Study of nuclear recoils in liquid argon with monoenergetic neutrons

For the development of liquid argon dark matter detectors we assembled a setup in the laboratory to scatter neutrons on a small liquid argon target. The neutrons are produced mono-energetically (E_kin=2.45 MeV) by nuclear fusion in a deuterium plasma and are collimated onto a 3" liquid argon cell operating in single-phase mode (zero electric field). Organic liquid scintillators are used to tag scattered neutrons and to provide a time-of-flight measurement. The setup is designed to study light pulse shapes and scintillation yields from nuclear and electronic recoils as well as from {\alpha}-particles at working points relevant to dark matter searches. Liquid argon offers the possibility to scrutinise scintillation yields in noble liquids with respect to the populations of the two fundamental excimer states. Here we present experimental methods and first results from recent data towards such studies.Comment: 9 pages, 8 figures, proceedings of TAUP 2011, to be published in Journal of Physics: Conference Series (JCPS

Damage of calcarenite stone in archaeological site: relationship between wheathering, pollution and biological agents

For thousand of years, when magnificence and beauty were the goals of architecture, stones were the most widely used durable materials. The deterioration of building stones causes irreparable damages to our cultural heritage, not only as loss of architecture and ancient art, but especially as loss of symbols of human cultural identity and continuity. Sun, frost, wind, rain, pollution etc. contribute to a gradual process of weathering. Biological activity also plays a role and its association with physico-chemical phenomena should be considered essential for understanding long term deterioration. In this contest appear necessary to understand the weight of each single environmental parameter in order to assess and to plan not only a suitable restoration project and a preventive maintenance but also to test natural products (specific biocides) to be used to limit the degradation caused by bio deterioration agents We studied the influence and synergistic effects of climatic parameters (temperature, light irradiation, wind intensity, humidity), pollution (SO2, CO, NO2, Ozone and heavy metals), and biological attacks on a building placed between an archaeological site of Lavello, a little town located in the Basilicata Region, and the industrial area surrounding this town. Moreover, X-ray diffraction, X-ray induced photoelectron spectroscopy (XPS), X-ray fluorescence spectrometry (XRF), ground penetrating radar and geo-electrical measurements (GPR and MGE), Fourier Transform Infrared spectroscopy (FT-IR) and biological investigations were carried out on powdered calcarenite and on stones samples. Preliminary results show that climatic parameters and pollution undermine the structure and the compactness of stones (i.e. micro-fractures, increase of salts’ concentration) favouring the biological colonization (bacteria, mushrooms and lichens) especially in south–east direction of prevailing winds

The Argon Dark Matter Experiment (ArDM)

The ArDM experiment, a 1 ton liquid argon TPC/Calorimeter, is designed for the detection of dark matter particles which can scatter off the spinless argon nuclei. These events producing a recoiling nucleus will be discerned by their light to charge ratio, as well as the time structure of the scintillation light. The experiment is presently under construction and will be commissioned on surface at CERN. Here we describe the detector concept and give a short review on the main detector components.Comment: Proceedings of 4th Patras workshop (DESY) on Axions, Wimps and Wisps (4 pages, 4 figures

Deletion of the Williams Beuren syndrome critical region unmasks facioscapulohumeral muscular dystrophy

Among 1339 unrelated cases accrued by the Italian National Registry for facioscapulohumeral muscular dystrophy (FSHD), we found three unrelated cases who presented signs of Williams-Beuren Syndrome (WBS) in early childhood and later developed FSHD. All three cases carry the molecular defects associated with the two disorders. The rarity of WBS and FSHD, 1 in 7500 and 1 in 20,000 respectively, makes a random association of the two diseases unlikely. These cases open novel and unexpected interpretation of genetic findings. The nonrandom association of both FSHD and WBS points at a gene co-expression network providing hints for the identification of modules and functionally enriched pathways in the two conditions

First operation of a double phase LAr Large Electron Multiplier Time Projection Chamber with a two-dimensional projective readout anode

We have previously reported on the construction and successful operation of the novel double phase Liquid Argon Large Electron Multiplier Time Projection Chamber (LAr LEM-TPC). This detector concept provides a 3D-tracking and calorimetric device capable of adjustable charge amplification, a promising readout technology for next-generation neutrino detectors and direct Dark Matter searches. In this paper, we report on the first operation of a LAr LEM-TPC prototype - with an active area of 10$\times$10 cm$^2$ and 21 cm drift length - equipped with a single 1 mm thick LEM amplifying stage and a two dimensional projective readout anode. Cosmic muon events were collected, fully reconstructed and used to characterize the performance of the chamber. The obtained signals provide images of very high quality and the energy loss distributions of minimum ionizing tracks give a direct estimate of the amplification. We find that a stable gain of 27 can be achieved with this detector configuration corresponding to a signal-over-noise ratio larger than 200 for minimum ionizing tracks. The decoupling of the amplification stage and the use of the 2D readout anode offer several advantages which are described in the text.Comment: 25 pages, 17 figure

Towards a liquid Argon TPC without evacuation: filling of a 6 m^3 vessel with argon gas from air to ppm impurities concentration through flushing

In this paper we present a successful experimental test of filling a volume of 6 m$^3$ with argon gas, starting from normal ambient air and reducing the impurities content down to few parts per million (ppm) oxygen equivalent. This level of contamination was directly monitored measuring the slow component of the scintillation light of the Ar gas, which is sensitive to {\it all} sources of impurities affecting directly the argon scintillation.Comment: 9 pages, 6 figures, to appear in Proc. 1st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment (GLA2010), Tsukuba, March 201

First results on light readout from the 1-ton ArDM liquid argon detector for dark matter searches

ArDM-1t is the prototype for a next generation WIMP detector measuring both the scintillation light and the ionization charge from nuclear recoils in a 1-ton liquid argon target. The goal is to reach a minimum recoil energy of 30\,keVr to detect recoiling nuclei. In this paper we describe the experimental concept and present results on the light detection system, tested for the first time in ArDM on the surface at CERN. With a preliminary and incomplete set of PMTs, the light yield at zero electric field is found to be between 0.3-0.5 phe/keVee depending on the position within the detector volume, confirming our expectations based on smaller detector setups.Comment: 14 pages, 10 figures, v2 accepted for publication in JINS

Mutation profile of BBS genes in patients with Bardet-Biedl syndrome : An Italian study

Background: Bardet-Biedl syndrome (BBS) is a rare inherited multisystemic disorder with autosomal recessive or complex digenic triallelic inheritance. There is currently no treatment for BBS, but some morbidities can be managed. Accurate molecular diagnosis is often crucial for the definition of appropriate patient management and for the development of a potential personalized therapy. Methods: We developed a next-generation-sequencing (NGS) protocol for the screening of the 18 most frequently mutated genes to define the genotype and clarify the mutation spectrum of a cohort of 20 BBS Italian patients. Results: We defined the causative variants in 60% of patients; four of those are novel. 33% of patients also harboured variants in additional gene/s, suggesting possible oligogenic inheritance. To explore the function of different genes, we looked for correlations between genotype and phenotype in our cohort. Hypogonadism was more frequently detected in patients with variants in BBSome proteins, while renal abnormalities in patients with variations in BBSome chaperonin genes. Conclusions: NGS is a powerful tool that can help understanding BBS patients' phenotype through the identification of mutations that could explain differences in phenotype severity and could provide insights for the development of targeted therapy. Furthermore, our results support the existence of additional BBS loci yet to be identified

DM: a ton-scale LAr detector for direct Dark Matter searches

The Argon Dark Matter (ArDM-1t) experiment is a ton-scale liquid argon (LAr) double-phase time projection chamber designed for direct Dark Matter searches. Such a device allows to explore the low energy frontier in LAr with a charge imaging detector. The ionization charge is extracted from the liquid into the gas phase and there amplified by the use of a Large Electron Multiplier in order to reduce the detection threshold. Direct detection of the ionization charge with fine spatial granularity, combined with a measurement of the amplitude and time evolution of the associated primary scintillation light, provide powerful tools for the identification of WIMP interactions against the background due to electrons, photons and possibly neutrons if scattering more than once. A one ton LAr detector is presently installed on surface at CERN to fully test all functionalities and it will be soon moved to an underground location. We will emphasize here the lessons learned from such a device for the design of a large LAr TPC for neutrino oscillation, proton decay and astrophysical neutrinos searches