Some mechanisms for a theory of the reticular formation Final report, 15 Nov. 1965 - 14 Nov. 1966

Nonlinear, probabilistic hybrid computer concepts for specifying operational schemata of central nervous system model

Scaling in Complex Systems: Analytical Theory of Charged Pores

In this paper we find an analytical solution of the equilibrium ion distribution for a toroidal model of a ionic channel, using the Perfect Screening Theorem (PST). The ions are charged hard spheres, and are treated using a variational Mean Spherical Approximation (VMSA) . Understanding ion channels is still a very open problem, because of the many exquisite tuning details of real life channels. It is clear that the electric field plays a major role in the channel behaviour, and for that reason there has been a lot of work on simple models that are able to provide workable theories. Recently a number of interesting papers have appeared that discuss models in which the effect of the geometry, excluded volume and non-linear behaviour is considered. We present here a 3D model of ionic channels which consists of a charged, deformable torus with a circular or elliptical cross section, which can be flat or vertical (close to a cylinder). Extensive comparisons to MC simulations were performed. The new solution opens new possibilities, such as studying flexible pores, and water phase transformations inside the pores using an approach similar to that used on flat crystal surfaces

The Stellar Content of Obscured Galactic Giant HII Regions. VI: W51A

We present K-band spectra of newly born OB stars in the obscured Galactic giant H II region W51A and ~ 0.8'' angular resolution images in the J, H and K_S-bands. Four objects have been spectroscopically classified as O-type stars. The mean spectroscopic parallax of the four stars gives a distance of 2.0 \pm 0.3 kpc (error in the mean), significantly smaller than the radio recombination line kinematic value of 5.5 kpc or the values derived from maser propermotion observations (6--8 kpc). The number of Lyman continuum photons from the contribution of all massive stars (NLyc ~ 1.5 x 10^{50} s^{-1}) is in good agreement with that inferred from radio recombination lines (NLyc = 1.3 x 10^{50} s^{-1}) after accounting for the smaller distance derived here. We present analysis of archival high angular resolution images (NAOS CONICA at VLT and T-ReCS at Gemini) of the compact region W51 IRS2. The K_S--band images resolve the infrared source IRS~2 indicating that it is a very young compact HII region. Sources IRS2E was resolved into compact cluster (within 660 AU of projected distance) of 3 objects, but one of them is just bright extended emission. W51d1 and W51d2 were identified with compact clusters of 3 objects (maybe 4 in the case of W51d1) each one. Although IRS~2E is the brightest source in the K-band and at 12.6 \micron, it is not clearly associated with a radio continuum source. Our spectrum of IRS~2E shows, similar to previous work, strong emission in Br$\gamma$ and HeI, as well as three forbidden emission lines of FeIII and emission lines of molecular hydrogen (H_2) marking it as a massive young stellar object.Comment: 31 pages and 9 figures, submitted to A

A corresponding states approach to Small-Angle-Scattering for polydisperse ionic colloidal fluids

Approximate scattering functions for polydisperse ionic colloidal fluids are obtained by a corresponding states approach. This assumes that all pair correlation functions $g_{\alpha \beta}(r)$ of a polydisperse fluid are conformal to those of an appropriate monodisperse binary fluid (reference system) and can be generated from them by scaling transformations. The correspondence law extends to ionic fluids a {\it scaling approximation} (SA) successfully proposed for nonionic colloids in a recent paper. For the primitive model of charged hard spheres in a continuum solvent, the partial structure factors of the monodisperse binary reference system are evaluated by solving the Orstein-Zernike (OZ) integral equations coupled with an approximate closure. The SA is first tested within the mean spherical approximation (MSA) closure, which allows analytical solutions. The results are found in good overall agreement with exact MSA predictions up to relevant polidispersity. The SA is shown to be an improvement over the ``decoupling approximation'' extended to the ionic case. The simplicity of the SA scheme allows its application also when the OZ equations can be solved only numerically. An example is then given by using the hypernetted chain (HNC) closure. Shortcomings of the SA approach, its possible use in the analysis of experimental scattering data and other related points are also briefly addressed.Comment: 29 pages, 7 postscript figures (included), Latex 3.0, uses aps.sty, to appear in Phys. Rev. E (1999

Ruxolitinib in the treatment of polycythemia vera: patient selection and special considerations.

The discovery of JAK2 V617F mutation in the mid-2000s started to fill the gap between clinical presentation of polycythemia vera (PV), first described by Vaquez at the end of the 19th century, and spontaneous erythroid colony formation, reported by Prchal and Axelrad in the mid-1970s. The knowledge on this mutation brought an important insight to our understanding of PV pathogenesis and led to a revision of the World Health Organization diagnostic criteria in 2008. JAK-STAT is a major signaling pathway implicated in survival and proliferation of hematopoietic precursors. High prevalence of JAK2 V617F mutation among myeloproliferative neoplasms (>95% in PV and ~50% in primary myelofibrosis and essential thrombocythemia) together with its role in constitutively activating JAK-STAT made JAK2 a privileged therapeutic target. Ruxolitinib, a JAK 1 and 2 inhibitor, has already proven to be efficient in relieving symptoms in primary myelofibrosis and PV. In the latter, it also appears to improve microvascular involvement. However, evidence regarding its potential role in altering the natural course of PV and its use as an adjunct to current standard therapies is sparse. Therapeutic advances are needed in PV as phlebotomy, low-dose aspirin, cytoreductive agents, and interferon alpha are the only therapeutic tools available at the moment to influence outcome. Even though several questions are still unanswered, this review aims to serve as an overview article of the potential role of ruxolitinib in PV according to current literature and expert opinion. It should help hematologists to visualize the place of this tyrosine kinase inhibitor in the field of current practice and offer criteria for a careful patient selection

Cytosol to Lysosome Transport of Intracellular Antigens During Immune Surveillance

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.The delivery of intracellular substrates such as misfolded proteins and damaged organelles from the cytosol to the lysosome for degradation is crucial for cell survival. Multiple transport pathways including bulk autophagy (microautophagy and macroautophagy) and chaperone‐mediated autophagy (CMA) have been identified to efficiently facilitate this transit of macromolecules from the cytoplasm to acidic vacuolar organelles. While autophagy plays a role in the general housekeeping of cells, it also functions in more specialized processes such as development and differentiation, responses to physiological stress and immunity. The presentation of both exogenous and endogenous antigens (Ag) by major histocompatibility complex (MHC) class II molecules to CD4+ T lymphocytes is critical for the induction of tolerance to self Ag as well as the development of immunity against intracellular pathogens and tumors. Here, we discuss the class II‐mediated presentation of several endogenous Ag, dependent on either macroautophagy or CMA for their transport from the cytosol to endosomal/lysosomal compartments. Thus, the various pathways of autophagy as routes of cytoplasmic Ag delivery to lysosomes have significant implications for the MHC class II‐mediated immune response to intracellular pathogens and cancer

Ion observations from geosynchronous orbit as a proxy for ion cyclotron wave growth during storm times

[1] There is still much to be understood about the processes contributing to relativistic electron enhancements and losses in the radiation belts. Wave particle interactions with both whistler and electromagnetic ion cyclotron (EMIC) waves may precipitate or accelerate these electrons. This study examines the relation between EMIC waves and resulting relativistic electron flux levels after geomagnetic storms. A proxy for enhanced EMIC waves is developed using Los Alamos National Laboratory Magnetospheric Plasma Analyzer plasma data from geosynchronous orbit in conjunction with linear theory. In a statistical study using superposed epoch analysis, it is found that for storms resulting in net relativistic electron losses, there is a greater occurrence of enhanced EMIC waves. This is consistent with the hypothesis that EMIC waves are a primary mechanism for the scattering of relativistic electrons and thus cause losses of such particles from the magnetosphere

Parts of Quantum States

It is shown that generic N-party pure quantum states (with equidimensional subsystems) are uniquely determined by their reduced states of just over half the parties; in other words, all the information in almost all N-party pure states is in the set of reduced states of just over half the parties. For N even, the reduced states in fewer than N/2 parties are shown to be an insufficient description of almost all states (similar results hold when N is odd). It is noted that Real Algebraic Geometry is a natural framework for any analysis of parts of quantum states: two simple polynomials, a quadratic and a cubic, contain all of their structure. Algorithmic techniques are described which can provide conditions for sets of reduced states to belong to pure or mixed states.Comment: 10 pages, 1 figur