126 research outputs found
Analysis of electronic structure and X-ray absorption and emission spectra in MgO within the FP-LAPW method
In this work we calculated MgO ab initio X-ray Absorption and Emission spectra using the Full Potential Linearized Augmented Plane Wave method within the Density Functional Theory formalism. The X-ray Absorption and Emission spectra for the K and L2;3 edges of Mg and O atoms were calculated including a core hole in order to study the electronic structure of valence and conduction bands of the system. Both kinds of spectra were compared with experimental data obtaining a very good agreement and the improvement in the spectra due to the use of Tran Blaha modified Becke-Johnson (TB-mBJ)potential is manifested. This potential describes better the insulator properties, produces a band gap that is in good agreement with the experimental value and improves the intensities and the structure of the spectra. Was interesting to find the presenceof Mg d states below the Fermi energy in the equilibrium volume of MgO. The XANES experiments were better reproduced by introducing the full core hole in the calculationsusing TB-mBJ potential while for XES the best agreement was obtained without core hole. The Bader?s topological method was employed to analyse the ionic behaviour. Using the electronic charges obtained with the Bader?s Method and the equilibrium lattice parameter, we obtained the value of the Lattice Energy and we compared it with the value obtained by the Born-Haber cycle showing a good agreement. The charge density for MgO was plotted, and a maximally localized Wannier function for O is shown.Fil: Grad, Gabriela Beatriz. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, Astronomia y FĂsica. Grupo de Espectroscopia Atomica y Nuclear; ArgentinaFil: GonzĂĄlez, Enrique. R.. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, Astronomia y FĂsica. Grupo de Espectroscopia Atomica y Nuclear; ArgentinaFil: Torres DĂaz, Jorge. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, Astronomia y FĂsica. Grupo de Espectroscopia Atomica y Nuclear; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; ArgentinaFil: Bonzi, Edgardo. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, Astronomia y FĂsica. Grupo de Espectroscopia Atomica y Nuclear; Argentin
Study of the characteristic parameters of the normal voices of Argentinian speakers
The voice laboratory permits to study the human voices using a method that is objective and noninvasive. In this work, we have studied the parameters of the human voice such as pitch, formant, jitter, shimmer and harmonic-noise ratio of a group of young people. This statistical information of parameters is obtained from Argentinian speakers.publishedVersionFil: Bonzi, Edgardo Venusto. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, AstronomĂa y FĂsica; Argentina.Fil: Bonzi, Edgardo Venusto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de FĂsica Enrique Gaviola; Argentina.Fil: Grad, G. B. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, AstronomĂa y FĂsica; Argentina.Fil: Maggi, A. M. Universidad Nacional de CĂłrdoba. Facultad de Ciencias MĂ©dicas. Escuela de FonoaudiologĂa; Argentina.Fil: Muñóz, M. R. Universidad Nacional de CĂłrdoba. Facultad de Ciencias MĂ©dicas. Escuela de FonoaudiologĂa; Argentina.Otras Ciencias FĂsica
The stomach cancer pooling (STOP) project: a global consortium of epidemiological studies of gastric cancer, updated to 2021
The assessment of risk factors in cancer etiology is necessary for defining optimal preventive strategies, as well as for identifying high risk individuals, and it is therefore relevant for medical practice and cancer prevention. The Stomach cancer Pooling (StoP) Project is a consortium of epidemiological studies of gastric cancer (GC), established in year 2012. The StoP Project aims to examine the role of lifestyle, environmental and genetic determinants of GC through pooled analyses of subject-level data. The consortium is the major GC dataset globally, including original data from 35 studies â with caseâcontrol study design, including 5 nested caseâcontrol within cohort studies â conducted in the Americas, Asia and Europe (Table 1), for a total of about 13,500 cases and 32,000 controls, and it is continuously expanding. To date, the StoP Project contributed a detailed quantification of the risk of GC associated to several factors, including cigarette smoking (relative risk, RR, of 1.32 for heavy vs. never smokers), alcohol drinking (RR=1.48 for heavy vs. never drinkers), socio-economic status (RR=0.60 for high vs. low education), selected dietary factors (RR=1.30 for high vs. low meat intake; RR=0.65 for high vs. low vegetables consumption; RR=0.80 for high vs. low citrus fruit; RR=0.67 for high vs. low polyphenols intake) and occupational exposures (RR=1.70 for miners; RR=1.30 for construction workers; RR=1.33 for agricultural and animal husbandry workers; RR=1.41 for blacksmiths and machine-tool operators). Planned future developments are to analyze the role of rare exposures on GC risk and to examine risk factors in understudied patient subgroups (e.g., young onset GC, gastric cardia cancer, etc.); to integrate additional studies from East Asia; to develop a genome-wide modeling of polygenic risk score in GC; to include survival analyses and to apply machine learning methods in GC risk prediction and prognostication
Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of CaseâControl Studies of the Stop Consortium
Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 caseâcontrol studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83â0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77â0.94) and nonâcardia GC (OR = 0.87, 95% CI = 0.81â0.94), and for diffuse (OR = 0.79, 95% CI = 0.69â0.89) and intestinal type (OR = 0.88, 95% CI = 0.79â0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.This study was supported by the Fondazione AIRC per la Ricerca sul Cancro, Project no. 21378 (Investigator Grant). The Unidade de Investigação em EpidemiologiaâInstituto de SaĂșde PĂșblica da Universidade do Porto (EPIUnit; UIDB/04750/2020) and the LaboratĂłrio para a Investigação Integrativa e Translacional em SaĂșde Populacional (ITR; LA/P/0064/2020) were funded by the Foundation for Science and TechnologyâFCT (Portuguese Ministry of Science, Technology and Higher Education). SM was supported by the project âNEONâPCâNeuroâoncological complications of prostate cancer: longitudinal study of cognitive declineâ (POCIâ01â0145âFEDERâ032358; ref. PTDC/SAUâEPI/32358/2017), which is funded by FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnitâJunior ResearchâProg Financing (UIDP/04750/2020). The authors thank the European Cancer Prevention (ECP) Organization for providing support for the StoP Project meetings and all MCCâSpain study collaborators (CIBERESP, ISCIII, ISGlobal, ICO, University of Huelva, University of Oviedo, University of Cantabria, ibs.Granada, Instituto Salud PĂșblica de Navarra, FISABIO, Murcia Regional Health Authority and cols)
Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of CaseâControl Studies of the Stop Consortium
Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 caseâcontrol studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83â0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77â0.94) and nonâcardia GC (OR = 0.87, 95% CI = 0.81â0.94), and for diffuse (OR = 0.79, 95% CI = 0.69â0.89) and intestinal type (OR = 0.88, 95% CI = 0.79â0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis
The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firthâs penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07â4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77â1.39). Conclusions. In the pooled analysis of 11 caseâcontrol studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk. © 2022 by the authors.This work is supported by Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant); Fondazione Italiana per la Ricerca sul Cancro (FIRC); Italian League for the Fight Against Cancer (LILT); European Cancer Prevention (ECP) Organization; and UPMC Start-up Grant (to HNL). P Paragomi was supported by a cancer research training grant from NIH (grant # T32CA186873)
The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firthâs penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07â4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77â1.39). Conclusions. In the pooled analysis of 11 caseâcontrol studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk
Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
Purpose: Previous studies show that consuming foods preserved by salting increases the risk of gastric cancer, while results on the association between total salt or added salt and gastric cancer are less consistent and vary with the exposure considered. This study aimed to quantify the association between dietary salt exposure and gastric cancer, using an individual participant data meta-analysis of studies participating in the Stomach cancer Pooling (StoP) Project. Methods: Data from 25 studies (10,283 cases and 24,643 controls) from the StoP Project with information on salt taste preference (tasteless, normal, salty), use of table salt (never, sometimes, always), total sodium intake (tertiles of grams/day), and high-salt and salt-preserved foods intake (tertiles of grams/day) were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age, and gastric cancer risk factors) odds ratios (aORs), and the corresponding 95% confidence intervals (95% CI). Results: Gastric cancer risk was higher for salty taste preference (aOR 1.59, 95% CI 1.25â2.03), always using table salt (aOR 1.33, 95% CI 1.16â1.54), and for the highest tertile of high-salt and salt-preserved foods intake (aOR 1.24, 95% CI 1.01â1.51) vs. the lowest tertile. No significant association was observed for the highest vs. the lowest tertile of total sodium intake (aOR 1.08, 95% CI 0.82â1.43). The results obtained were consistent across anatomic sites, strata of Helicobacter pylori infection, and sociodemographic, lifestyle and study characteristics. Conclusion: Salty taste preference, always using table salt, and a greater high-salt and salt-preserved foods intake increased the risk of gastric cancer, though the association was less robust with total sodium intake. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.This study was funded by national funds from the Foundation for Science and TechnologyâFCT (Portuguese Ministry of Science, Technology and Higher Education), under the Unidade de Investigação em EpidemiologiaâInstituto de SaĂșde PĂșblica da Universidade do Porto (EPIUnit; UIDB/04750/2020), by the Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant), and the Agency for Management of University and Research Grants (AGAUR) of the Catalan Government (Grant 2017SGR723). AC and SM were funded under the scope of the project "NEON-PCâNeuro-oncological complications of prostate cancer: longitudinal study of cognitive decline" (POCI-01-0145-FEDER-032358; ref. PTDC/SAU-EPI/32358/2017). SM was also funded under EPIUnitâJunior ResearchâProg Financing (UIDP/04750/2020). An individual grant attributed to NA (SFRH/BD/119390/2016) was funded by FCT and the âPrograma Operacional Capital Humanoâ (POCH/FSE). The authors thank the European Cancer Prevention (ECP) Organization for providing support for the project meetings, all MCC-Spain study collaborators (CIBERESP, ISCIII, ISGlobal, ICO, University of Huelva, University of Oviedo, University of Cantabria, University of LeĂłn, ibs. Granada, Instituto Salud PĂșblica de Navarra, FISABIO, Murcia Regional Health Authority and cols). The funding sources had no role in the study design; collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication
Coffee consumption and gastric cancer: A pooled analysis from the Stomach cancer Pooling Project consortium
open41siThis study was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant), and by the Italian League for the Fight Against Cancer (LILT). The authors thank the European Cancer Prevention (ECP) Organization for providing support for the StoP meetings. The Unidade de Investigação em Epidemiologia â Instituto de SaĂșde PĂșblica da Universidade do Porto (EPIUnit; UIDB/04750/2020) was funded by the Foundation for Science and Technology â FCT (Portuguese Ministry of Science, Technology and Higher Education). SM was also funded by the project âNEON-PC - Neuro-oncological complications of prostate cancer: longitudinal study of cognitive declineâ (POCI-01-0145-FEDER-032358; ref. PTDC/SAU-EPI/32358/2017), which is funded by FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT. We also thank all MCC-Spain study collaborators (CIBERESP, ISCIII, ISGlobal, ICO, University of Huelva, University of Oviedo, University of Cantabria, ibs.Granada, Instituto Salud PĂșblica de Navarra, FISABIO, Murcia Regional Health Authority and cols).Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. Results Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. Conclusions These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.openMartimianaki G.; Bertuccio P.; Alicandro G.; Pelucchi C.; Bravi F.; Carioli G.; Bonzi R.; Rabkin C.S.; Liao L.M.; Sinha R.; Johnson K.; Hu J.; Palli D.; Ferraroni M.; Lunet N.; Morais S.; Tsugane S.; Hidaka A.; Hamada G.S.; Lopez-Carrillo L.; Hernandez-Ramirez R.U.; Zaridze D.; Maximovitch D.; Aragones N.; Martin V.; Ward M.H.; Vioque J.; Garcia De La Hera M.; Zhang Z.-F.; Kurtz R.C.; Lagiou P.; Lagiou A.; Trichopoulou A.; Karakatsani A.; Malekzadeh R.; Camargo M.C.; Curado M.P.; Boccia S.; Boffetta P.; Negri E.; La Vecchia C.Martimianaki G.; Bertuccio P.; Alicandro G.; Pelucchi C.; Bravi F.; Carioli G.; Bonzi R.; Rabkin C.S.; Liao L.M.; Sinha R.; Johnson K.; Hu J.; Palli D.; Ferraroni M.; Lunet N.; Morais S.; Tsugane S.; Hidaka A.; Hamada G.S.; Lopez-Carrillo L.; Hernandez-Ramirez R.U.; Zaridze D.; Maximovitch D.; Aragones N.; Martin V.; Ward M.H.; Vioque J.; Garcia De La Hera M.; Zhang Z.-F.; Kurtz R.C.; Lagiou P.; Lagiou A.; Trichopoulou A.; Karakatsani A.; Malekzadeh R.; Camargo M.C.; Curado M.P.; Boccia S.; Boffetta P.; Negri E.; La Vecchia C
A small world of citations? The influence of collaboration networks on citation practices
This paper examines the proximity of authors to those they cite using degrees
of separation in a co-author network, essentially using collaboration networks
to expand on the notion of self-citations. While the proportion of direct
self-citations (including co-authors of both citing and cited papers) is
relatively constant in time and across specialties in the natural sciences (10%
of citations) and the social sciences (20%), the same cannot be said for
citations to authors who are members of the co-author network. Differences
between fields and trends over time lie not only in the degree of co-authorship
which defines the large-scale topology of the collaboration network, but also
in the referencing practices within a given discipline, computed by defining a
propensity to cite at a given distance within the collaboration network.
Overall, there is little tendency to cite those nearby in the collaboration
network, excluding direct self-citations. By analyzing these social references,
we characterize the social capital of local collaboration networks in terms of
the knowledge production within scientific fields. These results have
implications for the long-standing debate over biases common to most types of
citation analysis, and for understanding citation practices across scientific
disciplines over the past 50 years. In addition, our findings have important
practical implications for the availability of 'arm's length' expert reviewers
of grant applications and manuscripts
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