2,585 research outputs found
The Structure and C=C Vibrational Frequencies of the all- trans Polyenes C2nH2n+2(n=2-15), C2nH2n(Me)2(n=2-13), and C2nH2n(tert-Butyl)2(n=2-5): Computational Results
Carbon-carbon bond lengths and C=C vibrational frequencies are reported for the linear, all-trans unsubstituted C2nH2n+2 (n=2-15), methyl capped C2nH2nMe2 (n=2-13), and tert-butyl capped C2nH2n(tert-butyl)2 (n=2-5) polyenes (C2h) calculated at the B3LYP/6-311++G(d,p) level. The C=C/C-C bond length alternation remains evident at this level for the unsubstituted and methyl capped polyenes as the chain length increases; the center-most difference in the length of the C-C/C=C bonds is ~0.06 Å for C30H32 and C26H26Me2. The Ag, in-phase, harmonic C=C Raman frequency for the unsubstituted polyenes decreases from 1699.2 cm-1 (n = 2) to 1528.9 cm-1 (n=15); the anharmonic frequency decreases from 1651.5 cm-1 (n = 2) to 1547.7 cm-1 (n = 8). The harmonic C=C frequency for the methyl capped polyenes decreases from 1717.9 cm-1 (n = 2) to 1539.6 cm- 1 (n= 13), and the anharmonic C=C frequency decreases from 1675.0 cm-1 (n = 2) to 1562.8 cm-1 (n = 7)
Analytic models and forward scattering from accelerator to cosmic-ray energies
Analytic models for hadron-hadron scattering are characterized by analytical
parametrizations for the forward amplitudes and the use of dispersion relation
techniques to study the total cross section and the
parameter. In this paper we investigate four aspects related to the application
of the model to and scattering, from accelerator to cosmic-ray
energies: 1) the effect of different estimations for from
cosmic-ray experiments; 2) the differences between individual and global
(simultaneous) fits to and ; 3) the role of the
subtraction constant in the dispersion relations; 4) the effect of distinct
asymptotic inputs from different analytic models. This is done by using as a
framework the single Pomeron and the maximal Odderon parametrizations for the
total cross section. Our main conclusions are the following: 1) Despite the
small influence from different cosmic-ray estimations, the results allow us to
extract an upper bound for the soft pomeron intercept: ;
2) although global fits present good statistical results, in general, this
procedure constrains the rise of ; 3) the subtraction constant as
a free parameter affects the fit results at both low and high energies; 4)
independently of the cosmic-ray information used and the subtraction constant,
global fits with the odderon parametrization predict that, above GeV, becomes greater than , and
this result is in complete agreement with all the data presently available. In
particular, we infer at GeV and
at 500 GeV (BNL RHIC energies).Comment: 16 pages, 7 figures, aps-revtex, wording changes, corrected typos, to
appear in Physical Review
HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC., compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HTV-1 infection
Density wave instabilities of tilted fermionic dipoles in a multilayer geometry
We consider the density wave instability of fermionic dipoles aligned by an
external field, and moving in equidistant layers at zero temperature. Using a
conserving Hartree-Fock approximation, we show that correlations between
dipoles in different layers significantly decrease the critical coupling
strength for the formation of density waves when the distance between the
layers is comparable to the inter-particle distance within each layer. This
effect, which is strongest when the dipoles are oriented perpendicular to the
planes, causes the density waves in neighboring layers to be in-phase for all
orientations of the dipoles. We furthermore demonstrate that the effects of the
interlayer interaction can be understood from a classical model. Finally, we
show that the interlayer correlations are important for experimentally relevant
dipolar molecules, including the chemically stable NaK and
KCs, where the density wave regime is within experimental reach.Comment: 18 pages, 11 figures; new version with expanded discussion on
experimental relevance including one new figur
Photogeneration Dynamics of a Soliton Pair in Polyacetylene
Dynamical process of the formation of a soliton pair from a photogenerated
electron-hole pair in polyacetylene is studied numerically by adopting the SSH
Hamiltonian. A weak local disorder is introduced in order to trigger the
formation. Starting from an initial configuration with an electron at the
bottom of the conduction band and a hole at the top of the valence band,
separated by the Peierls gap, the time dependent Schrndinger
equation for the electron wave functions and the equation of motion for the
lattice displacements are solved numerically. After several uniform
oscillations of the lattice system at the early stage, a large distortion
corresponding to a pair of a soliton and an anti-soliton develops from a point
which is determined by the location and type of the disorder. In some cases,
two solitons run in opposite directions, leaving breather like oscillations
behind, and in other cases they form a bound state emitting acoustic lattice
vibrational modes.Comment: 16 pages 7 figure
Pion photoproduction on the nucleon in the quark model
We present a detailed quark-model study of pion photoproduction within the
effective Lagrangian approach. Cross sections and single-polarization
observables are investigated for the four charge channels, , , , and .
Leaving the coupling strength to be a free parameter, we obtain a
reasonably consistent description of these four channels from threshold to the
first resonance region. Within this effective Lagrangian approach, strongly
constrainted by the quark model, we consider the issue of double-counting which
may occur if additional {\it t}-channel contributions are included.Comment: Revtex, 35 pages, 16 eps figures; version to appear on PR
The Influence of Solar Flares on the Lower Solar Atmosphere: Evidence from the Na D Absorption Line Measured by GOLF/SOHO
Solar flares presumably have an impact on the deepest layers of the solar
atmosphere and yet the observational evidence for such an impact is scarce.
Using ten years of measurements of the Na D and Na D Fraunhofer
lines, measured by GOLF onboard SOHO, we show that this photospheric line is
indeed affected by flares. The effect of individual flares is hidden by solar
oscillations, but a statistical analysis based on conditional averaging reveals
a clear signature. Although GOLF can only probe one single wavelength at a
time, we show that both wings of the Na line can nevertheless be compared. The
varying line asymmetry can be interpreted as an upward plasma motion from the
lower solar atmosphere during the peak of the flare, followed by a downward
motion.Comment: 13 pages, 7 figure
Direct mass measurements beyond the proton drip-line
First on-line mass measurements were performed at the SHIPTRAP Penning trap
mass spectrometer. The masses of 18 neutron-deficient isotopes in the
terbium-to-thulium region produced in fusion-evaporation reactions were
determined with relative uncertainties of about , nine of them
for the first time. Four nuclides (Ho and Tm) were
found to be proton-unbound. The implication of the results on the location of
the proton drip-line is discussed by analyzing the one-proton separation
energies
Spin- generalization of fractional exclusion statistics
We study fractional exclusion statistics for quantum systems with SU(2)
symmetry (arbitrary spin ), by generalizing the thermodynamic equations with
squeezed strings proposed by Ha and Haldane. The bare hole distributions as
well as the statistical interaction defined by an infinite-dimensional matrix
specify the universality class. It is shown that the system is described by the
level- WZW model and has a close relationship to non-abelian fractional
quantum Hall states. As a low-energy effective theory, the sector of {\it
massless} Z parafermions is extracted, whose statistical interaction is
given by a finite-dimensional matrix.Comment: 11pages, REVTE
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia.
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material.The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-3, commonly known to have executioner role for apoptosis, was uncovered in the microglia activation process. A central question emerging from this finding is what prevents caspase-3 during the microglia activation from killing those cells? Caspase-3 activation occurs as a two-step process, where the zymogen is first cleaved by upstream caspases, such as caspase-8, to form intermediate, yet still active, p19/p12 complex; thereafter, autocatalytic processing generates the fully mature p17/p12 form of the enzyme. Here, we show that the induction of cellular inhibitor of apoptosis protein 2 (cIAP2) expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit and is responsible for restraining caspase-3 in terms of activity and subcellular localization. We demonstrate that counteracting the repressive effect of cIAP2 on caspase-3 activation, using small interfering RNA targeting cIAP2 or a SMAC mimetic such as the BV6 compound, reduced the pro-inflammatory activation of microglia cells and promoted their death. We propose that the different caspase-3 functions in microglia, and potentially other cell types, reside in the active caspase-3 complexes formed. These results also could indicate cIAP2 as a possible therapeutic target to modulate microglia pro-inflammatory activation and associated neurotoxicity observed in neurodegenerative disorders
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