SMAGEXP: a galaxy tool suite for transcriptomics data meta-analysis

Bakground: With the proliferation of available microarray and high throughput sequencing experiments in the public domain, the use of meta-analysis methods increases. In these experiments, where the sample size is often limited, meta-analysis offers the possibility to considerably enhance the statistical power and give more accurate results. For those purposes, it combines either effect sizes or results of single studies in a appropriate manner. R packages metaMA and metaRNASeq perform meta-analysis on microarray and NGS data, respectively. They are not interchangeable as they rely on statistical modeling specific to each technology. Results: SMAGEXP (Statistical Meta-Analysis for Gene EXPression) integrates metaMA and metaRNAseq packages into Galaxy. We aim to propose a unified way to carry out meta-analysis of gene expression data, while taking care of their specificities. We have developed this tool suite to analyse microarray data from Gene Expression Omnibus (GEO) database or custom data from affymetrix microarrays. These data are then combined to carry out meta-analysis using metaMA package. SMAGEXP also offers to combine raw read counts from Next Generation Sequencing (NGS) experiments using DESeq2 and metaRNASeq package. In both cases, key values, independent from the technology type, are reported to judge the quality of the meta-analysis. These tools are available on the Galaxy main tool shed. Source code, help and installation instructions are available on github. Conclusion: The use of Galaxy offers an easy-to-use gene expression meta-analysis tool suite based on the metaMA and metaRNASeq packages

Industrial GaInP/GaAs Power HBT MMIC Process

UMS has developed an industrial power HBT process especially dedicated to power MMICs in the 10GHz frequency range. The process has been qualified and meets the very demanding specifications required for X-Band high power amplifiers. Aside from the obvious RF performances, this includes the demonstration of the necessary stability and reproducibility of the process, associated with state-of-art reliability. It is important to note that the later has been achieved without affecting the high frequency capability of the devices, and demonstrated directly on high power transistors. Thanks to its intrinsic qualities this process can naturally also be used for other applications, like low phase noise voltage controlled oscillators, and power amplifiers at lower frequencies (for mobile phones for instance)

Power HBT reliability for space applications

High power HBT process developed by UMS for X-band application have been space evaluated under CNES and ESA funding.The reliability assessment plan features high temperatures storage tests,DC life-tests,RF step test stress,ESD and radiation tests.A set of evaluation test vehicles was defined for this purpose.Activation energy have been determined,failure rate calculations are in line with the space requirement

In vivo dose measurement using TLDs and MOSFET dosimeters for cardiac radiosurgery.

In vivo measurements were made of the dose delivered to animal models in an effort to develop a method for treating cardiac arrhythmia using radiation. This treatment would replace RF energy (currently used to create cardiac scar) with ionizing radiation. In the current study, the pulmonary vein ostia of animal models were irradiated with 6 MV X-rays in order to produce a scar that would block aberrant signals characteristic of atrial fibrillation. The CyberKnife radiosurgery system was used to deliver planned treatments of 20-35 Gy in a single fraction to four animals. The Synchrony system was used to track respiratory motion of the heart, while the contractile motion of the heart was untracked. The dose was measured on the epicardial surface near the right pulmonary vein and on the esophagus using surgically implanted TLD dosimeters, or in the coronary sinus using a MOSFET dosimeter placed using a catheter. The doses measured on the epicardium with TLDs averaged 5% less than predicted for those locations, while doses measured in the coronary sinus with the MOSFET sensor nearest the target averaged 6% less than the predicted dose. The measurements on the esophagus averaged 25% less than predicted. These results provide an indication of the accuracy with which the treatment planning methods accounted for the motion of the target, with its respiratory and cardiac components. This is the first report on the accuracy of CyberKnife dose delivery to cardiac targets

Accommodating Employees With and Without Disabilities

Efforts to recruit and retain employees with disabilities are often tempered by employers’ concerns over potential workplace accommodation costs. This study reports on accommodations requested and granted in intensive case studies of eight companies, based on more than 5,000 employee and manager surveys, and interviews and focus groups with 128 managers and employees with disabilities. Two unique contributions are that we analyze accommodations for employees without disabilities as well as for those with disabilities, and compare perspectives on accommodation costs and benefits among employees, their coworkers, and their managers. We find people with disabilities are more likely than those without disabilities to request accommodations, but the types of accommodations requested and the reported costs and benefits are similar for disability and non-disability accommodations. In particular, fears of high accommodation costs and negative reactions of coworkers are not realized; all groups tend to report generally positive coworker reactions. Multilevel models indicate granting accommodations has positive spillover effects on attitudes of coworkers, as well as a positive effect on attitudes of requesting employees, but only when coworkers are supportive. Consistent with recent theorizing and other studies, our results suggest the benefits from a corporate culture of flexibility and attention to the individualized needs of employees

Vater-Sohn-Beziehungen in ausgewählten Romanen und Stories von Richard Russo, Raymond Carver, Richard Ford und John Updike

von Genia BlanckPaderborn, Univ., Diss., 200

Contributions to the Metamathematics of Arithmetic: Fixed Points, Independence, and Flexibility

This thesis concerns the incompleteness phenomenon of first-order arithmetic: no consistent, r.e. theory T can prove every true arithmetical sentence. The first incompleteness result is due to Gödel; classic generalisations are due to Rosser, Feferman, Mostowski, and Kripke. All these results can be proved using self-referential statements in the form of provable fixed points. Chapter 3 studies sets of fixed points; the main result is that disjoint such sets are creative. Hierarchical generalisations are considered, as well as the algebraic properties of a certain collection of bounded sets of fixed points. Chapter 4 is a systematic study of independent and flexible formulae, and variations thereof, with a focus on gauging the amount of induction needed to prove their existence. Hierarchical generalisations of classic results are given by adapting a method of Kripke’s. Chapter 5 deals with end-extensions of models of fragments of arithmetic, and their relation to flexible formulae. Chapter 6 gives Orey-Hájek-like characterisations of partial conservativity over different kinds of theories. Of particular note is a characterisation of partial conservativity over IΣ₁. Chapter 7 investigates the possibility to generalise the notion of flexibility in the spirit of Feferman’s theorem on the ‘interpretability of inconsistency’. Partial results are given by using Solovay functions to extend a recent theorem of Woodin

SIND ERFOLGREICHE BETRIEBSLEITER TATSÄCHLICH ERFOLGREICH? DAS POTENZIAL FÜR FEHLINTERPRETATIONEN BEI DER KENNZAHL ‚NETTORENTABILITÄT‘

Nettorentabilität, Testbetriebsnetz, Bodenbewertung, Betriebsanalyse, Research Methods/ Statistical Methods,

DIE WIRKSAMKEIT UND DAS BUDGETBELASTUNGSPOTENZIAL EINER RISIKOAUSGLEICHSRÜCKLAGE IN DER DEUTSCHEN LANDWIRTSCHAFT

Der vorliegende Beitrag ermittelt auf Basis von Daten des deutschen Testbetriebsnetzes den steuerentlastenden Effekt, den die Einführung einer Risikoausgleichsrücklage für landwirtschaftliche Betriebe im Ertragsteuerrecht bewirken könnte. Zu diesem Zweck werden anhand zehnjähriger Datenreihen von gut 5.300 ‚identischen Betrieben‘ unterschiedliche Versteuerungsvarianten berechnet und eine optimierte Rücklagenbildung und -auflösung in den Einzeljahren unterstellt. Dazu wird die Risikoausgleichsrücklage in die Systematik der Einkommensermittlung eingeordnet und eine anteilige Zurechnung der Wirtschaftsjahre zu den Kalenderjahren sowie die Verlustausgleichsregelungen des deutschen Einkommensteuerrechts in formalisierter Form berücksichtigt. Neben dem Progressions- bzw. Glättungseffekt wird auch die Wirkung des Zinseffekts ermittelt. Die Berechnungen für die Risikoausgleichsrücklage erfolgen in unterschiedlichen Variationen und berücksichtigen neben einer zehnjährigen restriktionslosen Variante auch die vom Deutschen Bauernverband in Anlehnung an das Forstschäden-Ausgleichsgesetz bei der Bildung der Rücklage zunächst vorgeschlagenen Restriktionen. Im Ergebnis führt der Glättungseffekt der Risikoausgleichsrücklage zu einer im Durchschnitt moderaten steuerlichen Entlastung für landwirtschaftliche Betriebe, die aber betriebsindividuell sehr unterschiedlich ausfallen kann.Risikoausgleichsrücklage, Einkommensglättung, Progressionseffekt, Testbetriebsnetz, Einkommensteuer, Landwirtschaft, Agribusiness, Agricultural Finance, Financial Economics,