Topological interactions between ring polymers: Implications for chromatin loops

Chromatin looping is a major epigenetic regulatory mechanism in higher eukaryotes. Besides its role in transcriptional regulation, chromatin loops have been proposed to play a pivotal role in the segregation of entire chromosomes. The detailed topological and entropic forces between loops still remain elusive. Here, we quantitatively determine the potential of mean force between the centers of mass of two ring polymers, i.e. loops. We find that the transition from a linear to a ring polymer induces a strong increase in the entropic repulsion between these two polymers. On top, topological interactions such as the non-catenation constraint further reduce the number of accessible conformations of close-by ring polymers by about 50%, resulting in an additional effective repulsion. Furthermore, the transition from linear to ring polymers displays changes in the conformational and structural properties of the system. In fact, ring polymers adopt a markedly more ordered and aligned state than linear ones. The forces and accompanying changes in shape and alignment between ring polymers suggest an important regulatory function of such a topology in biopolymers. We conjecture that dynamic loop formation in chromatin might act as a versatile control mechanism regulating and maintaining different local states of compaction and order.Comment: 12 pages, 11 figures. The article has been accepted by The Journal Of Chemical Physics. After it is published, it will be found at http://jcp.aip.or

Pair Wave Functions in Atomic Fermi Condensates

Recent experiments have observed condensation behavior in a strongly interacting system of fermionic atoms. We interpret these observations in terms of a mean-field version of resonance superfluidity theory. We find that the objects condensed are not bosonic molecules composed of bound fermion pairs, but are rather spatially correlated Cooper pairs whose coherence length is comparable to the mean spacing between atoms. We propose experiments that will help to further probe these novel pairs

Tunable asymmetric magnetoimpedance effect in ferromagnetic NiFe/Cu/Co films

We investigate the magnetization dynamics through the magnetoimpedance effect in ferromagnetic NiFe/Cu/Co films. We observe that the magnetoimpedance response is dependent on the thickness of the non-magnetic Cu spacer material, a fact associated to the kind of the magnetic interaction between the ferromagnetic layers. Thus, we present an experimental study on asymmetric magnetoimpedance in ferromagnetic films with biphase magnetic behavior and explore the possibility of tuning the linear region of the magnetoimpedance curves around zero magnetic field by varying the thickness of the non-magnetic spacer material, and probe current frequency. We discuss the experimental magnetoimpedance results in terms of the different mechanisms governing the magnetization dynamics at distinct frequency ranges, quasi-static magnetic properties, thickness of the non-magnetic spacer material, and the kind of the magnetic interaction between the ferromagnetic layers. The results place ferromagnetic films with biphase magnetic behavior exhibiting asymmetric magnetoimpedance effect as a very attractive candidate for application as probe element in the development of auto-biased linear magnetic field sensors.Comment: 5 figure

Chaotic Orbits in Thermal-Equilibrium Beams: Existence and Dynamical Implications

Phase mixing of chaotic orbits exponentially distributes these orbits through their accessible phase space. This phenomenon, commonly called ``chaotic mixing'', stands in marked contrast to phase mixing of regular orbits which proceeds as a power law in time. It is operationally irreversible; hence, its associated e-folding time scale sets a condition on any process envisioned for emittance compensation. A key question is whether beams can support chaotic orbits, and if so, under what conditions? We numerically investigate the parameter space of three-dimensional thermal-equilibrium beams with space charge, confined by linear external focusing forces, to determine whether the associated potentials support chaotic orbits. We find that a large subset of the parameter space does support chaos and, in turn, chaotic mixing. Details and implications are enumerated.Comment: 39 pages, including 14 figure

Could Stannern-trend eucrites be crustal-contaminated melts?

In this paper, we show that the composition of Stannern trend eucrites can be satisfactorily explained by contamination of normal main group eucrites by a crustal partial melt

Development of longitudinal handling qualities criteria for large advanced supersonic aircraft

Longitudinal handling qualities criteria in terms of airplane response characteristics were developed. The criteria cover high speed cruise maneuvering, landing approach, and stall recovery. Data substantiating the study results are reported

Measurement and Modeling of Infrared Nonlinear Absorption Coefficients and Laser-induced Damage Thresholds in Ge and GaSb

Using a simultaneous fitting technique to extract nonlinear absorption coefficients from data at two pulse widths, we measure two-photon and free-carrier absorption coefficients for Ge and GaSb at 2.05 and 2.5 μm for the first time, to our knowledge. Results agreed well with published theory. Single-shot damage thresholds were also measured at 2.5 μm and agreed well with modeled thresholds using experimentally determined parameters including nonlinear absorption coefficients and temperature dependent linear absorption. The damage threshold for a single-layer Al2O3 anti-reflective coating on Ge was 55% or 35% lower than the uncoated threshold for picosecond or nanosecond pulses, respectively