53 research outputs found
Study of the Effect of a Closed-End Side Branch on Sinusoidally Perturbed Flow of Liquid in a Line
Classical undamped acoustic-wave theory was used to determine analytical relations among sinusoidal perturbations of pressure and flow at the ends of a hydraulic-transmission line having a closed-end branch of arbitrary length attached at an arbitrary point. Experimental data were obtained for the equilateral case (a branch half as long as the main line connected to the main line at the midpoint) at mean flow speeds of 5 to 10 feet per second. Measured pressure-perturbation ratios agreed closely with analytical predictions. As frequencies for which the branch length was an odd multiple of 1/4 wavelength, waves in the main line were almost completely reflected at the junction point
The Vehicle, Fall 1970
Vol. 13, No. 1
Table of Contents
A Thought Written in a Locked RoomJudy Huntpage 1
The Eggshell MoonWilliam Probeckpage 2
PoemBarb Parkerpage 3
4/5, May, 1970J. Michael Sainpage 5
A TreeRichard Stickannpage 6
both or noneMichelle Hallpage 6
The TrainSteve Sestinapage 8
Attempted DiscoveryDonald R. Johnsonpage 16
Island of SmokeVerna L. Jonespage 18
AwakeRobert Bladepage 19
PoemMary Klinkerpage 19
In ChurchMuriel Poolpage 21
PoemBarb Parkerpage 21
PoemMichelle Hallpage 22
Pod\u27nerVerna L. Jonespage 23
Rain and Other ThingsCarol Staniecpage 24
PoemAnn Graffpage 24
Examination of StudentdomMelvin Zaloudekpage 26
Women\u27s LiberationTonya Mortonpage 27
Morning Reflections on the Evening NewsPrudence Herberpage 29
Art and Photography Credits
Jim Diaspage 4
Mike Dorseypages 7, 20
David Griffithpages 8, 17, 25
Cover PhotographyMark McKinneyhttps://thekeep.eiu.edu/vehicle/1024/thumbnail.jp
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NACA Research Memorandums
Memorandum presenting an investigation conducted in the icing research tunnel to determine the icing characteristics, the effects of icing on radar operation, and the protection requirements for two radome configurations. The radomes were for the F-89 airplane and were investigated at airspeeds up to 290 miles per hour, air total temperatures from -15 to 20 degrees Fahrenheit, water contents up to 1.0 gram per cubic meter, and angles of attack of 0 and 4 degrees
Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1
Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1
Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: an analysis of 10 549 patients from the International Myeloma Working Group
Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: An analysis of 10 549 patients from the International Myeloma Working Group
We analyzed the presenting features and survival in 1689 patients with multiple myeloma aged younger than 50 years compared with 8860 patients 50 years of age and older. Of the total 10 549 patients, 7765 received conventional therapy and 2784 received high-dose therapy. Young patients were more frequently male, had more favorable features such as low International Staging System (ISS) and Durie-Salmon stage as well as less frequently adverse prognostic factors including high C-reactive protein (CRP), low hemoglobin, increased serum creatinine, and poor performance status. Survival was significantly longer in young patients (median, 5.2 years vs 3.7 years; P< .001) both after conventional (median, 4.5 years vs 3.3 years; P < .001) or high-dose therapy (median, 7.5 years vs 5.7 years; P = .04). The 10-year survival rate was 19% after conventional therapy and 43% after high-dose therapy in young patients, and 8% and 29%, respectively, in older patients. Multivariate analysis revealed age as an independent risk factor during conventional therapy, but not after autologous transplantation. A total of 5 of the 10 independent risk factors identified for conventional therapy were also relevant for autologous transplantation. After adjusting for normal mortality, lower ISS stage and other favorable prognostic features seem to account for the significantly longer survival of young patients with multiple myeloma with age remaining a risk factor during conventional therapy
The importance of bone marrow examination in determining complete response to therapy in patients with multiple myeloma
The current definition of complete response in multiple myeloma includes a requirement for a bone marrow (BM) examination showing less than 5% plasma cells in addition to negative serum and urine immunofixation. There have been suggestions to eliminate the need for BM examinations when defining complete response. We evaluated 92 patients with multiple myeloma who achieved negative immunofixation in the serum and urine after therapy and found that 14% had BM plasma cells more than or equal to 5%. Adding a requirement for normalization of the serum-free light chain ratio to negative immunofixation studies did not negate the need for BM studies; 10% with a normal serum-free light chain ratio had BM plasma cells more than or equal to 5%. We also found that, on achieving immunofixation-negative status, patients with less than 5% plasma cells in the BM had improved overall survival compared with those with 5% or more BM plasma cells (6.2 years vs 2.3 years, respectively; P = .01)
Novel approaches for reducing free light chains in patients with myeloma kidney
Myeloma kidney is a tubulointerstitial pathology that accounts for
approximately 80-90% of severe acute kidney injury in patients with
multiple myeloma. Unless there is rapid intervention, progressive
irreversible damage from interstitial fibrosis and tubular atrophy
occurs. Work over the past decade has demonstrated that an early
sustained reduction in serum concentrations of pathogenic monoclonal
free light chains (FLCs) leads to improved renal recovery rates. In
turn, an early improvement in renal function is associated with improved
patient survival. An early reduction in FLC levels should therefore
become standard of care, although the optimum mechanisms to achieve this
depletion of FLCs remain to be determined. To provide a coordinated,
cross-disciplinary approach to research in this disease, the
International Kidney and Monoclonal Gammopathy Research Group was
formed. In this Review, we address the current state of knowledge in the
management of myeloma kidney
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