Демографски развој на град Скопј за ГУП (2022-2032)

Демографската анализа на населението и населеноста воопшто, меѓу другите е дна од клучните студии за изработка на регионалните и урбанистичките планови. Во тој контекст е поставена и анализата за демографскиот развој на градот Скопје за изработка на Генерален урбанистички план (2022-2032

RAZINE VITAMINA D U PACIJENATA S OPSTRUKCIJSKOM APNEJOM TIJEKOM SPAVANJU

Objectives: Obstructive sleep apnea is pathological condition characterized by recurrent episodes of upper airway collapse during sleep and is associated with multiple metabolic conditions including metabolic syndrome and osteoporosis. The aim of the presented study was to compare 25-dihydroxy vitamin D concentrations and other laboratory parameters between OSA patients and healthy control group. Patients and methods: The study included 30 male patients that were diagnosed with OSA and a control group with 30 gender and BMI matched healthy volunteers. All study subjects underwent physical examination and anthropometric measuring. In detailed interview, information regarding physical activity was taken. Polysomnographic recording (PSG) was used on all study group participants. Automated Chemiluminescence Sandwich Immunoassay (CLIA) method was used to assess 25-dihydroxy vitamin D (Immunodiagnostic Systems, Frankfurt, Germany) levels. Intact parathyroid hormone (iPTH) was analyzed with the electrochemiluminescence immunoassay (ECLIA) method on Roche Cobas e601 (Roche Diagnostics, Mannheim, Germany), while calcium and phosphorus concentrations were determined using standard laboratory procedures. Results: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however aaverage 25-dihydroxy vitamin D levels were low in both groups (49.3 ± 15.8 nmol/L vs. 48.2 ± 17.6 nmol/L, P=0.744). There was a significant negative correlation between 25-dihydroxy vitamin D concentrations and BMI (r=-0.304, P=0.018) and waist circumference (r=-0.359, P=0.004). The correlation between AHI and 25-dihydroxy vitamin D levels was not observed (r=0.024, P=0.900). There was no difference in iPTH, calcium or phosphorus levels between OSA patients and controls. Conclusion: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however serum concentrations of 25-dihydroxy vitamin D were low in both groups. Further studies with a larger number of OSA patients are needed to investigate the relationship between OSA and 25-dihydroxy vitamin D levels.Cilj: Opstrukcijska apneja tijekom spavanja (OSA) je patološko stanje karakterizirano ponavljajućim epizodama kolapsa gornjih dišnih putova tijekom spavanja i povezano je s više metaboličkih stanja uključujući metabolički sindrom i osteoporozu. Cilj ovog istraživanja bio je usporediti koncentracije 25-dihidroksi vitamina D i druge laboratorijske parametre između OSA bolesnika i zdrave kontrolne skupine. Ispitanici i metode: Istraživanje je uključilo 30 muških bolesnika kojima je dijagnosticirana OSA i 30 zdravih dobrovoljaca uparenih prema spolu i indeksu tjelesne mase (ITM). Svi ispitanici su podvrgnuti fizikalnom pregledu i antropometrijskim mjerenjima. Detaljnim intervjuom su prikupljene informacije o tjelesnoj aktivnosti. Svi ispitanici su podvrgnuti polisomnografskom snimanju (PSG). Kemiluminiscencijska imunokemijska analiza (CLIA) metoda je korištena za procjenu razine 25-dihidroksi vitamina D (Immunodiagnostic Systems, Frankfurt, Njemačka). Intaktni paratiroidni hormon (iPTH) analiziran je metodom elektrokemiluminiscencijskog imunotesta (ECLIA) na Roche Cobas e601 (Roche Diagnostics, Mannheim, Njemačka), dok su koncentracije kalcija i fosfora određene standardnim laboratorijskim postupcima. Rezultati: Nije bilo razlike u serumskim koncentracijama 25-dihidroksi vitamina D u OSA bolesnika i zdravih kontrola, međutim, prosječne vrijednosti 25-dihidroksi vitamina D bile su niske u obje skupine (49,3 ± 15,8 nmol/L naprema 48,2 ± 17,6 nmol/L, P=0,744). Opažena je značajna negativne korelacija između koncentracija 25-dihidroksi vitamina D i indeksa tjelesne mase (r =-0,304, P=0,018) i opsega struka (r=-0,359, P=0,004). Korelacija između AHI i razina 25-dihidroksi vitamina D nije uočena (r=0,024, P=0,900). Nije bilo razlike u razinama iPTH, kalcija ili fosfora između bolesnika s OSA-om i kontrola. Zaključci: Nije bilo razlike u serumskim koncentracijama 25-dihidroksi vitamina D u OSA bolesnika i zdravim kontrolama, međutim serumske koncentracije 25-dihidroksi vitamina D bile su niske u obje skupine. Potrebna su daljnja istraživanja s većim brojem OSA pacijenata kako bi se istražio odnos između OSA-e i razine 25-dihidroksi vitamina D

Хидро-мелиоративен систем Стрежево

Стручен труд за ХМ „Стрежево“. Општи и посебни податоци за хидромелиоративниот систем Стрежево

Хидромелиоративен систем „Стрежово“

Во пелагониската котлина во периодот од 1945 година до 1975 година се извршени мошне обемни мелиоративни зафати во смисла на одвојување на котлината. Притоа одвојувањето е извршенона површина од 65150 хектари. Меѓутоа, со оглед на тоа што процесите одводнување и наводнување се тесно поврзани и чинат една целина, започнаа да се разработуваат идејни решенија по прашањето на наводнувањето на котлината

RAZINE VITAMINA D U PACIJENATA S OPSTRUKCIJSKOM APNEJOM TIJEKOM SPAVANJU

Objectives: Obstructive sleep apnea is pathological condition characterized by recurrent episodes of upper airway collapse during sleep and is associated with multiple metabolic conditions including metabolic syndrome and osteoporosis. The aim of the presented study was to compare 25-dihydroxy vitamin D concentrations and other laboratory parameters between OSA patients and healthy control group. Patients and methods: The study included 30 male patients that were diagnosed with OSA and a control group with 30 gender and BMI matched healthy volunteers. All study subjects underwent physical examination and anthropometric measuring. In detailed interview, information regarding physical activity was taken. Polysomnographic recording (PSG) was used on all study group participants. Automated Chemiluminescence Sandwich Immunoassay (CLIA) method was used to assess 25-dihydroxy vitamin D (Immunodiagnostic Systems, Frankfurt, Germany) levels. Intact parathyroid hormone (iPTH) was analyzed with the electrochemiluminescence immunoassay (ECLIA) method on Roche Cobas e601 (Roche Diagnostics, Mannheim, Germany), while calcium and phosphorus concentrations were determined using standard laboratory procedures. Results: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however aaverage 25-dihydroxy vitamin D levels were low in both groups (49.3 ± 15.8 nmol/L vs. 48.2 ± 17.6 nmol/L, P=0.744). There was a significant negative correlation between 25-dihydroxy vitamin D concentrations and BMI (r=-0.304, P=0.018) and waist circumference (r=-0.359, P=0.004). The correlation between AHI and 25-dihydroxy vitamin D levels was not observed (r=0.024, P=0.900). There was no difference in iPTH, calcium or phosphorus levels between OSA patients and controls. Conclusion: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however serum concentrations of 25-dihydroxy vitamin D were low in both groups. Further studies with a larger number of OSA patients are needed to investigate the relationship between OSA and 25-dihydroxy vitamin D levels.Cilj: Opstrukcijska apneja tijekom spavanja (OSA) je patološko stanje karakterizirano ponavljajućim epizodama kolapsa gornjih dišnih putova tijekom spavanja i povezano je s više metaboličkih stanja uključujući metabolički sindrom i osteoporozu. Cilj ovog istraživanja bio je usporediti koncentracije 25-dihidroksi vitamina D i druge laboratorijske parametre između OSA bolesnika i zdrave kontrolne skupine. Ispitanici i metode: Istraživanje je uključilo 30 muških bolesnika kojima je dijagnosticirana OSA i 30 zdravih dobrovoljaca uparenih prema spolu i indeksu tjelesne mase (ITM). Svi ispitanici su podvrgnuti fizikalnom pregledu i antropometrijskim mjerenjima. Detaljnim intervjuom su prikupljene informacije o tjelesnoj aktivnosti. Svi ispitanici su podvrgnuti polisomnografskom snimanju (PSG). Kemiluminiscencijska imunokemijska analiza (CLIA) metoda je korištena za procjenu razine 25-dihidroksi vitamina D (Immunodiagnostic Systems, Frankfurt, Njemačka). Intaktni paratiroidni hormon (iPTH) analiziran je metodom elektrokemiluminiscencijskog imunotesta (ECLIA) na Roche Cobas e601 (Roche Diagnostics, Mannheim, Njemačka), dok su koncentracije kalcija i fosfora određene standardnim laboratorijskim postupcima. Rezultati: Nije bilo razlike u serumskim koncentracijama 25-dihidroksi vitamina D u OSA bolesnika i zdravih kontrola, međutim, prosječne vrijednosti 25-dihidroksi vitamina D bile su niske u obje skupine (49,3 ± 15,8 nmol/L naprema 48,2 ± 17,6 nmol/L, P=0,744). Opažena je značajna negativne korelacija između koncentracija 25-dihidroksi vitamina D i indeksa tjelesne mase (r =-0,304, P=0,018) i opsega struka (r=-0,359, P=0,004). Korelacija između AHI i razina 25-dihidroksi vitamina D nije uočena (r=0,024, P=0,900). Nije bilo razlike u razinama iPTH, kalcija ili fosfora između bolesnika s OSA-om i kontrola. Zaključci: Nije bilo razlike u serumskim koncentracijama 25-dihidroksi vitamina D u OSA bolesnika i zdravim kontrolama, međutim serumske koncentracije 25-dihidroksi vitamina D bile su niske u obje skupine. Potrebna su daljnja istraživanja s većim brojem OSA pacijenata kako bi se istražio odnos između OSA-e i razine 25-dihidroksi vitamina D

RAZINE VITAMINA D U PACIJENATA S OPSTRUKCIJSKOM APNEJOM TIJEKOM SPAVANJU

Objectives: Obstructive sleep apnea is pathological condition characterized by recurrent episodes of upper airway collapse during sleep and is associated with multiple metabolic conditions including metabolic syndrome and osteoporosis. The aim of the presented study was to compare 25-dihydroxy vitamin D concentrations and other laboratory parameters between OSA patients and healthy control group. Patients and methods: The study included 30 male patients that were diagnosed with OSA and a control group with 30 gender and BMI matched healthy volunteers. All study subjects underwent physical examination and anthropometric measuring. In detailed interview, information regarding physical activity was taken. Polysomnographic recording (PSG) was used on all study group participants. Automated Chemiluminescence Sandwich Immunoassay (CLIA) method was used to assess 25-dihydroxy vitamin D (Immunodiagnostic Systems, Frankfurt, Germany) levels. Intact parathyroid hormone (iPTH) was analyzed with the electrochemiluminescence immunoassay (ECLIA) method on Roche Cobas e601 (Roche Diagnostics, Mannheim, Germany), while calcium and phosphorus concentrations were determined using standard laboratory procedures. Results: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however aaverage 25-dihydroxy vitamin D levels were low in both groups (49.3 ± 15.8 nmol/L vs. 48.2 ± 17.6 nmol/L, P=0.744). There was a significant negative correlation between 25-dihydroxy vitamin D concentrations and BMI (r=-0.304, P=0.018) and waist circumference (r=-0.359, P=0.004). The correlation between AHI and 25-dihydroxy vitamin D levels was not observed (r=0.024, P=0.900). There was no difference in iPTH, calcium or phosphorus levels between OSA patients and controls. Conclusion: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however serum concentrations of 25-dihydroxy vitamin D were low in both groups. Further studies with a larger number of OSA patients are needed to investigate the relationship between OSA and 25-dihydroxy vitamin D levels.Cilj: Opstrukcijska apneja tijekom spavanja (OSA) je patološko stanje karakterizirano ponavljajućim epizodama kolapsa gornjih dišnih putova tijekom spavanja i povezano je s više metaboličkih stanja uključujući metabolički sindrom i osteoporozu. Cilj ovog istraživanja bio je usporediti koncentracije 25-dihidroksi vitamina D i druge laboratorijske parametre između OSA bolesnika i zdrave kontrolne skupine. Ispitanici i metode: Istraživanje je uključilo 30 muških bolesnika kojima je dijagnosticirana OSA i 30 zdravih dobrovoljaca uparenih prema spolu i indeksu tjelesne mase (ITM). Svi ispitanici su podvrgnuti fizikalnom pregledu i antropometrijskim mjerenjima. Detaljnim intervjuom su prikupljene informacije o tjelesnoj aktivnosti. Svi ispitanici su podvrgnuti polisomnografskom snimanju (PSG). Kemiluminiscencijska imunokemijska analiza (CLIA) metoda je korištena za procjenu razine 25-dihidroksi vitamina D (Immunodiagnostic Systems, Frankfurt, Njemačka). Intaktni paratiroidni hormon (iPTH) analiziran je metodom elektrokemiluminiscencijskog imunotesta (ECLIA) na Roche Cobas e601 (Roche Diagnostics, Mannheim, Njemačka), dok su koncentracije kalcija i fosfora određene standardnim laboratorijskim postupcima. Rezultati: Nije bilo razlike u serumskim koncentracijama 25-dihidroksi vitamina D u OSA bolesnika i zdravih kontrola, međutim, prosječne vrijednosti 25-dihidroksi vitamina D bile su niske u obje skupine (49,3 ± 15,8 nmol/L naprema 48,2 ± 17,6 nmol/L, P=0,744). Opažena je značajna negativne korelacija između koncentracija 25-dihidroksi vitamina D i indeksa tjelesne mase (r =-0,304, P=0,018) i opsega struka (r=-0,359, P=0,004). Korelacija između AHI i razina 25-dihidroksi vitamina D nije uočena (r=0,024, P=0,900). Nije bilo razlike u razinama iPTH, kalcija ili fosfora između bolesnika s OSA-om i kontrola. Zaključci: Nije bilo razlike u serumskim koncentracijama 25-dihidroksi vitamina D u OSA bolesnika i zdravim kontrolama, međutim serumske koncentracije 25-dihidroksi vitamina D bile su niske u obje skupine. Potrebna su daljnja istraživanja s većim brojem OSA pacijenata kako bi se istražio odnos između OSA-e i razine 25-dihidroksi vitamina D

PRINCIPLES AND METHODS OF CARTOGRAPHY IN TOURISM

A map is a document and an instrument of multidisciplinary significance, which, among other things, has a distinct functionality in the field of tourism. The article covers the principles and methods of mapping in tourism.The aim is to provide tourism workers with more precise information about the principles of cartographic expression, so that they are able to demand more appropriate requirements in the process of the immediate development of a specific tourist map. In this context, the inevitable cartographic elements, cartographic means of expression and the most appropriate cartographic methods for making a tourist map are emphasized. Some short remarks regarding the use of tourist maps are also included in the text.Key words: tourist map, cartographic mapping, cartographic expression

ДОЈРАНСКА КОТЛИНА

Во географската и сродна литература во Република Македонија, Дојранското Езеро и неговото непосредно опкружување вообичаено се проучува и презентира само делот кој административно политички припаѓа на Република Македонија. За покомплексно согледување на географските карактеристики на езерото и неговото сливно подрачје како проблем на проучување е поставена територијата на целата Дојранска Котлина, односно сливната површина на Дојранското Езеро

Trace elements in the soils and ashes of the plants Violla Alsharica and Thymus Alsharensis of the Alshar site-Macedonia

The paper presents detailed geochemical investigations carried out in part of the Alshar polymetallic depos it in terms of the presence of individual microlements in the s oils and plants such as Violla alsharica and Thymus alsharens is

Баба Планина со Пелистер - планинарско-туристичка карта Baba Mountain with Pelister - mountaineer-tourist map

Планинарско-туристичка карта mountaineer-tourist ma