158 research outputs found
Photonics Integrations Enabling High-end Applications Of Inp In Optical Data Transmissions
We present here results from a uniquely designed InP modulator chip combined with advanced packaging concepts, which enables high-end applications in optical data communications. An electroabsorption (EA) modulator, with a strained InGaAsP or InGaAlAs multiple quantum well structure, is monolithically integrated with a semiconductor optical amplifier. This design offers broad wavelength tunability while maintaining high extinction ratio, high optical output power, and high dispersion tolerance. The amplified EA modulator chip is co-packaged with a distributed feed back (DFB) laser ensuring separate optimization of the laser and modulator sections. The optical isolator, placed between the laser and modulator, completely eliminates adiabatic chirp. This Telcordia-qualified laser integrated modulator platform enables superior performance previously not thought possible for InP absorption based modulators. 11 dB of dynamic extinction ratio, 5dBm of modulated output power, and ±1200ps/nm or +1600ps/nm dispersion tolerance can be simultaneously achieved in un-amplified 10Gb/s data transmission. Full C-band tunability using a single device is also demonstrated with the LIM module. Extensive simulations and transmission system evaluations shows that with the controllable chirp, the cost-effective LIM performs as well as a Mach-Zehnder modulator in dispersion managed and amplified long-haul WDM systems. Lastly, the first uncooled 10Gb/s long-reach operation at 1550nm was demonstrated with LIM packages. Using a simple control algorithm, a constant modulated output power of IdBm with less than IdB dispersion penalty over 1600ps/nm single mode fiber is achieved in an 80 degrees environmental temperature range without any module temperature control. Utilizing the Al-based material system, also allows a reduced variation of the extinction ratio.6013Kaminow, I.P., Koch, T.L., (1997) Optical Fiber Telecommunications IIIA, , San Diego CA: Academic PressChoi, W., Bond, A.E., Kim, J., Zhang, J., Jambunathan, R., Foulk, H., O'Brien, S., Cao, H., Low insertion loss and low dispersion penalty InGaAsP quantum well high speed electroabsorption modulators (2002) IEEE Journal of Lightwave Technologies, 20, pp. 2052-2056Choi, W., Frateschi, N., Zhang, J., Gebretsadik, H., Jambunathan, R., Bond, A.E., Van Norman, J., Wanamaker, C., Full C-band tunable high fiber output power electroabsorption modulator integrated with semiconductor optical amplifier (2003) Electronics Letters, 39, p. 1271. , 2003Zhang, L., Cao, X.D., Long haul transmission using electro-absorption modulators (2002) Technical Proceeding of NFOEC'2002, p. 1204. , paper P447www.vpiphotonics.comMikhailov, V., Killey, R.I., Prat, J., Bayvel, P., Limitation to WDM transmission distance due to cross-phase modulation induced spectral broadening in dispersion compensated standard fiber systems (1999) IEEE Photon. Technol. Lett., 11, pp. 994-996Zhang, J., Frateschi, N., Choi, W., Gebretsadik, H., Jambunathan, R., Bond, A.E., A laser integrated modulator module for uncooled, 10Gbit/s 1550 nm long reach data transmission (2003) Electronics Letters, 39, pp. 1841-1842Frateschi, N.C., Zhang, J., Choi, W.J., Gebretsadik, H., Jambunathan, R., Bond, A.E., High performance uncooled C-band, 10 Gb/s InGaAlAs MQW electro-absorption modulator integrated to Semiconductor Amplifier in Laser integrated modules (2004) Electronics Letters, 40, pp. 140-141. , JanFrateschi, N.C., Zhang, J., Jambunathan, R., Choi, W.J., Ebert, C., Bond, A.E., Long reach uncooled performance of 10 Gb/s Laser integrated modules with InGaAlAs/InP and InGaAsP/InP MQW electroabsorption modulators monolithically integrated with Semiconductor Amplifiers IEEE Photon. Technol. Lett., 17, pp. 1378-138
Strengthening impact assessment: a call for integration and focus
We suggest that the impact assessment community has lost its way based on our observation that impact assessment is under attack because of a perceived lack of efficiency. Specifically, we contend that the proliferation of different impact assessment types creates separate silos of expertise and feeds arguments for not only a lack of efficiency but also a lack of effectiveness of the process through excessive specialisation and a lack of interdisciplinary practice. We propose that the solution is a return to the basics of impact assessment with a call for increased integration around the goal of sustainable development and focus through better scoping. We rehearse and rebut counter arguments covering silo-based expertise, advocacy, democracy, sustainability understanding and communication. We call on the impact assessment community to rise to the challenge of increasing integration and focus, and to engage in the debate about the means of strengthening impact assessment
An accelerated closed universe
We study a model in which a closed universe with dust and quintessence matter
components may look like an accelerated flat Friedmann-Robertson-Walker (FRW)
universe at low redshifts. Several quantities relevant to the model are
expressed in terms of observed density parameters, and
, and of the associated density parameter related
to the quintessence scalar field .Comment: 11 pages. For a festschrift honoring Alberto Garcia. To appear in
Gen. Rel. Gra
Bomb-<sup>14</sup>C analysis of ecosystem respiration reveals that peatland vegetation facilitates release of old carbon
The largest terrestrial-to-atmosphere carbon flux is respired CO<sub>2</sub>. However, the partitioning of soil and plant sources, understanding of contributory mechanisms, and their response to climate change are uncertain. A plant removal experiment was established within a peatland located in the UK uplands to quantify respiration derived from recently fixed plant carbon and that derived from decomposition of soil organic matter, using natural abundance <sup>13</sup>C and bomb-<sup>14</sup>C as tracers. Soil and plant respiration sources were found respectively to contribute ~ 36% and between 41-54% of the total ecosystem CO<sub>2</sub> flux. Respired CO<sub>2</sub> produced in the clipped (‘soil’) plots had a mean age of ~ 15 years since fixation from the atmosphere, whereas the <sup>14</sup>C content of ecosystem CO<sub>2</sub> was statistically indistinguishable from the contemporary atmosphere. Results of carbon mass balance modelling showed that, in addition to respiration from bulk soil and plant respired CO<sub>2</sub>, a third, much older source of CO<sub>2</sub> existed. This source, which we suggest is CO<sub>2</sub> derived from the catotelm constituted between ~ 10 and 23% of total ecosystem respiration and had a mean radiocarbon age of between several hundred to ~ 2000 years before present (BP). These findings show that plant-mediated transport of CO<sub>2</sub> produced in the catotelm may form a considerable component of peatland ecosystem respiration. The implication of this discovery is that current assumptions in terrestrial carbon models need to be re-evaluated to consider the climate sensitivity of this third source of peatland CO<sub>2</sub>
First Results from the Arcminute Cosmology Bolometer Array Receiver
We review the first science results from the Arcminute Cosmology Bolometer
Array Receiver (ACBAR); a multifrequency millimeter-wave receiver optimized for
observations of the Cosmic Microwave Background (CMB) and the
Sunyaev-Zel'dovich (SZ) effect in clusters of galaxies. ACBAR was installed on
the 2 m Viper telescope at the South Pole in January 2001 and the results
presented here incorporate data through July 2002. We present the power
spectrum of the CMB at 150 GHz over the range \ell = 150 - 3000 measured by
ACBAR as well as estimates for the values of the cosmological parameters within
the context of Lambda-CDM models. We find that the inclusion of Omega_Lambda
greatly improves the fit to the power spectrum. We also observe a slight excess
of small-scale anisotropy at 150 GHz; if interpreted as power from the SZ
effect of unresolved clusters, the measured signal is consistent with CBI and
BIMA within the context of the SZ power spectrum models tested.Comment: To be published in the proceedings of "The Cosmic Microwave
Background and its Polarization", New Astronomy Reviews, (eds. S. Hanany and
K.A. Olive). 10 pages, 2 figure
Is cosmology consistent?
We perform a detailed analysis of the latest CMB measurements (including
BOOMERaNG, DASI, Maxima and CBI), both alone and jointly with other
cosmological data sets involving, e.g., galaxy clustering and the Lyman Alpha
Forest. We first address the question of whether the CMB data are internally
consistent once calibration and beam uncertainties are taken into account,
performing a series of statistical tests. With a few minor caveats, our answer
is yes, and we compress all data into a single set of 24 bandpowers with
associated covariance matrix and window functions. We then compute joint
constraints on the 11 parameters of the ``standard'' adiabatic inflationary
cosmological model. Out best fit model passes a series of physical consistency
checks and agrees with essentially all currently available cosmological data.
In addition to sharp constraints on the cosmic matter budget in good agreement
with those of the BOOMERaNG, DASI and Maxima teams, we obtain a heaviest
neutrino mass range 0.04-4.2 eV and the sharpest constraints to date on gravity
waves which (together with preference for a slight red-tilt) favors
``small-field'' inflation models.Comment: Replaced to match accepted PRD version. 14 pages, 12 figs. Tiny
changes due to smaller DASI & Maxima calibration errors. Expanded neutrino
and tensor discussion, added refs, typos fixed. Combined CMB data, window and
covariance matrix at http://www.hep.upenn.edu/~max/consistent.html or from
[email protected]
Measuring CMB Polarization with BOOMERANG
BOOMERANG is a balloon-borne telescope designed for long duration (LDB)
flights around Antarctica. The second LDB Flight of BOOMERANG took place in
January 2003. The primary goal of this flight was to measure the polarization
of the CMB. The receiver uses polarization sensitive bolometers at 145 GHz.
Polarizing grids provide polarization sensitivity at 245 and 345 GHz. We
describe the BOOMERANG telescope noting changes made for 2003 LDB flight, and
discuss some of the issues involved in the measurement of polarization with
bolometers. Lastly, we report on the 2003 flight and provide an estimate of the
expected results.Comment: 12 pages, 8 figures, To be published in the proceedings of "The
Cosmic Microwave Background and its Polarization", New Astronomy Reviews,
(eds. S. Hanany and K.A. Olive). Fixed typos, and reformatted citation
Biological and geophysical feedbacks with fire in the Earth system
Roughly 3% of the Earth's land surface burns annually, representing a critical exchange of energy and matter between the land and atmosphere via combustion. Fires range from slow smouldering peat fires, to low-intensity surface fires, to intense crown fires, depending on vegetation structure, fuel moisture, prevailing climate, and weather conditions. While the links between biogeochemistry, climate and fire are widely studied within Earth system science, these relationships are also mediated by fuels—namely plants and their litter—that are the product of evolutionary and ecological processes. Fire is a powerful selective force and, over their evolutionary history, plants have evolved traits that both tolerate and promote fire numerous times and across diverse clades. Here we outline a conceptual framework of how plant traits determine the flammability of ecosystems and interact with climate and weather to influence fire regimes. We explore how these evolutionary and ecological processes scale to impact biogeochemical and Earth system processes. Finally, we outline several research challenges that, when resolved, will improve our understanding of the role of plant evolution in mediating the fire feedbacks driving Earth system processes. Understanding current patterns of fire and vegetation, as well as patterns of fire over geological time, requires research that incorporates evolutionary biology, ecology, biogeography, and the biogeosciences
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major
Background
The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic microorganisms. It has previously been demonstrated that small-molecule compounds designed to target Mip from the Gram-negative bacterium Burkholderia pseudomallei bind at the site of enzymatic activity of the protein, inhibiting the in vitro activity of Mip.
Objectives
In this study, co-crystallography experiments with recombinant B. pseudomallei Mip (BpMip) protein and Mip inhibitors, biochemical analysis and computational modelling were used to predict the efficacy of lead compounds for broad-spectrum activity against other pathogens.
Methods
Binding activity of three lead compounds targeting BpMip was verified using surface plasmon resonance spectroscopy. The determination of crystal structures of BpMip in complex with these compounds, together with molecular modelling and in vitro assays, was used to determine whether the compounds have broad-spectrum antimicrobial activity against pathogens.
Results
Of the three lead small-molecule compounds, two were effective in inhibiting the PPIase activity of Mip proteins from Neisseria meningitidis, Klebsiella pneumoniae and Leishmania major. The compounds also reduced the intracellular burden of these pathogens using in vitro cell infection assays.
Conclusions
These results indicate that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad-spectrum drug candidates in vitro. Further optimization of compounds is required for in vivo evaluation and future clinical applications
Cosmological parameters from SDSS and WMAP
We measure cosmological parameters using the three-dimensional power spectrum
P(k) from over 200,000 galaxies in the Sloan Digital Sky Survey (SDSS) in
combination with WMAP and other data. Our results are consistent with a
``vanilla'' flat adiabatic Lambda-CDM model without tilt (n=1), running tilt,
tensor modes or massive neutrinos. Adding SDSS information more than halves the
WMAP-only error bars on some parameters, tightening 1 sigma constraints on the
Hubble parameter from h~0.74+0.18-0.07 to h~0.70+0.04-0.03, on the matter
density from Omega_m~0.25+/-0.10 to Omega_m~0.30+/-0.04 (1 sigma) and on
neutrino masses from <11 eV to <0.6 eV (95%). SDSS helps even more when
dropping prior assumptions about curvature, neutrinos, tensor modes and the
equation of state. Our results are in substantial agreement with the joint
analysis of WMAP and the 2dF Galaxy Redshift Survey, which is an impressive
consistency check with independent redshift survey data and analysis
techniques. In this paper, we place particular emphasis on clarifying the
physical origin of the constraints, i.e., what we do and do not know when using
different data sets and prior assumptions. For instance, dropping the
assumption that space is perfectly flat, the WMAP-only constraint on the
measured age of the Universe tightens from t0~16.3+2.3-1.8 Gyr to
t0~14.1+1.0-0.9 Gyr by adding SDSS and SN Ia data. Including tensors, running
tilt, neutrino mass and equation of state in the list of free parameters, many
constraints are still quite weak, but future cosmological measurements from
SDSS and other sources should allow these to be substantially tightened.Comment: Minor revisions to match accepted PRD version. SDSS data and ppt
figures available at http://www.hep.upenn.edu/~max/sdsspars.htm
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