Skin Tumors in Patients Aged 90 Years and Older

Background: The aging of the population in the developed world is an accepted fact. Consequently, the number of patients aged 90 years or over with cutaneous cancer will increase in coming years. Objective: The objective was to determine the nature of skin lesions amenable to dermatologic surgery in patients aged 90 years or more. Methods: We studied the clinical histories of 52 outpatients in their 90 s, who had had histopathologic studies made of their skin tumors when attended in the Hospital General de Alicante (Spain) between January 1999 and July 2002. We studied sex, age, type of tumor, site, associated disorders, regular medications, type of anesthesia, and type of treatment given. Results: The average age of the patients was 92.4 years. Thirty-six patients were women and 16 were men. Altogether the 52 patients had a total of 72 lesions. The most frequent diagnosis was basal cell carcinoma with 36 lesions, followed by 20 squamous cell carcinomas. The overall ratio of basal cell carcinoma to squamous cell carcinoma was 1.8. Patients had an average of 1.5 comorbid medical conditions and were taking an average of 2.3 regular medications. Conclusion: Dermatologists often attend patients aged 90 years or over with nonmelanoma skin cancer. The most important decision is as to what is the best management of these patients

CVS-Q teen©: computer vision syndrome in adolescents and its relationship with digital textbooks

Objetivo: Analizar la prevalencia y la evolución del síndrome visual informático en estudiantes de secundaria y bachillerato mediante el CVS-Q© adaptado y validado para adolescentes, según empleen libros en papel o en soporte digital. Método: Se adaptará el CVS-Q© mediante un pilotaje en adolescentes y un grupo nominal compuesto por especialistas en salud visual, profesorado y padres/madres. Se evaluarán la calidad y la aplicabilidad de la versión resultante (CVS-Q teen©) y se realizará un estudio de validación con pruebas visuales, retest y análisis psicométrico. Posteriormente, se realizará un estudio prospectivo longitudinal con cuatro medidas repetidas en adolescentes de dos institutos de San Juan de Alicante (uno ha sustituido libros por tabletas). Se medirá el síndrome visual informático mediante el CVS-Q teen© con tres seguimientos. Se analizará la prevalencia de síndrome visual informático según factores sociodemográficos, visuales y de uso de dispositivos digitales. Se realizarán modelos de regresión logística con efecto aleatorio por estudiante y tiempo de uso.Objective: To analyse the prevalence and progression of computer vision syndrome in secondary and high school students with the CVS-Q© adapted and validated for adolescents, depending on whether they use textbooks or digital books. Method: The CVS-Q© will be adapted by a pilot study in adolescents and a nominal group of visual health specialists, teachers and parents. The resulting version (CVS-Q teen©) will be tested to confirm its quality and applicability and a validation study will be done with visual tests, retest and psychometric analysis. Subsequently, a prospective longitudinal study with four repeated measures will be carried out in adolescents from two secondary schools of San Juan de Alicante (one has replaced textbooks by tablets). Computer vision syndrome will be measured by the CVS-Q teen© with three follow-ups. The prevalence of computer vision syndrome will be analysed according to sociodemographic, visual and digital device use variables. Logistic regression models will be performed, with random effect by student and time of use.Los autores agradecen al Vicerrectorado de Investigación de la Universidad de Alicante por el contrato de formación predoctoral de la segunda autora (UAFPU2019-08). El presente proyecto ha sido financiado por la convocatoria «Proyectos de Investigación en Salud», Fondo de Investigación en Salud del Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación y Unión Europea, a través de los Fondos Europeos de Desarrollo Regional (FEDER) «Una manera de hacer Europa», con la referencia PI20/01629

Brentuximab vedotin in the treatment of cutaneous T-cell lymphomas: Data from the Spanish Primary Cutaneous Lymphoma Registry

[Background] Brentuximab vedotin (BV) has been approved for CD30-expressing cutaneous T-cell lymphoma (CTCL) after at least one previous systemic treatment. However, real clinical practice is still limited.[Objectives] To evaluate the response and tolerance of BV in a cohort of patients with CTCL.[Methods] We analysed CTCL patients treated with BV from the Spanish Primary Cutaneous Lymphoma Registry (RELCP).[Results] Sixty-seven patients were included. There were 26 females and the mean age at diagnosis was 59 years. Forty-eight were mycosis fungoides (MF), 7 Sézary syndrome (SS) and 12 CD30+ lymphoproliferative disorders (CD30 LPD). Mean follow-up was 18 months. Thirty patients (45%) showed at least 10% of CD30+ cells among the total lymphocytic infiltrate. The median number of BV infusions received was 7. The overall response rate (ORR) was 67% (63% in MF, 71% in SS and 84% in CD30 LPD). Ten of 14 patients with folliculotropic MF (FMF) achieved complete or partial response (ORR 71%). The median time to response was 2.8 months. During follow-up, 36 cases (54%) experienced cutaneous relapse or progression. The median progression free survival (PFS) was 10.3 months. The most frequent adverse event was peripheral neuropathy (PN) (57%), in most patients (85%), grades 1 or 2.[Conclusions] These results confirm the efficacy and safety of BV in patients with advanced-stage MF, and CD30 LPD. In addition, patients with FMF and SS also showed a favourable response. Our data suggest that BV retreatment is effective in a proportion of cases.The Spanish Primary Cutaneous Lymphoma Registry (RELCP) is promoted by the Fundación Piel Sana Academia Española de Dermatología y Venereología, which received an unrestricted grant support from Kyowa Kirin.Peer reviewe

All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997Ł2010

Abstract Background: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIVinfected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 personyears (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997. Conclusion: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Introduction to the binder jet technology in additive manufacturing of metals

La fabricació additiva de metall ha experimentat un creixement molt ràpid gràcies als desenvolupaments tecnològics i a les inversions en recerca. Entre els diferents mètodes de fabricació additiva hi està la tècnica d'injecció d'aglomerant, la qual es basa en la fabricació d'una peça capa per capa mitjançant la deposició selectiva d'aglutinant fluid sobre un llit de pols metàl·lic. Després del procés d'impressió, les peces obtingudes s'han de sotmetre a un curat i a una densificació posterior. En aquest treball es recopila informació necessària per poder comprendre aquesta tècnica, a més de ser una guia sobre la selecció de la matèria primera i l'optimització dels paràmetres del procés. Es revisen les característiques de la pols, les propietats de l'aglutinant i els paràmetres del procés d'impressió que més influeixen en les propietats de les peces finals. Per tant, el que es tracta és que aquest treball sigui com una avantsala a futurs projectes en col·laboració amb HP on es procedeixi a estudiar la pols metàl·lic i la seva influència en la selecció d'alguns paràmetres de de el procés.La fabricación aditiva de metal ha experimentado un crecimiento muy rápido gracias a los desarrollos tecnológicos y a las inversiones en investigación. Entre los diferentes métodos de fabricación aditiva existe la técnica de inyección de aglomerante o binder jetting en inglés, el cual se basa en la fabricación de una pieza capa por capa mediante la deposición selectiva de aglutinante fluido sobre un lecho de polvo metálico. Tras el proceso de impresión, las piezas obtenidas deben de someterse a un curado y a una densificación posterior. En este trabajo se recopila información necesaria para poder comprender dicha técnica, además de ser una guía sobre la selección de la materia prima y la optimización de los parámetros del proceso. Se revisan las características del polvo, las propiedades del aglutinante y los parámetros del proceso de impresión que más influyen en las propiedades de las piezas finales. Por lo tanto, lo que se trata es de que este trabajo sea como una antesala a futuros proyectos en colaboración con HP donde se proceda a estudiar el polvo metálico y su influencia en la selección de algunos parámetros de del proceso.Metal additive manufacturing has seen very rapid growth in recent years thanks to technological developments and research investments. Among the different additive manufacturing methods, there is the technique of Binder Jetting, which is based on the manufacture of piece layer by layer by the selective deposition of fluid binder on a bed of metallic powder. After the printing process, the pieces obtained must undergo curing and subsequent densification. This work collects the information necessary to understand this technique, in addition to being a guide on the selection of the raw material and the optimization of the process parameters. The characteristics of the powder, the properties of the binder, and the parameters of the printing process that most influence the properties of the final pieces are reviewed. Therefore, what this is about is that this work is a prelude to future projects in collaboration with HP where the metallic powder is studied and its influence on the selection of some process parameters

Estudio técnico-económico de una línea de fabricación industrial para la obtención de plastificantes naturales de ácido poliláctico (PLA) a partir de aceites vegetales

[ES] El objetivo central del proyecto es el desarrollo de una línea de fabricación industrial de plastificantes naturales para ácido poliláctico (PLA) a partir de aceites vegetales modificados químicamente, concretamente, mediante procesos de maleinización. El proyecto contempla el estudio y optimización del proceso de extracción de los aceites, evaluación de rendimientos, así como la definición de las condiciones de maleinización del aceite seleccionado, con el fin de transferir estos parámetros en el proceso de escalado industrial. Este escalado contemplará el predimensionamiento de la línea de fabricación en términos de equipos, instalaciones, etc., junto con un estudio sobre la viabilidad económica de la línea.[EN] Design of a plasticizer production plant for the PLA from the maleinization process of castor oil. In this project, the design, assembly and study of the economic viability of a plant for the production of a plasticizer from vegetable oils through the maleinization of it is carried out. The control of the quality of the plasticizer is also carried out by analytical techniques. From the simulations, the reaction speed is studied in order to then dimension the process. On the other hand, the properties that will be granted by plasticiser to the new polymer will be studied to ensure that it is a good plasticizer.[CA] En aquest projecte es realitza el disseny, el muntatge i l'estudi de la viabilitat econòmica d'una planta de producció d'un plastificant a partir d'olis vegetals per mitjà de la maleinizació d'este. Paral·lelament es defineixen les tècniques d'anàlisi per a controlar la qualitat d'este plastificant. A partir de les simulacions s'estudia la velocitat de reacció para a continuació poder dimensionar el procés. D'altra banda, s'estudiaran les propietats que atorgarà al polímer per a assegurar que el nou material és un bon plastificant.Blanes Martínez, MDM. (2017). Estudio técnico-económico de una línea de fabricación industrial para la obtención de plastificantes naturales de ácido poliláctico (PLA) a partir de aceites vegetales. http://hdl.handle.net/10251/97868TFG

Proyecto Cel.Obert: una intervención educativa para la biblioteca Bon Pastor

Cel.Obert es un proyecto educativo basado en favorecer el uso de la biblioteca por parte de los niños/as del barrio del Bon Pastor en Barcelona, usando su creatividad como hilo conductor. Para conseguirlo se ha llevado a cabo una actividad educativa con los grupos de educación infantil y primaria de las escuelas del barrio. El material obtenido en esta actividad se ha adaptado a otros formatos para crear una instalación permanente en la biblioteca. La finalidad de esta instalación es que los usuarios encuentren en la biblioteca aquello que les permita sentir el lugar y el espacio como propios, que les permita sentirse parte activa de la vida de la biblioteca

Testen a Blanes dues boies que estudiaran el desglaç de l'Àrtic

El CSIC testa al CEAB les boies geodèsiques que s'enviaran a l'Àrtida per un projecte per estudiar el desglaç de les regions polars · Els aparells mesuren amb precisió extrema els canvis que s'estan produint al punt més septentrional del planetaPeer reviewe