Synergistic and Interdisciplinary Approaches for the Conservation of Monumental Heritage: Cupola of Santa Maria del Fiore in Florence, Italy

This paper presents the results of an interdisciplinary study carried out on Brunelleschi’s Cupola of Santa Maria del Fiore in Florence, Italy, one of the most emblematic masonry domes in the world. The cupola has been affected since the beginning of its construction by a widespread cracking phenomenon, and several studies were done over the centuries to clarify its safety conditions. To have a direct and indirect record of the cracks opening or closing, a complex monitoring system was installed on the monument during the last century. An accurate analysis of crack widths and global displacements, performed considering both historical and recent monitoring data, has allowed for the identification of the movements developed in the monument, evaluating their relationship with environmental and seismic events. In line with the interdisciplinary approach strongly recommended in the field of assessment and conservation of monumental heritage, this paper reconsiders some issues concerning the causes of the actual damage to the cupola. In particular, in light of the obtained results, the famous seventeenth century Viviani’s conclusions about the cupola’s damage, confirmed by Chiarugi in the 1980s, are compared with other hypotheses, such as the differential settlement of pillars (Cecchini in 1698 and Ximenes in 1757) and the influence of temperature variations (Nervi in 1934). The large amount of measured data and the results of the last numerical models of the cupola, combined with recent dynamic measurements, allowed the updating of some previous conclusions on damage causes and trends. Starting from these conclusions, a more reliable forecasting model of the monument can be set up that could be useful in identifying effective conservation strategy for this outstanding monument

Quantification and economic assessment of surplus bread in Italian small-scale bakeries: An explorative study

The generation of bread waste at suppliers and retailers is often linked to the production of surplus bread. This study reports the results of the first direct quantification and economic assessment of surplus bread conducted in Italy, involving a panel of 12 bakeries and their branches located in the Lazio region, which compiled a daily diary for 5 months. They are small-scale bakeries which reflect the typical structure of the Italian businesses in the bakery sector, producing fresh bread and selling it directly to consumers. The surplus bread measured during the study consists of 6,694 kg in total, with an average quantity of 4.83 kg/day per bakery. Studying the three main products (common bread, focaccia bread and bread rolls), the average rate of surplus is respectively 5.88 %, 3.99 % and 5.28 % of the production. The corresponding economic loss represents, on average, 5.44 % of the daily turnover. A set of factors seems to exert highest influence on the generation of surplus, as the range of production, location and number of customers. When surplus bread occurs, in 63 % of the cases it is managed on alternative routes to avoid disposal. Even if detected surplus bread does not necessarily become waste, it indeed represents a big loss for bakeries

The role of network creation and actor engagement in the adoption and diffusion of sustainable innovations in food value chains

The paper aims at understanding how innovations, that are promoted and facilitated by private actors, can be fostered by network creation and actor engagement in the agri-food value chains. More specifically, we investigated innovative governance mechanisms related to the introduction of new sustainable practices in food value chains and tried to evaluate the environmental, economic and social effects of these new practices. We use information derived from a case study based on an ongoing project in the North of Italy, where in 2013 a multinational corporation operating in the pasta and bakery sector has initiated an agreement with other three agri-food companies in order to facilitate sustainable sourcing from a group of farmers

Farmers in the transition toward sustainability: what is the role of their entrepreneurial identity?

IntroductionThe European Union has recently prompted a shift toward Ecological Intensification (EI) practices, aiming to harmonize agricultural productivity and environmental conservation. Despite the benefits of EI, its implementation has been limited, as farmers face challenges in business reorganization and supply chain adaptation. This paper investigates the role of contract farming (CF) in promoting the adoption of sustainable practices among Italian wheat producers. Specifically, it analyzes the influence of farmers’ entrepreneurial identity on their engagement in such initiatives.MethodsUsing the case study of Barilla Group’s Carta del Mulino initiative, an innovative contract farming scheme incentivizing sustainable EI practices, the study explores the relationship between entrepreneurial identity and participation in CF schemes supporting EI. Data from a sample of 314 soft wheat farmers in four regions of Northern Italy were collected to examine the role of entrepreneurial identity in the adoption of sustainable practices and participation in CF schemes. To evaluate the research hypotheses, two distinct econometric models were developed.Results and discussionThe findings reveal that farmers with a more developed entrepreneurial identity are more likely to adopt more sustainable agricultural practices and engage in contractual schemes involving EI practices. The study highlights the importance of fostering and supporting farmers’ entrepreneurial identity while increasing their knowledge of alternative agricultural techniques to address the challenges of the agricultural sector. This integration of individual perspectives (entrepreneurial identity) with a systems view (contract farming schemes) offers valuable insights for future research, policy, and practice in agri-food systems sustainability

Stroke Gait Rehabilitation: A Comparison of End-Effector, Overground Exoskeleton, and Conventional Gait Training

Gait recovery is one of the main goals of post-stroke rehabilitation and Robot-Assisted Gait Training (RAGT) has shown positive outcomes. However, there is a lack of studies in the literature comparing the effects of different devices. This paper aims to study the effects, in terms of clinical and gait outcomes, of treadmill-based and overground RAGT, compared to conventional gait training in stroke subjects. The results showed a significant improvement of clinical outcomes in both robotic treatments and in conventional therapy. The performance of locomotor tasks was clinically significant in the robotic groups only. The spatio-temporal gait parameters did not reveal any significant difference. Results suggest future multicentre studies on a larger number of subjects

A multi-society position paper on the prevention and management of nosocomial and severe infections: the Italian Society for Infectious Diseases, the Italian Multidisciplinary Society of Hospital Infections, the Italian Society of Chemotherapy, the Italian Society of Respiratory Medicine, the Italian Society of Clinical Microbiology, the Italian Society of Microbiology, and GISIG (Italian Study Group on Severe Infections)

Amulti-society position paper on the prevention and management of nosocomial and severe infections: the Italian Society for Infectious Diseases, the Italian Multidisciplinary Society of Hospital Infections, the Italian Society of Chemotherapy, the Italian Society of Respiratory Medicine, the Italian Society of Clinical Microbiology, the Italian Society of Microbiology, and GISIG (Italian Study Group on Severe Infections

Comparative in vitro and ex vivo studies on the bactericidal activity of Tetraclean, a new generation endodontic irrigant, and sodium hypochlorite

The aim of this study was to compare the efficacy of a new generation endodontic irrigant, Tetraclean, to the widely used sodium hypochlorite. Tetraclean combines a powerful detergent effect with a strong antimicrobial efficacy, whereas sodium hypochlorite has several drawbacks and is sometimes ineffective in preventing microbial-mediated endodontic failure. The bactericidal activity of both irrigants against Enterococcus faecalis, the most commonly isolated species from root canals of teeth with post-treatment disease, was assessed i) in vitro, according to the European Standard lines for the evaluation of the bactericidal activity of chemical disinfectants, and ii) with an ex vivo model of extracted and decoronated human teeth, infected with E. faecalis and subsequently irrigated with either of the irrigants. Both irrigants display very similar bactericidal activity against E. faecalis in vitro. However, the ex vivo model shows that only in the teeth irrigated with Tetraclean did the bacterial burden gradually drop until no bacteria were detectable a few days post-irrigation. Vice versa, in the teeth irrigated with sodium hypochlorite, the drop in the bacterial burden was rapid but temporary and most of the teeth were colonized again by 48 hours post-irrigation

Prognostic value of copeptin and mid-regional proadrenomedullin in COVID-19-hospitalized patients.

BackgroundBiomarkers are used for diagnosis, risk stratification and medical decisions. Copeptin and mid-regional proadrenomedullin (MR-proADM) are markers of stress and endothelial function, respectively, which have been studied in pneumonia, sepsis and septic shock. This study aimed to assess whether copeptin and MR-proADM could predict coronavirus disease 2019 (COVID-19) in-hospital outcomes, that is multi-system complications, length of stay and mortality.MethodsCopeptin and MR-proADM were assessed at admission in 116 patients hospitalized with COVID-19. Data were retrospectively extracted from an online database. The primary endpoint was in-hospital mortality. The secondary endpoints were in-hospital complications, the composite outcome 'death, or admission to intensive care unit, or in-hospital complications', and length of stay. The predictive power was expressed as area under the receiver operator characteristic curve (AUROC).ResultsCopeptin was increased in non-survivors (median 29.7 [interquartile range 13.0-106.2] pmol/L) compared to survivors (10.9 [5.9-25.3] pmol/L, p  25.3 pmol/L. MR-proADM differentiated survivors (0.8 [0.6-1.1] nmol/L) from non-survivors (1.5 [1.1-2.8] nmol/L, p  1.0 nmol/L. Copeptin and MR-proADM predicted sepsis (AUROC 0.95 and 0.96 respectively), acute kidney injury (0.87 and 0.90), the composite outcome (0.69 and 0.75) and length of stay (r = 0.42, p ConclusionsAdmission MR-proADM and copeptin may be implemented for early risk stratification in COVID-19-hospitalized patients to help identify those eligible for closer monitoring and care intensification

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice