5 research outputs found
Enfermedad carcinoide cardiaca multivalvular
- Publication venue
- Published by Elsevier España S.L.
- Publication date
- 01/09/2015
- Field of study
Get PDFResumenHombre de 67 años de edad, enviado a valoración ecocardiográfica por cuadro clínico de 6meses de evolución con: disnea de esfuerzo, edemas de miembros inferiores y fatiga. Se encuentra doble lesión de la válvula tricúspide con: estenosis e insuficiencia severa, insuficiencia pulmonar severa; y compromiso valvular izquierdo con: insuficiencia mitral y aórtica severas, asociadas a engrosamiento y rigidez valvular. El paciente tenía como antecedente tumor neuroendocrino de íleon, metastásico a pulmón e hígado.En este caso se discuten los hallazgos ecocardiográficos característicos del síndrome carcinoide con compromiso multivalvular como hallazgo inusual de este raro síndrome.AbstractA 67 year-old man is sent to echocardiographic assessment for 6 month history of exertional: dyspnea, edema of the lower extremities, fatigue, double lesions in tricuspid valve with: severe stenosis and severe regurgitation, severe pulmonary valve regurgitation; and left side valvular disease with: severe aortic regurgitation and severe mitral regurgitation, all of them associated with valvular thickening, rigidity, in a patient with history of neuroendocrine tumor, with lung and liver metastases.This case discuss the echocardiographic findings suggestive of carcinoid multivalvular and left side valvular disease as unusual finding in this rare syndrome
Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
- Author
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
No full textBackground: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was 13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
No full textBackground: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. ODYSSEY OUTCOMES is registered with ClinicalTrials.gov, number NCT01663402. Findings: At study baseline, 5444 patients (28·8%) had diabetes, 8246 (43·6%) had prediabetes, and 5234 (27·7%) had normoglycaemia. There were no significant differences across glycaemic categories in median LDL cholesterol at baseline (2·20–2·28 mmol/L), after 4 months' treatment with alirocumab (0·80 mmol/L), or after 4 months' treatment with placebo (2·25–2·28 mmol/L). In the placebo group, the incidence of the primary endpoint over a median of 2·8 years was greater in patients with diabetes (16·4%) than in those with prediabetes (9·2%) or normoglycaemia (8·5%); hazard ratio (HR) for diabetes versus normoglycaemia 2·09 (95% CI 1·78–2·46, p<0·0001) and for diabetes versus prediabetes 1·90 (1·65–2·17, p<0·0001). Alirocumab resulted in similar relative reductions in the incidence of the primary endpoint in each glycaemic category, but a greater absolute reduction in the incidence of the primary endpoint in patients with diabetes (2·3%, 95% CI 0·4 to 4·2) than in those with prediabetes (1·2%, 0·0 to 2·4) or normoglycaemia (1·2%, −0·3 to 2·7; absolute risk reduction pinteraction=0·0019). Among patients without diabetes at baseline, 676 (10·1%) developed diabetes in the placebo group, compared with 648 (9·6%) in the alirocumab group; alirocumab did not increase the risk of new-onset diabetes (HR 1·00, 95% CI 0·89–1·11). HRs were 0·97 (95% CI 0·87–1·09) for patients with prediabetes and 1·30 (95% CI 0·93–1·81) for those with normoglycaemia (pinteraction=0·11). Interpretation: After a recent acute coronary syndrome, alirocumab treatment targeting an LDL cholesterol concentration of 0·65–1·30 mmol/L produced about twice the absolute reduction in cardiovascular events among patients with diabetes as in those without diabetes. Alirocumab treatment did not increase the risk of new-onset diabetes. Funding: Sanofi and Regeneron Pharmaceuticals
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah mouhamad
- Abdullakutty Jabir
- Abdullkutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A
- Aidar Ayoub José Carlos
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alings Marco
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F
- Alves De Lima Alberto E
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Anderson Jay
- Ando Kenji
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arambula Rafael Suarez
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroca Carlos Cotes
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Aswegen Dina Van
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Azizad Masoud M
- Babić Zdravko
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Baldari Duccio
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- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
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- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
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- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
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- Benbernou Fadela
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- Cianciarulo Joseph
- Claeys Marc
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- Davidson Laura
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- Fairlamb James
- Faluközy József
- Fan Zhongcai
- Fang Chih-Yuan
- Fang Weiyi
- Farhat Naim
- Farrar Michael
- Faustino Douglas
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- fenton Sarah
- Fernandez Ruiz Ricardo L
- Fernandez Mauricio
- Fernando Kaputella
- Fernando Nimali
- Ferrari Emile
- Ferratini Maurizio
- Ferrolino Arthur
- Filardi Pasquale Perrone
- Filho Pedro Pimentel
- Fillat Angel R. Cequier
- Fischer Stuart
- Fishberg Robert
- Fisher Daniel
- Fisher Nicholas
- Fisher Raewyn
- Florenzano Fernando
- Flores Enrique
- Fong Peter
- Fontecave Sylvie
- Forgosh Les
- Foster Malcolm
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- Fournie-Lloret Dominique
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- Fras Zlatko
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- Fujinaga Hiroyuki
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- Guardigli Gabriele
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- Hagström Emil
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- Hahalis Georgios
- Halabi Majdi
- Hald Flemming
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- Hansen Ole
- Haraguchi Takuya
- Harding Scott
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- Harrington Robert A.
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- Harris Barry
- Harris Bill
- Harrison Robert W.
- Hart Hamish
- Hasan Mian
- Hasin Yonathan
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- Healy Jan
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- Hemetsberger Rayyan
- Henderson David
- Henkin Yaakov
- Henry John
- Hepditch Anita
- Herath Jagath I
- Hermans Kurt
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- Hernandez Zuniga Jose D
- Herrman Johannes PR
- Hersbach Ferry MRJ
- Herzog William
- Hess Connie Ng
- Hidalgo Urbano Rafael Jesus
- Higashikata Toshinori
- Higuera Juan Diego
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- Hirayama Atsushi
- Hirooka Keiji
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- Hodes Zachary
- Hoffer Etienne
- Hoffman David
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- Huang Lan
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- Huber Kurt
- Huidobro Laura
- Huikuri Heikki
- Hunter John
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- Huynh Thao
- Hwang Juey- Jen
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- Ilieva- Pandeva Katya A
- Ilya Masterov
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- Irimpen Anand
- Islam Othman
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- Istratoaie Octavian
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- Jacoby Douglas
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- Jaiwal Gayatri
- Jakimov Tamara
- Janik Matthew
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- Javierre Carine
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- Jensen Steen Agergaard
- Jeong Myung Ho
- Jeppesen Jørgen
- Jeserich Michael
- Jiang Weihong
- Jimenez Francisco Fuentes
- Jintapakorn Woravut
- Johansen Peter
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- Jonas Michael
- Jones William Schuyler
- Jong Geert T
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- Joshi Abhijeet B
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- Jujjuru Srimannarayana
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- Jurgaitiene Ruta
- Jurgenson Tiina
- Kadr Honer
- Kaewsuwanna Pinij
- Kahali Dhiman
- Kaiser Sergio
- Kalashetti Suhas
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- Kamensky Gabriel
- Kamiya Haruo
- Kandasamy Balachandran
- Kanorsky Sergey
- Kapin Tibor
- Kaplan Refik
- Kapp Ilse E
- Karadzic Ana
- Karakas Mahir
- Karalis Ioannis
- Karlsberg Ronald
- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Kathryn Rohr
- Katona András
- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawakami Anelise
- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
- Kedev Sasko
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- Kerkar Prafulla
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- Khaira Ajit S
- Khaisheva Larisa
- Khan Abul
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- Khasanov Niiaz
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- Khlevchuk Tatiana
- Khurana Sandeep
- Kibarskis Aleksandras
- Kichukov Kostadin N
- Killat Holger
- Kim Chongjin
- Kim Hack-Lyoung
- Kim Hae Young
- Kim Hyo Soo
- Kim Hyo-Soo
- Kim Moo Hyun
- Kim Sang-Hyun
- Kim Sang-Hyun
- Kim Youngkwon
- Kimmelstiel Carey
- Kimura Kazuo
- Kimura Takeshi
- Kimura Takeshi
- King Marilyn
- Kinzfogl III George
- Kirma Cevat
- Kishi Koichi
- Kiss Robert Gabor
- Kjovkaroski Aleksandar
- Klancke Kim
- Klantsa Andriy
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- Klutstein Marc
- Knickelbine Thomas
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- Koba Shinji
- Kobalava Zhanna
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- Koldas Lale
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- Kondo Nicholas I
- Kong David F.
- Kopytsya Mykola
- Koren Michael
- Kormann Adrian
- Kornder Jan
- Kornowski Ran
- Korol Marek
- Kosinski Edward
- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
- Kouz Simon
- Kovalskyi Ihor
- Kozuma Ken
- Kralova Katarina
- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S
- Kristjan Arved
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- Kulić Mehmed
- Kultursay Hakan
- Kumar Yerra Shiv
- Kumar Anil
- Kumar Priya
- Kumar Vinay
- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
- Kurian John
- Kushnir Mykola
- Kutniy Oles
- Kuvin Jeffrey
- Kyiak Yulian
- Labeirie Julien
- Labroo Ajay
- Lai Christopher
- Lai Wen-Ter
- Lambert Charles
- Lamoureux Maud
- Landeo Javier Heredia
- Landmesser Ulf
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- Landzberg Joel
- Larry John
- Larsen John
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- Laufs Ulrich
- Laxson David
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- Leo Alessandro De
- Leonard Parilak
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- Leone Attilio
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- Lester F. Martin
- Leung Raymond
- Levite Howard
- Levy Terry
- Li Huanming
- Li Jianping
- Li Tianchang
- Li Xiang
- Li Xiaodong
- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
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- Liberopoulos Evangelos
- Libov Igor
- Licciardello Giovanni
- Lieber Ira
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- Lin Wenhua
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- Linhart Ales
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- Lip Gregory YH
- Lipko Jan Andrzej
- Lishner Michael
- Liu Ming-En
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- Luca Giuseppe De
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- Marusincova Ivana
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- Massey Clara
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- Matei Adrian V
- Mathews Robin
- Mathur Rishabh
- Matiga Generoso
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- May Ole
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- Metra Marco
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- Michalaros Yorghos L
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- Miklaszewicz Beata
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- Montenegro Valdovinos Pablo Carlos
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- Morais Joao
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- Moriarty Andrew
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- Morisset Anne
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- Munusamy Vengatesh
- Murillo Fernando Civeira
- Murin Jan
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- Musumeci Giuseppe
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- Mutlu Bulent
- Mynhardt Joseph H
- Myshanych Halyna
- Märtsin Kaja
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- Müller Gábor
- Müller-Wieland Dirk
- Nacoud Ackar Alfredo
- Nager Paul
- Nagy Lajos
- Nahhas Ahed
- Nahuelpan Leonardo
- Nakao Koichi
- Nani Sebastian
- Naplava Robert
- Natour Mohammed
- Negron Miguel Sandra A
- Nelson William
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- Nicol Peter
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- Nikolaev Konstantin
- Nikolov Fedya P
- Nikolsky Eugenia
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- Nociar Jan
- Nogareda Gustavo
- Norkiene Sigute
- Normand Mickael
- Novaretto Leonardo P
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nuding Sebastian
- Nygård Ottar
- Núñez Fragoso Juan Carlos
- Ofer Havakuk
- Offers Elmar
- Okan Betim
- Olexa Peter
- Olivares Claudia
- Olivari Zoran
- Oliveira Janaina
- Oliver Richard
- Olsson Anders G.
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- Ono Yujiro
- Oomen Antonius
- Oomman Abraham
- Oqueli Flores Romulo E
- Orcajo Norberto Alonso
- Orlikova Olga
- Osokina Natalya
- Ossei-Gerning Nicholas
- Ostadal Petr
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- Pagava Zurab
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- Palka Juraj
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- Palvarini Michela
- Panchal Vipul
- Pancholy Samir
- Pandey Amritanshu
- Pandurangi Ulhas
- Parada Jeffrey Castellanos
- Parepa Irinel R
- Park Hyeun (Tom)
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- Pawlowicz Lidia
- Payeras Antonio Coca
- Pearce Stephen
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- Pella Daniel
- Pellan Valerie
- Pellegrin Annamaria De
- Peng Daoquan
- Penny William
- Pepine Carl
- Pereira Edward
- Pereira Helder H
- Pereira Sabrina Bernardez
- Perez Ignacio Plaza
- Perez Luis
- Pericas Laia Matas
- Peris Vicente Bodí
- Perkins Lynn
- Perlmutter Neal
- Perthuis Aurelie
- Peršić Viktor
- Pesant Yves
- Petranov Stanislav L
- Petrulioniene Zaneta
- Pećin Ivan
- Piatti Piermarco
- Picault Patrick
- Picone Mark
- Piepiorka Marek
- Pillay Thayabran
- Pincetti Cristian
- Pintarić Hrvoje
- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
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- Poh Kian-Keong
- Pojskic Belma
- Poklukar Janez
- Pollock Stewart
- Ponce George
- Ponnamperuma Chandrike
- Pontaga Natalija
- Pope Theodore
- Pordy Robert
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- Portales Javier Fernandez
- Porwal Sanjay
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- Prvulović Đeiti
- Puccioni Enrico
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- Purow Joshua
- Puymirat Etienne
- Pérez Ríos Jesús Antonio
- Qu Baiming
- Quintero Ossa Alvaro M.
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- Rahman Aref
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- Raisinghani Ajit
- Rajapaksha Ajantha
- Ramin Ebrahimi
- Ramos López Gabriel Arturo
- Ramos López Gabriel Arturo
- Ramos Walter Mogrovejo
- Ranadive Nandkishore
- Ranasinghe Gotabhaya
- Ranjith Naresh
- Rao Sunder
- Rasmanis Gundars
- Rasoul Saman
- Ratky Caroline
- Rauch-Kröhnert Ursula
- Raungaard Bent
- Ray Kausik K.
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- Recena Javier Balaguer
- Rech Rafael
- Reddy Proddutur Naveen
- Regella Reddy
- Reiner Zeljko
- Reis Gilmar
- Reis Helder JL
- Rensing Bernard JWM
- Repincay Jérôme
- Reshetko Olga
- Reshotko Dmytro
- Reuter Helmuth
- Reynolds Timothy
- Rha Seungwoon
- Riaz Garda
- Richard Kerensky
- Rider James
- Rieker Werner
- Rincon Pablo Loma-Osorio
- Rishko Mykola
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- Rodes-Cabau Josep
- Rodriguez Chavez Víctor E
- Rodriguez De Leon Edgar R
- Rodriguez Javier Botas
- Roe Matthew T.
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- Roldan Concha Yudy M
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- Rondel Christelle
- Ronner Eelko
- Roosen John
- Rorick Tyrus
- Rosas Enrique López
- Rose Gregory
- Rosenberg Michael
- Rosenschein Uri
- Rosenson Robert
- Rossi Joseph
- Rossi Paulo RF
- Rossi Peter
- Rosu Doina
- Rouleau Jean-Lucien
- Rozeman Phillip
- Rozenman Yoseph
- Rubenstein Howard
- Rudenko Anatolii
- Rudenko Leonid
- Saaiman Jan A
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- Saavedra Silvia S
- Sabatino Kenneth
- Sabbah Eric
- Sachin Patil
- Sader Mark
- Sakagami Satoru
- Sakalyte Gintare
- Salmón Guillermo Fanghänel
- Salomone Oscar
- Salvioni Alessandro
- Saminski Krzysztof
- Sanabria Perez Enrique S
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- Sansanayudh Nakarin
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- Sarkar David
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- Sassone Sonia A
- Sastravaha Krisada
- Sathe Shireesh
- Sato Katsuhiko
- Savard Daniel
- Sawhney Jitendra
- Scalise Filippo
- Scemama Michel
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- Schaeufele Tim
- Schellenberg Detlev
- Schiavi Lilia B
- Schiele Francois
- Schifferdecker Branislav
- Schmalfuss Carsten
- Schmedtje John F
- Schmidberg Jorge M
- Schmidt Ekkehard
- Schmitt Susanne
- Schuchard Timothy
- Schwartz Gregory G.
- Schwartz Gregory G.
- Schwartz Michael
- Schwartz Steven
- Scott Douglas
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- Seferovic Petar
- Seixo Filipe
- Selecky Juraj
- Senaratne Manohara
- Senaratne Vajira
- Senni Michelle
- Serrano Antolin Jose Maria
- Sethi Sumeet
- Shaburishvili Tamaz
- Shah Anil V
- Shah Bimal R.
- Shah Vipul
- Shalaev Sergey
- Sharma Mukesh
- Sharman David
- Shaw James
- Shaw Michelle
- Shchekotov Vladimir
- Shechter Michael
- Shehova-Yankova Nina S
- Sheldon William
- Sheller Jennifer
- Sherwood Matthew W.
- Shetty Sanjay
- Shi Xubo
- Shimatani Yuji
- Shimizu Masatoshi
- Shinde Rituparna
- Shinke Toshiro
- Shou Xiling
- Shoukfeh Mohammad
- Shustov Sergey
- Shvarts Yury
- Sijbrands Eric J.G.
- Sik Park Hun
- Silva Pedro
- Silva Ricardo P
- Silveira Jose A
- Silver Kevin
- Simaitis Audrius
- Sime Iveta
- Simic Dragan
- Simon Tabassome
- Simonis Gregor
- Simoons Maarten L.
- Singal Dinesh
- Singh Narendra
- Singsaas Erlend gyllensten
- Sinha Dhurjati
- Sinnaeve Peter
- Sinnaeve Peter
- Sinnaeve Peter
- Sionis Dimitrios
- Sirisena Thilak
- Siu David CW
- Skonieczny Grzegorz
- Skorski Marcin
- Skoumas Ioannis
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- Smik Rudolf
- Smith Lucile
- Smith Simon
- Soggia Ana Priscila
- Soonfuang Wasant
- Soopõld Üllar
- Soots Mai
- Sopena Sebastien
- Soran Handrean
- Soroka Eugene
- Sotnikova Tatiana
- Sotomayor Herazo Aristides
- Sotty Marc
- Sousa Luciano
- Souza Weimar KSB
- Soward Allan
- Sparby Jon Arne
- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
- Spriging david
- Sritara Piyamitr
- Sritara Piyamitr
- Staneta Pawel
- Stanislavchuk Mykola
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- Vogel Robert
- Vohra Rakesh
- Vora Kishor
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias CM
- Vulic Dusko
- Vuurmans Tycho
- Vázquez de Prada José Antonio
- Vázquez Eduardo Salcido
- Vöhringer Hans Friedrich
- Völler Heinz
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D
- Waites Jonathon H
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wan Mohamed Wan Mohd Izani
- Wang Jianzhong
- Wang Jian’An
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weiss Robert
- Weißbrodt Matthias
- Welka Stephen
- Welker James
- Welker James
- Wells Terry
- Wells Terry
- Werner Christian
- Werner Nikos
- Westbrook Melissa
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- Wilkinson Peter
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- Wilson Samuel
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
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- Wojewoda Pawel
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- Wolfovitz Efrat
- Wollaert Bart
- Wong Yuk- Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wozniak Julianna
- Wright Scott
- Wu Chun
- Xavier Denis
- Xenakis Mark
- Xiang Meixiang
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yee Ong Hean
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Yusoff Khalid
- Zahger Doron
- Zahr Firas
- Zaidman Cesar J
- Zainea Mark
- Zaman Azfar
- Zamorano Jose Luis
- Zapata Gerardo
- Zea Nunez Carlos A
- Zeiher Andreas M.
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Édes István
- Šikić Jozica
- Štambuk Kresimir
- Šuligoj Nataša Černič
- Žuran Ivan
- Publication venue
- American Heart Association
- Publication date
- 30/08/2022
- Field of study
No full textBackground: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score–matched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9–3.6], 4.0 [95% CI, 3.6–4.5], and 5.5 [95% CI, 5.0–6.1] events per 100 patient-years in strata 35–<50, and ≤35 mg/dL, respectively). Compared with propensity score–matched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as ≤35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.gov; Unique identifier: NCT01663402.URL: https://www
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah Mouhamad
- Abdullakutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Agergaard Jensen Steen
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alexopoulos Dimitrios
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Orcajo Norberto
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Andrzej Lipko Jan
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E.
- Ayoub José Carlos Aidar
- Azizad Masoud M
- Babić Zdravko
- Baccara-Dinet Marie
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
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- Ball Eric
- Ball Eric
- Bang Lia E
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- Batushkin Valeriy
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- Bednarski Janusz
- Behrens Steffen
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- Bekkouche Mhamed
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- Jacoby Douglas
- Jafar Zubair
- Jaffrani Naseem
- Jain Diwakar
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- Janik Matthew
- Janosik Denise
- Jaramillo Nicolas
- Javierre Carine
- Jaworska Krystyna
- Jayawardena Jayanthimala
- Jeong Myung Ho
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- Kahali Dhiman
- Kaiser Sergio
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- Kanorsky Sergey
- Kapin Tibor
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- Karlsberg Ronald
- Karna Sunil
- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Kathryn Rohr
- Katona András
- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawakami Anelise
- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
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- Khan Abul
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- Kibarskis Aleksandras
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- Kimmelstiel Carey
- Kimura Kazuo
- Kimura Takeshi
- Kimura Takeshi
- King Marilyn
- Kinzfogl III George
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- Kiss Robert Gabor
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- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
- Kouz Simon
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- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S
- Kristjan Arved
- Kubica Jacek
- Kubilius Raimondas
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- Kumar Priya
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- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
- Kurian John
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- Labeirie Julien
- Labroo Ajay
- Lai Christopher
- Lai Wen-Ter
- Lambert Charles
- Lamoureux Maud
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- Leung Raymond
- Levite Howard
- Levy Terry
- Li Huanming
- Li Jianping
- Li Tianchang
- Li Xiang
- Li Xiaodong
- Li Ying
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- Pincetti Cristian
- Pintarić Hrvoje
- Piovaccari Giancarlo
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- Podoleanu Cristian GC
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- Pojskic Belma
- Poklukar Janez
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- Slapikas Rimvydas
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- Soonfuang Wasant
- Soopõld Üllar
- Soots Mai
- Sopena Sebastien
- Soran Handrean
- Soroka Eugene
- Sotnikova Tatiana
- Sotomayor Herazo Aristides
- Sotty Marc
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- Spinar Jindrich
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- Steg Ph. Gabriel
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- Stratmann Matthias
- Strbova Jaroslava
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- Striekwold Harry
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- Subkovas Eduardas
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- Sukonthasarn Apichard
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- Todorov Georgi V
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- Toma Mustafa
- Tomala Tadeusz
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- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weiss Robert
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- Wong Yuk-Ki
- Wongpraparut Nattawut
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- Wozniak Julianna
- Wright Scott
- Wu Chun
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- Yakushin Sergey
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- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
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- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Édes István
- Černič Šuligoj Nataša
- Šikić Jozica
- Štambuk Kresimir
- Žuran Ivan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
No full textBackground After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1.4-1.8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes
