Web 2.0 Tools for Network Management and Patent Analysis for Health Public

Intensity in research on drugs and medicines contributes significantly to innovation and technological development in the country's health. Thus, this work aimed evinces how Web 2.0 tools of free access can help developing nations and undeveloped in the network management and patent analysis for health care, in this case for tuberculosis. The co-relation of a lot of experts in the world with several knowledge bases can contribute to generation of new approaches and results as well as assist in better decision making by managers of companies, governments and organisations. Countries and publications by research networks in tuberculosis are listed in worldwide. We also describe a specific example for technological management using tuberculosis patents.DOI: 10.5585/rgss.v2i1.4

2-Chloro-6,6-dimethyl-5,6-dihydro­indazolo[2,3-c]quinazoline

Two independent but virtually identical mol­ecules comprise the asymmetric unit of the title compound, C16H14ClN3. The mol­ecules have a slightly curved shape owing to puckering in the six-membered C4N2 ring; the respective dihedral angles formed between the benzene rings are 12.64 (7) and 11.72 (7)°. In the crystal, layers sustained by a combination of N—H⋯N hydrogen bonding as well as C—H⋯N and C—H⋯π contacts are formed; these stack along [011] and are connected by further C—H⋯π contacts

N-(4-Chloro­phen­yl)-1,1,1-trifluoro-N-(trifluoro­methyl­sulfon­yl)methane­sulfonamide

The title mol­ecule, also called 4-chloro-N,N-bis­(trifluoro­methane­sulfon­yl)aniline, C8H4ClF6NO4S2, has non-crystallographic twofold symmetry with the pseudo-axis aligned along the Cl—C⋯C—N backbone of the mol­ecule: the SO2CF3 residues lie to either side of the benzene ring. In the crystal, the presence of C—H⋯O contacts lead to the formation of a sequence of 12-membered {⋯HC2NSO}2 synthons within a supra­molecular chain aligned along [101]

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis. Compound 7 is not used clinically due to its mutagenic and genotoxic properties, but has been largely used as a lead compound. Here, we compared the activity of 7 with its 4H-1,2,4-triazole bioisostere (8) in bloodstream forms of T. brucei and T. cruzi and evaluated their activation by T. brucei type I nitroreductase (TbNTR) enzyme. We also analysed the cytotoxic and genotoxic effects of these compounds in whole human blood using Comet and fluorescein diacetate/ethidium bromide assays. Although the only difference between 7 and 8 is the substitution of sulphur (in the thiadiazole in 7) for nitrogen (in the triazole in 8), the results indicated that 8 had poorer antiparasitic activity than 7 and was not genotoxic, whereas 7 presented this effect. The determination of Vmax indicated that although 8 was metabolised more rapidly than 7, it bounds to the TbNTR with better affinity, resulting in equivalent kcat/KM values. Docking assays of 7 and 8 performed within the active site of a homology model of the TbNTR indicating that 8 had greater affinity than 7

Web 2.0 Tools for Network Management and Patent Analysis for Health Public

Intensity in research on drugs and medicines contributes significantly to innovation and technological development in the country's health. Thus, this work aimed evinces how Web 2.0 tools of free access can help developing nations and undeveloped in the network management and patent analysis for health care, in this case for tuberculosis. The co-relation of a lot of experts in the world with several knowledge bases can contribute to generation of new approaches and results as well as assist in better decision making by managers of companies, governments and organisations. Countries and publications by research networks in tuberculosis are listed in worldwide. We also describe a specific example for technological management using tuberculosis patents.DOI: 10.5585/rgss.v2i1.4

SELECTIVE FLUORINATION METHODS OF ORGANIC MOLECULES

Presently, the world depends on a wide variety of new materials based on organofluorine compounds. These compounds can be used as surfactants, high resistance polymers, liquid crystals, agrochemicals, radiopharmaceuticals for positron emission tomography, and drugs. However, the selective formation of C–F bonds remains a challenge. This study reviews our knowledge of organofluorine compounds and describes conventional and modern selective fluorination methods for obtaining these compounds. Here, we highlight the most common fluorination reagents and describe the fluorination reactions. This review is organized by the type of fluorine transfer: nucleophilic, electrophilic, and enzymati

Internalização de farmoquímicos e medicamentos para doenças tropicais negligenciadas: proposta de interação entre Governo - Universidade - Empresa

History shows that public health actions to combat epidemics are most effective when there is constant synergy of both government and society, exemplified by prevention actions in the fight against dengue fever, H1N1 influenza etc. Private-public-partnerships (PPP) can also provide more dynamic and consistent results in production through interaction among Government, University and Enterprise actors. This article puts forward proposals to tackle the problem of neglected tropical diseases via the formation of a Management Council using Etzkowitz's Triple Helix concept to attenuate this public health issue in Brazil