Ludificación de la Historia de Veterinaria: Fase II

En esta convocatoria se ha aprovechado la experiencia del anterior proyecto y se ha continuado con la metodología de la ludificación o gamificación como herramienta de aprendizaje mejorando y adaptando más aun la metodología a los fines de docencia del grado. Se ha logrado incrementar la motivación entre el alumnado y se ha añadido un nuevo componente: el efecto integrador o identitario del alumnado, profesorado y PAS con la profesión y el centro. Los productos obtenidos como material audiovisual y textos y las representaciones se han expuesto en actos conmemorativos o celebraciones del centro. Por otro lado se ha incrementado el repositorio de material didáctico que con cada proyecto se elabora. En este nuevo proyecto se han realizado interpretaciones histórico-teatrales de personajes relevantes en la historia de la veterinaria, realizadas por los propios alumnos matriculados y profesores, abordando distintas problemáticas de profesionales o en diferentes períodos históricos. Entre los productos elaborados están los textos con los guiones elaborados, 9 videos con escenificaciones y 20 breves presentaciones de personajes. Otro de los productos finales en formato de video de 6,19 minutos de duración se ha presentado ante la comunidad universitaria en la Gala atrévete de la Facultad de Veterinaria de 2019, ante más de doscientos alumnos y profesores. Los productos y el proyecto han sido presentados dentro de una comunicación oral en el XXIV Congreso Nacional y XV Iberoamericano de Historia de la Veterinaria que tuvo lugar en Almería del 26 al 28 de octubre de 2018. El impacto del proyecto se ha podido verificar a lo largo de los meses de escenificación por el nivel de actividad de las redes sociales entre los alumnos y la asistencia de más profesores y alumnos incluso no involucrados, con deseo de aprender y ver esta nueva herramienta docente

Elaboración de píldoras educativas sobre Historia de la Veterinaria

Tras el éxito de la utilización de la ludificación como motivación para el estudio de la Historia de la Veterinaria, nos propusimos crear pequeños vídeos o píldoras de conocimiento sobre hechos o personajes históricos que fueran reusables (se pueden utilizar en diferentes contextos), interoperables (sirven para propósitos diferentes) y accesibles por su formato digital que facilita el almacenaje y su recuperación. En este proyecto se ha grabado más escenas antes del confinamiento y preparados la historioteca con una de las píldoras ya definitivas

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Hacia un massive online open course (MOOC) para el aprendizaje de la higiene y seguridad alimentarias

Sección Dptal. de Nutrición y Ciencia de los Alimentos (Veterinaria)Fac. de VeterinariaFALSEsubmitte

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population