Geometric phases in open tripod systems

We first consider stimulated Raman adibatic passages (STIRAP) in a closed four-level tripod system. In this case, the adiabatic eigenstates of the system acquire real geometric phases. When the system is open and subject to decoherence they acquire complex geometric phases that we determine by a Monte Carlo wave function approach. We calculate the geometric phases and the state evolution in the closed as well as in the open system cases and describe the deviation between these in terms of the phases acquired. When the system is closed, the adiabatic evolution implements a Hadamard gate. The open system implements an imperfect gate and hence has a fidelity below unity. We express this fidelity in terms of the acquired geometric phases.Comment: 10 pages 7 figure

A quantitative comparison of amplitude versus intensity interferometry for astronomy

Astronomical imaging can be broadly classified into two types. The first type is amplitude interferometry, which includes conventional optical telescopes and very large baseline interferometry (VLBI). The second type is intensity interferometry, which relies on Hanbury Brown and Twiss-type measurements. At optical frequencies, where direct phase measurements are impossible, amplitude interferometry has an effective numerical aperture that is limited by the distance from which photons can coherently interfere. Intensity interferometry, on the other hand, correlates only photon fluxes and can thus support much larger numerical apertures, but suffers from a reduced signal due to the low average photon number per mode in thermal light. It has hitherto not been clear which method is superior under realistic conditions. Here, we give a comparative analysis of the performance of amplitude and intensity interferometry, and we relate this to the fundamental resolution limit that can be achieved in any physical measurement. Using the benchmark problem of determining the separation between two distant thermal point sources, e.g., two adjacent stars, we give a short tutorial on optimal estimation theory and apply it to stellar interferometry. We find that for very small angular separations the large baseline achievable in intensity interferometry can more than compensate for the reduced signal strength. We also explore options for practical implementations of very large baseline intensity interferometry (VLBII)

Solonamide B Inhibits Quorum Sensing and Reduces Staphylococcus aureus Mediated Killing of Human Neutrophils

Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a serious human pathogen, and particularly the spread of community associated (CA)-MRSA strains such as USA300 is a concern, as these strains can cause severe infections in otherwise healthy adults. Recently, we reported that a cyclodepsipeptide termed Solonamide B isolated from the marine bacterium, Photobacterium halotolerans strongly reduces expression of RNAIII, the effector molecule of the agr quorum sensing system. Here we show that Solonamide B interferes with the binding of S. aureus autoinducing peptides (AIPs) to sensor histidine kinase, AgrC, of the agr two-component system. The hypervirulence of USA300 has been linked to increased expression of central virulence factors like α-hemolysin and the phenol soluble modulins (PSMs). Importantly, in strain USA300 Solonamide B dramatically reduced the activity of α-hemolysin and the transcription of psma encoding PSMs with an 80% reduction in toxicity of supernatants towards human neutrophils and rabbit erythrocytes. To our knowledge this is the first report of a compound produced naturally by a Gram-negative marine bacterium that interferes with agr and affects both RNAIII and AgrA controlled virulence gene expression in S. aureus

Heat Resistance Mediated by a New Plasmid Encoded Clp ATPase, ClpK, as a Possible Novel Mechanism for Nosocomial Persistence of Klebsiella pneumoniae

Klebsiella pneumoniae is an important opportunistic pathogen and a frequent cause of nosocomial infections. We have characterized a K. pneumoniae strain responsible for a series of critical infections in an intensive care unit over a two-year period. The strain was found to be remarkably thermotolerant providing a conceivable explanation of its persistence in the hospital environment. This marked phenotype is mediated by a novel type of Clp ATPase, designated ClpK. The clpK gene is encoded by a conjugative plasmid and we find that the clpK gene alone renders an otherwise sensitive E. coli strain resistant to lethal heat shock. Furthermore, one third of a collection of nosocomial K. pneumoniae isolates carry clpK and exhibit a heat resistant phenotype. The discovery of ClpK as a plasmid encoded factor and its profound impact on thermal stress survival sheds new light on the biological relevance of Clp ATPases in acquired environmental fitness and highlights the challenges of mobile genetic elements in fighting nosocomial infections

Encouraging and supporting children's voices

Children are considered not to be full members of society and that their participation should be limited. Further, that this limitation is imposed by adults. In order to counter these views it is key to afford space for children’s voices and that these are facilitated in some way. Philosophy with Children, in all its variety of approaches and practices, lays claim to being a tool that allows children to develop the skills necessary for citizenship such as participation and airing their views. The chapter focuses on the role of Community of Philosophical Inquiry (CoPI), a specific method of practical philosophy with children, to empower children and give them a voice. CoPI has a series of distinctive features that make it especially apt in meeting this goal. Children are able articulate their views on a particular topic and this is supported by the structure of the dialogue itself. In addition, though, their statements must build on previous statements by demonstrating dis/agreement and the participants must provide reasons to justify that dis/agreement. The method also emphasises the primacy of the children’s thinking and the facilitator works to juxtapose speakers in order to drive the dialogue further philosophically. In this chapter, these features of CoPI are illustrated by examples from dialogues on the Good Life, stimulated by the question "What kind of society would you like to live in?" CoPI is shown to give children voice with a view to promoting their participation in society while also eschewing the imbalance in the adult/child power relationship. Here, we see what is important to children in the lives they want to live, for themselves and for those around them. What is of particular interest is the manner in which the children appear to collude with the adult/child power divide in how they talk about the kind of society in which they’d like to live

Template Removal via Boudouard Equilibrium Allows for Synthesis of Mesostructured Molybdenum Compounds

Oxidative thermal removal of the polymeric templates is not trivial for molybdenum oxides and hampers mesostructuring of this material. At ambient oxygen fugacity, MoVI is the thermodynamically stable oxidation state and sublimation of MoO3 leads to a quick loss of the mesostructure through Oswald ripening. Taking advantage of the Boudouard equilibrium allows to fix the oxygen fugacity at a level where non‐volatile MoO2−x is stable while carbonaceous material may be oxidized by CO2. Mesostructured MoO2−x can be chemically converted into MoO3 or MoN under retention of the mesostructure

Template Removal via Boudouard Equilibrium Allows for Synthesis of Mesostructured Molybdenum Compounds

Oxidative thermal removal of the polymeric templates is not trivial for molybdenum oxides and hampers mesostructuring of this material. At ambient oxygen fugacity, MoVI is the thermodynamically stable oxidation state and sublimation of MoO3 leads to a quick loss of the mesostructure through Oswald ripening. Taking advantage of the Boudouard equilibrium allows to fix the oxygen fugacity at a level where non-volatile MoO2-x is stable while carbonaceous material may be oxidized by CO2. Mesostructured MoO2-x can be chemically converted into MoO3 or MoN under retention of the mesostructure

Direct synthesis of inverse hexagonally ordered diblock copolymer/polyoxometalate nanocomposite films

Nanostructured inverse hexagonal polyoxometalate composite films were cast directly from solution using poly(butadiene-block-2-(dimethylamino)ethyl methacrylate) (PB-b-PDMAEMA) diblock copolymers as structure directing agents for phosphomolybdic acid (H(3)[PMo(12)O(40)], H(3)PMo). H(3)PMo units are selectively incorporated into the PDMAEMA domains due to electrostatic interactions between protonated PDMAEMA and PMo(3-) anions. Long solvophilic PB chains stabilized the PDMAEMA/H(3)PMo aggregates in solution and reliably prevented macrophase separation. The choice of solvent is crucial. It appears that all three components, both blocks of the diblock copolymer as well as H(3)PMo, have to be soluble in the same solvent which turned out to be tetrahydrofuran, THF. Evaporation induced self-assembly resulted in highly ordered inverse hexagonal nanocomposite films as observed from transmission electron microscopy and small-angle X-ray scattering. This one-pot synthesis may represent a generally applicable strategy for integrating polyoxometalates into functional architectures and devices