1,450 research outputs found

    Effect of Correlated Lateral Geniculate Nucleus Firing Rates on Predictions for Monocular Eye Closure Versus Monocular Retinal Inactivation

    Get PDF
    Monocular deprivation experiments can be used to distinguish between different ideas concerning properties of cortical synaptic plasticity. Monocular deprivation by lid suture causes a rapid disconnection of the deprived eye connected to cortical neurons whereas total inactivation of the deprived eye produces much less of an ocular dominance shift. In order to understand these results one needs to know how lid suture and retinal inactivation affect neurons in the lateral geniculate nucleus (LGN) that provide the cortical input. Recent experimental results by Linden et al. showed that monocular lid suture and monocular inactivation do not change the mean firing rates of LGN neurons but that lid suture reduces correlations between adjacent neurons whereas monocular inactivation leads to correlated firing. These, somewhat surprising, results contradict assumptions that have been made to explain the outcomes of different monocular deprivation protocols. Based on these experimental results we modify our assumptions about inputs to cortex during different deprivation protocols and show their implications when combined with different cortical plasticity rules. Using theoretical analysis, random matrix theory and simulations we show that high levels of correlations reduce the ocular dominance shift in learning rules that depend on homosynaptic depression (i.e., Bienenstock-Cooper-Munro type rules), consistent with experimental results, but have the opposite effect in rules that depend on heterosynaptic depression (i.e., Hebbian/principal component analysis type rules)

    A theoretical/experimental program to develop active optical pollution sensors

    Get PDF
    Light detection and ranging (LIDAR) technology was applied to the assessment of air quality, and its usefulness was evaluated by actual field tests. Necessary hardware was successfully constructed and operated in the field. Measurements of necessary physical parameters, such as SO2 absorption coefficients were successfully completed and theoretical predictions of differential absorption performance were reported. Plume modeling improvements were proposed. A full scale field test of equipment, data analysis and auxiliary data support was conducted in Maryland during September 1976

    Use of LARS system for the quantitative determination of smoke plume lateral diffusion coefficients from ERTS images of Virginia

    Get PDF
    A technique for measuring smoke plume of large industrial sources observed by satellite using LARSYS is proposed. A Gaussian plume model is described, integrated in the vertical, and inverted to yield a form for the lateral diffusion coefficient, Ky. Given u, wind speed; y sub l, the horizontal distance of a line of constant brightness from the plume symmetry axis a distance x sub l, downstream from reference point at x=x sub 2, y=0, then K sub y = u ((y sub 1) to the 2nd power)/2 x sub 1 1n (x sub 2/x sub 1). The technique is applied to a plume from a power plant at Chester, Virginia, imaged August 31, 1973 by LANDSAT I. The plume bends slightly to the left 4.3 km from the source and estimates yield Ky of 28 sq m/sec near the source, and 19 sq m/sec beyond the bend. Maximum ground concentrations are estimated between 32 and 64 ug/cu m. Existing meteorological data would not explain such concentrations

    Selectivity and Metaplasticity in a Unified Calcium-Dependent Model

    Get PDF
    A unified, biophysically motivated Calcium-Dependent Learning model has been shown to account for various rate-based and spike time-dependent paradigms for inducing synaptic plasticity. Here, we investigate the properties of this model for a multi-synapse neuron that receives inputs with different spike-train statistics. In addition, we present a physiological form of metaplasticity, an activity-driven regulation mechanism, that is essential for the robustness of the model. A neuron thus implemented develops stable and selective receptive fields, given various input statistic

    Dynamics of encrypted information in the presence of imperfect operations

    Full text link
    The original dense coding protocol is achieved via quantum channel generated between a single Cooper pair and a cavity. The dynamics of the coded and decoded information are investigated for different values of the channel's parameters. The efficiency of this channel for coding and decoding information depends on the initial state settings of the Cooper pair. It is shown that, these information increase as the detuning parameter increases or the number of photons inside the cavity decreases. The coded and decoded information increase as the ratio of the capacities between the box and gate decreases. In the presence of imperfect operation, the sensitivity of the information to the phase error is much larger than the bit flip error

    Strong spin-photon coupling in silicon

    Full text link
    We report the strong coupling of a single electron spin and a single microwave photon. The electron spin is trapped in a silicon double quantum dot and the microwave photon is stored in an on-chip high-impedance superconducting resonator. The electric field component of the cavity photon couples directly to the charge dipole of the electron in the double dot, and indirectly to the electron spin, through a strong local magnetic field gradient from a nearby micromagnet. This result opens the way to the realization of large networks of quantum dot based spin qubit registers, removing a major roadblock to scalable quantum computing with spin qubits

    Remote detection of aerosol pollution by ERTS

    Get PDF
    Photogrammetric and densitometric examination of ERTS-1 MSS imagery of Eastern Virginia coupled with extensive ground truth air quality and meteorological data has shown that the identification and surveying of fixed particulate emitters (smoke plumes) is feasible. A description of the ground truth network is included. The quantitative monitoring of smoke stacks from orbital altitudes over state size regions appears possible when tied to realistic plume models and minimal ground truth. Contrast reductions over urban areas can possibly be utilized to produce isopleths of particulates when supplemented by local measurements

    Recovery From Monocular Deprivation Using Binocular Deprivation: Experimental Observations and Theoretical Analysis

    Get PDF
    Ocular dominance (OD) plasticity is a robust paradigm for examining the functional consequences of synaptic plasticity. Previous experimental and theoretical results have shown that OD plasticity can be accounted for by known synaptic plasticity mechanisms, using the assumption that deprivation by lid suture eliminates spatial structure in the deprived channel. Here we show that in the mouse, recovery from monocular lid suture can be obtained by subsequent binocular lid suture but not by dark rearing. This poses a significant challenge to previous theoretical results. We therefore performed simulations with a natural input environment appropriate for mouse visual cortex. In contrast to previous work we assume that lid suture causes degradation but not elimination of spatial structure, whereas dark rearing produces elimination of spatial structure. We present experimental evidence that supports this assumption, measuring responses through sutured lids in the mouse. The change in assumptions about the input environment is sufficient to account for new experimental observations, while still accounting for previous experimental results

    Eigenvalue Distributions for a Class of Covariance Matrices with Applications to Bienenstock-Cooper-Munro Neurons Under Noisy Conditions

    Full text link
    We analyze the effects of noise correlations in the input to, or among, BCM neurons using the Wigner semicircular law to construct random, positive-definite symmetric correlation matrices and compute their eigenvalue distributions. In the finite dimensional case, we compare our analytic results with numerical simulations and show the effects of correlations on the lifetimes of synaptic strengths in various visual environments. These correlations can be due either to correlations in the noise from the input LGN neurons, or correlations in the variability of lateral connections in a network of neurons. In particular, we find that for fixed dimensionality, a large noise variance can give rise to long lifetimes of synaptic strengths. This may be of physiological significance.Comment: 7 pages, 7 figure

    Free-expansion experiments and modeling in detonation: Chemistry and hydrodynamics on a laboratory scale

    Get PDF
    Laboratory-scale (25-50 mg) detonations of PETN, RDX, HNS, and TNT have been carried out in a high-vacuum chamber, and collisionless molecular beams of the freely expanding detonation products have been analyzed as a function of time with a mass spectrometer. Concurrently, time-sequenced schlieren and shadowgraph images of the initial expansion of the product plume are recorded using a pulsed laser for illumination. These data tie the chemistry and hydrodynamics of the detonation event together. The results, interpreted with the aid of a computer model, suggest that this experiment freezes the chemical reactions of detonation by rapid adiabatic cooling and provides a continuum of samples in the molecular beam, representing the sequence of reactions in the detonating charge. With a suitable model of the expansion hydrodynamics, the hydrodynamic histories of a sequence of volume elements can be associated with their frozen chemistries. We expect experiments like this to provide a test for molecular models of detonation. 10 refs., 5 figs
    • …
    corecore