General Relativity as Classical Limit of Evolutionary Quantum Gravity

We analyze the dynamics of the gravitational field when the covariance is restricted to a synchronous gauge. In the spirit of the Noether theorem, we determine the conservation law associated to the Lagrangian invariance and we outline that a non-vanishing behavior of the Hamiltonian comes out. We then interpret such resulting non-zero ``energy'' of the gravitational field in terms of a dust fluid. This new matter contribution is co-moving to the slicing and it accounts for the ``materialization'' of a synchronous reference from the corresponding gauge condition. Further, we analyze the quantum dynamics of a generic inhomogeneous Universe as described by this evolutionary scheme, asymptotically to the singularity. We show how the phenomenology of such a model overlaps the corresponding Wheeler-DeWitt picture. Finally, we study the possibility of a Schr\"odinger dynamics of the gravitational field as a consequence of the correspondence inferred between the ensemble dynamics of stochastic systems and the WKB limit of their quantum evolution. We demonstrate that the time dependence of the ensemble distribution is associated with the first order correction in $\hbar$ to the WKB expansion of the energy spectrum.Comment: 23 pages, to appear on Class. Quant. Gra

Integrin-mediated Tyrosine Phosphorylation and Cytokine Message Induction in Monocytic Cells: A POSSIBLE SIGNALING ROLE FOR THE Syk TYROSINE KINASE

Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins. In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa. In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta. The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events. The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk. In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin. In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected. These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages

Quantum Gravitational Corrections to the Real Klein-Gordon Field in the Presence of a Minimal Length

The (D+1)-dimensional $(\beta,\beta')$-two-parameter Lorentz-covariant deformed algebra introduced by Quesne and Tkachuk [C. Quesne and V. M. Tkachuk, J. Phys. A: Math. Gen. \textbf {39}, 10909 (2006).], leads to a nonzero minimal uncertainty in position (minimal length). The Klein-Gordon equation in a (3+1)-dimensional space-time described by Quesne-Tkachuk Lorentz-covariant deformed algebra is studied in the case where $\beta'=2\beta$ up to first order over deformation parameter $\beta$. It is shown that the modified Klein-Gordon equation which contains fourth-order derivative of the wave function describes two massive particles with different masses. We have shown that physically acceptable mass states can only exist for $\beta<\frac{1}{8m^{2}c^{2}}$ which leads to an isotropic minimal length in the interval $10^{-17}m<(\bigtriangleup X^{i})_{0}<10^{-15}m$. Finally, we have shown that the above estimation of minimal length is in good agreement with the results obtained in previous investigations.Comment: 10 pages, no figur

String-inspired cosmology: Late time transition from scaling matter era to dark energy universe caused by a Gauss-Bonnet coupling

The Gauss-Bonnet (GB) curvature invariant coupled to a scalar field $\phi$ can lead to an exit from a scaling matter-dominated epoch to a late-time accelerated expansion, which is attractive to alleviate the coincident problem of dark energy. We derive the condition for the existence of cosmological scaling solutions in the presence of the GB coupling for a general scalar-field Lagrangian density $p(\phi, X)$, where $X=-(1/2)(\nabla \phi)^2$ is a kinematic term of the scalar field. The GB coupling and the Lagrangian density are restricted to be in the form $f(\phi) \propto e^{\lambda \phi}$ and $p=Xg (Xe^{\lambda \phi})$, respectively, where $\lambda$ is a constant and $g$ is an arbitrary function. We also derive fixed points for such a scaling Lagrangian with a GB coupling $f(\phi) \propto e^{\mu \phi}$ and clarify the conditions under which the scaling matter era is followed by a de-Sitter solution which can appear in the presence of the GB coupling. Among scaling models proposed in the current literature, we find that the models which allow such a cosmological evolution are an ordinary scalar field with an exponential potential and a tachyon field with an inverse square potential, although the latter requires a coupling between dark energy and dark matter.Comment: 18 pages, 4 figures, version to appear in JCA

Hawking Temperature in Taub-NUT (A)dS spaces via the Generalized Uncertainty Principle

Using the extended forms of the Heisenberg uncertainty principle from string theory and the quantum gravity theory, we drived Hawking temperature of a Taub-Nut-(A)dS black hole. In spite of their distinctive natures such as asymptotically locally flat and breakdown of the area theorem of the horizon for the black holes, we show that the corrections to Hawking temperature by the generalized versions of the the Heisenberg uncertainty principle increases like the Schwarzschild-(A)dS black hole and give the reason why the Taub-Nut-(A)dS metric may have AdS/CFT dual picture.Comment: version published in General Relativity and Gravitatio

On (Cosmological) Singularity Avoidance in Loop Quantum Gravity

Loop Quantum Cosmology (LQC), mainly due to Bojowald, is not the cosmological sector of Loop Quantum Gravity (LQG). Rather, LQC consists of a truncation of the phase space of classical General Relativity to spatially homogeneous situations which is then quantized by the methods of LQG. Thus, LQC is a quantum mechanical toy model (finite number of degrees of freedom) for LQG(a genuine QFT with an infinite number of degrees of freedom) which provides important consistency checks. However, it is a non trivial question whether the predictions of LQC are robust after switching on the inhomogeneous fluctuations present in full LQG. Two of the most spectacular findings of LQC are that 1. the inverse scale factor is bounded from above on zero volume eigenstates which hints at the avoidance of the local curvature singularity and 2. that the Quantum Einstein Equations are non -- singular which hints at the avoidance of the global initial singularity. We display the result of a calculation for LQG which proves that the (analogon of the) inverse scale factor, while densely defined, is {\it not} bounded from above on zero volume eigenstates. Thus, in full LQG, if curvature singularity avoidance is realized, then not in this simple way. In fact, it turns out that the boundedness of the inverse scale factor is neither necessary nor sufficient for curvature singularity avoidance and that non -- singular evolution equations are neither necessary nor sufficient for initial singularity avoidance because none of these criteria are formulated in terms of observable quantities.After outlining what would be required, we present the results of a calculation for LQG which could be a first indication that our criteria at least for curvature singularity avoidance are satisfied in LQG.Comment: 34 pages, 16 figure

Integration of cell of origin into the clinical CNS International Prognostic Index improves CNS relapse prediction in DLBCL

Central nervous system (CNS) relapse carries a poor prognosis in diffuse large B-cell lymphoma (DLBCL). Integrating biomarkers into the CNS-International Prognostic Index (CNS-IPI) risk model may improve identification of patients at high risk for developing secondary CNS disease. CNS relapse was analyzed in 1418 DLBCL patients treated with obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone chemotherapy in the phase 3 GOYA study. Cell of origin (COO) was assessed using gene-expression profiling. BCL2 and MYC protein expression was analyzed by immunohistochemistry. The impact of CNS-IPI, COO, and BCL2/MYC dual-expression status on CNS relapse was assessed using a multivariate Cox regression model (data available in n = 1418, n = 933, and n = 688, respectively). High CNS-IPI score (hazard ratio [HR], 4.0; 95% confidence interval [CI], 1.3-12.3; P = .02) and activated B-cell\u2012like (ABC) (HR, 5.2; 95% CI, 2.1-12.9; P = .0004) or unclassified COO subtypes (HR, 4.2; 95% CI, 1.5-11.7; P = .006) were independently associated with CNS relapse. BCL2/MYC dual-expression status did not impact CNS relapse risk. Three risk subgroups were identified based on the presence of high CNS-IPI score and/or ABC/unclassified COO (CNS-IPI-C model): low risk (no risk factors, n = 450 [48.2%]), intermediate risk (1 factor, n = 408 [43.7%]), and high risk (both factors, n = 75 [8.0%]). Two-year CNS relapse rates were 0.5%, 4.4%, and 15.2% in the respective risk subgroups. Combining high CNS-IPI and ABC/unclassified COO improved CNS relapse prediction and identified a patient subgroup at high risk for developing CNS relapse. The study was registered at www.clinicaltrials.gov as #NCT01287741

Assessing the co-occurrence of intimate partner violence domains across the life-course: relating typologies to mental health

Background: The inter-generational transmission of violence (ITV) hypothesis and polyvictimisation have been studied extensively. The extant evidence suggests that individuals from violent families are at increased risk of subsequent intimate partner violence (IPV) and that a proportion of individuals experience victimisation across multiple rather than single IPV domains. Both ITV and polyvictimisation are shown to increase the risk of psychiatric morbidity, alcohol use, and anger expression. Objective: The current study aimed to 1) ascertain if underlying typologies of victimisation across the life-course and over multiple victimisation domains were present and 2) ascertain if groupings differed on mean scores of posttraumatic stress disorder (PTSD), depression, alcohol use, and anger expression. Method: University students (N=318) were queried in relation to victimisation experiences and psychological well-being. Responses across multiple domains of IPV spanning the life-course were used in a latent profile analysis. ANOVA was subsequently used to determine if profiles differed in their mean scores on PTSD, depression, alcohol use, and anger expression. Results: Three distinct profiles were identified; one of which comprised individuals who experienced “life-course polyvictimisation,” another showing individuals who experienced “witnessing parental victimisation,” and one which experienced “psychological victimisation only.” Life-course polyvictims scored the highest across most assessed measures. Conclusion: Witnessing severe physical aggression and injury in parental relationships as a child has an interesting impact on the ITV into adolescence and adulthood. Life-course polyvictims are shown to experience increased levels of psychiatric morbidity and issues with alcohol misuse and anger expression

Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays

Average charged multiplicities have been measured separately in $b$, $c$ and light quark ($u,d,s$) events from $Z^0$ decays measured in the SLD experiment. Impact parameters of charged tracks were used to select enriched samples of $b$ and light quark events, and reconstructed charmed mesons were used to select $c$ quark events. We measured the charged multiplicities: $\bar{n}_{uds} = 20.21 \pm 0.10 (\rm{stat.})\pm 0.22(\rm{syst.})$, $\bar{n}_{c} = 21.28 \pm 0.46(\rm{stat.}) ^{+0.41}_{-0.36}(\rm{syst.})$ $\bar{n}_{b} = 23.14 \pm 0.10(\rm{stat.}) ^{+0.38}_{-0.37}(\rm{syst.})$, from which we derived the differences between the total average charged multiplicities of $c$ or $b$ quark events and light quark events: $\Delta \bar{n}_c = 1.07 \pm 0.47(\rm{stat.})^{+0.36}_{-0.30}(\rm{syst.})$ and $\Delta \bar{n}_b = 2.93 \pm 0.14(\rm{stat.})^{+0.30}_{-0.29}(\rm{syst.})$. We compared these measurements with those at lower center-of-mass energies and with perturbative QCD predictions. These combined results are in agreement with the QCD expectations and disfavor the hypothesis of flavor-independent fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters

The impact of decision aids to enhance shared decision making for diabetes (the DAD study): protocol of a cluster randomized trial

Background. Shared decision making contributes to high quality healthcare by promoting a patientcentered approach. Patient involvement in selecting the components of a diabetes medication program that best match the patient's values and preferences may also enhance medication adherence and improve outcomes. Decision aids are tools designed to involve patients in shared decision making, but their adoption in practice has been limited. In this study, we propose to obtain a preliminary estimate of the impact of patient decision aids vs. usual care on measures of patient involvement in decision making, diabetes care processes, medication adherence, glycemic and cardiovascular risk factor control, and resource utilization. In addition, we propose to identify, describe, and explain factors that promote or inhibit the routine embedding of decision aids in practice. Methods. We will be conducting a mixed-methods study comprised of a cluster-randomized, practical, multicentered trial enrolling clinicians and their patients (n = 240) with type 2 diabetes from rural and suburban primary care practices (n = 8), with an embedded qualitative study to examine factors that influence the incorporation of decision aids into routine practice. The intervention will consist of the use of a decision aid (Statin Choice and Aspirin Choice, or Diabetes Medication Choice) during the clinical encounter. The qualitative study will include analysis of video recordings of clinical encounters and in-depth, semi-structured interviews with participating patients, clinicians, and clinic support staff, in both trial arms. Discussion. Upon completion of this trial, we will have new knowledge about the effectiveness of diabetes decision aids in these practices. We will also better understand the factors that promote or inhibit the successful implementation and normalization of medication choice decision aids in the care of chronic patients in primary care practices