Stakeholder involvement in wastewater treatment design

The design option appraisal stage of new water industry capital investment projects involve greater levels of complexity than those generally encountered in other stages of the design process. It is at this stage that the issues related to sustainable development will be introduced, as decisions are multi-stakeholder and therefore decision criteria that reflect the views of a wide range of stakeholders with a range of different viewpoints need to be incorporated. This paper describes a case study which maps information flows, identifies decision criteria and evaluates the extent of stakeholder involvement in the design stage of a major UK wastewater system project. A mapping technique was developed to document and represent the flow of information during the decision making process. An in-depth study of the information flows enabled the researchers to establish the extent to which sustainability criteria were actually used. This was compared with recognised sustainability criteria identified in previous research involving the authors to allow an assessment of the effectiveness of stakeholder representation. Recommendations are given regarding ways of improving stakeholder involvement in water industry asset investment decisions

The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK)

Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid assessment of intervention efficacy. Conversely, clinical arenas are open systems where factors relating to context, resources, interpretation and actions of individuals will affect implementation and effectiveness of interventions. Consequently, the comparator (usual care) can be difficult to define and variable in multi-centre trials. Hence outcomes cannot be understood without considering usual care and factors that may affect implementation and impact on the intervention. Methods: Using a fieldwork approach, we describe PICU context, ‘usual’ practice in sedation and weaning from mechanical ventilation, and factors affecting implementation prior to designing a trial involving a sedation and ventilation weaning intervention. We collected data from 23 UK PICUs between June and November 2014 using observation, individual and multi-disciplinary group interviews with staff. Results: Pain and sedation practices were broadly similar in terms of drug usage and assessment tools. Sedation protocols linking assessment to appropriate titration of sedatives and sedation holds were rarely used (9 % and 4 % of PICUs respectively). Ventilator weaning was primarily a medical-led process with 39 % of PICUs engaging senior nurses in the process: weaning protocols were rarely used (9 % of PICUs). Weaning methods were variably based on clinician preference. No formal criteria or use of spontaneous breathing trials were used to test weaning readiness. Seventeen PICUs (74 %) had prior engagement in multi-centre trials, but limited research nurse availability. Barriers to previous trial implementation were intervention complexity, lack of belief in the evidence and inadequate training. Facilitating factors were senior staff buy-in and dedicated research nurse provision. Conclusions: We examined and identified contextual and organisational factors that may impact on the implementation of our intervention. We found usual practice relating to sedation, analgesia and ventilator weaning broadly similar, yet distinctively different from our proposed intervention, providing assurance in our ability to evaluate intervention effects. The data will enable us to develop an implementation plan; considering these factors we can more fully understand their impact on study outcomes

Exfiltration from sewers - is it a serious problem?

This paper contends that estimates of exfiltration leakage from sewers, and the problems arising from it may be too high due to an underestimation of the “self-repairing” action of sewage and sewage sediments in raw sewage. Two aspects of a continuing programme of research are reported;(i) the measurement of exfiltration rates from a range of defects in a sewer pipe with pipe bedding effects simulated by a dry gravel trench surround to the pipe, and (ii) an assessment of the persistence of pathogens in the gravel and soil beneath the test rig pipe, using coliforms as a biological indicator. The results show that the introduction of a gravel surround resulted in more rapid and effective sealing across the entire range of defects tested compared to previously performed experiments with the defects discharging to air. Complete sealing eventually occurred on every run for a 10 mm x 10 mm defect situated at the invert of the sewer and the lowest recorded levels in each experiment for a 10 mm wide radial defect were of the order 10-3 to 10-4 ls-1. These results have been scaled-up to estimate leakage rates in lengths of sewers and sub-catchments and levels significantly lower than previously estimated are indicated. Additionally, the pilot experiment to investigate the fate of biological contaminants in the exfiltrate suggests rapid reduction in microorganisms levels beneath the sewer pipe

Tax Professional Internships And Subsequent Professional Performance

How do internships influence the socialization and performance of accounting students employed in the tax department of a CPA firm?  Previous research on accounting internships primarily focuses on auditing personnel.  There is evidence in the literature that indicates audit and tax professionals have different work cultures.  This paper examines the relationship between internships and subsequent professional performance of tax professionals as measured by promotion velocity and employee turnover.  The human resource department, from seven regional CPA firms with similarly structured internship programs, provided performance, promotion and turnover data on employees who completed internships and employees who did not complete internships.  The results of the study indicate that internships positively affect performance evaluations, promotions, and employee retention of tax professionals

Streaming and 3D mapping of agri-data on mobile devices

Farm monitoring and operations generate heterogeneous AGRI-data from a variety of different sources that have the potential to be delivered to users ‘on the go’ and in the field to inform farm decision making. A software framework capable of interfacing with existing web mapping services to deliver in-field farm data on commodity mobile hardware was developed and tested. This raised key research challenges related to: robustness of data steaming methods under typical farm connectivity scenarios, and mapping and 3D rendering of AGRI-data in an engaging and intuitive way. The presentation of AGRI-data in a 3D and interactive context was explored using different visualisation techniques; currently the 2D presentation of AGRI- data is the dominant practice, despite the fact that mobile devices can now support sophisticated 3D graphics via programmable pipelines. The testing found that WebSockets were the most reliable streaming method for high resolution image/texture data. From our focus groups there was no single visualisation technique that was preferred demonstrating that a range of methods is a good way to satisfy a large user base. Improved 3D experience on mobile phones is set to revolutionize the multimedia market and a key challenge is identifying useful 3D visualisation methods and navigation tools that support the exploration of data driven 3D interactive visualisation frameworks for AGRI-data

Spin flip from dark to bright states in InP quantum dots

We report measurements of the time for spin flip from dark (non-light emitting) exciton states in quantum dots to bright (light emitting) exciton states in InP quantum dots. Dark excitons are created by two-photon excitation by an ultrafast laser. The time for spin flip between dark and bright states is found to be approximately 200 ps, independent of density and temperature below 70 K. This is much shorter than observed in other quantum dot systems. The rate of decay of the luminescence intensity, approximately 300 ps, is not simply equal to the radiative decay rate from the bright states, because the rate of decay is limited by the rate of conversion from dark excitons into bright excitons. The dependence of the luminescence decay time on the spin flip time is a general effect that applies to many experiments.Comment: 3 figure

Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea.

The HerA ATPase cooperates with the NurA nuclease and the Mre11-Rad50 complex for the repair of double-strand DNA breaks in thermophilic archaea. Here we extend our structural knowledge of this minimal end-resection apparatus by presenting the first crystal structure of hexameric HerA. The full-length structure visualizes at atomic resolution the N-terminal HerA-ATP synthase domain and a conserved C-terminal extension, which acts as a physical brace between adjacent protomers. The brace also interacts in trans with nucleotide-binding residues of the neighbouring subunit. Our observations support a model in which the coaxial interaction of the HerA ring with the toroidal NurA dimer generates a continuous channel traversing the complex. HerA-driven translocation would propel the DNA towards the narrow annulus of NurA, leading to duplex melting and nucleolytic digestion. This system differs substantially from the bacterial end-resection paradigms. Our findings suggest a novel mode of DNA-end processing by this integrated archaeal helicase-nuclease machine.The SAXS data collection was supported by funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under BioStruct-X (grant agreement N°283570). Research in the N.P.R. laboratory is funded by the Medical Research Council [Career Development Award G0701443]. Research in the L.P. laboratory is funded by a Wellcome Trust Senior Fellowship Award in Basic Biomedical Sciences [grant number 08279/Z/07/Z]. Work in the L.P. and N.P.R. laboratories is also supported by an Isaac Newton Trust Research Grant, and S.M.B. is supported by a BBSRC Doctoral Training Grant.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ncomms650