7th Drug hypersensitivity meeting: part two

No abstract availabl

Synthesis and microstructure of manganese ferrite colloidal nanocrystals

The atomic level structure of a series of monodisperse single crystalline nanoparticles with a magnetic core of manganese ferrite was studied using X-ray absorption fine structure (EXAFS) and X-ray absorption near edge structure (XANES) techniques at both the Fe and Mn K-edges, and conventional and high resolution transmission electron microscopy (TEM and HRTEM). In particular, insights on the non-stoichiometry and on the inversion degree of manganese ferrite nanocrystals of different size were obtained by the use of complementary structural and spectroscopic characterization techniques. The inversion degree of the ferrite nanocrystals, i.e. the cation distribution between the octahedral and tetrahedral sites in the spinel structure, was found to be much higher (around 0.6) than the literature values reported for bulk stoichiometric manganese ferrite (around 0.2). The high inversion degree of the nanoparticles is ascribed to the partial oxidation of Mn2+ to Mn3+ which was evidenced by XANES, leading to non-stoichiometric manganese ferrite

Aspects diagnostiques et thérapeutiques des cancers de l’estomac en milieu oncologique à Conakry

L’objectif de ce travail était d’analyser les résultats de la prise en charge diagnostique et thérapeutique des cancers de l’estomac à l’unité de chirurgie oncologique de Donka. Il s’agissait d’une étude observationnelle, rétrospective de type descriptif de 2007 à 2016. Le profil épidémiologique, les aspects anatomocliniques, le diagnostic, le bilan d’extension et les modalités thérapeutiques ont été décrits et analysés. Nous avons colligé 41 patients avec un âge moyen de 53,8 ans. Le sexratio était de 1,7. Les patients avaient consulté pour épigastralgie (85,4%), vomissements (75,6%) et anorexie (26,8%) avec un délai de consultation de 15,8 mois. Une masse épigastrique (61,0%), l’hépatomégalie (46,3%) et une ascite (31,7%) étaients présents. L’aspect endoscopique était bourgeonnant (37,5%) et dans 50,0%, le siège était antral. Ils’agissait d’adénocarcinome (18 cas), de carcinomes gastriques (9 cas), de dysplasie de haut grade (1 cas) et de tumeur stromale gastro-intestinale (GIST) (1 cas). Les métastases étaient présentes dans 27 cas (65,8%). Le traitement chirurgical a été réalisé chez 20 patients (48,8%) avec un taux de résécabilité de 55 % (11 cas). La gastrectomie des 4⁄5 avec curage de type D2 a été réalisée dans 18 cas (72,2%).La mortalité opératoire était de 2 cas(7,4%). Dix patients (24,4%) ont été l’objet d’un traitement adjuvant dont 9 par chimiothérapie et 1 par radiothérapie.Les patients ont été suivis avec un délai moyen de 43,8±8,6 mois [IC95% 27,0-60,0] au cours duquel 4 récidives (9,7%) et 32 décès (78%) ont été enregistrés. Le cancer de l’estomac est fréquent et de diagnostic tardif dans notre contexte. Le traitement chirurgical des formes précoces et la chimiothérapie périopératoire permettent d’améliorer le pronostic de ces cancers. Mots clés : cancers, estomac, diagnostic, traitement, Conakry. The aim was to analyze the results of the diagnostic and therapeutic management of stomach cancers at the Donka Oncology Surgery Unit. This was a retrospective study of the descriptive type from 2007 to 2016. The epidemiological profile, the anatomoclinical aspects, the diagnosis, the extension assessment and the therapeutic modalities were described and analyzed. We collected 41 patients with a mean age of 53.8 years. The sex ratio was 1.7. Patients had consulted for epigastralgia (85.4%), vomiting (75.6%) and anorexia (26.8%) with a consultation time of 15.8 months. An epigastric mass(61.0%), hepatomegaly (46.3%) and ascites (31.7%) were present. The endoscopic aspect was budding (37.5%) and in 50.0%, the seat was antral. These included adenocarcinoma (18 cases), gastric carcinomas (9 cases), high grade dysplasia (1 case) and gastrointestinal stromal tumors (GIST) (1 case). Metastases were present in 27 cases(65.8%). Surgical treatment was performed in 20 patients with a resectability rate of 55% (11 cases). Gastrectomy of 4/5 with D2- type dissection was performed in 18 cases(72.2%) and the operative mortality was 2 cases (7.4%). Ten patients (24.4%) received adjuvant therapy, 9 with chemotherapy and 1 with radiotherapy. Patients were followed after a mean delay of 43.8 ± 8.6 months [95% CI 27.0-60 , 0] in which 4 recurrences (9.7%) and 32 deaths (78.04%) were recorded. Stomach cancer is common and of late diagnosisin our context. Surgical treatment of early forms and perioperative chemotherapy could improve the prognosis of these cancers. Keywords: stomach cancer, diagnosis, treatment, Conakr

Interstitial and large chromosome 1p deletion occurs in localized and disseminated neuroblastomas and predicts an unfavourable outcome

We studied chromosome Ip loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%) NBs. We detected interstitial and large deletion in both localized and disseminated tumours and in one tumour of a patient at stage 4S. Allelic loss was frequently observed in 1p36 and 1p32 regions. In patients older than 1 year of age (53 Versus 13%, P < 0.002) we detected significant chromosome 1p deletion and it was associated with MYCN amplification (P = 0.001). Overall survival (OS) analysis showed that 1p-LOH is predictive of a poor outcome (odds ratio 16.5, 95% CI 5.4-50.9%); therefore, 1p-LOH should be regarded as an additional tumour progression marker in neuroblastoma. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved

Sero-Prevalence Surveillance to Predict Vaccine-Preventable Disease Outbreaks; A Lesson from the 2014 Measles Epidemic in Northern Vietnam

Contains fulltext : 203048.pdf (publisher's version ) (Open Access)Background: During the first half of 2014, a severe outbreak of measles occurred in northern Vietnam, causing 15 033 confirmed cases and 146 deaths. Methods: To evaluate the population-level seroprevalence of protection against measles in the period before the outbreak, we made use of an existing age-stratified serum bank, collected over the year before the outbreak, between November 2012 and December 2013, from 4 sites across the country (Hanoi, Hue, Dak Lak, and Ho Chi Minh City). Data from the UNICEF's Multiple Indicator Clustered Surveys (MICS), carried out in Vietnam during the first quarter of 2014, were used to assess the vaccine coverage in 6 ecological regions of Vietnam. Results: Results revealed a large discrepancy between levels of protection, as estimated from the serology and vaccine coverage estimated by UNICEF's MICS. Variation in seroprevalence across locations and age groups corresponded with reported numbers of measles cases, most of which were among the 0-2-year-old age group and in the northern part of the country. Conclusions: Our study presents a strong case in favor of a serosurveillance sentinel network that could be used to proactively tune vaccination policies and other public health interventions

Comparative genomics of Cryptococcus neoformans var. grubii associated with meningitis in HIV infected and uninfected patients in Vietnam

10.1371/journal.pntd.0005628PLoS Neglected Tropical Diseases116e000562