European Respiratory Society International Congress best abstract preview from the allied respiratory professionals from assembly 9

The 28th European Respiratory Society (ERS) International Congress [2018] in Paris features interesting research findings within the allied respiratory professional assembly (assembly 9). Excellent and high ranked abstracts were selected for this year’s ERS International Congress preview of assembly 9 and are put in the spotlights. A summary of the best three abstracts of every group, i.e., lung function technologists, physiotherapists and nurses, within assembly 9 is presented. Session, timing and location of the presentation of the abstract at this year’s ERS International Congress is indicated in squared brackets following the authors’ name.info:eu-repo/semantics/publishedVersio

Defining the appropriate waiting time between multiple-breath nitrogen washout measurements

Research lette

相対作用素エントロピーをめぐって(作用素不等式とその周辺)

Independent Ethics Committees and Institutional Review Boards for ClinicalTrial.gov: NCT01072396. (PDF 71 kb

Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials.

BackgroundPrecision and accuracy assurance in cardiopulmonary exercise testing (CPET) facilitates multicenter clinical trials by maximizing statistical power and minimizing participant risk. Current guidelines recommend quality control that is largely based on precision at individual testing centers (minimizing test-retest variability). The aim of this study was to establish a multicenter biological quality control (BioQC) method that considers both precision and accuracy in CPET.MethodsBioQC testing was 6-min treadmill walking at 20 W and 70 W (below the lactate threshold) with healthy non-smoking laboratory staff (15 centers; ~16 months). Measurements were made twice within the initial 4 weeks and quarterly thereafter. Quality control was based on: 1) within-center precision (coefficient of variation [CV] for oxygen uptake [V̇O2], carbon dioxide output [V̇CO2], and minute ventilation [V̇E] within ±10%); and 2) a criterion that V̇O2 at 20 W and 70 W, and ∆V̇O2/∆WR were each within ±10 % predicted. "Failed" BioQC tests (i.e., those outside the predetermined criterion) prompted troubleshooting and repeated measurements. An additional retrospective analysis, using a composite z-score combining both BioQC precision and accuracy of V̇O2 at 70 W and ∆V̇O2/∆WR, was compared with the other methods.ResultsOf 129 tests (5 to 8 per center), 98 (76%) were accepted by within-center precision alone. Within-center CV was <9%, but between-center CV remained high (9.6 to 12.5%). Only 43 (33%) tests had all V̇O2 measurements within the ±10% predicted criterion. However, a composite z-score of 0.67 identified 67 (52%) non-normal outlying tests, exclusion of which coincided with the minimum CV for CPET variables.ConclusionsStudy-wide BioQC using a composite z-score can increase study-wide precision and accuracy, and optimize the design and conduct of multicenter clinical trials involving CPET.Trial registrationClinicalTrials.gov identifier: NCT01072396; February 19, 2010