396 research outputs found
Hyper-complex four-manifolds from the Tzitz\'eica equation
It is shown how solutions to the Tzitz\'eica equation can be used to
construct a family of (pseudo) hyper-complex metrics in four dimensions.Comment: To be published in J.Math.Phy
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating the sufficiency of miR-155 to drive GM expansion, enforced expression in mouse bone marrow cells caused GM proliferation in a manner reminiscent of LPS treatment. However, the miR-155–induced GM populations displayed pathological features characteristic of myeloid neoplasia. Of possible relevance to human disease, miR-155 was found to be overexpressed in the bone marrow of patients with certain subtypes of acute myeloid leukemia (AML). Furthermore, miR-155 repressed a subset of genes implicated in hematopoietic development and disease. These data implicate miR-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML, emphasizing the importance of proper miR-155 regulation in developing myeloid cells during times of inflammatory stress
The technologies of using generating gas in cogeneration installations
The paper discusses the experimental setup of gas generation from wood waste. The obtained experimental dependence of the composition of the generator gas temperature at the exit of the gasifier.В работе рассмотрена экспериментальная установка генерации газа из древесных отходов. Получены экспериментальные зависимости состава генераторного газа от температуры на выходе из газогенератора
Air ions induced aerosol sensing by eye-safe LIDAR
Low concentrations aerosols quantification is rather challenging for LIDAR
instruments due to eye-safety restrictions so high energy pulses cannot be
utilized to improve the sensitivity. Highly sensitive but eye-save LIDAR has
been developed for the quantification of the water droplet aerosol which was
induced by air ions. Few days sensing of aerosols in closed tunnel revealed a
strong correlation between air optical transparency (LIDAR measurements) and
concentrations of positive/negative ions (ion counter Sapphir 3-M). The
correlation coefficient was observed to be almost unity for the air
transparency signal and air ions unipolarity coefficient. High sensitivity of
the water droplet aerosol quantification makes the developed eye-safe LIDAR a
perspective instrument for space resolved measurements of the air ions
distribution. Space and time resolved measurements of air ions exhalation can
be a new instrument for tectonic activity study including new earthquake
forecasting indicators search
Diagnosis and treatment of muscle pain according to Tipaldos (literature review)
This review contents the information on the theory of the structure and mechanisms of damage to the body fascial system, proposed by American osteopath S. Tipaldos and named by him the Fascial Distortion Model (FDM), as well as on the original method of diagnosis and treatment of muscle pain syndromes associated with fascial damage (distortion). The author describes classifications of connective tissue and fascial structures, created by S. Tipaldos, which are based on anatomical and functional features that determine the role of each type of fascia in compensating for various types of external influences. The conditions, mechanisms of formation and characteristics of six types of fascial lesions identified by S. Tipaldos are considered in detail: triggerband, herniated triggerpoint, continuum distortion, folding distortion, cylinder distortion, tectonic fixation. All elements of the fascial distortions diagnosis are discussed in detail, including the specification of complaints (characteristics of pain syndrome), anamnesis (history of the pain onset and its development) and an objective examination (the actual diagnostic techniques). At the same time, the special role of the patient’s description of his own painful sensations with the help of specific gestures and movements, called «body language», is emphasized. The principles and some methods of therapeutic effects used in FDM-therapy, indications and contraindications for the use of the considered manual techniques, possible side reactions that may occur during manipulation or after a session of FDMtherapy are presented. Particular attention is paid to the evidence base of FDM therapy effectiveness in comparison with traditional methods of myofascial pain syndromes manual treatment: the results of controlled studies by foreign authors, confirming the new technique effectiveness in the treatment of certain muscle algic phenomena types, are considered
Strominger--Yau--Zaslow geometry, Affine Spheres and Painlev\'e III
We give a gauge invariant characterisation of the elliptic affine sphere
equation and the closely related Tzitz\'eica equation as reductions of real
forms of SL(3, \C) anti--self--dual Yang--Mills equations by two
translations, or equivalently as a special case of the Hitchin equation.
We use the Loftin--Yau--Zaslow construction to give an explicit expression
for a six--real dimensional semi--flat Calabi--Yau metric in terms of a
solution to the affine-sphere equation and show how a subclass of such metrics
arises from 3rd Painlev\'e transcendents.Comment: 38 pages. Final version. To appear in Communications in Mathematical
Physic
Tungstate Based Ceramics Obtained By Spark Plasma Sintering Method – Possible Material for Consolidation of Radioactive Wastes’ Components
The Spark Plasma Sintering method was used to produce high-density ceramics from tungstates SrWO4 and NaNd(WO4)2 with scheelite structure. These compounds are proposed as possible matrices for the consolidation of radwaste components. Powder samples were obtained by coprecipitation method and studied by X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). After sintering, the samples retained their phase identity (scheelite structure). The total duration of sintering was ∼ 13-15 min, the relative density was reached ∼ 92, 99%.
Keywords: Tungstates, RW, Spark Plasma Sintering, high density, microstructur
NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies
MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow. Spleen and marrow cells show increased transcription of NF-κB–regulated genes and tumors have higher nuclear p65. Genetic ablation of NF-κB p50 suppresses the myeloproliferation, showing that dysregulation of NF-κB is responsible for the myeloproliferative disease
Complex proximal femoral fractures in the elderly managed by reconstruction nailing – complications & outcomes: a retrospective analysis
Investigation of the microstructure of the fine-grained YPO:Gd ceramics with xenotime structure after Xe irradiation
The paper reports on the preparation of xenotime-structured ceramics by the
Spark Plasma Sintering (SPS) method. Phosphates YGdPO
(YPO:Gd) were obtained by the sol-gel method. The synthesized nanopowders
are collected in large agglomerates 10-50 mkm in size. Ceramics has a
fine-grained microstructure and a high relative density (98.67%). The total
time of the SPS process was approximately 18 min. High-density sintered
ceramics YPO:Gd with a xenotime structure were irradiated with Xe
ions (E = 167 MeV) to fluences of - cm.
Complete amorphization at maximum fluence was not achieved. As the fluence
increases, an insignificant increase in the depth of the amorphous layer is
observed. According to the results of grazing incidence XRD (GIXRD), with an
increase in fluence from - cm, an
increase in the volume fraction of the amorphous structure from 20 to 70% is
observed. The intensity of XRD peak 200 YPO:Gd after recovery annealing
(700C, 18 h) reached a value of ~80% of the initial intensity I0.Comment: 16 pages, 10 figure
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