10 research outputs found
Implementing the EU accounting directives in Sweden â practitioners' views
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/1999
- Field of study
Original article can be found at: http://www.sciencedirect.com/science/journal/00207063 Copyright University of Illinois. DOI: 10.1016/S0020-7063(99)00023-0 [Full text of this article is not available in the UHRA]Sweden legislated in 1995 to implement the European Union (EU) directives relating to harmonization of accounting. This article reports the results of an empirical study, based upon interviews and a questionnaire survey, on the attitudes of Swedish practitioners to the harmonizing legislation and to the current state of Swedish accounting. The research finds that the Germanic influence on Swedish accounting is lessening in importance, with a likely weakening of the close link between taxation and accounting and a perception amongst practitioners of the increasing importance of the International Accounting Standards Committee (IASC) and US influences.Peer reviewe
Clinical Characteristics and Outcomes of Endophthalmitis Before and During the COVID-19 Pandemic
- Publication venue
- Knowledge E
- Publication date
- 01/07/2023
- Field of study
Abstract Purpose: To evaluate the clinical characteristics and visual acuity outcomes of patients who presented with endophthalmitis prior to and during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This multicenter retrospective case series with historical controls included consecutive patients presenting with any form of endophthalmitis from March 1, 2019 to September 1, 2019 (pre-COVID-19) and from March 1, 2020 to September 1, 2020 (COVID-19) at Mayo Clinic Rochester (MCR), Health System (MCHS), Arizona (MCA), and Florida (MCF) sites. Cases were divided into âpre-COVID-19â versus âCOVID-19â groups depending on when they first presented with endophthalmitis. Results: Twenty-eight cases of endophthalmitis presented to all Mayo Clinic sites during the study period. Of these, 10 patients presented during the first six months of the COVID-19 pandemic. During the same six-month period the year prior, 18 patients presented with endophthalmitis. Endophthalmitis etiology (post-injection, post-cataract extraction, post-glaucoma filtering surgery, post-pars plana vitrectomy, endogenous, and others) was similar between both groups (P = 0.34), as was post-injection endophthalmitis rate (P = 0.69), days to presentation (P = 0.07), initial management (P = 0.11), culture-positivity rate (P = 0.70), and need for subsequent pars plana vitrectomy (P = 1). Visual acuity outcomes were similar between both groups at six months, however, the mean LogMAR visual acuity at presentation was worse in the COVID-19 group compared to the pre-COVID-19 group (2.44 vs 1.82; P = 0.026). Conclusion: Clinical characteristics and the post-injection endophthalmitis rate were similar during both periods, however, patients presented with worse vision during the pandemic suggesting that the pandemic may have contributed to delayed presentation, regardless, outcomes are still poor
Diurnal variation of optical coherence tomographyâbased macular fluid in exudative age-related macular degeneration
- Author
- Publication venue
- BMC
- Publication date
- 01/09/2023
- Field of study
Abstract Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3Â mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3Â mm total retinal volume (pâ=â0.56), central 3Â mm neurosensory retinal volume (pâ=â0.25), central 1Â mm total retinal mean thickness (pâ=â0.96), or central 1Â mm neurosensory retinal mean thickness (pâ=â0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively
Numerical simulation of breakup and detachment of an axially stretching Newtonian liquid bridge with a moving contact line phase field method
- Author
- A Zosel
- AJ Chorin
- B Qian
- C Huh
- D Jacqmin
- D Kim
- E Olsson
- F Magaletti
- H Ding
- H Kusumaatmaja
- H Matallah
- HS Udaykumar
- I DemirdĆŸiÄ
- J Eggers
- J Li
- JA Lee
- Kishore Singh Patel
- MA Fortes
- MS Dodd
- P Yue
- PD Thomas
- R Falgout
- R Peyret
- Ratnesh K Shukla
- RK Shukla
- RK Shukla
- S Dodds
- S Dong
- S Kumar
- S Marella
- T Qian
- TD Blake
- VE Badalassi
- VV Khatavkar
- X Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
INCORPORATION OF Mo6+ IN FERRIHYDRITE, GOETHITE, AND HEMATITE
- Author
- A Gualtieri
- A Khan
- A Le Bail
- A Manceau
- AC Scheinost
- AD Fortes
- AR Barron
- B Ravel
- BA Balko
- C NeunhÀuser
- CE MartĂnez
- CE MartĂnez
- CL Ciobanu
- CL Peacock
- D Carroll
- D Wang
- DM Sherman
- E Jansen
- EL Stiefel
- F Lang
- FM Michel
- H Aritani
- H Bortels
- HP Vu
- JC Linehan
- JE Post
- K Dardenne
- K Rout
- KD Sieber
- L Brinza
- L Brinza
- L Liang
- M Daturi
- M Mullet
- M Tarassov
- M ĆœemberyovĂĄ
- MA Wells
- MF Hochella
- MH Rapposch
- MJ De Leon
- N GĂĄlvez
- P Orlandi
- R Benchrifa
- RD Shannon
- RJP Williams
- RL Blake
- RM Bolanz
- RM Bolanz
- RM Bolanz
- RM Cornell
- RM Cornell
- RM Hazen
- RR Mendel
- S Das
- S Goldberg
- S Kerisit
- S Kerisit
- S Kreissl
- SE Fendorf
- SR Bare
- TA Marshall
- V PetĆĂÄek
- WR Richmond
- Y Arai
- Y Cudennec
- ZLL He
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
«Levitas y guardianes del prójimo»
- Author
- Alexander R. D.
- Alexander R. D.
- Alley T. R.
- Altman S. A.
- Amato P. R.
- Amato P. R.
- Axelrod R.
- Bar-Tal D.
- Bar-Tal D.
- Barash D. P.
- Batson C. D.
- Beall C. M.
- Blake J. A.
- Bouchard T. J.
- Bouchard T. J.
- Brown J. L.
- Buss D. M.
- Campbell D. T.
- Campbell D. T.
- Carnevale P. J.
- Cash T. J.
- Chagnon N.
- Cordell L. S
- Crosby F.
- Cunningham M. R.
- Cunningham M. R.
- Cunningham M. R.
- Cunningham M. R.
- Cunningham M. R.
- Darley J.
- Dawkins R.
- Durham W.
- Essock-Vitale S. M.
- Essock-Vitale S. M.
- Farber B.
- Fellner C. H.
- Fisher J. D.
- Fogelman E.
- Fortes M.
- Freedman D. G.
- Goldberg S.
- Greenberg L.
- Hames R. B.
- Hamilton W. D.
- Harrison A. A.
- Hatfield E.
- Hildebrandt K. A.
- Hill J.
- Holmes W. G.
- Johnson C. L.
- Kraut R. E.
- Krebs D. L.
- Leigh G. K.
- Lenik-Oberstein M.
- Lumsden C. J.
- Matessi C.
- Mayer J. P.
- Mckillip J.
- Michael R. Cunningham
- Milgram S.
- Mills J.
- Nadler A.
- Paloutzian R. F.
- Paulhus D. L.
- Pearce P.
- Plliavln J.
- Plotkin H. C.
- Plutchik R.
- Ridley M.
- Romer D.
- Rosen S.
- Rosenblatt P. C.
- Rosenblatt P. C.
- Rushton J. P.
- Rusthon J. P.
- Sadler H. H.
- Segal N. L.
- Shalins M.
- Shapiro E. G.
- Sherman P. W.
- Shortland R. D. L.
- Sigall H.
- Silk J.
- Simmons R. G.
- Simmons R. G.
- Smith R.J.
- Snyder M.
- Trivers R. L.
- Trivers R. L.
- Trivers R. L.
- Turke P. W.
- Weiner B.
- Weiner B.
- West Eberhard M.J.
- Wilson E. O.
- Zajonc R. B.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Enzyme Handbook
- Author
- 339-349
- [10]Siffert O., Emöd, I.
- [11] Fricker L.D., Snyder, S.H.
- [11] Taylor A., Volz, K.W., Lipscomb, W.N., Takemoto, L. J.
- [3] Schmidt U., Weller, D., Holder, A.
- [9]Fujiwara K., Tsuru, D.
- [hie J.N., Dure, L.S.
- A Amory
- A Baccarini-Melandri
- A Barth
- A Beaumont
- A Benajiba
- A Björklind
- A Björklind
- A Bourne
- A Carne
- A Cunningham
- A Dubin
- A Ducruix
- A Endo
- A Enyedi
- A Fujiwara
- A Gladhaug
- A Goffeau
- A Goffeau
- A Grubb
- A Guranowski
- A Guranowski
- A Guranowski
- A Hachimori
- A Hachimori
- A Hanck
- A Hasilik
- A Hasilik
- A Hiramatsu
- A Hui
- A Ichikawa
- A Impoolsup
- A Impoolsup
- A Iwayama
- A Journet
- A Kato
- A Kiener
- A Kilara
- A Kishimoto
- A Kitahara
- A Koheil
- A Koide
- A Kornberg
- A Kumon
- A Lauwers
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Light
- A Light
- A Light
- A Light
- A Manthey
- A Marquet
- A Melo
- A Merta
- A Moreno
- A Moriyama
- A Moriyama
- A Murai
- A Nicholson-Weller
- A Nordwig
- A Nordwig
- A Okitani
- A Okitani
- A Okitani
- A Ota
- A Pierre
- A PĂ€hler
- A Radzicka
- A Reboul
- A Reboul
- A Rinne
- A Ritonja
- A Rosenberg
- A Sancar
- A Sharma
- A Soumarmon
- A Stockell
- A Storer
- A Suhar
- A Suzuki
- A Suzuki
- A Szewczuk
- A Szewczuk
- A Taylor
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- A Thomson
- A Traverso-Cori
- A Wolos
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- A Wolos
- A Yaron
- A Yaron
- A Yaron
- A Yaron
- A Yawetz
- A Yiotakis
- A-C Ryden
- A-M Gilles
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- A-M Lacoste
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- AA Taylor
- AB Bennett
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- AD Olstein
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- AR Beaudoin
- AR Price
- AR Salem
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- AS Balasubramanian
- ATP Skrabanja
- AV Hoffbrand
- AYH Lu
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- AZ Eisen
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- B Asgeirsson
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- BY Hiraoka
- BY Hiraoka
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- C Gabeloteau
- C Gagnon
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- C Hanski
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- C Hurtado
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- C Kettner
- C Largman
- C Largman
- C Neuberg
- C Nolan
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- C Rodriguez
- C Sampaio
- C Shing-Yang
- C Tetu
- C Tiruppathi
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- C-M Lee
- C-S Chiu
- C-T Chang
- C-W Vogel
- C-W Vogel
- CA Auffret
- CA Collins
- CA GrĂŒndig
- CA Menzies
- CA Ryan
- CA Ryan
- CA Smith
- CA Spilburg
- CC Levy
- CC Levy
- CC Levy
- CD Anderson
- CD Lobatön
- CE Odya
- CE Odya
- CE Stauffer
- CF Scott
- CG Miller
- CG Vallejo
- CG Vallejo
- CH Lack
- CH Miller
- Chan. S.A.T., Jones, T.H.D., Sweeney, J.P., Toursarkissian, K.
- Chih-Min Kam Fujikawa, K.
- CJ Brandl
- CJ Chern
- CJ Decedue
- CJ Gray
- CJ Gray
- CJ Jaspers
- CJ Male
- CJ Peuch
- CK Omoto
- CL Hermsdorf
- CL Krumdieck
- CL Krumdieck
- CL Liu
- CL Liu
- CL Pinsley
- CM Baugh
- CM Baugh
- CM Lovett
- CM Szego
- CO Piggott
- CR Brown
- CR Brown
- CRH Raetz
- CS Sweet
- CS Tsai
- CV Balakrishnan
- CV Balakrishnan
- CW Angus
- CW Bell
- CW Bell
- CW Garner
- CW Garner
- CW Garner
- CW Garner
- CW Garner
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- CW Wharton
- D Barrett
- D Behnke
- D Bobb
- D Brömme
- D Brömme
- D Chenoweth
- D Chenoweth
- D Depierre
- D Eisenhauer
- D Ellis
- D Gibson
- D Gradmann
- D Grenier
- D Grenier
- D Grossmann
- D Hendriks
- D Hendriks
- D Kruze
- D Lebel
- D Lee
- D Lordachescu
- D Lordachescu
- D Mantle
- D Moir
- D Papadopoulos
- D Pennica
- D Rabier
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- D Sinha
- D Sinha
- D Tsernoglou
- D Tsuru
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- D Tsuru
- D Tsuru
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- DA Egan
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- DD Jones
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- Z Bohak
- Z Kucerova
- Z Wasylewski
- â (Turk V., Neville, M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- Abbott J. Dawn
- Abdullah S.
- Abib E.
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- Zannad Faiez
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- Zubek V.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUN
Laboratory Studies Towards Understanding Comets
- Author
- A. Bar-Nun
- A. Bar-Nun
- A. Bar-Nun
- A. Cochran
- A. Dalgarno
- A. Drouart
- A. Falenty
- A. Fresneau
- A. Hachikubo
- A. Hachikubo
- A. Kouchi
- A. Kouchi
- A. Li
- A. Lignell
- A. Wekhof
- A.D. Fortes
- A.G. Suits
- A.H. Mohammadi
- A.H. Mohammadi
- A.H. Mohammadi
- A.H. Mohammadi
- A.H. Mohammadi
- A.J. Remijan
- A.L. Cochran
- A.L. Cochran
- A.M.F. Tomescu
- A.R. May
- B. Gundlach
- B. Gundlach
- B. Gundlach
- B. Gundlach
- B. Jost
- B. Marty
- B. Schmitt
- B.J.R. Davidsson
- B.L. Henderson
- B.L. Henderson
- Bastian Gundlach
- C. Arpigny
- C. Ceccarelli
- C. Lecluse
- C. Meinert
- C. Szopa
- C. Szopa
- C. Szopa
- C. Szopa
- C. Thomas
- C. Thomas
- C.A. Varotsos
- C.D. Neish
- C.J. Bennett
- C.K. Materese
- C.M. Fedo
- C.M. Lisse
- C.M. Lisse
- C.M.O. Alexander
- C.N. Matthews
- D. Blake
- D. Bockelée-Morvan
- D. Bockelée-Morvan
- D. Bockelée-Morvan
- D. Bockelée-Morvan
- D. Gautier
- D. Hutsemékers
- D. Laufer
- D. Laufer
- D. Prialnik
- D.C. Lis
- D.G. Schleicher
- D.H. Wooden
- D.J. Eicher
- D.K. Staykova
- D.L. Mitchell
- E. Dartois
- E. Dartois
- E. Herbst
- E. Herbst
- E. Kuhrt
- E. Shpolskii
- E. Shpolskii
- E. Szymanska
- E. Szymanska
- E.D. Sloan
- E.F. Dishoeck van
- E.L. Gibb
- E.L. Schaller
- F. Carelli
- F. Carelli
- F. Carelli
- F. Duvernay
- F. Duvernay
- F. Hersant
- F. Hersant
- F. Mispelaer
- F. Moreno
- F. Robert
- F. Trixler
- F.E. Livingston
- F.G.A. Islam
- Fabrice Duvernay
- G. Cremonese
- G. Danger
- G. Danger
- G. Danger
- G. Danger
- G. Danger
- G. Danger
- G. Moreels
- G. Notesco
- G. Notesco
- G. Zasowski
- G.B. Hansen
- G.F. Kirkbright
- G.L. Villanueva
- G.M. Muñoz-Caro
- G.M. Muñoz-Caro
- G.M. Muñoz-Caro
- G.M. Muñoz-Caro
- G.P. Smith
- Grégoire Danger
- H. Balsiger
- H. Cottin
- H. Cottin
- H. Cottin
- H. Kawakita
- H. Kobayashi
- H. Massey
- H. Sierks
- H.D. Holder
- H.M. Butner
- H.W. Zhang
- I. Simonia
- I. Simonia
- I. Simonia
- I. Simonia
- I. Simonia
- I. Waluyo
- I.A. Simonia
- I.A. Simonia
- Irakli Simonia
- J. Aléon
- J. Berkowitz
- J. Berkowitz
- J. Blum
- J. Cernicharo
- J. Clairemidi
- J. Crovisier
- J. Duprat
- J. Geiss
- J. Horner
- J. Licandro
- J.A. Noble
- J.A. Smith
- J.B. Bossa
- J.B. Bossa
- J.B. Bossa
- J.E. Bertie
- J.E. Elsila
- J.H. Waal Van der
- J.I. Lunine
- J.I. Lunine
- J.J. Kavelaars
- J.L. Burch
- J.L. Daschbach
- J.M. Greenberg
- J.P. Dworkin
- J.P. Dworkin
- J.S. Lewis
- JĂŒrgen Blum
- K. Altwegg
- K. Altwegg
- K. Lodders
- K. Shin
- K. Yasuda
- K.H. Walsh
- K.I. Churyumov
- K.I. Churyumov
- K.I. Churyumov
- K.I. Churyumov
- K.I. Ăberg
- K.J. Kim
- K.J. Kossacki
- K.J. Meech
- L. Gibb
- L. Yang
- L.A. Nakhimovsky
- L.I. Cleeves
- L.J. Allamandola
- M. Choukroun
- M. Choukroun
- M. Krause
- M. Nuevo
- M. Nuevo
- M. Nuevo
- M. Rubin
- M.A. Allodi
- M.A. Cordiner
- M.A. Cordiner
- M.B. Rydzy
- M.C. McCarthy
- M.E. Brown
- M.F. AâHearn
- M.F. AâHearn
- M.H. Moore
- M.J. Mumma
- M.K. Spencer
- M.P. Bernstein
- M.P. Bernstein
- M.P. Bernstein
- M.P. Collings
- M.P. Collings
- M.R. Hogerheijde
- M.S. Gudipati
- M.S. Gudipati
- Martin A. Cordiner
- Murthy S. Gudipati
- N. Abou Mrad
- N. Biver
- N. Dello Russo
- N. Fray
- N. Gortsas
- N. Iro
- N.D. Morrison
- N.E.B. Zellner
- N.J. English
- N.T. Bobrovnikoff
- N.T. Bobrovnikoff
- Ninette Abou Mrad
- O. Andersson
- O. Andersson
- O. Groussin
- O. Groussin
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- O. Mousis
- Olivier Mousis
- P. Chaizy
- P. Eberhardt
- P. Ehrenfreund
- P. Hartogh
- P. Jenniskens
- P. Linga
- P. Marcellus de
- P. Marcellus de
- P. Modica
- P. Modica
- P. Schmitt-kopplin
- P. Theule
- P.A. Gerakines
- P.C. Thomas
- Patrice Theulé
- Paul Hartogh
- Q.J. Hu
- R. Gomes
- R. Martin-Domenech
- R. Meier
- R. Yang
- R.A. May
- R.H. Brown
- R.M. Barrer
- R.S. Smith
- Rui Yang
- S. Andersson
- S. Gulkis
- S. Hegler
- S. Maity
- S. Wyckoff
- S. Wyckoff
- S.-P. Kang
- S.A. Sandfordet
- S.D. Rodgers
- S.J. Clemett
- Steven B. Charnley
- T. Albertsson
- T. Hama
- T. Hama
- T. Maekawa
- T. Poppe
- T. Spohn
- T.A. Teplitskaiya
- T.J. Millar
- T.J. Millar
- Thierry Chiavassa
- Tsitsino Simonia
- U. Marboeuf
- U. Marboeuf
- U. Marboeuf
- U. Marboeuf
- U. Marboeuf
- U.J.L. Meierhenrich
- Ulysse Marboeuf
- V. Vinogradoff
- V. Vinogradoff
- V. Vinogradoff
- V. Vinogradoff
- W. Schutte
- W.A. Schutte
- W.A. Schutte
- W.B. Huebner
- W.F. Bottke
- W.F. Kuhs
- W.M. Irvine
- W.R. Parrish
- X. Wang
- Y.J. Chen
- Y.P. Handa
- Y.V. Skorov
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- A A
- Abbott Jd
- Abdullah S
- Abib E Jr
- Ables Lr
- Abrantes Ja
- Acosta R
- Adams A
- Adams F
- Adroer Martori R
- Agafina As
- Agaiby Jm
- Aggarwala G
- Agraou B
- Aguilarsalinas Ca
- Ahmad A
- Ajala B
- Akdeniz B
- Akhtar N
- Akright L
- Aksentiev S
- Al-Zoebi A
- Alappat P
- Albert M
- Alfieri Ad
- Alhakim M
- Allaw Ma
- Alpizar-Salazar M
- Altafullah Im
- Alvarado Op
- Alvarez Ca
- Alvarez Jg
- Alvarez Ms
- Alvarez-Sala Walther La
- Alves AR Jr
- Alwine Lk
- Alzand B
- Amarenco P.
- Ambrovicova V
- Amerena J
- Andersen Jl
- Andersen Lt
- Anderson P
- Anderson Tj
- Andrassy P
- Andrei Ld
- Andreka P
- Angoulvant D
- Angun M
- Annamalai N
- Ansari Sh
- Anselmi M
- Antonicelli R
- Appel Kf
- Aracil Villar J
- Arain S
- Arambula Rm
- Araz M
- Arca M
- Arcanese Ml
- Arden C
- Areas Ca
- Ari H
- Ariani Mk
- Arif I
- Aroney C
- Aronson R
- Arstall M
- Arstila L
- Arya Kw
- Asamoah-Owusu N
- Askonen K
- Aslam Aa
- Assadourian A
- Assef V
- Atar S
- Auriel E
- Avaca H
- Averna M
- Avornyo Aa
- Avram Ri
- Axthelm C
- Ayesu K
- Aylward Pe
- Ayoub Jc
- Baar M
- Babapulle M
- Badat Ae
- Bailey Sr
- Bajaj H
- Bajcsi D
- Baker J
- Bakhai A
- Baldari D
- Ball Em
- Ballantyne Cm
- Ballyuzek M
- Balo T
- Banaszkiewicz K
- Bandeira e Farias FA
- Banerjee M
- Banik M
- Banyai M
- Baranova E
- Barbarash Ol
- Barbieri Ds
- Barettella Mb
- Barker Ba
- Barnum O
- Barreda Gonzalez Mj
- Barrera Cm
- Barrington P
- Baultrukonis D
- Bax Wa
- Bayat J
- Bayron Cj
- Bays He
- Beaudry P
- Beckett Pl
- Begg A
- Behmanesh B
- Behnke T
- Belenkiy Di
- Belicova M
- Bellido Guerrero D
- Bellingar B
- Beltran Lg
- Benacka J
- Benatar Jr
- Benczur B
- Benitez O
- Benjamin Sa
- Berenguer Ra
- Bergeron J
- Bergerot C
- Berk Mr
- Berli M
- Berlingieri Jc
- Bernard Jv
- Berrouschot J
- Bertolet Bd
- Bhindi R
- Bianco Ht
- Bijata-Bronisz R
- Bilz S
- Bittar Gd
- Bitzur R
- Bjasker Kr
- Blach E
- Black H
- Blagden Md
- Blaha V
- Blake G
- Blanco Coronado Jl
- Blaze K
- Blignault Sc
- Blokhin A
- Bloom Sa
- Bocek P
- Bod E
- Bogaard K
- Bogdanov E
- Bokern Mj
- Boman K
- Bonansea Tc
- Bonfanti Ja
- Bonner Jh
- Bonora E
- Boonyavarakul A
- Borer Js
- Botas Rodrigues J
- Botelho Rv
- Botella Serrano M
- Botero-Lopez R
- Botta Ce
- Bourgeois R
- Bourhaial H
- Boye A
- Boyett Be
- Brandon Dm
- Brar Hs
- Brauer C
- Bravo P
- Bredlau Ce
- Breedveld Rw
- Brenner H
- Breton Cf
- Bretton Em
- Brito Sanfiel Ma
- Broncel M
- Bronnum Schou J
- Brotons Cuixart C
- Broughton R
- Bruguera Cortada J
- Brunell R.
- Bruno Rl
- Budassi N
- Budoff Mj
- Bueno Diez M
- Bufka V
- Buganova I
- Bulanova N
- Buonanno M
- Burgess Lj
- Burnier M
- Burova N
- Busch Rs
- Busegeanu M
- Butuk Dj
- Buynak Rj
- Buysschaert I
- Bybee Ka
- Cabella Pr
- Cabezas Mc
- Caccavo A
- Calin A
- Calvo Gomez C
- Camp Ad
- Capiau L
- Caputo Rp
- Caramori Pr
- Carlier M
- Carlier Sg
- Carmena R
- Carnero Gs
- Carroll Pa
- Casabella Te
- Casaubon L
- Castro Montes Be
- Castro Ma
- Castro Nm
- Catano Js
- Caudmont S
- Cayla G
- Cech V
- Cecil Jt
- Cequier Fillat Ar
- Cerci R
- Ceska R
- Ceyhan C
- Cha Jy
- Chahin M
- Chakrabarti A
- Chambers Jd
- Chandna H
- Chang Ar
- Chang Kc
- Changlani M
- Chati Z
- Chaudhuri S
- Cheek Hb
- Chen J
- Chen Jc
- Cherlin Rs
- Chernyatina Ma
- Cheung Ss
- Chiang Ce
- Chilka S
- Chiong R
- Cho Br
- Cho Ys
- Chochinov Rh
- Chorin E
- Chouinard G
- Chueca Fernandez Je
- Chun H
- Cifkova R
- Ciomag Rm
- Civeira Murillo F
- Civeira F.
- Clark Gb
- Clark R
- Claudio J
- Clemens Pc
- Codutti Or
- Coetzer Tf
- Cohen Aj
- Cohen Ss
- Coisne D
- Collier Dj
- Colombo Hr
- Colquhoun D
- Colquhoun D
- Comlekci A
- Conde Dg
- Cone Cl
- Connelly T
- Connery L
- Contzen C
- Conway Jr
- Cools F
- Copaci I
- Corder Cn
- Corin A
- Cornett Gm
- Cortada Jb
- Couffinhal T
- Cramer E
- Crater Ta
- Crean P
- Crimmins Ds
- Crisby M
- Cropp A
- Cruz Fernandez Jm
- Csanadi Ma
- Cuadrado Ja
- Cucher Fh
- Cui G
- Curiac D
- Curto M
- Cusimano S
- Czarnecka D
- D'Emden M
- da Costa Fa
- Da Stephan U
- Dada Fa
- Dahl Cf
- Dan Ga
- Dan Ga
- Dart Am
- Dave Kn
- Davidovits Z
- Davidsen F
- Davidson E
- Davis Sm
- Davis T
- de Barros e Silva PG
- De Belder M
- De Bruyne L
- De Castro R
- De Dios Garcia Diaz J
- De La Cuesta Mayor C
- De La Fuente Ra
- de Lima e Silva FA
- De Looze F
- De los Rios Ibarra Mo
- de Mora Martin M
- de Moraes Junior Jb
- De Nooijer C
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- de Santos Mo
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- Delgado Jp
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- Demin A
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- den Hartog Fr
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- Dimas Al
- Dion D
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- Drozdz J
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- Zarandon Rb
- Zarich Sw
- Zateyshchikov D
- Zavaro Sh
- Zebrack Js
- Zeig S
- Zemek S
- Zemour G
- Zeng X
- Zeno Ml
- Zhang L
- Zhang X
- Zhang Y
- Zhao Y
- Zhou C
- Zhou Y
- Zhu Y
- Zidkova E
- Zieba B
- Zilahi Z
- Zoet-Nugteren Sk
- Zrazhevskiy K
- Zubek V
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin- kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction from baseline of 64.2% (P<0.001). In the lower-risk, shorter-duration trial (in which the patients had a baseline LDL cholesterol level of â„70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P = 0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of â„100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P = 0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P = 0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P<0.001). CONCLUSIONS In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients