Connections: A Journal of Public Education Advocacy - Fall 2002, Vol. 9, No. 2

President's Message - Wendy D. Puriefoy sees education as the universal liberator and children as our nation's most valuable resource.Richard Riley on Transforming American Education - Don't shortchange adolescents, urges Richard W. Riley, Clinton administration secretary of education, as we build for a knowledge-driven economy.Q&A: Bob Moses - Civil rights activist Bob Moses promotes math literacy as the key to education and economic access.Making It Happen - Phyllis McClure, Title I expert, alerts parents and communities to valuable NCLB-mandated information on schools, districts, and states coming their way.Viewpoint - Boeing Company CEO Philip M. Condit links the need for a worldclass workforce to the need for quality public education.Conversations - Grassroots organizer Donna Cooper, Maryland lawmaker Pete Rawlings, and New York attorney Michael Rebell discuss accountability, adequacy, and fiscal equity as long-term investments in the future of our nation.End Notes - William Novelli, CEO, on how AARP members put lifelong learning into action

External validation of clinical prediction models:simulation-based sample size calculations were more reliable than rules-of-thumb

INTRODUCTION: Sample size "rules-of-thumb" for external validation of clinical prediction models suggest at least 100 events and 100 non-events. Such blanket guidance is imprecise, and not specific to the model or validation setting. We investigate factors affecting precision of model performance estimates upon external validation, and propose a more tailored sample size approach.METHODS: Simulation of logistic regression prediction models to investigate factors associated with precision of performance estimates. Then, explanation and illustration of a simulation-based approach to calculate the minimum sample size required to precisely estimate a model's calibration, discrimination and clinical utility.RESULTS: Precision is affected by the model's linear predictor (LP) distribution, in addition to number of events and total sample size. Sample sizes of 100 (or even 200) events and non-events can give imprecise estimates, especially for calibration. The simulation-based calculation accounts for the LP distribution and (mis)calibration in the validation sample. Application identifies 2430 required participants (531 events) for external validation of a deep vein thrombosis diagnostic model.CONCLUSION: Where researchers can anticipate the distribution of the model's LP (eg, based on development sample, or a pilot study), a simulation-based approach for calculating sample size for external validation offers more flexibility and reliability than rules-of-thumb.</p

Magnetoencephalography as a Putative Biomarker for Alzheimer's Disease

Alzheimer's Disease (AD) is the most common dementia in the elderly and is estimated to affect tens of millions of people worldwide. AD is believed to have a prodromal stage lasting ten or more years. While amyloid deposits, tau filaments, and loss of brain cells are characteristics of the disease, the loss of dendritic spines and of synapses predate such changes. Popular preclinical detection strategies mainly involve cerebrospinal fluid biomarkers, magnetic resonance imaging, metabolic PET scans, and amyloid imaging. One strategy missing from this list involves neurophysiological measures, which might be more sensitive to detect alterations in brain function. The Magnetoencephalography International Consortium of Alzheimer's Disease arose out of the need to advance the use of Magnetoencephalography (MEG), as a tool in AD and pre-AD research. This paper presents a framework for using MEG in dementia research, and for short-term research priorities

The Vehicle, Spring 1994

Table of Contents Thoughts in the IGASue Songerpage 6 The Cries of an Innocent Tea BagWojnarowski Yvonnepage 7 Proud HarpySusan Eisenhourpage 8 Bus Number TwoMindy Glazepage 9 My Home TownScott Langenpage 10 MemoriesMaggie Willpage 11 Vase (Artwork)Gail Valkerpage 12 The Last HuntMark Kannmacherpage 13 Corn DanceJulia A. Canhampage 14 Untitled (Photography)Rachel Corbettpage 14 Paradise (Artwork)Gail Valkerpage 15 Holding Back A ScreamElise Kirarpage 16 poetry isJonathan W. Iwanskipage 17 loveCatherine DeGraafpage 18 The OneTim Rileypage 18 Reading His Words on a Frosty EveningTom McGrathpage 19 UntitledBob Newellpage 19 The Ice StormMindy Glazepage 20 UntitledJonathan W. Iwanskipage 21 Untitled (Photography)Rachel Corbettpage 23 cityscapeChris Pomeroypage 24 Untitled (Photography)Rachel Corbettpage 25 Quarter Pound TemptationBryan Levekpage 26 Photograph (Artwork)Gail Valkerpage 29 Don\u27t Talk to StrangersJon Montgomerypage 30 Untitled (Photography)Rachel Corbettpage 33 Charleston, U.S.A. (Artwork)Gail Valkerpage 34 Fun With Nature (Artwork)Gail Valkerpage 34https://thekeep.eiu.edu/vehicle/1064/thumbnail.jp

Self-love and sociability: the ‘rudiments of commerce’ in the state of nature

Istvan Hont’s classic work on the theoretical links between the seventeenth-century natural jurists Hugo Grotius and Samuel Pufendorf and the eighteenth-century Scottish political economists remains a popular trope among intellectual and economic historians of various stamps. Despite this, a common criticism levelled at Hont remains his relative lack of engagement with the relationship between religion and economics in the early modern period. This paper challenges this aspect of Hont’s narrative by drawing attention to an alternative, albeit complementary, assessment of the natural jurisprudential heritage of eighteenth-century British political economy. Specifically, the article attempts to map on to Hont’s thesis the Christian Stoic interpretation of Grotius and Pufendorf which has gained greater currency in recent years. In doing so, the paper argues that Grotius and Pufendorf’s contributions to the ‘unsocial sociability’ debate do not necessarily lead directly to the Scottish school of political economists, as is commonly assumed. Instead, it contends that a reconsideration of Grotius and Pufendorf as neo-Stoic theorists, particularly via scrutiny of their respective adaptations of the traditional Stoic theory of oikeiosis, steers us towards the heart of the early English ‘clerical’ Enlightenment

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Bridgewater College, Bob Riley (photographer), Bowman Hall groundbreaking, 1 March 1952

Archival photograph from Bridgewater College Special Collectionshttps://digitalcommons.bridgewater.edu/bowman_hall/1036/thumbnail.jp

Bridgewater College, Bob Riley (photographer), Bowman Hall groundbreaking, 1 March 1952

Archival photograph from Bridgewater College Special Collectionshttps://digitalcommons.bridgewater.edu/bowman_hall/1037/thumbnail.jp

Peach Bowl football program, University of Maryland football, December 28, 1973

The cover of the Peach Bowl football program, University of Maryland versus the University of Georgia in Atlanta Stadium, Georgia, December 28, 1973. The cover features a photo of the Peach Bowl trophy