The Physical Characteristics of the Small-Scale Interstellar Structure towards Mu Crucis

We present HST/GHRS echelle observations of multiple interstellar lines of CI, MgI, CrII, and ZnII towards both stars in the mu Cru binary system. Despite large differences in the profiles of the neutral species, no significant variations between the stars are seen in the CrII and ZnII line profiles. In particular, the ZnII absorption observed at -8.6 km/sec towards mu Cru is constant despite greatly enhanced columns of the neutral species at this velocity towards mu^1 Cru. An analysis of the fine-structure excitation of CI in this cloud implies that the density is n_H < 250 cm^{-3}. From the lack of variation in the (optical) NaI D2 line profiles towards mu^1 and mu^2 Cru in spectra taken 21 months apart, we can place a lower limit to the size of the structures of ~10 AU. These results are discussed in the context of recent radio and optical studies of apparently pervasive high density small-scale interstellar structure.Comment: 10 pages, 2 figures, to appear in the Astrophysical Journal (Letters

Reconstruction of cumulative daylight illumination fields from high dynamic range imaging: Theory, deployment and in-situ validation

A novel high-dynamic range (HDR) camera-based approach to measure the cumulative daylight dose in historic/conservation spaces has been devised and tested in a real-world setting under normal viewing conditions. The technique derives illuminance from the HDR-acquired luminance at numerous patches of the wall surfaces visible in the HDR image. These patches serve as proxy illuminance meters, thereby allowing the prevailing illumination field across the entire visible wall to be derived using a Kriging algorithm. The technique was validated under both controlled and in-situ conditions over periods of several months and shown to have comparable accuracy to the illuminance logging devices commonly used in historic/conservation settings. The set-up comprising a consumer digital camera and tethered computer proved remarkably resilient and allowed for continuous monitoring periods of six months or more. Application in a real-world setting revealed operational practicalities that would not have been found in a controlled environment.</div

New tools for managing daylight exposure of works of art: case study of Hambletonian, Mount Stewart, Northern Ireland

This paper describes a project to reduce the excessive daylight exposure of an oil painting, Hambletonian, Rubbing Down, displayed at Mount Stewart, Northern Ireland. Climate-­based daylight modelling (CBDM) was used to understand the light exposure of Hambletonian and to assess the impact of control measures on the annual light exposure and viewing condition of the painting in the winter months. The computer model was used in conjunction with measured lux data to establish the base case light exposure and the effect of the control measures. Light control was implemented through the use of darker paint finishes on the walls and ceiling, which reduced the amount of reflected light reaching Hambletonian;; and the addition of a mesh screen to the outside of the glazed dome above the painting. These interventions were cost-­effective and straightforward to implement and manage. CBDM suggests the interventions reduced Hambletonian’s annual daylight exposure from 3.5 mlxhr to 0.63 mlxhr

Illumination and conservation: a case study evaluation of daylight exposure for an artwork displayed in an historic building

This paper describes the application of climate-based daylight modelling to predict the annual daylight exposure received by an 18th century painting oil displayed on the Stone Staircase at Mount Stewart, near Belfast, Northern Ireland. The simulation predicted that the painting was receiving several times the recommended daylight exposure limit of 0.6 Mlux hrs for this type of artefact. The predictions were compared against the limited monitored data that were taken at the site. Notwithstanding the shortcomings of the monitored data, the agreement with simulation was sufficiently encouraging to allow recommendations to be made regarding interventions to help reduce the daylight exposure experienced by the painting

New developments in understanding daylight exposure in heritage interiors

This paper reports on an investigation into daylight exposure in National Trust (England, Wales and Northern Ireland) interiors. Developing a study of a top lit staircase at Mount Stewart, the focus of this research is the daylight performance of side lit rooms. The multistrand methodology involved: conventional use of light data loggers with a novel camera system based on high dynamic range (HDR) imaging; simulation using climate based daylight modelling (CBDM); and detailed recording of room use by staff. Although integrating this data has proved challenging, early results from both the simulation and the HDR system already provide insights into collections management practises for Trust staff

Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra

SummaryIn contrast to the well mapped molecular orchestration of circadian timekeeping in terrestrial organisms, the mechanisms that direct tidal and lunar rhythms in marine species are entirely unknown. Using a combination of biochemical and molecular approaches we have identified a series of metabolic markers of the tidal clock of the intertidal isopod Eurydice pulchra. Specifically, we show that the overoxidation of peroxiredoxin (PRX), a conserved marker of circadian timekeeping in terrestrial eukaryotes [1], follows a circatidal (approximately 12.4 hours) pattern in E. pulchra, in register with the tidal pattern of swimming. In parallel, we show that mitochondrially encoded genes are expressed with a circatidal rhythm. Together, these findings demonstrate that PRX overoxidation rhythms are not intrinsically circadian; rather they appear to resonate with the dominant metabolic cycle of an organism, regardless of its frequency. Moreover, they provide the first molecular leads for dissecting the tidal clockwork

Search for Interstellar Water in the Translucent Molecular Cloud toward HD 154368

We report an upper limit of 9 x 10^{12} cm-2 on the column density of water in the translucent cloud along the line of sight toward HD 154368. This result is based upon a search for the C-X band of water near 1240 \AA carried out using the Goddard High Resolution Spectrograph of the Hubble Space Telescope. Our observational limit on the water abundance together with detailed chemical models of translucent clouds and previous measurements of OH along the line of sight constrain the branching ratio in the dissociative recombination of H_3O+ to form water. We find at the $3\sigma$ level that no more than 30% of dissociative recombinations of H_3O+ can lead to H_2O. The observed spectrum also yielded high-resolution observations of the Mg II doublet at 1239.9 \AA and 1240.4 \AA, allowing the velocity structure of the dominant ionization state of magnesium to be studied along the line of sight. The Mg II spectrum is consistent with GHRS observations at lower spectral resolution that were obtained previously but allow an additional velocity component to be identified.Comment: Accepted by ApJ, uses aasp

High Throughput Discovery of Lightweight Corrosion-Resistant Compositionally Complex Alloys

Compositionally complex alloys hold the promise of simultaneously attaining superior combinations of properties such as corrosion resistance, light-weighting, and strength. Achieving this goal is a challenge due in part to a large number of possible compositions and structures in the vast alloy design space. High throughput methods offer a path forward, but a strong connection between the synthesis of a given composition and structure with its properties has not been fully realized to date. Here we present the rapid identification of light weight highly corrosion-resistant alloys based on combinations of Al and Cr in a Cantor-like base alloy (Al-Co-Cr-Fe-Ni). Previously unstudied alloy stoichiometries were identified using a combination of high throughput experimental screening coupled with key metallurgical and electrochemical corrosion tests, identifying alloys with excellent passivation behavior. Importantly, the electrochemical impedance modulus of the exposure-modified, air-formed film at the corrosion potential was found as an accurate non-destructive predictor of corrosion and passivation characteristics. Multi-element EXAFS analyses connected more ordered type chemical short range order in the Ni-Al 1st nn shell to poorer corrosion. This report underscores the utility of high throughput exploration of compositionally complex alloys for the identification and rapid screening of vast stoichiometric space

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial fluid was aspirated from inflamed joints of patients with inflammatory arthritis of duration 3 months or less, whose outcomes were subsequently determined by follow up. For comparison, synovial fluid was aspirated from patients with acute crystal arthritis, established RA and osteoarthritis. Rheumatoid factor activity was blocked in the synovial fluid samples, and a panel of 23 cytokines and chemokines measured using a multiplex based system. Patients with early inflammatory arthritis who subsequently developed RA had a distinct but transient synovial fluid cytokine profile. The levels of a range of T cell, macrophage and stromal cell related cytokines ( e. g. IL-2, IL-4, IL-13, IL-17, IL-15, basic fibroblast growth factor and epidermal growth factor) were significantly elevated in these patients within 3 months after symptom onset, as compared with early arthritis patients who did not develop RA. In addition, this profile was no longer present in established RA. In contrast, patients with non-rheumatoid persistent synovitis exhibited elevated levels of interferon-gamma at initiation. Early synovitis destined to develop into RA is thus characterized by a distinct and transient synovial fluid cytokine profile. The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA

Pressed for Space: The Effects of Justification and the Printing Process on Fifteenth-Century Orthography

There is a long-held belief that, prior to the standardisation of written English, printers altered spellings to justify their type. I investigate this claim through an analysis of spelling changes in William Caxton’s two editions of the Canterbury Tales—by examining text within one book, written by one author, and set by one compositor, the only difference between the sections of verse and the sections of prose should be the requirement for justification within the latter. Were the compositors altering spellings to justify their type, we would expect to see a greater number of altered spellings in the prose sections of text. This is not what the results of this study show—instead there is no statistically significant difference between the frequency of spelling changes in justified and non-justified text. However, there is a significantly higher number of abbreviations introduced into the justified text. These results suggest that the compositor of Caxton’s second edition Canterbury Tales did not change spellings to justify his type