De grondgebonden landbouw in Zuid-Holland; Structuur en ontwikkeling

Dit rapport is gemaakt in opdracht van de provincie Zuid-Holland en gaat in op de huidige structurele situatie in de grondgebonden landbouw in Zuid-Holland en de opgetreden ontwikkelingen in de afgelopen tien jaar. Ook wordt een beeld geschetst van de economische omvang van het grondgebonden agrocomplex en wordt aandacht besteed aan een aantal ontwikkelingen op de grondmarkt. This report was commissioned by the province of Zuid-Holland (South Holland) and examines the current structural situation in land-based farming in Zuid-Holland, as well as the developments which have appeared over the past ten years. In addition it describes the economic significance of the land-based agro-complex, and attention is devoted to a number of developments in the land market

Ammoniakemissie uit de landbouw in 1990 en 2005-2008. Achtergrondrapportage

In opdracht van het Planbureau voor de Leefomgeving en de WOT Natuur & Milieu heeft LEI Wageningen UR de definitieve berekening van de ammoniakemissie voor 2007 en een voorlopige berekening voor 2008 uitgevoerd. Daarnaast zijn herberekeningen uitgevoerd voor de jaren 1990 en 2005. Deze rapportage is een verantwoording van de uitgangspunten voor MAMBO en een beschrijving van de resultaten. Voor het jaar 2007 is de ammoniakemissie uit de landbouw (inclusief hobbybedrijven) geschat op 120 mln. kg NH3 en voor het jaar 2008 op 118 mln. kg NH3

Promiscuity of the AlloHLA-A2 Restricted T Cell Repertoire Hampers the Generation of Minor Histocompatibility Antigen-specific Cytotoxic T Cells across HLA Barriers

AbstractHematopoietic system-specific miHAs are ideal targets for adoptive immunotherapy after allogeneic HLA (alloHLA)-matched SCT. Adoptive immunotherapy with cytotoxic T cells targeting hematopoietic system-specific miHAs restricted by alloHLA molecules is an attractive strategy to treat relapsed hematologic malignancies after HLA-mismatched SCT. As a proof of principle, we exploited 2 new strategies to generate alloHLA-A2-restricted miHA-specific T cells from HLA-A2neg donors using a HLA/miHA multimer-guided approach. In one strategy, autologous DCs coated with HLA-A2/miHA complexes were used for in vitro generation of miHA-specific T cells from HLA-A2neg male donors. In the other strategy, miHA-specific T cells were directly isolated from the peripheral blood of HLA-A2neg parous females with HLA-A2pos offspring. Both methods introduced recombinant HLA-A2/miHA complexes as the sole allogeneic target antigen. However, neither method yielded high avidity miHA-specific T cells or prevented the emergence of peptide-dependent promiscuous T cells. The latter T cells resembled miHA-specific T cells so closely with regard to tetramer binding and cytokine production that only extensive testing at a clonal level revealed their nonspecific nature. Therefore, promiscuity of the alloHLA-A2 T cell repertoire of HLA-A2neg individuals hampers in vitro generation of genuine miHA-specific T cells and limits its use for adoptive immunotherapy after HLA-A2 mismatched SCT

Resultaat en financiering primaire landbouw

Dit hoofdstuk behandelt de resultaten van de sector land-en tuinbouw als geheel en van de verschillende typen land-en tuinbouwbedrijven

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Optical properties of low-dimensional semiconductor nanostructures

Contains fulltext : 74873.pdf (publisher's version ) (Open Access)RU Radboud Universiteit Nijmegen, 6 januari 2010123 p

Elektronen en gaten in halfgeleiderquantumdots

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Photoluminescence of PbS nanocrystals at high magnetic fields up to 30 T

Contains fulltext : 84223.pdf (publisher's version ) (Open Access)4 p

Carrier mass measurements in degenerate indium nitride

Contains fulltext : 75271.pdf (publisher's version ) (Open Access)6 p