605 research outputs found
Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex
Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) whose complex architecture is generated from a set of only ∼30 proteins, termed nucleoporins. Here, we explore the domain structure of Nup133, a nucleoporin in a conserved NPC subcomplex that is crucial for NPC biogenesis and is believed to form part of the NPC scaffold. We show that human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed β-propeller. The surface properties and conservation of the Nup133 β-propeller suggest it may mediate multiple interactions with other proteins. Other β-propellers are predicted in a third of all nucleoporins. These and several other repeat-based motifs appear to be major elements of nucleoporins, indicating a level of structural repetition that may conceptually simplify the assembly and disassembly of this huge protein complex
Relativistic Compact Objects in Isotropic Coordinates
We present a matrix method for obtaining new classes of exact solutions for
Einstein's equations representing static perfect fluid spheres. By means of a
matrix transformation, we reduce Einstein's equations to two independent
Riccati type differential equations for which three classes of solutions are
obtained. One class of the solutions corresponding to the linear barotropic
type fluid with an equation of state is discussed in detail.Comment: 9 pages, no figures, accepted for publication in Pramana-Journal of
Physic
On the galactic rotation curves problem within an axisymmetric approach
In U. Nucamendi et al. Phys. Rev. D63 (2001) 125016 and K. Lake, Phys. Rev.
Lett. 92 (2004) 051101 it has been shown that galactic potentials can be
kinematically linked to the observed red/blue shifts of the corresponding
galactic rotation curves under a minimal set of assumptions: the emitted
photons come from stable timelike circular geodesic orbits of stars in a static
spherically symmetric gravitational field, and propagate to us along null
geodesics. It is remarkable that this relation can be established without
appealing at all to a concrete theory of gravitational interaction. Here we
generalize this kinematical spherically symmetric approach to the galactic
rotation curves problem to the stationary axisymmetric realm since this is
precisely the symmetry that spiral galaxies possess. Thus, by making use of the
most general stationary axisymmetric metric, we also consider stable circular
orbits of stars that emit signals which travel to a distant observer along null
geodesics and express the galactic red/blue shifts in terms of three arbitrary
metric functions, clarifying the contribution of the rotation as well as the
dragging of the gravitational field. This stationary axisymmetric approach
distinguishes between red and blue shifts emitted by circularly orbiting
receding and approaching stars, respectively, even when they are considered
with respect to the center of a spiral galaxy, indicating the need of precise
measurements in order to confront predictions with observations. We also point
out the difficulties one encounters in the attempt of determining the metric
functions from observations and list some possible strategies to overcome them.Comment: 7 pages in latex (MNRAS format), no figures, discussion and
references adde
An ecological analysis of colorectal cancer incidence and mortality: Differences by sexual orientation
<p>Abstract</p> <p>Background</p> <p>Some have suggested gays and lesbians may carry a greater burden of colorectal cancer. To date, individual sexual orientation data are not available in cancer surveillance registries. This prevents an assessment of differences in colorectal cancer incidence and mortality by sexual orientation, using individual-level data.</p> <p>Methods</p> <p>We use an ecological approach to examine differences in colorectal cancer incidence and mortality by county-level sexual orientation data. From the Surveillance, Epidemiology and End Results (SEER) Program we obtain population-based surveillance data on colorectal cancer incidence and mortality from 1996 to 2004. We use Census 2000 data on same-sex partnered households, a proxy of sexual orientation, to derive county-level sexual orientation data. Using multiple regression models, we examined the county-level association of sexual minority density with colorectal cancer incidence and mortality.</p> <p>Results</p> <p>After controlling for race and SES, we identify a significant positive association between greater density of sexual minority men and women and colorectal cancer incidence. With respect to colorectal cancer mortality, we identify a positive association with density of sexual minority men, but not women.</p> <p>Conclusions</p> <p>In the absence of surveillance data on sexual minority individuals, ecological analyses provide estimates of associations at the aggregate level, thereby providing crucial information for follow-up studies.</p
Relaxation in glassforming liquids and amorphous solids
The field of viscousliquid and glassysolid dynamics is reviewed by a process of posing the key questions that need to be answered, and then providing the best answers available to the authors and their advisors at this time. The subject is divided into four parts, three of them dealing with behavior in different domains of temperature with respect to the glass transition temperature, Tg,and a fourth dealing with “short time processes.” The first part tackles the high temperature regime T\u3eTg, in which the system is ergodic and the evolution of the viscousliquid toward the condition at Tg is in focus. The second part deals with the regime T∼Tg, where the system is nonergodic except for very long annealing times, hence has time-dependent properties (aging and annealing). The third part discusses behavior when the system is completely frozen with respect to the primary relaxation process but in which secondary processes, particularly those responsible for “superionic” conductivity, and dopart mobility in amorphous silicon, remain active. In the fourth part we focus on the behavior of the system at the crossover between the low frequency vibrational components of the molecular motion and its high frequency relaxational components, paying particular attention to very recent developments in the short time dielectric response and the high Qmechanical response
Breast cancer in lesbians and bisexual women: Systematic review of incidence, prevalence and risk studies
This article is made available through the Brunel Open Access Publishing Fund. © 2013 Meads and Moore; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.Background: The UK Parliamentary Enquiry and USA Institute of Medicine state that lesbians may be at a higher risk of breast cancer but there is insufficient information. Lesbians and bisexual (LB) women have behavioural risk-factors at higher rates compared to heterosexuals such as increased alcohol intake and higher stress levels. Conversely, breast cancer rates are higher in more affluent women yet income levels in LB women are relatively low. This systematic review investigated all evidence on whether there is, or likely to be, higher rates of breast cancer in LB women. Methods: Cochrane library (CDSR, CENTRAL, HTA, DARE, NHSEED), MEDLINE, EMBASE, PsychINFO, CAB abstracts, Web of Science (SCI, SSCI), SIGLE and Social Care Online databases were searched to October 2013. Unpublished research and specific lesbian, gay and bisexual websites were checked, as were citation lists of relevant papers. Included were studies in LB populations reporting breast cancer incidence or prevalence rates, risk model results or risk-factor estimates. Inclusions, data-extraction and quality assessment were by two reviewers with disagreements resolved by discussion. Results: Searches found 198 references. No incidence rates were found. Nine studies gave prevalence estimates - two showed higher, four showed no differences, one showed mixed results depending on definitions, one had no comparison group and one gave no sample size. All studies were small with poor methodological and/or reporting quality. One incidence modelling study suggested a higher rate. Four risk modelling studies were found, one Rosner-Colditz and three Gail models. Three suggested higher and one lower rate in LB compared to heterosexual women. Six risk-factor estimates suggested higher risk and one no difference between LB and heterosexual women. Conclusions: The only realistic way to establish rates in LB women would be to collect sexual orientation within routine statistics, including cancer registry data, or from large cohort studies
Minimum mass of galaxies from BEC or scalar field dark matter
Many problems of cold dark matter models such as the cusp problem and the
missing satellite problem can be alleviated, if galactic halo dark matter
particles are ultra-light scalar particles and in Bose-Einstein condensate
(BEC), thanks to a characteristic length scale of the particles. We show that
this finite length scale of the dark matter can also explain the recently
observed common central mass of the Milky Way satellites ()
independent of their luminosity, if the mass of the dark matter particle is
about .Comment: 10 pages, 1 figure, accepted in JCA
Risks, alternative knowledge strategies and democratic legitimacy: the conflict over co-incineration of hazardous industrial waste in Portugal.
The decision to incinerate hazardous industrial waste in cement plants (the socalled
‘co-incineration’ process) gave rise to one of the most heated environmental
conflicts ever to take place in Portugal. The bitterest period was between 1997 and
2002, after the government had made a decision. Strong protests by residents,
environmental organizations, opposition parties, and some members of the
scientific community forced the government to backtrack and to seek scientific
legitimacy for the process through scientific expertise. The experts ratified the
government’s decision, stating that the risks involved were socially acceptable.
The conflict persisted over a decade and ended up clearing the way for a more
sustainable method over which there was broad social consensus – a multifunctional
method which makes it possible to treat, recover and regenerate most
wastes. Focusing the analysis on this conflict, this paper has three aims: (1) to
discuss the implications of the fact that expertise was ‘confiscated’ after the
government had committed itself to the decision to implement co-incineration and
by way of a reaction to the atmosphere of tension and protest; (2) to analyse the
uses of the notions of ‘risk’ and ‘uncertainty’ in scientific reports from both
experts and counter-experts’ committees, and their different assumptions about
controllability and criteria for considering certain practices to be sufficiently safe
for the public; and (3) to show how the existence of different technical scientific
and political attitudes (one more closely tied to government and the corporate
interests of the cement plants, the other closer to the environmental values of reuse
and recycling and respect for the risk perception of residents who challenged
the facilities) is closely bound up with problems of democratic legitimacy. This
conflict showed how adopting more sustainable and lower-risk policies implies a
broader view of democratic legitimacy, one which involves both civic movements
and citizens themselves
Effect of volcanic dykes on coastal groundwater flow and saltwater intrusion : a field-scale multiphysics approach and parameter evaluation
Acknowledgments This research was primarily based on research grant‐aided by the Irish Department of Communications, Energy and Natural Resources under the National Geoscience Programme 2007–2013. It also benefited from complementary funding from the Scottish Alliance for Geoscience, Environment and Society (SAGES). We acknowledge the contribution in data acquisition of the MSc students in Environmental Engineering at Queen's University Belfast, the landowner for access to the inland fields and the Department of Geography, Archaeology and Paleoecology at QUB for provision of the tidal model of Belfast Lough. The data used are listed in the references, tables, and figures and are available from the corresponding author upon demand. We acknowledge the constructive comments by the Associate Editor and three reviewers, which helped in improving the final manuscript.Peer reviewedPublisher PD
- …