2015 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1002/thumbnail.jp

A Decision Theoretic Framework for Hypothesis and Significance Testing

Thesis (Master's)--University of Washington, 2018From its inception, statistical testing has been a controversial area. There are several philosophies of testing and inference, the most common among them being the so-called frequentist and Bayesian approaches. These approaches have often been viewed as at odds with one another. In this paper, we suggest that in many common testing scenarios this is not the case. We will approach testing from a decision theoretic standpoint, framing testing and inference as decisions to be made about a parameter. In doing so, we show that the commonly used methods of testing and inference answer different questions but can both provide valuable knowledge. We aim to help researchers move away from the viewpoint that one must be either a "frequentist" or a "Bayesian", as statisticians have often divided themselves in the past, and toward the recognition that both schools of thought can make relevant contributions to their research

The Role of Social Networks in Agricultural Innovation:The Sutherland Reclamations and the Fowler Steam Plough, c.1855-c.1885

The nineteenth century saw an explosion in creativity and innovation, often applied to and motivated by an urge to improve, refine and make more efficient industrial and agricultural processes. There were many innovations in the field of agriculture, supported by the sponsorship of societies and associations and, in the 1850s and 1860s, by strong investment under High Farming. This article examines one of these innovations, the steam plough, with reference to its application in the Scottish Highlands in the 1870s and 1880s. In particular, it illuminates the social networks which lay behind the development and utilisation of the steam plough in the rural Highland context, delineating how aristocratic, religious and local networks combined to have a major impact on rural society in Scotland and beyond. It will examine how these networks interacted to promote the contemporary culture for agricultural and rural innovation through the development of the Fowler’s steam plough.What makes this example of particular interest is the fact that agriculturally and financially, the Sutherland land reclamations were an unconditional failure. The environment was too challenging for the technology and despite vast financial resources, the landowner, the third Duke of Sutherland, was, after fifteen years, finally convinced by his advisors that further efforts were futile and irresponsible. This article will interrogate why, despite its essential unfeasibility, the project was pursued, and will argue that the momentum created by the dynamic between the three networks involved propelled it forward despite growing evidence of failure. This article therefore uses an inductive approach by examining a particular example of agricultural design innovation and analysing the pertinent social issues in what would have been termed by contemporaries ‘entrepreneurial spirit’

Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression.

IntroductionPrevious studies have provided equivocal evidence of antidepressant use on subsequent cognitive impairment; this could be due to inconsistent modeling approaches. Our goals are methodological and clinical. We evaluate the impact of statistical modeling approaches on the associations between antidepressant use and risk of Mild Cognitive Impairment (MCI) in older adults with depression.Methods716 participants were enrolled. Our primary analysis employed a time-dependent Cox proportional hazards model. We also implemented two fixed-covariate proportional hazards models-one based on having ever used antidepressants during follow-up, and the other restricted to baseline use only.ResultsTreating antidepressant use as a time-varying covariate, we found no significant association with incident MCI (HR = 0.92, 95% CI: 0.70, 1.20). In contrast, when antidepressant use was treated as a fixed covariate, we observed a significant association between having ever used antidepressants and lower risk of MCI (HR = 0.40, 95% CI: 0.28, 0.56). However, in the baseline-use only model, the association was non-significant (HR = 0.84, 95% CI: 0.60, 1.17).DiscussionOur results were dependent upon statistical models and suggest that antidepressant use should be modeled as a time-varying covariate. Using a robust time-dependent analysis, antidepressant use was not significantly associated with incident MCI among cognitively normal persons with depression

Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy

It remains unclear what clinical features inform the accuracy of a clinical diagnosis of Alzheimer disease (AD). Data were obtained from the National Alzheimer's Coordinating Center to compare clinical and neuropathologic features among participants who did or did not have Alzheimer disease neuropathologic changes (ADNC) at autopsy. Participants (1854) had a clinical Alzheimer dementia diagnosis and ADNC at autopsy (Confirmed-AD), 204 participants had an AD diagnosis and no ADNC (AD-Mimics), and 253 participants had no AD diagnosis and ADNC (Unidentified-AD). Compared to Confirmed-AD participants, AD-Mimics had less severe cognitive impairment, while Unidentified-AD participants displayed more parkinsonian signs, depression, and behavioral problems. This study highlights the importance of developing a complete panel of biomarkers as a tool to inform clinical diagnoses, as clinical phenotypes that are typically associated with diseases other than AD may result in inaccurate diagnoses