The Method for Testing the Dynamic of Take-off

Among various sport branches there are such in which the take-off efficiency, and consequently, performing of the exercise depends upon technique and muscles ability to release the maximal energy in a short time. Long and high jumps, acrobatic jumps, ski jumps, volley-ball and basket-ball jumps should be included among the above described branches. In these sports take-offs with one or both legs are employed. Certain elements which may be treated as belonging to technique have some influence upon the efficiency of the energy released during a take-off. In the case of the features in question they are: a degree and velocity of flexion of legs' joints before their extension. On the basis of their research, Murray et al. (1970) and Scudder (1980) stated that the optimum angle for achieving the maximal knee extension strength is the angle of 120° (in isokinetic conditions). Lindahl et al. (1969) obtained similar results in isometric conditions. Osterning et al. (1982) proved that the maximal strength can be reached at the angle form 100° to 110°. Secher et al. (1976) were examining the maximal strength of the leg extensors during a take-off with one leg and with both legs. They noted obvious differences between the strength measures in both tests, which must be connected with the take-off efficiency. The above mentioned question was dealt with by Van Soest et al. (1985). While examining take-off with one and both legs of well-trained volley-ball players they obtained jumps' results: 0.31 m and 0.54 m respectively. In this paper we intend to test the take-off with one leg and the take-off with both legs employing a pendulum which makes it possible to eliminate gravity force which normally influences a take-off. Take-off tested in this way analysed on the background of the static strength of legs

An analytical and experimental comparison of the flow field of an advanced swept turboprop

An argon ion laser velocimeter with four beams was used to measure the detailed flow-field of an advanced eight blade propeller with 45% of tip sweep in an 8x6 foot supersonic wind tunnel. Data were obtained at a free stream Mach number of 0.8, the design advance ratio of 3.06 and a power coefficient of 1.8. Data are presented for inlet flow, exit flow, flow within the blades and flow slightly outside the blade tips. The data are compared to a lifting line theory. In general, the results of the comparison are considered favorable

New test techniques and analytical procedures for understanding the behavior of advanced propellers

Analytical procedures and experimental techniques were developed to improve the capability to design advanced high speed propellers. Some results from the propeller lifting line and lifting surface aerodynamic analysis codes are compared with propeller force data, probe data and laser velocimeter data. In general, the code comparisons with data indicate good qualitative agreement. A rotating propeller force balance demonstrated good accuracy and reduced test time by 50 percent. Results from three propeller flow visualization techniques are shown which illustrate some of the physical phenomena occurring on these propellers

Lubricant study in ultrahigh vacuum and in various gas environments Final report, 26 Jan. 1965 - 15 Mar. 1966

Wear and friction of lubricated and unlubricated stainless steel bearings in sliding and rolling contact in ultrahigh vacuum and various gas environment

Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo

The early stages of otic placode development depend on signals from neighbouring tissues including the hindbrain. The identity of these signals and of the responding placodal genes, however, is not known. We have identified a chick homeobox gene cNkx5-1, which is expressed in the otic placode beginning at stage 10 and exhibits a dynamic expression pattern during formation and further differentiation of the otic vesicle. In a series of heterotopic transplantation experiments, we demonstrate that cNkx5-1 can be activated in ectopic positions. However, significant differences in otic development and cNkx5-1 gene activity were observed when placodes were transplanted into the more rostral positions within the head mesenchyme or into the wing buds of older hosts. These results indicate that only the rostral tissues were able to induce and/or maintain ear development. Ectopically induced cNkx5-1 expression always reproduced the endogenous pattern within the lateral wall of the otocyst that is destined to form vestibular structures. In contrast, cPax2 which is expressed in the medial wall of the early otic vesicle later forming the cochlea never resumed its correct expression pattern after transplantation. Our experiments illustrate that only some aspects of gene expression and presumably pattern formation during inner ear development can be established and maintained ectopically. In particular, the dorsal vestibular structures seem to be programmed earlier and differently from the ventral cochlear part

MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis

Commitment of progenitors in the dermomyotome to myoblast fate is the first step in establishing the body musculature. Pax3 is a crucial transcription factor, important for skeletal muscle development and expressed in myogenic progenitors in the dermomyotome of developing somites and in migratory muscle progenitors that populate the limb buds. Down-regulation of Pax3 is essential to ignite the myogenic program, including up-regulation of myogenic regulators, Myf-5 and MyoD. MicroRNAs (miRNAs) confer robustness to developmental timing by posttranscriptional repression of genetic programs that are related to previous developmental stages or to alternative cell fates. Here we demonstrate that the muscle-specific miRNAs miR-1 and miR-206 directly target Pax3. Antagomir-mediated inhibition of miR-1/miR-206 led to delayed myogenic differentiation in developing somites, as shown by transient loss of myogenin expression. This correlated with increased Pax3 and was phenocopied using Pax3-specific target protectors. Loss of myogenin after antagomir injection was rescued by Pax3 knockdown using a splice morpholino, suggesting that miR-1/miR-206 control somite myogenesis primarily through interactions with Pax3. Our studies reveal an important role for miR-1/miR-206 in providing precision to the timing of somite myogenesis. We propose that posttranscriptional control of Pax3 downstream of miR-1/miR-206 is required to stabilize myoblast commitment and subsequent differentiation. Given that mutually exclusive expression of miRNAs and their targets is a prevailing theme in development, our findings suggest that miRNA may provide a general mechanism for the unequivocal commitment underlying stem cell differentiation

Concurrent thermochemoradiotherapy for brain high-grade glioma

Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas

Fibre-optic delivery of time and frequency to VLBI station

The quality of Very Long Baseline Interferometry (VLBI) radio observations predominantly relies on precise and ultra-stable time and frequency (T&F) standards, usually hydrogen masers (HM), maintained locally at each VLBI station. Here, we present an operational solution in which the VLBI observations are routinely carried out without use of a local HM, but using remote synchronization via a stabilized, long-distance fibre-optic link. The T&F reference signals, traceable to international atomic timescale (TAI), are delivered to the VLBI station from a dedicated timekeeping laboratory. Moreover, we describe a proof-of-concept experiment where the VLBI station is synchronized to a remote strontium optical lattice clock during the observation.Comment: 8 pages, 8 figures, matches the version published in A&A, section Astronomical instrumentatio