Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice

Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn's disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice

Lärarhandledning för SFI-undervisning i kulturmiljöer

Denna lärarhandledning har tagits fram som del av forskningsprojektet Kulturmiljörelaterad SFI, ett samarbete mellan Södertörns högskola, Blekinge museum och Stockholms stad. Handledningen vänder sig till SFI-lärare som vill lägga en del av sin undervisning utomhus i relation till den närliggande kultur- och naturmiljön. Här presenteras exempel på utomhusundervisning som på ett enkelt sätt kombinerar språkinlärning med omvärldskunskaper