Towards active microfluidics: Interface turbulence in thin liquid films with floating molecular machines

Thin liquid films with floating active protein machines are considered. Cyclic mechanical motions within the machines, representing microscopic swimmers, lead to molecular propulsion forces applied to the air-liquid interface. We show that, when the rate of energy supply to the machines exceeds a threshold, the flat interface becomes linearly unstable. As the result of this instability, the regime of interface turbulence, characterized by irregular traveling waves and propagating machine clusters, is established. Numerical investigations of this nonlinear regime are performed. Conditions for the experimental observation of the instability are discussed.Comment: 9 pages, 8 figures, RevTeX, submitted to Physical Review

Molecular Discreteness in Reaction-Diffusion Systems Yields Steady States Not Seen in the Continuum Limit

We investigate the effects of spatial discreteness of molecules in reaction-diffusion systems. It is found that discreteness within the so called Kuramoto length can lead to a localization of molecules, resulting in novel steady states that do not exist in the continuous case. These novel states are analyzed theoretically as the fixed points of accelerated localized reactions, an approach that was verified to be in good agreement with stochastic particle simulations. The relevance of this discreteness-induced state to biological intracellular processes is discussed.Comment: 5 pages, 3 figures, revtex

Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients

A recent, non-peer-reviewed meta-analysis suggests that smoking may reduce the risk of hospitalization with COVID-19 because the prevalence of smoking among hospitalized COVID-19 is less than that of the general population. However, there are alternative explanations for this phenomena based on (1) the failure to report, or accurately record, smoking history during emergency hospital admissions and (2) a pre-disposition to avoid smoking among COVID-19 patients with tobacco-related comorbidities (a type of “reverse” causation). For example, urine testing of hospitalized patients in Australia for cotinine showed that smokers were under-counted by 37% because incoming patients failed to inform staff about their smoking behavior. Face-to-face interviews can introduce bias into the responses to attitudinal and behavioral questions not present in the self-completion interviews typically used to measure smoking prevalence in the general population. Subjects in face-to-face interviews may be unwilling to admit socially undesirable behavior and attitudes under direct questioning. Reverse causation may also contribute to the difference between smoking prevalence in the COVID-19 and general population. Patients hospitalized with COVID-19 may be simply less prone to use tobacco than the general population. A potentially robust “reverse causation” hypothesis for reduced prevalence of smokers in the COVID-19 population is the enrichment of patients in that population with serious comorbidities that motivates them to quit smoking. We judge that this “smoking cessation” mechanism may account for a significant fraction of the reduced prevalence of smokers in the COVID-19 population. Testing this hypothesis will require a focused research program

Singular Laplacian Growth

The general equations of motion for two dimensional Laplacian growth are derived using the conformal mapping method. In the singular case, all singularities of the conformal map are on the unit circle, and the map is a degenerate Schwarz-Christoffel map. The equations of motion describe the motions of these singularities. Despite the typical fractal-like outcomes of Laplacian growth processes, the equations of motion are shown to be not particularly sensitive to initial conditions. It is argued that the sensitivity of this system derives from a novel cause, the non-uniqueness of solutions to the differential system. By a mechanism of singularity creation, every solution can become more complex, even in the absence of noise, without violating the growth law. These processes are permitted, but are not required, meaning the equation of motion does not determine the motion, even in the small.Comment: 8 pages, Latex, 4 figures, Submitted to Phys. Rev.

Status of the HIE-ISOLDE project at CERN

The HIE-ISOLDE project represents a major upgrade of the ISOLDE nuclear facility with a mandate to significantly improve the quality and increase the intensity and energy of radioactive nuclear beams produced at CERN. The project will expand the experimental nuclear physics programme at ISOLDE by focusing on an upgrade of the existing Radioactive ion beam EXperiment (REX) linac with a 40 MV superconducting linac comprising thirty-two niobium-on-copper sputter-coated quarter-wave resonators housed in six cryomodules. The new linac will raise the energy of post-accelerated beams from 3 MeV/u to over 10 MeV/u. The upgrade will be staged to first deliver beam energies of 5.5 MeV/u using two high-$\beta$ cryomodules placed downstream of REX, before the energy variable section of the existing linac is replaced with two low-$\beta$ cryomodules and two additional high-$\beta$ cryomodules are installed to attain over 10 MeV/u with full energy variability above 0.45 MeV/u. An overview of the project including a status summary of the different R&D activities and the schedule will outlined.Comment: 7 pages, 12 figures, submitted to the Heavy Ion Accelerator Technology conference (HIAT) 2012, in Chicag

Probing pre-formed alpha particles in the ground state of nuclei

In this Letter, we report on alpha particle emission through the nuclear break-up in the reaction 40Ca on a 40Ca target at 50A MeV. It is observed that, similarly to nucleons, alpha particles can be emitted to the continuum with very specific angular distribution during the reaction. The alpha particle properties can be understood as resulting from an alpha cluster in the daughter nucleus that is perturbed by the short range nuclear attraction of the collision partner and emitted. A time-dependent theory that describe the alpha particle wave-function evolution is able to reproduce qualitatively the observed angular distribution. This mechanism offers new possibilities to study alpha particle properties in the nuclear medium.Comment: 4 pages, 3 figure

Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients

A recent, non-peer-reviewed meta-analysis suggests that smoking may reduce the risk of hospitalization with COVID-19 because the prevalence of smoking among hospitalized COVID-19 is less than that of the general population. However, there are alternative explanations for this phenomena based on (1) the failure to report, or accurately record, smoking history during emergency hospital admissions and (2) a pre-disposition to avoid smoking among COVID-19 patients with tobacco-related comorbidities (a type of “reverse” causation). For example, urine testing of hospitalized patients in Australia for cotinine showed that smokers were under-counted by 37% because incoming patients failed to inform staff about their smoking behavior. Face-to-face interviews can introduce bias into the responses to attitudinal and behavioral questions not present in the self-completion interviews typically used to measure smoking prevalence in the general population. Subjects in face-to-face interviews may be unwilling to admit socially undesirable behavior and attitudes under direct questioning. Reverse causation may also contribute to the difference between smoking prevalence in the COVID-19 and general population. Patients hospitalized with COVID-19 may be simply less prone to use tobacco than the general population. A potentially robust “reverse causation” hypothesis for reduced prevalence of smokers in the COVID-19 population is the enrichment of patients in that population with serious comorbidities that motivates them to quit smoking. We judge that this “smoking cessation” mechanism may account for a significant fraction of the reduced prevalence of smokers in the COVID-19 population. Testing this hypothesis will require a focused research program

Field Theory And Second Renormalization Group For Multifractals In Percolation

The field-theory for multifractals in percolation is reformulated in such a way that multifractal exponents clearly appear as eigenvalues of a second renormalization group. The first renormalization group describes geometrical properties of percolation clusters, while the second-one describes electrical properties, including noise cumulants. In this context, multifractal exponents are associated with symmetry-breaking fields in replica space. This provides an explanation for their observability. It is suggested that multifractal exponents are ''dominant'' instead of ''relevant'' since there exists an arbitrary scale factor which can change their sign from positive to negative without changing the Physics of the problem.Comment: RevTex, 10 page

Structure of unbound neutron-rich 9^{9}He studied using single-neutron transfer

The 8He(d,p) reaction was studied in inverse kinematics at 15.4A MeV using the MUST2 Si-CsI array in order to shed light on the level structure of 9He. The well known 16O(d,p)17O reaction, performed here in reverse kinematics, was used as a test to validate the experimental methods. The 9He missing mass spectrum was deduced from the kinetic energies and emission angles of the recoiling protons. Several structures were observed above the neutron-emission threshold and the angular distributions were used to deduce the multipolarity of the transitions. This work confirms that the ground state of 9He is located very close to the neutron threshold of 8He and supports the occurrence of parity inversion in 9He.Comment: Exp\'erience GANIL/SPIRAL1/MUST

Explanation of the Gibbs paradox within the framework of quantum thermodynamics

The issue of the Gibbs paradox is that when considering mixing of two gases within classical thermodynamics, the entropy of mixing appears to be a discontinuous function of the difference between the gases: it is finite for whatever small difference, but vanishes for identical gases. The resolution offered in the literature, with help of quantum mixing entropy, was later shown to be unsatisfactory precisely where it sought to resolve the paradox. Macroscopic thermodynamics, classical or quantum, is unsuitable for explaining the paradox, since it does not deal explicitly with the difference between the gases. The proper approach employs quantum thermodynamics, which deals with finite quantum systems coupled to a large bath and a macroscopic work source. Within quantum thermodynamics, entropy generally looses its dominant place and the target of the paradox is naturally shifted to the decrease of the maximally available work before and after mixing (mixing ergotropy). In contrast to entropy this is an unambiguous quantity. For almost identical gases the mixing ergotropy continuously goes to zero, thus resolving the paradox. In this approach the concept of ``difference between the gases'' gets a clear operational meaning related to the possibilities of controlling the involved quantum states. Difficulties which prevent resolutions of the paradox in its entropic formulation do not arise here. The mixing ergotropy has several counter-intuitive features. It can increase when less precise operations are allowed. In the quantum situation (in contrast to the classical one) the mixing ergotropy can also increase when decreasing the degree of mixing between the gases, or when decreasing their distinguishability. These points go against a direct association of physical irreversibility with lack of information.Comment: Published version. New title. 17 pages Revte