Evidence That Obesity Risk Factor Potencies Are Weight Dependent, a Phenomenon That May Explain Accelerated Weight Gain in Western Societies

We have shown that individuals at the highest percentiles of the body mass index (BMI) distribution (i.e., most overweight) experience greater increases in body weight from sedentary lifestyle than those from the lowest percentiles. The purpose of the current analyses was to assess whether recent, accelerated increases in obesity could potentially be due to increased vulnerability to obesity risk factors as the population has become more overweight.Quantile regression was used to compare BMI population percentiles to obesity risk factors (lower education, diets characterized by high-meat/low-fruit content, parental adiposity) in two independent samples of men (N(1) = 3,513, N(2) = 11,365) and women (N(1) = 15,809, N(2) = 10,159). The samples were subsets of the National Walkers' (Study 1) and Runners' (Study 2) Health Studies whose physical activities fell short of nationally recommended activity levels. The data were adjusted for age, race, and any residual effects of physical activity. The regression slopes for BMI vs. education, diet, and family history became progressively stronger from the lowest (e.g., 5(th), 6(th)…) to the highest (e.g., …, 94(th), 95(th)) BMI percentiles. Compared to the 10(th) BMI percentile, their effects on the 90(th) BMI percentile were: 1) 2.7- to 8.6-fold greater in women and 2.0- to 2.4-fold greater in men for education; 2) 3.6- to 4.8-fold greater in women and 1.7- to 2.7-fold greater in men for diet; and 3) 2.0- to 2.6-fold greater in women and 1.7-fold greater in men for family history.Thus we propose risk factors that produce little weight gain in lean individuals may become more potent with increasing adiposity. This leads us to hypothesize that an individual's obesity is itself a major component of their obesogenic environment, and that, the cycle of weight gain and increased sensitivity to obesity risk factors may partly explain recent increases in obesity in western societies

BLAST-EXPLORER helps you building datasets for phylogenetic analysis

<p>Abstract</p> <p>Background</p> <p>The right sampling of homologous sequences for phylogenetic or molecular evolution analyses is a crucial step, the quality of which can have a significant impact on the final interpretation of the study. There is no single way for constructing datasets suitable for phylogenetic analysis, because this task intimately depends on the scientific question we want to address, Moreover, database mining softwares such as BLAST which are routinely used for searching homologous sequences are not specifically optimized for this task.</p> <p>Results</p> <p>To fill this gap, we designed BLAST-Explorer, an original and friendly web-based application that combines a BLAST search with a suite of tools that allows interactive, phylogenetic-oriented exploration of the BLAST results and flexible selection of homologous sequences among the BLAST hits. Once the selection of the BLAST hits is done using BLAST-Explorer, the corresponding sequence can be imported locally for external analysis or passed to the phylogenetic tree reconstruction pipelines available on the Phylogeny.fr platform.</p> <p>Conclusions</p> <p>BLAST-Explorer provides a simple, intuitive and interactive graphical representation of the BLAST results and allows selection and retrieving of the BLAST hit sequences based a wide range of criterions. Although BLAST-Explorer primarily aims at helping the construction of sequence datasets for further phylogenetic study, it can also be used as a standard BLAST server with enriched output. BLAST-Explorer is available at <url>http://www.phylogeny.fr</url></p

Impaired Control of Body Cooling during Heterothermia Represents the Major Energetic Constraint in an Aging Non-Human Primate Exposed to Cold

Daily heterothermia is used by small mammals for energy and water savings, and seems to be preferentially exhibited during winter rather than during summer. This feature induces a trade-off between the energy saved during daily heterothermia and the energy cost of arousal, which can impact energy balance and survival under harsh environmental conditions. Especially, aging may significantly affect such trade off during cold-induced energy stress, but direct evidences are still lacking. We hypothesized that aging could alter the energetics of daily heterothermia, and that the effects could differ according to season. In the gray mouse lemur (Microcebus murinus), a non-human primate species which exhibits daily heterothermia, we investigated the effects of exposures to 25 and 12°C on body composition, energy balance, patterns of heterothermia and water turnover in adult (N = 8) and aged animals (N = 7) acclimated to winter-like or summer-like photoperiods

High-Level Behavior Regulation for Multi-Robot Systems

International audienceWe propose a new collaborative guidance platform for a team of robots that should protect a fixed ground target from one or several threats. The team of robots performs high-level behaviors. These are hand-coded since they consist in driving the robots to some given position. However, deciding when and how to use these behaviors is much more challenging. Scripting high-level interception strategies is a complex problem and applicable to few specific application contexts. We propose to use a gene regulatory network to regulate high-level behaviors and to enable the emergence of efficient and robust interception strategies

Optimisation d'une structure de conversion DC-DC réversible pour application aéronautique

International audienceLe véhicule aérien a connu de nombreusesrévolutions durant les dernières décennies afin d'être pluséconome en énergie et plus respectueux de l'environnement. [1]Dans cet objectif, l'électricité est apparue comme le vecteurénergétique le plus adapté associé aux sources conventionnellesd'énergie. C'est dans ce contexte que nos recherches se sontportées sur ce mode de transport qui va voir des bouleversementsstructurels importants et de plus en plus d'équipementsélectriques installés à bord. Cet article s'intéresse à une brique deconversion DC/DC nécessaire au transfert d'énergie entre les busHVDC et LVDC présent sur les avions actuels, pour cela nousétudierons la structure, le contrôle et les résultats expérimentauxde la topologie Dual Active Bridge. Une maquette basse puissancea permis la validation des lois de commande tandis qu'unprototype 3,75kW à forte densité d'intégration sera présenté avecpour objectif une puissance massique de 2kW/kg. L'originalité deses travaux réside dans la volonté de concevoir un produitindustrialisable dans le domaine de l'aéronautique en favorisantplusieurs ruptures technologiques jusqu'alors rédhibitoire chezles avionneurs.</p

Fracture triplane de l’extrémité supérieure du tibia: une lésion rare (étude d’un cas et revue de la littérature)

Nous rapportons le cas d’une fracture triplane de l’extrémité supérieure du tibia chez un jeune de 16 ans survenue dans les suites d’un accident de sport lors d’une course de vélo. La tomodensitométrie (TDM) a été réalisée pour une meilleure analyse lésionnelle. Après l’identification de tous les fragments nécessitant une ostéosynthèse, il a été réalisé à foyer fermé une réduction avec fixation des différents fragments fracturaires par des vis canulées. Au dernier recul, les résultats radiologiques et fonctionnels étaient excellents

An improved genome of the model marine alga Ostreococcus tauri unfolds by assessing Illumina de novo assemblies

Background: Cost effective next generation sequencing technologies now enable the production of genomic datasets for many novel planktonic eukaryotes, representing an understudied reservoir of genetic diversity. O. tauri is the smallest free-living photosynthetic eukaryote known to date, a coccoid green alga that was first isolated in 1995 in a lagoon by the Mediterranean sea. Its simple features, ease of culture and the sequencing of its 13 Mb haploid nuclear genome have promoted this microalga as a new model organism for cell biology. Here, we investigated the quality of genome assemblies of Illumina GAIIx 75 bp paired-end reads from Ostreococcus tauri, thereby also improving the existing assembly and showing the genome to be stably maintained in culture. Results: The 3 assemblers used, ABySS, CLCBio and Velvet, produced 95% complete genomes in 1402 to 2080 scaffolds with a very low rate of misassembly. Reciprocally, these assemblies improved the original genome assembly by filling in 930 gaps. Combined with additional analysis of raw reads and PCR sequencing effort, 1194 gaps have been solved in total adding up to 460 kb of sequence. Mapping of RNAseq Illumina data on this updated genome led to a twofold reduction in the proportion of multi-exon protein coding genes, representing 19% of the total 7699 protein coding genes. The comparison of the DNA extracted in 2001 and 2009 revealed the fixation of 8 single nucleotide substitutions and 2 deletions during the approximately 6000 generations in the lab. The deletions either knocked out or truncated two predicted transmembrane proteins, including a glutamate-receptor like gene. Conclusion: High coverage (>80 fold) paired-end Illumina sequencing enables a high quality 95% complete genome assembly of a compact ~13 Mb haploid eukaryote. This genome sequence has remained stable for 6000 generations of lab culture

A Short-Term Physical Activity Randomized Trial in the Lower Mississippi Delta

Background: The purpose of this study was to determine if a short-term pedometer-based intervention results in immediate increases in time spent in moderate-to-vigorous physical activity (MVPA) compared to a minimal educational intervention. Methods: A sample of 43 overweight adults 35 to 64 years of age participated in a one week pedometer-based feasibility trial monitored by accelerometry. Participants were randomized into a one-week education-only group or a group that also wore a pedometer. Accelerometer-measured MVPA was measured over 7 days at baseline and again for 7 days immediately post-intervention. Results: Minutes of MVPA increased significantly in the overall sample (p = 0.02); however, the effect of adding the pedometer to the education program was not significant (p = 0.89). Mean (6SE) MVPA increased from 12.762.4 min/day to 16.263.6 min/day in the education-only group and from 13.263.3 min/day to 16.363.9 min/day in the education+pedometer group. The correlation between change in steps/day and change in MVPA was 0.69 (p,0.0001). Conclusions: The results of this study suggest that the addition of a pedometer to a short-term education program doe

Validation of the surface downwelling solar irradiance estimates of the HelioClim-3 database in Egypt

International audienceHelioClim-3 (HC3) is a database providing time series of the surface downwelling solar irradiance that are computed from images of the Meteosat satellites. This paper presents the validation results of the hourly global horizontal irradiance (GHI) and direct normal irradiance (DNI), i.e., beam irradiance at normal incidence, of versions four and five of HC3 at seven Egyptian sites. The validation is performed for all-sky conditions, as well as cloud-free conditions. Both versions of HC3 provide similar OPEN ACCESS Remote Sens. 2015, 7 9270 performances whatever the conditions. Another comparison is made with the estimates provided by the McClear database that is restricted to cloud-free conditions. All databases capture well the temporal variability of the GHI in all conditions, McClear being superior for cloud-free cases. In cloud-free conditions for the GHI, the relative root mean square error (RMSE) are fairly similar, ranging from 6% to 15%; both HC3 databases exhibit a smaller bias than McClear. McClear offers an overall better performance for the cloud-free DNI estimates. For all-sky conditions, the relative RMSE for GHI ranges from 10% to 22%, except one station, while, for the DNI, the results are not so good for the two stations with DNI measurements

Seasonality in Biological Rhythms in Scandinavian brown Bears

Biological rhythms, such as rhythms in activity and body temperature, are usually highly synchronized and entrained by environmental conditions, such as photoperiod. However, how the expression of these rhythms changes during hibernation, when the perception of environmental cues is limited, has not yet been fully understood for all hibernators, especially in the wild. The brown bear (Ursus arctos) in Scandinavia lives in a highly seasonal environment and adapts to harsh winter conditions by exhibiting hibernation, characterized by reduced metabolism and activity. In this study, we aimed to explore the expression of biological rhythms in activity, body temperature and heart rate of free-ranging brown bears over the annual cycle, including active, hibernation and the transition states around den entry and exit. We found that rhythms in physiology and activity are mostly synchronized and entrained by the light-dark cycle during the bears’ active state with predominantly diel and ultradian rhythms for body temperature, activity, and heart rate. However, during hibernation, rhythms in body temperature and heart rate were considerably slowed down to infradian rhythms, influenced by the amount of snow in the denning area, whereas rhythms in activity remained diel. Rhythms in the transition states when bears prepared for entering or coming out of hibernation state displayed a combination of infradian and diel rhythms, indicating the preparation of the body for the change in environmental conditions. These results reveal that brown bears adjust their biological rhythms to the seasonal environment they inhabit. Rhythms in physiology and activity show simultaneity during the active state but are partly disconnected from each other during hibernation, when bears are most sheltered from the environment.publishedVersio