea, arthritis, rheumatism, and snake-bite. However, a number of factors, including policy vacuum, increased overharvesting of NTFPs, destruction of natural habitats, bushfires, poor farming practices, population growth, and market demand, are hindering the use and development of NTFPs in Ghana. The study also provides relevant information that policy-makers and development actors require for improving nutrition and health in Ghana

ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside

Tyrosine Kinase Inhibitors (TKI) have significantly changed the landscape of current cancer therapy. Understanding of mechanisms of aberrant TK signaling and strategies to inhibit TKs in cancer, further promote the development of novel agents

Effect of variations in depth of neuromuscular blockade on rating of surgical conditions by surgeon and anesthesiologist in patients undergoing laparoscopic renal or prostatic surgery (BLISS trial): study protocol for a randomized controlled trial

Perioperative Medicine: Efficacy, Safety and Outcom

Three Dimensional Hydrodynamic-Sedimentation Modeling Study : Hampton Roads Crossing, Lower James River, Virginia

A three-dimensional hydrodynamic-sedimentation computer model, HYSED-3D, was used to evaluate the effect of bridge-tunnel infrastructure for a proposed highway crossing of Hampton Roads on the physical characteristics (tides, currents, circulation, salinity, and sedimentation) of the James River estuary in Virginia. Model-represented infrastructure included tunnel islands and bridges on pilings connecting the islands to interstate highways in Newport News, Hampton, Norfolk, and Portsmouth, Virginia. Combinations of these elements occur in each of three proposed crossing routes designated Alternative 1 (Hampton-Norfolk), Alternative 2 (Hampton-Norfolk, Norfolk-Portsmouth), and Alternative 9 (Newport News-Portsmouth-Norfolk). Simulation comparisons were made between the existing waterways and infrastructure in Hampton Roads (Base Case) and the proposed construction in a series of model test runs representing both normal and extreme hydrologic conditions. Variations in tidal range were simulated using a three constituent tide model. Three levels of freshwater inflow into the headwaters of the James River were represented using historical stream gauge data. The simulation of sedimentation was designed based on the existence of a \u27turbidity maximum\u27 upstream from the area of concern

Preferential HLA usage in the influenza virus-specific CTL response

To study whether individual HLA class I alleles are used preferentially or equally in human virus-specific CTL responses, the contribution of individual HLA-A and -B alleles to the human influenza virus-specific CTL response was investigated. To this end, PBMC were obtained from three groups of HLA-A and -B identical blood donors and stimulated with influenza virus. In the virus-specific CD8(+) T cell population, the proportion of IFN-gamma- and TNF-alpha-producing cells, restricted by individual HLA-A and -B alleles, was determined using virus-infected C1R cells expressing a single HLA-A or -B allele for restimulation of these cells. In HLA-B*2705- and HLA-B*3501-positive individuals, these alleles were preferentially used in the influenza A virus-specific CTL response, while the contribution of HLA-B*0801 and HLA-A*0101 was minor in these donors. The magnitude of the HLA-B*0801-restricted response was even lower in the presence of HLA-B*2705. C1R cells expressing HLA-B*2705, HLA-A*0101, or HLA-A*0201 were preferentially lysed by virus-specific CD8(+) T cells. In contrast, the CTL response to influenza B virus was mainly directed toward HLA-B*0801-restricted epitopes. Thus, the preferential use of HLA alleles depended on the virus studied

A three-layer MRI-based head phantom for experimental validation of tES simulations

Transcranial electric stimulation (tES) is being investigated for the relief of seizures in medically refractory epilepsy patients. In a quest to optimize the electrode placement and current for improvement of the outcome, we are investigating the exploitation of the pre-stimulation planning using finite element simulations based on individual anatomy from MRI [RM1] scans. A crucial step is validating the stimulation modeling accuracy, but commercial setups for validation do not exist.Hereto, we developed a three-layer head phantom, consisting of skin, skull, and brain tissue, that captures the crucial anatomical features and provides a convenient way of verifying the induced electric fields. It also enables systematic characterization of the uncertainties and variations in conductivity and anatomy. Experiments on the three-layer phantom bridge the gap between simulations and clinical practice since they also allow for using clinical hardware and electrodes.The developed phantom consists of an agar and salt brain layer, a graphite-doped polyurethane skull, and a skin layer made from agar gel with a different conductivity. In this way the solid skull separates the two gel layers, preventing possible ion drift over the layers. The anatomy is based on the ICBM 152 linear model, an average of 152 MRI scans, which enables us to intuitively link measurements and simulations. To perform the systematic characterization experiments, hardware and software were designed in-house. This allows for stimulations and measurements on the phantom in a cheap and modular way. The designed hardware consists of a PID-controlled tES stimulator, which can deliver 4 mA with a frequency up to 100 Hz, and a four-channel differential sensing board based on the OpenBCI Ganglion board.A realistic and modular phantom expands the possibilities of preclinical tES research by providing a tool to validate electric field simulations as well as experiment with clinical hardware and anatomical variations