329 research outputs found

    SYNTHESES OF PRECURSORS TO FLUORINE-18 LABELED PET IMAGING AGENTS

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    On the Cauchy problem for the magnetic Zakharov system

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    In this paper, we study the Cauchy problem of the magnetic type Zakharov system which describes the pondermotive force and magnetic field generation effects resulting from the non-linear interaction between plasma-wave and particles. By using the energy method to derive a priori bounds and an approximation argument for the construction of solutions, we obtain local existence and uniqueness results for the magnetic Zakharov system in the case of d=2,3d=2,3

    Assimilatory nitrate utilization by bacteria on the West Florida Shelf as determined by stable isotope probing and functional microarray analysis

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    Dissolved inorganic nitrogen (DIN) uptake by marine heterotrophic bacteria has important implications for the global nitrogen (N) and carbon (C) cycles. Bacterial nitrate utilization is more prevalent in the marine environment than traditionally thought, but the taxonomic identity of bacteria that utilize nitrate is difficult to determine using traditional methodologies. 15N-based DNA stable isotope probing was applied to document direct use of nitrate by heterotrophic bacteria on the West Florida Shelf. Seawater was incubated in the presence of 2 mu M 15N ammonium or 15N nitrate. DNA was extracted, fractionated via CsCl ultracentrifugation, and each fraction was analyzed by terminal restriction fragment length polymorphism (TRFLP) analysis. TRFs that exhibited density shifts when compared to controls that had not received 15N amendments were identified by comparison with 16S rRNA gene sequence libraries. Relevant marine proteobacterial lineages, notably Thalassobacter and Alteromonadales, displayed evidence of 15N incorporation. RT-PCR and functional gene microarray analysis could not demonstrate the expression of the assimilatory nitrate reductase gene, nasA, but mRNA for dissimilatory pathways, i.e. nirS, nirK, narG, nosZ, napA, and nrfA was detected. These data directly implicate several bacterial populations in nitrate uptake, but suggest a more complex pattern for N flow than traditionally implied

    Performance of Tall Fescue Varieties [1984]

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    The objective of the tall fescue breeding program is the development of varieties characterized by superior nutritive value (including reduced contents of perloline and loline alkaloids and the fungal endophyte, Epichloe typhina, (Acremonium coenophialum), palatability, disease resistance, and adaptation through the utilization of intergeneric and interspecific hybrid derivatives of ryegtass and tall fescue species. Varieties previously released from the breeding program were Kentucky 31, Kenwell; and Kenhy. Johnstone tall fescue, developed cooperatively by the Kentucky Agricultural Experiment Station and USDA-ARS, was released March 1, 1982, as a new variety. Johnstone is characterized as having low levels of perloline alkaloid and the fungal endophyte; Acremonium coenophialum, and improved forage quality during summer. It is expected that seed of Johnstone will be available commercially during 1985, and a good supply should be available for spring and summer 1986 planting

    Nonlinear Schr\"odinger Equation: Generalized Darboux Transformation and Rogue Wave Solutions

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    In this paper, we construct a generalized Darboux transformation for nonlinear Schr\"odinger equation. The associated NN-fold Darboux transformation is given both in terms of a summation formula and in terms of determinants. As applications, we obtain compact representations for the NN-th order rogue wave solutions of the focusing nonlinear Schr\"odinger equation and Hirota equation. In particular, the dynamics of the general third order rogue wave is discussed and shown to exhibit interesting structure.Comment: 17 pages, 4 figures, replaced by revised versio

    Geriatric Interdisciplinary Team Training

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    Educational Objectives 1. To demonstrate the importance of training health care professionals in inter-disciplinary teamwork and geriatric health issues. 2. To increase one’s knowledge of the roles and responsibilities of the various disciplines involved in interdisciplinary teamwork

    Agronomic and Animal Performance of Different Tall Fescue Varieties

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    The objective of the tall fescue breeding program is the development of varieties characterized by superior nutritive value (including reduced contents of perloline and loline alkaloids and minimal infestation of the fungal endophyte, Acremonium coenophialum), palatability, disease resistance, and adaptation through the utilization of intergeneric and interspecific hybrid derivatives of ryegrass and tall fescue species. Kentucky 31, Kenwell, and Kenhy were previously released from this breeding program. Johnstone tall fescue, developed cooperatively by the Kentucky Agricultural Experiment Station and USDA-ARS, was released March 1, 1982 as a new variety. Johnstone is characterized as having low levels of perloline alkaloid and the fungal endophyte (Acremonium coenophialum) and improved forage quality during summer. It is expected that seed of Johnstone will be available commercially during 1985, and a good supply be available for /\u27 spring and summer 1986 plantings

    1986 Update of Agronomic and Animal Performance of Different Tall Fescue Varieties

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    The objective of the tall fescue breeding program at the University of Kentucky is the development of varieties characterized by superior nutritive value (including reduced levels of perloline and loline alkaloids), minimal infestation of the fungal endophyte, Acremonium coenophialum), higher palatability, improved disease resistance, and wider adaptation through the derivation of intergeneric and interspecific hybrids of ryegrass and tall fescue species. Kentucky 31, Kenwell, and Kenhy were varieties released from this breeding program. Johnstone tall fescue, developed cooperatively by the Kentucky Agricultural Experiment Station and USDA-ARS, is the most recently released variety. It is characterized as having low levels of perloline alkaloid and the fungal endophyte (Acremonium coenophialum) and improved forage quality during summer. Ample Johnstone seed should be available to meet demand during 1986

    Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients

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    <p>Abstract</p> <p>Background</p> <p><it>XPC </it>is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for the variant allele of <it>XPC </it>c.1496C > T (p.Ala499Val) were shown in a large pooled analysis to have an increased bladder cancer risk, and we found two 3'UTR variants, *611T > A and c.*618A > G, to be in strong linkage disequilibrium with c.1496T. Here we determined if these two 3'UTR variants can affect mRNA stability and assessed the impact of all three variants on mRNA and protein expression.</p> <p>Methods</p> <p><it>In vitro </it>mRNA stability assays were performed and mRNA and protein expression measured both in plasmid-based assays and in lymphocytes and lymphoblastoid cell lines from bladder and breast cancer patients.</p> <p>Results</p> <p>The two 3'UTR variants were associated with reduced protein and mRNA expression in plasmid-based assays, suggesting an effect on mRNA stability and/or transcription/translation. A near-significant reduction in XPC protein expression (p = 0.058) was detected in lymphoblastoid cell lines homozygous for these alleles but no differences in mRNA stability in these lines was found or in mRNA or protein levels in lymphocytes heterozygous for these alleles.</p> <p>Conclusion</p> <p>The two 3'UTR variants may be the variants underlying the association of c.1496C > T and bladder cancer risk acting via a mechanism modulating protein expression.</p

    Incidence and prevalence of patellofemoral pain: a systematic review and meta-analysis

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    Background: Patellofemoral pain is considered one of the most common forms of knee pain, affecting adults, adolescents, and physically active populations. Inconsistencies in reported incidence and prevalence exist and in relation to the allocation of healthcare and research funding, there is a clear need to accurately understand the epidemiology of patellofemoral pain. Methods: An electronic database search was conducted, as well as grey literature databases, from inception to June 2017. Two authors independently selected studies, extracted data and appraised methodological quality. If heterogeneous, data were analysed descriptively. Where studies were homogeneous, data were pooled through a meta-analysis. Results: 23 studies were included. Annual prevalence for patellofemoral pain in the general population was reported as 22.7%, and adolescents as 28.9%. Incidence rates in military recruits ranged from 9.7 – 571.4/1,000 person-years, amateur runners in the general population at 1080.5/1,000 person-years and adolescents amateur athletes 5.1% - 14.9% over 1 season. One study reported point prevalence within military populations as 13.5%. The pooled estimate for point prevalence in adolescents was 7.2% (95% Confidence Interval: 6.3% - 8.3%), and in female only adolescent athletes was 22.7% (95% Confidence Interval 17.4% - 28.0%). Conclusion: This review demonstrates high incidence and prevalence levels for patellofemoral pain. Within the context of this, and poor long term prognosis and high disability levels, PFP should be an urgent research priority
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