Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor

The integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellular pathway is modulated by tight junctions between adjacent cells. Rupturing its integrity by H2O2 is monitored by the change of the output voltage in the transfer characteristics. It is demonstrated that by operating the OECT in a current-driven configuration, the sensitive and temporal resolution for monitoring the cell barrier integrity is strongly enhanced as compared to the OECT transient response measurement. As a result, current-driven OECTs are useful tools to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening

Поведение водорода при кристаллизации и охлаждении железа

С позиций теории направленной химической связи показано, что растворимость водорода в жидком железе и его аллотропических формах α–, γ– и δ–Fe коррелирует с изменением параметра Δе (положительная величина Δе соответствует донорному характеру связи, отрицательная – акцепторному)

Fokker-Planck equation with variable diffusion coefficient in the Stratonovich approach

We consider the Langevin equation with multiplicative noise term which depends on time and space. The corresponding Fokker-Planck equation in Stratonovich approach is investigated. Its formal solution is obtained for an arbitrary multiplicative noise term given by $g(x,t)=D(x)T(t)$, and the behaviors of probability distributions, for some specific functions of $D(x)$% , are analyzed. In particular, for $D(x)\sim | x| ^{-\theta /2}$, the physical solutions for the probability distribution in the Ito, Stratonovich and postpoint discretization approaches can be obtained and analyzed.Comment: 6 pages in LATEX cod

Specification and verification of atomic operations in GPGPU programs

We propose a specification and verification technique based on separation logic to reason about data race freedom and functional correctness of GPU kernels that use atomic operations as synchronisation mechanism. Our approach exploits the notion of resource invariant from Concurrent Separation Logic (CSL) to capture the behaviour of atomic operations. However, because of the different memory levels in the GPU architecture, we adapt this notion of resource invariant to these memory levels, i.e., group resource invariants capture the behaviour of atomic operations that access locations in local memory, while kernel resource invariants capture the behaviour of atomic operations that access locations in global memory. We show soundness of our approach and we provide tool support that enables us to verify kernels from standard benchmarks suites

Sensitive triplet exciton detection in polyfluorene using Pd-coordinated porphyrin

We developed a sensitive spectroscopic method to probe triplet concentration in thin films of polyfluorene (PF) at room temperature. The energy of photoexcited triplet excitons is transferred to the guest metal–organic complex, meso-tetratolylporphyrin-Pd (PdTPP), and detected as phosphorescent emission. The phosphorescence intensity of PdTPP–PF blends is proportional to the independently measured triplet concentration using photoinduced absorption experiments. The high sensitivity of this method allows room temperature detection of triplet excitons in spin-coated polymer films as thin as 10 nm. We found that the triplet lifetime is independent of PdTPP concentration and therefore this method is nearly non-perturbing for the triplet population.

COMPTEL observations of the quasar PKS 0528+134 during the first 3.5 years of the CGRO mission

The COMPTEL observations of the blazar-type quasar PKS 0528+134 in the energy range 0.75 MeV to 30 MeV carried out between April 1991 and September 1994 have been analyzed. During the first two years PKS 0528+134 was most significantly detected at energies above 3 MeV. During the last year there is only evidence for the quasar at energies below 3 MeV indicating a spectral change. The time-averaged COMPTEL energy spectrum between 0.75 MeV and 30 MeV is well represented by a power-law shape. Spectra collected from different observational periods reveal different power-law shapes: a hard state during flaring observations reported by EGRET, and a soft state otherwise. The combined simultaneous EGRET and COMPTEL spectra indicate these two spectral states as well. During low intensisty gamma-ray phases no spectral break is obvious from the combined COMPTEL and EGRET measurements. For the gamma-ray flaring phases however, the combined COMPTEL and EGRET data require a spectral bending at MeV-energies. By fitting broken power-law functions the best-fit values for the break in photon index range between 0.6 and 1.7, and for the break energy between ~5 MeV and ~20 MeV. Because the flux values measured by COMPTEL below 3 MeV in both states are roughly equal, the observations would be consistent with an additional spectral component showing up during gamma-ray flaring phases of PKS 0528+134. Such a component could be introduced by e.g. a high-energy electron-positron population with a low-energy cutoff in their bulk Lorentz factor distribution. The multiwavelength spectrum of PKS 0528+134 for gamma-ray flaring phases shows that the major energy release across the entire electro-magnetic spectrum is measured at MeV-energies.Comment: 10 pages, 8 postscript figures, latex, to appear in: A&A 328, 33 (1997

COMPTEL Observations of AGN at MeV-Energies

The COMPTEL experiment aboard CGRO, exploring the previously unknown sky at MeV-energies, has so far detected 10 Active Galactic Nuclei (AGN): 9 blazars and the radio galaxy Centaurus A. No Seyfert galaxy has been found yet. With these results COMPTEL has opened the field of extragalactic Gamma-ray astronomy in the MeV-band.Comment: 4 pages, 2 figures including 1 color plot, to appear in the Proceedings of the 3rd INTEGRAL Workshop "The Extreme Universe", held in Taormina, Italy, 14-18 September 199

Theory of anomalous magnetic interference pattern in mesoscopic SNS Josephson junctions

The magnetic interference pattern in mesoscopic SNS Josephson junctions is sensitive to the scattering in the normal part of the system. In this paper we investigate it, generalizing Ishii's formula for current-phase dependence to the case of normal scattering at NS boundaries in an SNS junction of finite width. The resulting flattening of the first diffraction peak is consistent with experimental data for S-2DEG-S mesoscopic junctions.Comment: 6 pages, 5 figures. Phys. Rev. B 68, 144514 (2003