Excerpts from the life of the bukharian artist

The article examines and scientifically analyzes the works of the famous Bukhara miniaturist Sadriddin Pochchayev, covering the history of the last period of the Bukhara Emirate and the former Soviet government. In particular, the study of the Middle Ages, the emirate, historical events of the former Soviet Union, miniatures, portraits, jewelry depicting subjects. The article also recommends visiting the Bukhara Museum of Fine Arts for an exhibition of works by the famous Bukhara miniaturist Sadriddin Pochchayev

Targeting neurons with small molecule probes: from imaging to modulation

Our body is governed through a complex network of diverse set of synapses created by many different neurons, which extend throughout the body. A great progress has been made to monitor and modulate these cells using genetic methods in limited settings, while chemical approaches have not achieved comparable successful results. Yet given the versatility of chemical probes, it has been important to create platforms which would allow us to generate compounds with characteristics of neuronal targeting and modulation. In our effort to modulate neurons and their synapses, a platform of assays was developed to find agonists and modulators of the brain derived neurotrophic factor, BDNF, and its receptor, TrkB, which is a central signaling system for neurogenesis and synaptic plasticity. These assays were used to evaluate reported TrkB agonists and perform a high throughput screen. In addition, an alternative approach in the form of phage display targeting TrkB was employed, since TrkB proved to be a challenging target for identification of small molecule agonist or modulator. To visualize different parts as well as various types of neurons, two different platforms were developed. A diversity oriented fluorescent library coupled with high content screening provided an opportunity to identify probes that could specifically stain neurons and synapses. In the second approach a new phage display method was developed that could identify probes with the ability to bind to neuronal cell surface markers. The developed platforms that we developed have a great potential to generate promising probes for vast array of applications

Multilayered Structures from Periodically Alternating Magnetic Island Layers: Magnetization Processes and Magnetoresistance

The multilayered structures from periodically alternating of island layers of various ferromagnetic are investigated. This island structures possessed a magnetoresistance of ~1-3 % and can detect of superweak magnetic fields up to 10-6 Oe at room temperature that allows using them as sensors of magnetic fields. The new specific vorticose states of magnetization which arises under some conditions in island structures is offered. Magnetization of these vortical states is distributed on many islands of island structures. It is supposed, what exactly this vortical magnetization is responsible for appearance of unidirectional magnetic anisotropy too. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3530

Electrical and Dielectric Properties of Nanoisland Systems Below Percolation Threshold

Electric and dielectric properties of nanoisland metal films were studied in this work. Permittivity of these films was determined from the analysis of the dependences of the susceptance of the films. It is found that the effective permittivity of the researched structures has abnormally high positive value (107-108). The temperature dependence of the permittivity of the films practically does not differ from the temperature dependence of the conductivity of these films. Such behavior of these dependences is possible, if the reasons for the change of permittivity and conductivity of the films with the temperature are of the same nature. With the growth of the electric field effective permittivity of the films decreases and the conductivity increases. The cause behind the high effective permittivity of the films is the island nature of these metal films, and it is associated with the polarization of the dipoles, formed by couples negatively and positively charged metal islands. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3481

Kichik biznesning moliyaviy resurs manbalari

Maqolada kichik biznesning moliyaviy resurs manbalari to‘g‘risida fikr yuritilgan. Shuningdek maqolada zarar ko’rib ishlayotgan kichik biznes korxonalarini moliyalashtirish manbalari to‘g‘risida bayon etilgan

Factors Affecting the Sensitivity of Moving Electromagnetic Screen Converters

The article found that by changing the parameters affecting the sensitivity of the moving screen converters, the screen should be made of materials with a small coefficient of temperature change, even if the specific resistance is large, and the high active resistance of the moving screen does not affect the linearity of the static characteristic

About coefficients and order of convergence of the optimal quadrature formula

Abstract In this paper we construct an optimal quadrature formula in the sense of Sard in the Hilbert space 2 3 ( ) K P . Using S.L. Sobolev's method we obtain new optimal quadrature formula and give explicit expressions for the corresponding optimal coefficients. Furthermore, we investigate order of convergence of the optimal formula

Synthesis and characterization by experimental and theory research suitable on the CdS and CdO materials

In this paper, we have compared and analyzed experimental and theoretical research on A2B6 types semiconductor materials CdS and CdO. The XRD spectra of the samples were examined using an atomic force microscope and X-ray diffraction microscopy. During film deposition, the temperature of the crucible with a source (CdS) varied in the range Tsourse ≈ 800 ÷ 850°C, and the substrate temperature was maintained within the range Tp ≈ 250 ÷ 270°C. In this case, to ensure the reproducibility of the structures, a shutter was used, with the help of which the CdS deposition time was set, which ensured that the film thickness was the same from experiment to experiment

Pre-incarceration police harassment, drug addiction and HIV risk behaviours among prisoners in Kyrgyzstan and Azerbaijan: results from a nationally representative cross-sectional study

Introduction: The expanding HIV epidemic in Azerbaijan and Kyrgyzstan is concentrated among people who inject drugs (PWID), who comprise a third of prisoners there. Detention of PWID is common but its impact on health has not been previously studied in the region. We aimed to understand the relationship between official and unofficial (police harassment) detention of PWID and HIV risk behaviours. Methods: In a nationally representative cross-sectional study, soon-to-be released prisoners in Kyrgyzstan (N=368) and Azerbaijan (N=510) completed standardized health assessment surveys. After identifying correlated variables through bivariate testing, we built multi-group path models with pre-incarceration official and unofficial detention as exogenous variables and pre-incarceration composite HIV risk as an endogenous variable, controlling for potential confounders and estimating indirect effects. Results: Overall, 463 (51%) prisoners reported at least one detention in the year before incarceration with an average of 1.3 detentions in that period. Unofficial detentions (13%) were less common than official detentions (41%). Optimal model fit was achieved (X2=5.83, p=0.44; Goodness of Fit Index (GFI) GFI=0.99; Comparative Fit Index (CFI) CFI=1.00; Root Mean Square Error of Approximation (RMSEA) RMSEA=0.00; PCLOSE=0.98) when unofficial detention had an indirect effect on HIV risk, mediated by drug addiction severity, with more detentions associated with higher addiction severity, which in turn correlated with increased HIV risk. The final model explained 35% of the variance in the outcome. The effect was maintained for both countries, but stronger for Kyrgyzstan. The model also holds for Kyrgyzstan using unique data on within-prison drug injection as the outcome, which was frequent in prisoners there. Conclusions: Detention by police is a strong correlate of addiction severity, which mediates its effect on HIV risk behaviour. This pattern suggests that police may target drug users and that such harassment may result in an increase in HIV risk-taking behaviours, primarily because of the continued drug use within prisons. These findings highlight the important negative role that police play in the HIV epidemic response and point to the urgent need for interventions to reduce police harassment, in parallel with interventions to reduce HIV transmission within and outside of prison