Topological interactions between ring polymers: Implications for chromatin loops

Chromatin looping is a major epigenetic regulatory mechanism in higher eukaryotes. Besides its role in transcriptional regulation, chromatin loops have been proposed to play a pivotal role in the segregation of entire chromosomes. The detailed topological and entropic forces between loops still remain elusive. Here, we quantitatively determine the potential of mean force between the centers of mass of two ring polymers, i.e. loops. We find that the transition from a linear to a ring polymer induces a strong increase in the entropic repulsion between these two polymers. On top, topological interactions such as the non-catenation constraint further reduce the number of accessible conformations of close-by ring polymers by about 50%, resulting in an additional effective repulsion. Furthermore, the transition from linear to ring polymers displays changes in the conformational and structural properties of the system. In fact, ring polymers adopt a markedly more ordered and aligned state than linear ones. The forces and accompanying changes in shape and alignment between ring polymers suggest an important regulatory function of such a topology in biopolymers. We conjecture that dynamic loop formation in chromatin might act as a versatile control mechanism regulating and maintaining different local states of compaction and order.Comment: 12 pages, 11 figures. The article has been accepted by The Journal Of Chemical Physics. After it is published, it will be found at http://jcp.aip.or

Pair Wave Functions in Atomic Fermi Condensates

Recent experiments have observed condensation behavior in a strongly interacting system of fermionic atoms. We interpret these observations in terms of a mean-field version of resonance superfluidity theory. We find that the objects condensed are not bosonic molecules composed of bound fermion pairs, but are rather spatially correlated Cooper pairs whose coherence length is comparable to the mean spacing between atoms. We propose experiments that will help to further probe these novel pairs

Tunable asymmetric magnetoimpedance effect in ferromagnetic NiFe/Cu/Co films

We investigate the magnetization dynamics through the magnetoimpedance effect in ferromagnetic NiFe/Cu/Co films. We observe that the magnetoimpedance response is dependent on the thickness of the non-magnetic Cu spacer material, a fact associated to the kind of the magnetic interaction between the ferromagnetic layers. Thus, we present an experimental study on asymmetric magnetoimpedance in ferromagnetic films with biphase magnetic behavior and explore the possibility of tuning the linear region of the magnetoimpedance curves around zero magnetic field by varying the thickness of the non-magnetic spacer material, and probe current frequency. We discuss the experimental magnetoimpedance results in terms of the different mechanisms governing the magnetization dynamics at distinct frequency ranges, quasi-static magnetic properties, thickness of the non-magnetic spacer material, and the kind of the magnetic interaction between the ferromagnetic layers. The results place ferromagnetic films with biphase magnetic behavior exhibiting asymmetric magnetoimpedance effect as a very attractive candidate for application as probe element in the development of auto-biased linear magnetic field sensors.Comment: 5 figure

Development of longitudinal handling qualities criteria for large advanced supersonic aircraft

Longitudinal handling qualities criteria in terms of airplane response characteristics were developed. The criteria cover high speed cruise maneuvering, landing approach, and stall recovery. Data substantiating the study results are reported

Measurement and Modeling of Infrared Nonlinear Absorption Coefficients and Laser-induced Damage Thresholds in Ge and GaSb

Using a simultaneous fitting technique to extract nonlinear absorption coefficients from data at two pulse widths, we measure two-photon and free-carrier absorption coefficients for Ge and GaSb at 2.05 and 2.5 μm for the first time, to our knowledge. Results agreed well with published theory. Single-shot damage thresholds were also measured at 2.5 μm and agreed well with modeled thresholds using experimentally determined parameters including nonlinear absorption coefficients and temperature dependent linear absorption. The damage threshold for a single-layer Al2O3 anti-reflective coating on Ge was 55% or 35% lower than the uncoated threshold for picosecond or nanosecond pulses, respectively

The role of elastic stresses on leaf venation morphogenesis

We explore the possible role of elastic mismatch between epidermis and mesophyll as a driving force for the development of leaf venation. The current prevalent 'canalization' hypothesis for the formation of veins claims that the transport of the hormone auxin out of the leaves triggers cell differentiation to form veins. Although there is evidence that auxin plays a fundamental role in vein formation, the simple canalization mechanism may not be enough to explain some features observed in the vascular system of leaves, in particular, the abundance of vein loops. We present a model based on the existence of mechanical instabilities that leads very naturally to hierarchical patterns with a large number of closed loops. When applied to the structure of high order veins, the numerical results show the same qualitative features as actual venation patterns and, furthermore, have the same statistical properties. We argue that the agreement between actual and simulated patterns provides strong evidence for the role of mechanical effects on venation development.Comment: 10 figures, published in PLoS Computational Biolog

Ultracold collisions of oxygen molecules

Collision cross sections and rate constants between two ground- state oxygen molecules are investigated theoretically at translational energies below $\sim 1$K and in zero magnetic field. We present calculations for elastic and spin- changing inelastic collision rates for different isotopic combinations of oxygen atoms as a prelude to understanding their collisional stability in ultracold magnetic traps. A numerical analysis has been made in the framework of a rigid- rotor model that accounts fully for the singlet, triplet, and quintet potential energy surfaces in this system. The results offer insights into the effectiveness of evaporative cooling and the properties of molecular Bose- Einstein condensates, as well as estimates of collisional lifetimes in magnetic traps. Specifically, $^{17}O_{2}$ looks like a good candidate for ultracold studies, while $^{16}O_{2}$ is unlikely to survive evaporative cooling. Since $^{17}O_{2}$ is representative of a wide class of molecules that are paramagnetic in their ground state we conclude that many molecules can be successfully magnetically trapped at ultralow temperatures.Comment: 15 pages, 9 figure