Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor

The integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellular pathway is modulated by tight junctions between adjacent cells. Rupturing its integrity by H2O2 is monitored by the change of the output voltage in the transfer characteristics. It is demonstrated that by operating the OECT in a current-driven configuration, the sensitive and temporal resolution for monitoring the cell barrier integrity is strongly enhanced as compared to the OECT transient response measurement. As a result, current-driven OECTs are useful tools to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening

Boer-en-zorg : onderzoek naar de kernkwaliteit van de zorgboerderij

De zorglandbouwsector heeft in de afgelopen periode een explosieve groei doorgemaakt en het aantal cliënten is navenant toegenomen. De toekomst van de zorglandbouw zal onder meer afhangen van de tevredenheid van de cliënten en de manier waarop vormgegeven wordt aan de professionalisering. Hoewel de kwaliteit en effectiviteit van zorgboerderijen duidelijk worden ervaren, zijn deze nog steeds niet wetenschappelijk onderbouwd. Er is daarom behoefte aan gegevens over meerwaarde van de zorgboerderij en informatie over aspecten die het succes van zorgboerderijen bepalen

Fokker-Planck equation with variable diffusion coefficient in the Stratonovich approach

We consider the Langevin equation with multiplicative noise term which depends on time and space. The corresponding Fokker-Planck equation in Stratonovich approach is investigated. Its formal solution is obtained for an arbitrary multiplicative noise term given by $g(x,t)=D(x)T(t)$, and the behaviors of probability distributions, for some specific functions of $D(x)$% , are analyzed. In particular, for $D(x)\sim | x| ^{-\theta /2}$, the physical solutions for the probability distribution in the Ito, Stratonovich and postpoint discretization approaches can be obtained and analyzed.Comment: 6 pages in LATEX cod

The Influence of Texting Language on Grammar and Executive Functions in Primary School Children

Contains fulltext : 160590.PDF (publisher's version ) (Open Access

IGR J22517+2218=MG3 J225155+2217: a new gamma-ray lighthouse in the distant Universe

We report on the identification of a new soft gamma ray source, namely IGR J22517+2218, detected with IBIS/INTEGRAL. The source, which has an observed 20-100 keV flux of ~4 x10^-11 erg cm-2 s-1, is spatially coincident with MG3 J225155+2217, a quasar at z=3.668. The Swift/XRT 0.5-10 keV continuum is flat (Gamma=1.5) with evidence for a spectral curvature below 1-2 keV either due to intrinsic absorption (NH=3 +/- 2 x 10^22 cm-2) or to a change in slope (Delta Gamma= 0.5). X-ray observations indicate flux variability over a 6 days period which is further supported by a flux mismatch between Swift and INTEGRAL spectra. IGR J22517+2218 is radio loud and has a flat radio spectrum; optically it is a broad line emitting quasar with the atypical property of hosting a narrow line absorption system. The Source Spectral Energy Distribution is unusual compared to blazars of similar type: either it has the synchrotron peak in the X/gamma-ray band (i.e. much higher than generally observed) or the Compton peak in the MeV range (i.e. lower than typically measured). IGR J22517+2218=MG3 J225155+2217 is the second most distant blazar detected above 20 keV and a gamma-ray lighthouse shining from the edge of our Universe.Comment: 4 pages, 4 figures, Accepted for publication in Astrophysical Journal Letter

Donor states in modulation-doped Si/SiGe heterostructures

We present a unified approach for calculating the properties of shallow donors inside or outside heterostructure quantum wells. The method allows us to obtain not only the binding energies of all localized states of any symmetry, but also the energy width of the resonant states which may appear when a localized state becomes degenerate with the continuous quantum well subbands. The approach is non-variational, and we are therefore also able to evaluate the wave functions. This is used to calculate the optical absorption spectrum, which is strongly non-isotropic due to the selection rules. The results obtained from calculations for Si/Si$_{1-x}$Ge$_x$ quantum wells allow us to present the general behavior of the impurity states, as the donor position is varied from the center of the well to deep inside the barrier. The influence on the donor ground state from both the central-cell effect and the strain arising from the lattice mismatch is carefully considered.Comment: 17 pages, 10 figure

Phase-sensitive quantum effects in Andreev conductance of the SNS system of metals with macroscopic phase breaking length

The dissipative component of electron transport through the doubly connected SNS Andreev interferometer indium (S)-aluminium (N)-indium (S) has been studied. Within helium temperature range, the conductance of the individual sections of the interferometer exhibits phase-sensitive oscillations of quantum-interference nature. In the non-domain (normal) state of indium narrowing adjacent to NS interface, the nonresonance oscillations have been observed, with the period inversely proportional to the area of the interferometer orifice. In the domain intermediate state of the narrowing, the magneto-temperature resistive oscillations appeared, with the period determined by the coherence length in the magnetic field equal to the critical one. The oscillating component of resonance form has been observed in the conductance of the macroscopic N-aluminium part of the system. The phase of the oscillations appears to be shifted by $\pi$ compared to that of nonresonance oscillations. We offer an explanation in terms of the contribution into Josephson current from the coherent quasiparticles with energies of order of the Thouless energy. The behavior of dissipative transport with temperature has been studied in a clean normal metal in the vicinity of a single point NS contact.Comment: 9 pages, 7 figures, to be published in Low Temp. Phys., v. 29, No. 12, 200