703 research outputs found

    An Adaptive Conjoint Analysis of Freight Service Alternatives: Evaluating the Maritime Alternative

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    The growing interest towards a re-balancing of freight traffic over the different modes, has brought renewed focus on the "Motorways of the sea" as they have been defined by the EU Commission in the recently issued White paper (2001). These could constitute a valid alternative to land transport over medium-long distance, favouring, at the same time, a greater integration among different modes. However, the great potential of this alternative - which is increasingly capturing the interest of policymakers - should be evaluated also in the light of the level of competitiveness nowadays required by the operators. The latter, in fact, need a flexible transport system capable of adapting to the modern system of production and completely integrated within the logistics networks (both existing and under construction). Furthermore, in order to effectively promote the use of this alternative, it is necessary to undertake a number of initiatives directed mainly at reducing the bottlenecks currently present within the ports and in the links between ports and their interland. In determining the necessary investments in intermodal sea-land infrastructures it is essential to evaluate the dimension and the extent of the potential re-orientation of traffic flows towards maritime transport which would yield insight on the appropriate/optimal dimension of such investments. In order to achieve this, it would be essential to have a set of information not only on the current movements but also on their potential reallocation. An estimation of the latter cannot be achieved without an in-depth analysis of shippers behaviour. However, while in the last year a number of documents have been put forward on the great opportunities offered by the development of the "Motorways of the sea" in re-directing freight flows, there is a lack of any empirical analysis on the determinants of such choice by operators. In other words, a lot has been done in analysing supply while very little in analysing demand. In this work we aim to identify the value that the user assigns to the specific transport alternative and the factors - related to both the mode and the specific organisation of the companies - that exert a significant influence on the choice of the shipper. These elements represent a necessary prerequisite for any previsions. The methodology used falls within the definition of conjoint Analysis. We will measure the trade-offs users of freight transport services make in choosing between alternative modes. We will also use the result to predict their choices with regards to alternatives which, at the moment might not be present, but which might be placed on the market. The assumption we make, following the approach of Bolis and Maggi (1999) and Fowkes and Tweddle (1996), is that the transport service can be ?broken down? into its component attributes. As it is well known, conjoint analysis allows to determine the value that individuals place on any product as equivalent to the sum of the utility they derive from all the attributes making up a product. In particular, given the successful applications to land transport, we use "Adaptive Stated Preferences" (ASP) techniques adjusted in order to carry out the analysis of freight transport demand in the maritime context. We aim to evaluate the preferences of operators in terms of service attributes of sea transport. Given the purposes of this study, for the moment we focus the empirical application on a specific geographical context. In particular, we analyse the preferences of operators localised in the north-west regions of Italy with respect to the possibility of accessing a maritime ro-ro service from the ports of Genoa or La Spezia. The analysis is carried out in two phases: a postal survey and a subsequent direct interview. The latter is done creating a ?transport experiment? and recording the behaviour and the choices of the interviewed. Following this approach, we obtain an accurate estimation of operators? willingness to pay for the specific service characteristics (hard output) and we induce them to reveal the rank of their preferences for a set of potential new services (soft output). In the first part of the paper we give details of the specific transport options we are considering and we describe the project carried out, in the second part we illustrate the methodology used the and the necessary modification we have had to carry out in order to implement the study in a maritime context. In the third part we discuss the data collection process and we carry out a preliminary data analysis, while, in the fourth section, we present the results of the econometric model (logit model) used to analyse the data and we give some interpretation. Finally, in the last section, we present some concluding remarks.

    European freight transport and the environment. Empirical applications and scenarios

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    Environmental issues have received a prominent place in transport policies of most European countries. The coordination of such policies however, is fraught with many difficulties. The increasing freight flows after the European integration are a source of concern, but have not yet led to straightforward and effective environmental strategies. The paper focuses on the Trans Alpine freight transport systems in the light of the future integration of single national transport systems into the European transport network. The environmental, social and institutional peculiarities of this ‘region’ have favoured—in the past—the development of strong nationally-oriented policies, partly in contrast with the goals promoted by the European Union. The present analysis aims to highlight opportunities, and limits inherent, in the implementation of various infrastructure projects oriented towards a drastic change of the Alpine transport systems structure. The Alpine countries, viz. Austria and Switzerland, play a central role in the promotion of environmental benign modes of transport of goods, with a clear focus on rail. The route choice and modal split of freight flows in Europe are taking place simultaneously. In this paper the results of European freight flow models (based on logit analysis and neural networks) will be presented. An important exercise is then to assess the consequences of various types of eco-taxes on road transport in Europe. In this context, several policy scenarios will be dealt with

    Tibolone in older postmenopausal women.

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    Monte Carlo simulation for the prediction of precision of absorbance measurements with a miniature CCD spectrometer

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    The precision characteristics of the absorbance measurements obtained with a low-cost miniature spectrometer incorporating an array detector were evaluated. Uncertainties in absorbance measurements were due to a combination of non-uniform light intensity and detector response over the wavelength range examined (350-850 nm), in conjunction with the digitization of the intensity indications and the intrinsic noise of the detecting elements. The precision characteristics are presented as contour plots displaying the expected RSD% of absorbances on the absorbance versus wavelength plane. The minimum RSD% for the spectrometer configuration tested was observed within the 0.2-1.5 absorbance units and 500-750 nm wavelength range. Without invoking signal enhancement features of the data-acquisition program (scan average, higher integration times, smoothing based on averaging the signal detected by adjacent pixels), the attainable precision within this range was 0.4-0.8%. A computer program based on Monte Carlo simulations was developed for the prediction of absorbance precision characteristics under various conditions of measurements

    Survival and prognostic factors of early ovarian cancer.

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    Survival and prognostic factors were analysed in 150 patients with histologically confirmed epithelial ovarian cancer stage IA-IIA. The relapse-free and overall survival rates were, respectively, 81% and 88% after 3 and 74% and 84% after 5 years. The analysis of various prognostic factors indicates as the main factor the grade differentiation of the tumour

    Effects of Alfaxalone or Propofol on Giant-Breed Dog Neonates Viability During Elective Caesarean Sections

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    Nowadays, thanks to the increased awareness of owners and breeders and to the most recent techniques available to veterinarians, the management of parturition, especially of C-sections, has become a topic of greater importance. Anesthesia is crucial and must be targeted to both the mother and neonates. The present study aimed to evaluate the effect of the induction agent alfaxalone on the vitality of puppies born from elective C-section, in comparison to propofol. After inducing general anesthesia for elective C-section, puppies from the mothers induced with alfaxalone had higher 5-min Apgar scores than those induced with propofol. The concentration of cortisol in fetal fluids collected at birth is neither influenced by the anesthetic protocol used, nor does it differ between amniotic and allantoic fluids. Nevertheless, the cortisol concentration in fetal fluids affects the relationship between anesthesia and the Apgar score: the present study highlights a significant relationship between the anesthetic protocol used and Apgar score in puppies, and fetal fluids cortisol concentration acts as a covariate of this relationship. Alfaxalone is a safe and effective drug for the induction of anesthesia in dogs, and it can be successfully employed for elective C-section, with neonatal wellbeing improvements

    Transumbilical versus transvaginal retrieval of surgical specimens at laparoscopy: a randomized trial.

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    Objective We sought to compare transumbilical (TU) and transvaginal (TV) route for retrieval of surgical specimens at laparoscopy. Study design Women scheduled for a laparoscopic resection of an adnexal mass were randomized to have their surgical specimen removed either through a posterior colpotomy (n = 34) or the umbilical port site (n = 32). Group allocation was concealed from patients and bedside clinicians. The primary outcome was postoperative incisional pain assessed by a 10-cm visual analog scale at 1, 3, and 24 hours after surgery. Results TV retrieval caused less postoperative pain than TU specimen extraction at each time point (visual analog scale score at 1 hour: 2.6 \ub1 2.9 vs 1.2 \ub1 2.0, P = .03; at 3 hours: 2.4 \ub1 2.0 vs 1.4 \ub1 2.0, P = .02; and at 24 hours: 1.1 \ub1 1.5 vs 0.5 \ub1 1.4, P = .02). A higher proportion of women in the TU group than in the TV group indicated the umbilicus as the most painful area at 1 and 3 hours postoperatively. Two months after surgery, the participants scored similarly as to their overall satisfaction, cosmetic outcome, and dyspareunia upon resumption of intercourse. Conclusion A TV approach for specimen removal after laparoscopic resection of adnexal masses offers the advantage of less postoperative pain than TU retrieva

    Methylation of phenol over high-silica beta zeolite: effect of zeolite acidity and crystal size on catalyst behaviour

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    A systematic investigation was carried out to elucidate several aspects of the gas/solid methylation of phenol over high Si/Al ratio beta-structured zeolite in protonated form, characterised by various techniques, including XRD, SEM, BET, ICP, FTIR, TGA, microcalorimetry, and modeling by ab initio calculations. Data on the characteristics and the kinetic and mechanistic features of the catalytic reaction, as well as on catalyst deactivation, show that these zeolites, besides being very active for the present reaction, lead to cresols and anisole as primary products. As catalyst deactivation proceeds, the selectivity to cresols and anisole increases substantially, accompanied by a rapid decrease in selectivity to polyalkylated species. Medium- to low-strength silanols are the main contributors to catalyst surface acidity. High-strength Lewis acid sites either are virtually absent (especially when metal cations partially substitute for protons) or play a role essentially in catalyst deactivation. Stacking faults in the zeolite framework, generated by the intergrowth of at least two beta polymorphs, lead to an increased concentration of silanol-based Br\uf8nsted acid sites. Deactivation is due to the interaction of phenol and oxygenated products with the silanol-based acid sites and of methanol only with the strong acid sites of both Lewis and Br\uf8nsted nature. Self-oligomerisation\u2013cyclisation of methanol to olefins and aromatics, followed by further alkylation to aromatic C atoms, contributes to catalyst deactivation. At any conversion level and at any temperature, the anisole/cresol ratio is systematically lower for the larger-crystal size zeolite, because the secondary transformations of anisole to cresols by both intramolecular rearrangement and intermolecular alkylation of phenol is favoured by the longer residence time of anisole within the zeolite pores

    Hodgkin's lymphoma: The pathologist's viewpoint

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    Despite its well known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B cell derivation of the tumour in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognises a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (CHL), reflecting the differences in clinical presentation and behaviour, morphology, phenotype, and molecular features. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between CHL and anaplastic large cell lymphoma have become sharper, whereas those between LP-HL and T cell rich B cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumour in at risk patients have been proposed and are on the way to being applied
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