ARMY SPECIAL FORCES IN THE ALASKAN ARCTIC

Army Special Operations Forces (ARSOF) are poorly manned, trained, organized, and equipped to conduct sustained operations in the Arctic. ARSOF currently conducts “Arctic Tourism”: misaligned and episodic training combined with personnel policies that dilute Arctic expertise and limit institutional knowledge and unit capability. This is compounded by the strained relationship between the U.S. government and Alaska Native communities, denying the U.S. military Arctic expertise and presenting a gap for malign influence. To address this issue, we examined the question: How can the United States Army Special Operations Command influence policy, improve strategy, and optimize readiness in the Alaskan Arctic in support of the 2022 NDS and NSS, 2019 DOD Arctic Strategy, and the 2022 Army Arctic Strategy? Through Arctic training events, conferences, and case studies, we determined ARSOF currently does not have a dedicated formation to provide Arctic capability or capacity. Historical U.S. and current Canadian indigenous units provide models for an Alaskan homeland defense and domain awareness force, but current cultural and political conditions prohibit implementation. Our main recommendation is that an Alaska-based National Guard Special Forces unit provides the best means to establish ARSOF Arctic capability, mend relationships with Alaska Natives for a potential indigenous homeland defense organization, and build future capacity to project power in Arctic regions abroad.Distribution Statement A. Approved for public release: Distribution is unlimited.Major, United States ArmyMajor, United States ArmyMajor, United States Arm

Cardiac arrest in a soccer player: a unique case of anomalous coronary origin detected by 16-row multislice computed tomography coronary angiography

Anomalous origin of the coronary arteries may be present in otherwise normal subjects without clinical significance, but can also be the cause of myocardial ischemia and sudden death in both adults and teenagers. In particular, the origin of the left main coronary artery or left anterior descending artery from the right sinus of Valsalva or right coronary artery may result in compression of the vessel during or immediately after exercise. We present a unique case of coronary anomaly with four separate coronary ostia originating from the right coronary sinus in a soccer player with sudden cardiac arrest. Multislice contrast-enhanced computed tomography has emerged as a valid noninvasive method for the diagnosis of coronary artery anomal

Unique probe of dark matter in the core of M87 with the Event Horizon Telescope

We demonstrate the unprecedented capabilities of the Event Horizon Telescope (EHT) to image the innermost dark matter profile in the vicinity of the supermassive black hole at the center of the M87 radio galaxy. We present the first model of the synchrotron emission induced by dark matter annihilations from a spiky profile in the close vicinity of a supermassive black hole, accounting for strong gravitational lensing effects. Our results show that the EHT should readily resolve dark matter spikes if present. Moreover, the photon ring surrounding the silhouette of the black hole is clearly visible in the spike emission, which introduces observable small-scale structure into the signal. We find that the dark matter-induced emission provides an adequate fit to the existing EHT data, implying that in addition to the jet, a dark matter spike may account for a sizable portion of the millimeter emission from the innermost (subparsec) region of M87. Regardless, our results show that the EHT can probe very weakly annihilating dark matter. Current EHT observations already constrain very small cross sections, typically down to a few 10−31 cm3 s−1 for a 10 GeV candidate, close to characteristic values for p-wave-suppressed annihilation. Future EHT observations will further improve constraints on the DM scenario

Orally Active MMP-1 Sparing α-tetrahydropyranyl and α-piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the bovine cartilage degradation ex vivo explant system. α-Piperidine 19v (SC-78080/SD-2590) was selected for development toward the initial indication of cancer, while α-piperidine and α-tetrahydropyranyl hydroxamates 19w (SC-77964) and 9i (SC-77774), respectively, were identified as backup compounds

Slowing the onset of hypoxia increases colony forming efficiency of connective tissue progenitor cells \u3ci\u3ein vitro\u3c/i\u3e

Background: Survival and colony formation by transplanted tissue derived connective tissue progenitor cells (CTPs) are thought to be important factors in the success of clinical tissue engineering strategies for bone regeneration. Transplantation of cells into defects larger than a few millimeters expose cells to a profoundly hypoxic environment. This study tested the hypothesis that delaying the onset of hypoxia will improve the survival and performance of CTPs in vitro. Methods: To mimic declines seen in an avascular in vivo bone defect, colony forming efficiency by marrow derived nucleated cells was assessed under osteogenic conditions. Variation in the rate of oxygen decline from an oxygen tension of 21% to 0.1% oxygen was explored using an incubator with programmable active control of gas concentrations. The effect of doping cultures with defined concentrations of RBCs was also used to evaluate the potential for RBCs to serve as a natural buffer in the setting of declining oxygen levels. Results: A delay in onset of hypoxia over 96 hours resulted in a 3-fold increase in the relative colony forming efficiency (rCFE) of CTPs as compared to an immediate onset of hypoxia. The presence of RBCs in vitro inhibited the rCFE of CTPs. Given the negative effects of RBCs, methods of RBC removal were evaluated and compared for their effectiveness of RBC removal and retention of colony forming efficiency. Conclusions: These data suggest that conditions of hypoxia compromise colony forming efficiency in marrow derived CTPs. However, slowing the rate of decline of oxygen preserved colony forming efficiency at levels achieved in a stable normoxic (3% O2) environment. These data also suggest that RBCs are detrimental to the rCFE of CTPs and that buffy coat is an effective and preferred method for removing RBCs from marrow aspirates while preserving CTPs. These findings may inform clinical strategies for CTP transplantation

Detection of an inner gaseous component in a Herbig Be star accretion disk: Near- and mid-infrared spectro-interferometry and radiative transfer modeling of MWC 147

We study the geometry and the physical conditions in the inner (AU-scale) circumstellar region around the young Herbig Be star MWC 147 using long-baseline spectro-interferometry in the near-infrared (NIR K-band, VLTI/AMBER observations and PTI archive data) as well as the mid-infrared (MIR N-band, VLTI/MIDIobservations). The emission from MWC 147 is clearly resolved and has a characteristic physical size of approx. 1.3 AU and 9 AU at 2.2 micron and 11 micron respectively (Gaussian diameter). The spectrally dispersed AMBER and MIDI interferograms both show a strong increase in the characteristic size towards longer wavelengths, much steeper than predicted by analytic disk models assuming power-law radial temperature distributions. We model the interferometric data and the spectral energy distribution of MWC 147 with 2-D, frequency-dependent radiation transfer simulations. This analysis shows that models of spherical envelopes or passive irradiated Keplerian disks (with vertical or curved puffed-up inner rim) can easily fit the SED, but predict much lower visibilities than observed; the angular size predicted by such models is 2 to 4 times larger than the size derived from the interferometric data, so these models can clearly be ruled out. Models of a Keplerian disk with optically thick gas emission from an active gaseous disk (inside the dust sublimation zone), however, yield a good fit of the SED and simultaneously reproduce the absolute level and the spectral dependence of the NIR and MIR visibilities. We conclude that the NIR continuum emission from MWC 147 is dominated by accretion luminosity emerging from an optically thick inner gaseous disk, while the MIR emission also contains contributions from the outer, irradiated dust disk.Comment: 44 pages, 15 figures, accepted for publication in The Astrophysical Journal. The quality of the figures was slightly reduced in order to comply with the astro-ph file-size restrictions. You can find a high-quality version of the paper at http://www.mpifr-bonn.mpg.de/staff/skraus/papers/mwc147.pd

Coronal thick CT reconstruction: an alternative for initial chest radiography in trauma patients

It has been proposed that the imaging workup of trauma patients be accelerated by omitting the initial chest radiography (CR) and directly performing a computed tomography (CT); however, the baseline CR is then lacking. The purpose of this study was to assess if coronal thick reconstructions generated from chest CT could present an adequate alternative for CR. Sixty trauma patients underwent bedside CR and multidetector row chest CT in the emergency room. The image quality of thoracic anatomical structures, the diagnostic accuracy for chest pathology, and the depiction of indwelling devices were assessed on both modalities. Main pulmonary arteries and perihilar bronchi were equally visualized with both modalities. Central bronchi, retrocardial lung parenchyma, diaphragm, descending aorta, and vertebral pedicles were better visualized on thick CT reconstructions, whereas peripheral lung vessels were better depicted on CR (p<0.05). The accuracy to delineate various pathological findings did not differ between both modalities, except for a higher sensitivity to diagnose bronchial cuffing on CR (p<0.05). The location of indwelling devices was similarly and correctly depicted with both modalities. Coronal thick CT reconstructions provide a similar image quality and diagnostic accuracy compared with CR. These reconstructions may serve as an equivalent baseline image in trauma patients in whom emergency radiological evaluation has to be accelerate

Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study

AbstractObjectiveWhite blood cells are known to predict cardiovascular mortality, but form a highly heterogeneous population. It is therefore possible that specific subtypes disproportionally contribute to the prediction of cardiovascular outcomes. Therefore, we compared leukocyte subsets alone and in conjunction with an established inflammatory marker, C-reactive protein, for predicting death due to cardiovascular disease in a high-risk population.MethodsPatients, 3316, (mean [SD] age, 62 [10] years) scheduled for coronary angiography were prospectively followed up. Neutrophil, monocyte and lymphocyte counts were determined. Neutrophil and monocyte subsets were further analysed on the basis of surface expression of CD11b, CD18, CD31, CD40 and CD58. Lymphocytes were further subdivided into CD3, CD4, CD8, and CD19 subsets. The association between each marker and subsequent cardiovascular mortality was assessed using multivariable Cox regression models.ResultsDuring a median follow-up period of 7.8 years, 745 (22.5%) patients died, of which 484 were due to cardiovascular events. After entering conventional risk factors and removing patients with a current infection, neutrophil count (HR [95% CI]=1.90 [1.39, 2.60], P<0.001) and the neutrophil/lymphocyte ratio (HR [95% CI]=1.68 [1.24, 2.27], P=0.003) emerged as independent predictors of cardiovascular mortality. After mutual adjustment, neutrophil count (HR [95% CI]=1.87 [1.35, 2.50], P<0.001) out-performed C-reactive protein (HR [95% CI] 1.32 [0.99, 1.78], P=0.06) as a predictor of cardiovascular mortality.ConclusionsDue to its predictive potential and inexpensive determination, assessment of high neutrophil counts may represent an important marker, possibly improving cardiovascular mortality risk prediction

Measurement of unique magnetic and superconducting phases in oxygen-doped high-temperature superconductors La_2-xSr_xCuO_4+y

We present a combined magnetic neutron scattering and muon spin rotation study of the nature of the magnetic and superconducting phases in electronically phase separated La(2-x)Sr(x)CuO(4+y), x = 0.04, 065, 0.09. For all samples, we find long-range modulated magnetic order below T_N ~ T_c = 39 K. In sharp contrast wit oxygen-stoichiometric La(2-x)Sr(x)CuO(4), we find that the magnetic propagation vector as well as the ordered magnetic moment is independent of Sr content and consistent with that of the 'striped' cuprates. Our study provides direct proof that superoxygenation in La(2-x)Sr(x)CuO(4+y) allows the spin stripe ordered phase to emerge and phase separate from superconducting regions with the hallmarks of optimally doped oxygen-stoichiometric La(2-x)Sr(x)CuO(4)