460 research outputs found
Design and operation of a prototype interaction point beam collision feedback system for the International Linear Collider
A high-resolution, intratrain position feedback system has been developed to
achieve and maintain collisions at the proposed future electron-positron
International Linear Collider (ILC). A prototype has been commissioned and
tested with a beam in the extraction line of the Accelerator Test Facility at
the High Energy Accelerator Research Organization in Japan. It consists of a
stripline beam position monitor (BPM) with analogue signal-processing
electronics, a custom digital board to perform the feedback calculation, and a
stripline kicker driven by a high-current amplifier. The closed-loop feedback
latency is 148 ns. For a three-bunch train with 154 ns bunch spacing, the
feedback system has been used to stabilize the third bunch to 450 nm. The
kicker response is linear, and the feedback performance is maintained, over a
correction range of over 60 {\mu}m. The propagation of the correction has
been confirmed by using an independent stripline BPM located downstream of the
feedback system. The system has been demonstrated to meet the BPM resolution,
beam kick, and latency requirements for the ILC
B meson decay constants f(Bc), f(Bs) and f(B) from QCD sum rules
Finite energy QCD sum rules with Legendre polynomial integration kernels are used to determine the heavy meson decay constant f(Bc), and revisit f(B) and f(Bs). Results exhibit excellent stability in a wide range of values of the integration radius in the complex squared energy plane, and of the order of the Legendre polynomial. Results are f(Bc) = 528 +/- 19 MeV, f(B) = 186 +/- 14 MeV, and f(Bs) = 222 +/- 12 MeV
Precise Charm- and Bottom-Quark Masses: Theoretical and Experimental Uncertainties
Recent theoretical and experimental improvements in the determination of
charm and bottom quark masses are discussed. A new and improved evaluation of
the contribution from the gluon condensate to the
charm mass determination and a detailed study of potential uncertainties in the
continuum cross section for production is presented, together with a
study of the parametric uncertainty from the -dependence of our
results. The final results, MeV and
MeV, represent, together with a closely related lattice
determination MeV, the presently most precise
determinations of these two fundamental Standard Model parameters. A critical
analysis of the theoretical and experimental uncertainties is presented.Comment: 12 pages, presented at Quarks~2010, 16th International Seminar of
High Energy Physics, Kolomna, Russia, June 6-12, 2010; v2: references adde
PARP1 suppresses homologous recombination events in mice in vivo
Recent studies suggest that PARP1 inhibitors, several of which are currently in clinical trial, may selectively kill BRCA1/2 mutant cancers cells. It is thought that the success of this therapy is based on immitigable lethal DNA damage in the cancer cells resultant from the concurrent loss or inhibition of two DNA damage repair pathways: single-strand break (SSB) repair and homologous recombination repair (HRR). Presumably, inhibition of PARP1 activity obstructs the repair of SSBs and during DNA replication, these lesions cause replication fork collapse and are transformed into substrates for HRR. In fact, several previous studies have indicated a hyper-recombinogenic phenotype in the absence of active PARP1 in vitro or in response to DNA damaging agents. In this study, we demonstrate an increased frequency of spontaneous HRR in vivo in the absence of PARP1 using the pun assay. Furthermore, we found that the HRR events that occur in Parp1 nullizygous mice are associated with a significant increase in large, clonal events, as opposed to the usually more frequent single cell events, suggesting an effect in replicating cells. In conclusion, our data demonstrates that PARP1 inhibits spontaneous HRR events, and supports the model of DNA replication transformation of SSBs into HRR substrates
Widespread detection of highly pathogenic H5 influenza viruses in wild birds from the Pacific Flyway of the United States
A novel highly pathogenic avian influenza virus belonging to the H5 clade 2.3.4.4 variant viruses was detected in North America in late 2014. Motivated by the identification of these viruses in domestic poultry in Canada, an intensive study was initiated to conduct highly pathogenic avian influenza surveillance in wild birds in the Pacific Flyway of the United States. A total of 4,729 hunter-harvested wild birds were sampled and highly pathogenic avian influenza virus was detected in 1.3% (n = 63). Three H5 clade 2.3.4.4 subtypes were isolated from wild birds, H5N2, H5N8, and H5N1, representing the wholly Eurasian lineage H5N8 and two novel reassortant viruses. Testing of 150 additional wild birds during avian morbidity and mortality investigations in Washington yielded 10 (6.7%) additional highly pathogenic avian influenza isolates (H5N8 = 3 and H5N2 = 7). The geographically widespread detection of these viruses in apparently healthy wild waterfowl suggest that the H5 clade 2.3.4.4 variant viruses may behave similarly in this taxonomic group whereby many waterfowl species are susceptible to infection but do not demonstrate obvious clinical disease. Despite these findings in wild waterfowl, mortality has been documented for some wild bird species and losses in US domestic poultry during the first half of 2015 were unprecedented
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