Factors Affecting Laminar Boundary Layer Measurements in a Supersonic Stream

The observed discrepancy at supersonic speeds between theoretical and apparent experimental average flat plate friction-drag coefficients calculated from boundary layer total-pressure surveys was investigated. Effects of the total-pressure probe, heat transfer through the leading edge region, change in leading-edge radius and strength of the leading-edge wave, possible early transition to turbulent flow or bursts of turbulence, and the slight stream-wise pressure gradient inherent in flat plate flow were investigated for plates with very sharp leading edges. Only one of these factors, the effect of the total-pressure probe, was found to be significant. Total-pressure probes of different tip heights, when placed in laminar boundary layers developing under identical conditions, were found to yield different values of friction drag coefficient. Extrapolation of these measurements indicates that a probe of vanishing size would yield the theoretical predicted values of average flat plate friction-drag coefficients. A correlation describing the relation between the friction-drag discrepancy and the probe tip height is presented

Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight

As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight. Historical missions have relied upon frequent resupply of onboard pharmaceuticals; as a result, there has been little study into the effects of long-term exposure of pharmaceuticals to the space environment. Of particular concern are the long-term effects of space radiation on drug stability, especially as missions venture away from the protective proximity of the Earth. Here we highlight the risk of space radiation to pharmaceuticals during exploration spaceflight, identifying the limitations of current understanding. We further seek to identify ways in which these limitations could be addressed through dedicated research efforts aimed towards the rapid development of an effective pharmacy for future spaceflight endeavors.Comment: in press, Nature Microgravit

Stability and Instability of Extreme Reissner-Nordstr\"om Black Hole Spacetimes for Linear Scalar Perturbations I

We study the problem of stability and instability of extreme Reissner-Nordstrom spacetimes for linear scalar perturbations. Specifically, we consider solutions to the linear wave equation on a suitable globally hyperbolic subset of such a spacetime, arising from regular initial data prescribed on a Cauchy hypersurface crossing the future event horizon. We obtain boundedness, decay and non-decay results. Our estimates hold up to and including the horizon. The fundamental new aspect of this problem is the degeneracy of the redshift on the event horizon. Several new analytical features of degenerate horizons are also presented.Comment: 37 pages, 11 figures; published version of results contained in the first part of arXiv:1006.0283, various new results adde

Defining Medical Capabilities for Exploration Missions

Exploration-class missions to the moon, Mars and beyond will require a significant change in medical capability from today's low earth orbit centric paradigm. Significant increases in autonomy will be required due to differences in duration, distance and orbital mechanics. Aerospace medicine and systems engineering teams are working together within ExMC to meet these challenges. Identifying exploration medical system needs requires accounting for planned and unplanned medical care as defined in the concept of operations. In 2017, the ExMC Clinicians group identified medical capabilities to feed into the Systems Engineering process, including: determining what and how to address planned and preventive medical care; defining an Accepted Medical Condition List (AMCL) of conditions that may occur and a subset of those that can be treated effectively within the exploration environment; and listing the medical capabilities needed to treat those conditions in the AMCL. This presentation will discuss the team's approach to addressing these issues, as well as how the outputs of the clinical process impact the systems engineering effort

A Semi-Lagrangian scheme for a modified version of the Hughes model for pedestrian flow

In this paper we present a Semi-Lagrangian scheme for a regularized version of the Hughes model for pedestrian flow. Hughes originally proposed a coupled nonlinear PDE system describing the evolution of a large pedestrian group trying to exit a domain as fast as possible. The original model corresponds to a system of a conservation law for the pedestrian density and an Eikonal equation to determine the weighted distance to the exit. We consider this model in presence of small diffusion and discuss the numerical analysis of the proposed Semi-Lagrangian scheme. Furthermore we illustrate the effect of small diffusion on the exit time with various numerical experiments

Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data

BACKGROUND: In the past few years, imputation approaches have been mainly used in population-based designs of genome-wide association studies, although both family- and population-based imputation methods have been proposed. With the recent surge of family-based designs, family-based imputation has become more important. Imputation methods for both designs are based on identity-by-descent (IBD) information. Apart from imputation, the use of IBD information is also common for several types of genetic analysis, including pedigree-based linkage analysis. METHODS: We compared the performance of several family- and population-based imputation methods in large pedigrees provided by Genetic Analysis Workshop 19 (GAW19). We also evaluated the performance of a new IBD mapping approach that we propose, which combines IBD information from known pedigrees with information from unrelated individuals. RESULTS: Different combinations of the imputation methods have varied imputation accuracies. Moreover, we showed gains from the use of both known pedigrees and unrelated individuals with our IBD mapping approach over the use of known pedigrees only. CONCLUSIONS: Our results represent accuracies of different combinations of imputation methods that may be useful for data sets similar to the GAW19 pedigree data. Our IBD mapping approach, which uses both known pedigree and unrelated individuals, performed better than classical linkage analysis

Linearized gravity and gauge conditions

In this paper we consider the field equations for linearized gravity and other integer spin fields on the Kerr spacetime, and more generally on spacetimes of Petrov type D. We give a derivation, using the GHP formalism, of decoupled field equations for the linearized Weyl scalars for all spin weights and identify the gauge source functions occuring in these. For the spin weight 0 Weyl scalar, imposing a generalized harmonic coordinate gauge yields a generalization of the Regge-Wheeler equation. Specializing to the Schwarzschild case, we derive the gauge invariant Regge-Wheeler and Zerilli equation directly from the equation for the spin 0 scalar.Comment: 24 pages, corresponds to published versio

Asymptotic distribution of quasi-normal modes for Kerr-de Sitter black holes

We establish a Bohr-Sommerfeld type condition for quasi-normal modes of a slowly rotating Kerr-de Sitter black hole, providing their full asymptotic description in any strip of fixed width. In particular, we observe a Zeeman-like splitting of the high multiplicity modes at a=0 (Schwarzschild-de Sitter), once spherical symmetry is broken. The numerical results presented in Appendix B show that the asymptotics are in fact accurate at very low energies and agree with the numerical results established by other methods in the physics literature. We also prove that solutions of the wave equation can be asymptotically expanded in terms of quasi-normal modes; this confirms the validity of the interpretation of their real parts as frequencies of oscillations, and imaginary parts as decay rates of gravitational waves.Comment: 66 pages, 6 figures; journal version (to appear in Annales Henri Poincar\'e

Metabolic characterization of overweight and obese adults

Traditional evaluations of metabolic health may overlook underlying dysfunction in individuals who show no signs of insulin resistance or dyslipidemia. The purpose of this study was to characterize metabolic health in overweight and obese adults using traditional and non-traditional metabolic variables. A secondary purpose was to evaluate differences between overweight/obese and male/female cohorts, respectively