3,888 research outputs found
High-power test results of a 3 GHz single-cell cavity
Compact, reliable and little consuming accelerators are required for the
treatment of tumours with ions. TERA proposes the "cyclinac", composed of a
high-frequency, fast-cycling linac which boosts the energy of the particles
previously accelerated in a cyclotron. The dimensions of the linac can be
reduced if high gradients are used. TERA initiated a high-gradient test program
to understand the operational limit of such structures. The program foresees
the design, prototyping and high-power test of several high-gradient structures
operating at 3 and 5.7 GHz. The high-power tests of the 3 GHz single-cell
cavity were completed in Winter 2012. The maximum BDR threshold measured for
Emax of 170 MV/m and RF pulses of 2.5 \mu s was 3 x 10-6 bpp/m
TrustShadow: Secure Execution of Unmodified Applications with ARM TrustZone
The rapid evolution of Internet-of-Things (IoT) technologies has led to an
emerging need to make it smarter. A variety of applications now run
simultaneously on an ARM-based processor. For example, devices on the edge of
the Internet are provided with higher horsepower to be entrusted with storing,
processing and analyzing data collected from IoT devices. This significantly
improves efficiency and reduces the amount of data that needs to be transported
to the cloud for data processing, analysis and storage. However, commodity OSes
are prone to compromise. Once they are exploited, attackers can access the data
on these devices. Since the data stored and processed on the devices can be
sensitive, left untackled, this is particularly disconcerting.
In this paper, we propose a new system, TrustShadow that shields legacy
applications from untrusted OSes. TrustShadow takes advantage of ARM TrustZone
technology and partitions resources into the secure and normal worlds. In the
secure world, TrustShadow constructs a trusted execution environment for
security-critical applications. This trusted environment is maintained by a
lightweight runtime system that coordinates the communication between
applications and the ordinary OS running in the normal world. The runtime
system does not provide system services itself. Rather, it forwards requests
for system services to the ordinary OS, and verifies the correctness of the
responses. To demonstrate the efficiency of this design, we prototyped
TrustShadow on a real chip board with ARM TrustZone support, and evaluated its
performance using both microbenchmarks and real-world applications. We showed
TrustShadow introduces only negligible overhead to real-world applications.Comment: MobiSys 201
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Lab-on-Chip for Testing Myelotoxic Effect of Drugs and Chemicals
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.In the last twenty years, one of the main goals in the drug discovery field has been the development
of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative
Methods (ECVAM) has approved the Colony forming Unit-Granulocytes-Macrophages (CFU-GM) test,
which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The
present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip (LoC)
platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput
regime
Coulomb corrections to low energy antiproton annihilation cross sections on protons and nuclei
We calculate, in a systematic way, the enhancement effect on
antiproton-proton and antiproton-nucleus annihilation cross sections at low
energy due to the initial state electrostatic interaction between the
projectile and the target nucleus. This calculation is aimed at future
comparisons between antineutron and antiproton annihilation rates on different
targets, for the extraction of pure isospin channels.Comment: 18 pages, 4 figures (latex format
Optimal self-stabilizing mobile byzantine-tolerant regular register with bounded timestamps
This paper proposes the first implementation of a self-stabilizing regular register emulated by n servers that is tolerant to both Mobile Byzantine Agents and transient failures in a round-free synchronous model. Differently from existing Mobile Byzantine Tolerant register implementations, this paper considers a weaker model where: (i) the computation of the servers is decoupled from the movements of the Byzantine agents, i.e., movements may happen before, concurrently, or after the generation or the delivery of a message, and (ii) servers are not aware of their failure state i.e., they do not know if and when they have been corrupted by a Mobile Byzantine agent. The proposed protocol tolerates (i) any finite number of transient failures, and (ii) up to f Mobile Byzantine agents. In addition, our implementation uses bounded timestamps from the Z13 domain and it is optimal with respect to the number of servers needed to tolerate f Mobile Byzantine agents in the given model (i.e., n>6f when Δ=2δ, and n>8f when Δ=δ, where Δ represents the period at which the Byzantine agents move and δ is the upper bound on the communication latency)
Limits on the low energy antinucleon-nucleus annihilations from the Heisenberg principle
We show that the quantum uncertainty principle puts some limits on the
effectiveness of the antinucleon-nucleus annihilation at very low energies.
This is caused by the fact that the realization a very effective short-distance
reaction process implies information on the relative distance of the reacting
particles. Some quantitative predictions are possible on this ground, including
the approximate A-independence of antinucleon-nucleus annihilation rates.Comment: 10 pages, no figure
ENDO-ERN expert opinion on the differential diagnosis of pubertal delay.
The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
Approximately one-third of the human proteome is made up of proteins that are entirely disordered or that contain extended disordered regions. Although these disordered proteins are closely linked with many major diseases, their binding mechanisms with small molecules remain poorly understood, and a major concern is whether their specificity can be sufficient for drug development. Here, by studying the interaction of a small molecule and a disordered peptide from the oncogene protein c-Myc, we describe a "specific-diffuse" binding mechanism that exhibits sequence specificity despite being of entropic nature. By combining NMR spectroscopy, biophysical measurements, statistical inference, and molecular simulations, we provide a quantitative measure of such sequence specificity and compare it to the case of the interaction of urea, which is diffuse but not specific. To investigate whether this type of binding can generally modify intermolecular interactions, we show that it leads to an inhibition of the aggregation of the peptide. These results suggest that the binding mechanism that we report may create novel opportunities to discover drugs that target disordered proteins in their monomeric states in a specific manner.G.T.H. is supported by the Churchill Scholarship and the Gates Cambridge Trust Scholarship
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