57 research outputs found
Gender Trespass and Masculine Privilege: “Male Trouble” in Jack Hodgins’s Spit Delaney’s Island
A question posed in the story "Separating," — 'Where is the dividing line?' — acts as a starting point from which to explore the dividing line between various sex/gender constructs in the collection of stories that makes up Jack Hodings's Split Delaney's Island. The differences between the ostensibly natural and the culturally constructed are explored in order to understand ideas and expressions of desire that are present in the stories in the collection. Using various recent theories concerning margins, peripheries, and centres to inform a reading of the stories in Split Delaney's Island allows one to explore and challenge what traditionally counts as viable notions of sexuality and desire. In particular, such an approach challenges notions of masculinity, male desire, and sexuality, or some combination of these. Hodgins's work challenges critics to expand and refigure modes of permissible literary criticism in Canada, particularly involving meanings of gender and masculinity
The Problem of the Rural Church in Minnesota
University of Minnesota Masters thesis. 1914. 1 computer file (PDF); 60 pages
Second cohomology for finite groups of Lie type
Let be a simple, simply-connected algebraic group defined over
. Given a power of , let
be the subgroup of -rational points. Let be the
simple rational -module of highest weight . In this paper we
establish sufficient criteria for the restriction map in second cohomology
to be an
isomorphism. In particular, the restriction map is an isomorphism under very
mild conditions on and provided is less than or equal to a
fundamental dominant weight. Even when the restriction map is not an
isomorphism, we are often able to describe in
terms of rational cohomology for . We apply our techniques to compute
in a wide range of cases, and obtain new
examples of nonzero second cohomology for finite groups of Lie type.Comment: 29 pages, GAP code included as an ancillary file. Rewritten to
include the adjoint representation in types An, B2, and Cn. Corrections made
to Theorem 3.1.3 and subsequent dependent results in Sections 3-4. Additional
minor corrections and improvements also implemente
First cohomology for finite groups of Lie type: simple modules with small dominant weights
Let be an algebraically closed field of characteristic , and let
be a simple, simply connected algebraic group defined over .
Given , set , and let be the corresponding
finite Chevalley group. In this paper we investigate the structure of the first
cohomology group where is the
simple -module of highest weight . Under certain very mild
conditions on and , we are able to completely describe the first
cohomology group when is less than or equal to a fundamental dominant
weight. In particular, in the cases we consider, we show that the first
cohomology group has dimension at most one. Our calculations significantly
extend, and provide new proofs for, earlier results of Cline, Parshall, Scott,
and Jones, who considered the special case when is a minimal nonzero
dominant weight.Comment: 24 pages, 5 figures, 6 tables. Typos corrected and some proofs
streamlined over previous versio
Changes in Practice/Outcomes of Pediatric/Congenital Catheterization in Response to the First Wave of COVID.
BACKGROUND: The COVID-19 pandemic has posed tremendous stress on the health care system. Its effects on pediatric/congenital catheterization program practice and performance have not been described. OBJECTIVES: The purpose of this study was to evaluate how case volumes, risk-profile, and outcomes of pediatric/congenital catheterization procedures changed in response to the first wave of COVID-19 and after that wave. METHODS: A multicenter retrospective observational study was performed using Congenital Cardiac Catheterization Project on Outcomes Registry (C3PO) data to study changes in volume, case mix, and outcomes (high-severity adverse events [HSAEs]) during the first wave of COVID (March 1, 2020, to May 31, 2020) in comparison to the period prior to (January 1, 2019, to February 28, 2020) and after (June 1, 2020, to December 31, 2020) the first wave. Multivariable analyses adjusting for case type, hemodynamic vulnerability, and age group were performed. Hospital responses to the first wave were captured with an electronic study instrument. RESULTS: During the study period, 12,557 cases were performed at 14 C3PO hospitals (with 8% performed during the first wave of COVID and 32% in the postperiod). Center case volumes decreased from a median 32.1 cases/month (IQR: 20.7-49.0 cases/month) before COVID to 22 cases/month (IQR: 13-31 cases/month) during the first wave (P = 0.001). The proportion of cases with risk factors for HSAE increased during the first wave, specifically proportions of infants and neonates (P < 0.001) and subjects with renal insufficiency (P = 0.02), recent cardiac surgery (P < 0.001), and a higher hemodynamic vulnerability score (P = 0.02). The observed HSAE risk did not change significantly (P = 0.13). In multivariable analyses, odds of HSAE during the first wave of COVID (odds ratio: 0.75) appeared to be lower than that before COVID, but the difference was not significant (P = 0.09). CONCLUSIONS: Despite increased case-mix complexity, C3PO programs maintained, if not improved, their performance in terms of HSAE. Exploratory analyses of practice changes may inform future harm-reduction efforts
Risk factors for breast cancer development by tumor characteristics among women with benign breast disease
Abstract
Background
Among women diagnosed with invasive breast cancer, 30% have a prior diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD patients that elevate invasive cancer risk. In the general population, risk factors differ in their associations by clinical pathologic features; however, whether women with BBD show etiologic heterogeneity in the types of breast cancers they develop remains unknown.
Methods
Using a nested case-control study of BBD and breast cancer risk conducted in a community healthcare plan (Kaiser Permanente Northwest), we assessed relationships of histologic features in BBD biopsies and patient characteristics with subsequent breast cancer risk and tested for heterogeneity of associations by estrogen receptor (ER) status, tumor grade, and size. The study included 514 invasive breast cancer cases (median follow-up of 9 years post-BBD diagnosis) and 514 matched controls, diagnosed with proliferative or non-proliferative BBD between 1971 and 2006, with follow-up through mid-2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using multivariable polytomous logistic regression models.
Results
Breast cancers were predominantly ER-positive (86%), well or moderately differentiated (73%), small (74% < 20 mm), and stage I/II (91%). Compared to patients with non-proliferative BBD, proliferative BBD with atypia conferred increased risk for ER-positive cancer (OR = 5.48, 95% CI = 2.14–14.01) with only one ER-negative case, P-heterogeneity = 0.45. The presence of columnar cell lesions (CCLs) at BBD diagnosis was associated with a 1.5-fold increase in the risk of both ER-positive and ER-negative tumors, with a 2-fold increase (95% CI = 1.21–3.58) observed among postmenopausal women (56%), independent of proliferative BBD status with and without atypia. We did not identify statistically significant differences in risk factor associations by tumor grade or size.
Conclusion
Most tumors that developed after a BBD diagnosis in this cohort were highly treatable low-stage ER-positive tumors. CCL in BBD biopsies may be associated with moderately increased risk, independent of BBD histology, and irrespective of ER status
Assessing the cost of global biodiversity and conservation knowledge
Knowledge products comprise assessments of authoritative information supported by stan-dards, governance, quality control, data, tools, and capacity building mechanisms. Considerable resources are dedicated to developing and maintaining knowledge productsfor biodiversity conservation, and they are widely used to inform policy and advise decisionmakers and practitioners. However, the financial cost of delivering this information is largelyundocumented. We evaluated the costs and funding sources for developing and maintain-ing four global biodiversity and conservation knowledge products: The IUCN Red List ofThreatened Species, the IUCN Red List of Ecosystems, Protected Planet, and the WorldDatabase of Key Biodiversity Areas. These are secondary data sets, built on primary datacollected by extensive networks of expert contributors worldwide. We estimate that US116–204 million), plus 293 person-years of volunteer time (range: 278–308 person-years) valued at US12–16 million), were invested inthese four knowledge products between 1979 and 2013. More than half of this financingwas provided through philanthropy, and nearly three-quarters was spent on personnelcosts. The estimated annual cost of maintaining data and platforms for three of these knowl-edge products (excluding the IUCN Red List of Ecosystems for which annual costs were notpossible to estimate for 2013) is US6.2–6.7 million). We esti-mated that an additional US12 million. These costs are much lower than those tomaintain many other, similarly important, global knowledge products. Ensuring that biodi-versity and conservation knowledge products are sufficiently up to date, comprehensiveand accurate is fundamental to inform decision-making for biodiversity conservation andsustainable development. Thus, the development and implementation of plans for sustain-able long-term financing for them is critical
System Engineering Paper
The Iowa State University team, Team LunaCY, is composed of the following sub-teams: the main student organization, the Lunabotics Club; a senior mechanical engineering design course, ME 415; a senior multidisciplinary design course, ENGR 466; and a senior design course from Wartburg College in Waverly, Iowa. Team LunaCY designed and fabricated ART-E III, Astra Robotic Tractor- Excavator the Third, for the team's third appearance in the NASA Lunabotic Mining competition. While designing ART-E III, the team had four main goals for this year's competition:to reduce the total weight of the robot, to increase the amount of regolith simulant mined, to reduce dust, and to make ART-E III autonomous. After many designs and research, a final robot design was chosen that obtained all four goals of Team LunaCY. A few changes Team LunaCY made this year was to go to the electrical, computer, and software engineering club fest at Iowa State University to recruit engineering students to accomplish the task of making ART-E III autonomous. Team LunaCY chose to use LabView to program the robot and various sensors were installed to measure the distance between the robot and the surroundings to allow ART-E III to maneuver autonomously. Team LunaCY also built a testing arena to test prototypes and ART-E III in. To best replicate the competition arena at the Kennedy Space Center, a regolith simulant was made from sand, QuickCrete, and fly ash to cover the floor of the arena. Team LunaCY also installed fans to allow ventilation in the arena and used proper safety attire when working in the arena . With the additional practice in the testing arena and innovative robot design, Team LunaCY expects to make a strong appearance at the 2012 NASA Lunabotic Mining Competition.
- …